IL156380A0 - Tir taste receptors and genes encoding same - Google Patents
Tir taste receptors and genes encoding sameInfo
- Publication number
- IL156380A0 IL156380A0 IL15638002A IL15638002A IL156380A0 IL 156380 A0 IL156380 A0 IL 156380A0 IL 15638002 A IL15638002 A IL 15638002A IL 15638002 A IL15638002 A IL 15638002A IL 156380 A0 IL156380 A0 IL 156380A0
- Authority
- IL
- Israel
- Prior art keywords
- methods
- taste
- genes
- receptors
- mammal
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Physiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25922701P | 2001-01-03 | 2001-01-03 | |
US28454701P | 2001-04-19 | 2001-04-19 | |
PCT/US2002/000198 WO2002064631A2 (en) | 2001-01-03 | 2002-01-03 | T1r taste receptors and genes encoding same |
Publications (1)
Publication Number | Publication Date |
---|---|
IL156380A0 true IL156380A0 (en) | 2004-01-04 |
Family
ID=26947173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15638002A IL156380A0 (en) | 2001-01-03 | 2002-01-03 | Tir taste receptors and genes encoding same |
Country Status (15)
Country | Link |
---|---|
US (16) | US7241880B2 (zh) |
EP (2) | EP1430083B1 (zh) |
JP (2) | JP5411400B2 (zh) |
CN (2) | CN1525981B (zh) |
AT (2) | ATE554100T1 (zh) |
AU (2) | AU2002251734B2 (zh) |
CA (1) | CA2433514C (zh) |
DE (1) | DE60228741D1 (zh) |
DK (2) | DK1985630T3 (zh) |
ES (2) | ES2385383T3 (zh) |
IL (1) | IL156380A0 (zh) |
MX (1) | MXPA03005989A (zh) |
NO (1) | NO20033030L (zh) |
TW (1) | TW201022287A (zh) |
WO (1) | WO2002064631A2 (zh) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7402400B2 (en) | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
TW201006846A (en) * | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
WO2001098323A2 (en) * | 2000-06-16 | 2001-12-27 | Incyte Genomics, Inc. | G-protein coupled receptors |
TW201022287A (en) * | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
US7763431B1 (en) | 2001-03-07 | 2010-07-27 | Senomyx, Inc. | Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste |
US7301009B2 (en) | 2001-06-26 | 2007-11-27 | Senomyx, Inc. | Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli |
US7368285B2 (en) * | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
US20080244761A1 (en) * | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
US7309577B2 (en) * | 2001-03-07 | 2007-12-18 | Senomyx, Inc. | Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste |
US6955887B2 (en) | 2001-03-30 | 2005-10-18 | Senomyx, Inc. | Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling |
IL158488A0 (en) * | 2001-04-20 | 2004-05-12 | Sinai School Medicine | Tir3 a novel taste receptor |
US7803982B2 (en) | 2001-04-20 | 2010-09-28 | The Mount Sinai School Of Medicine Of New York University | T1R3 transgenic animals, cells and related methods |
EP1412750B1 (en) * | 2001-06-26 | 2012-05-23 | Senomyx, Inc. | T1r2-t1r3 hetero-oligomeric sweet taste receptors and cell lines that express said receptors and use thereof for identification of sweet taste compounds |
DK2327985T3 (en) * | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
AU2007203680B8 (en) * | 2001-06-26 | 2010-07-08 | Senomyx, Inc. | T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
WO2003004992A2 (en) | 2001-07-03 | 2003-01-16 | The Regents Of The University Of California | Mammalian sweet and amino acid heterodimeric taste receptors |
AU2002329196B2 (en) | 2001-07-06 | 2008-08-07 | Senomyx, Inc. | Human olfactory nucleotide-gated ion channels |
AU2002336571A1 (en) | 2001-09-18 | 2003-04-01 | Irm, Llc | Sweet taste receptors |
US7527944B2 (en) | 2003-06-27 | 2009-05-05 | Monell Chemical Senses Center | Taste receptors of the T1R family from domestic cat |
RU2006106920A (ru) | 2003-08-06 | 2007-09-20 | Синомикс Инк. (Us) | Гетеро-олигомерные вкусовые рецепторы t1r, клеточные линии, которые экспрессируют указанные рецепторы и вкусовые соединения |
US20050106571A1 (en) | 2003-10-02 | 2005-05-19 | The Regents Of The University Of California | Mammalian T1R3 sweet taste receptors |
EP1753864A2 (en) | 2004-04-14 | 2007-02-21 | Monell Chemical Senses Center | Taste receptors of the t1r family from domestic dog |
US8017334B2 (en) * | 2004-06-28 | 2011-09-13 | Nihon University | Method for testing dysgeusia or stress by comparing expression patterns of taste receptor genes |
US20060045953A1 (en) * | 2004-08-06 | 2006-03-02 | Catherine Tachdjian | Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers |
US20060263476A1 (en) * | 2004-08-25 | 2006-11-23 | Cadbury Adams Usa, Llc. | Center-filled chewing gum with barrier layer |
WO2006068745A1 (en) | 2004-12-22 | 2006-06-29 | Cargill, Incorporated | Methods for determining cellular response to stimuli |
US20060257543A1 (en) * | 2005-02-04 | 2006-11-16 | Catherine Tachdjian | Molecules comprising linked organic moieties as flavor modifiers for comestible compositions |
MX2007009388A (es) * | 2005-02-04 | 2007-09-25 | Senomyx Inc | Compuestos que comprenden porciones heteroarilo unidas y su uso como modificadores del sabor unami, saborizantes y mejoradores del sabor para composiciones comestibles. |
US8796441B2 (en) | 2005-04-13 | 2014-08-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human sweet and umami taste receptor variants |
WO2006127935A1 (en) | 2005-05-23 | 2006-11-30 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
US7851006B2 (en) * | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
CN101179943B (zh) | 2005-05-23 | 2013-06-26 | 卡夫食品环球品牌有限责任公司 | 填充液体的咀嚼型胶基糖组合物 |
US7851005B2 (en) * | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
TW200715993A (en) * | 2005-06-15 | 2007-05-01 | Senomyx Inc | Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers |
KR101356892B1 (ko) * | 2006-04-20 | 2014-01-28 | 지보당 에스아 | 미각자극물질을 동정하는 기능적인 방법 |
EP2047254B1 (en) | 2006-04-20 | 2015-10-28 | Givaudan SA | Method relating to sweetness enhancement |
US20110097741A1 (en) * | 2006-04-20 | 2011-04-28 | Jay Patrick Slack | Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays |
DK3235811T3 (en) | 2006-04-21 | 2018-11-12 | Senomyx Inc | PROCEDURE FOR THE PREPARATION OF OXALAMIDS |
WO2007146120A2 (en) * | 2006-06-08 | 2007-12-21 | Senomyx, Inc. | Rationale, methods, and assays for identifying novel taste cell genes and salty taste receptor targets and assays using these identified genes or gene products |
WO2008008224A2 (en) * | 2006-07-10 | 2008-01-17 | Duke University | Sour taste receptor compositions and methods |
US20080026416A1 (en) * | 2006-07-27 | 2008-01-31 | Harish Radhakrishna | Model Taste Cells and Methods of Use for Identifying Modulators of Taste Sensation |
US8039233B2 (en) * | 2007-01-18 | 2011-10-18 | Givaudan S.A. | Nucleic acid sequences and their use in methods to identify umami modulatiors |
JP5465656B2 (ja) | 2007-03-30 | 2014-04-09 | ジボダン エス エー | 調節物質を同定するための方法 |
US8633186B2 (en) | 2007-06-08 | 2014-01-21 | Senomyx Inc. | Modulation of chemosensory receptors and ligands associated therewith |
US9603848B2 (en) * | 2007-06-08 | 2017-03-28 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
AU2013202912B2 (en) * | 2007-06-08 | 2016-10-27 | Firmenich Incorporated | Modulation of chemosensory receptors and ligands associated therewith |
WO2008153924A2 (en) * | 2007-06-08 | 2008-12-18 | Senomyx, Inc. | Rationale, methods, and assays for identifying human and non-human primate taste specific genes and use thereof in taste modulator and therapeutic screening assays |
US7928111B2 (en) * | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
GB0713297D0 (en) * | 2007-07-10 | 2007-08-15 | Cadbury Schweppes Plc | Chocolate compositions having improved flavour characteristics |
US20110003711A1 (en) * | 2008-02-01 | 2011-01-06 | Chromocell Corporation | Cell lines expressing gaba receptor and methods using them |
EP2093234A1 (en) | 2008-02-08 | 2009-08-26 | Nutrinova Nutrition Specialties & Food Ingredients GmbH | Oligopeptides for use as taste modulators |
TWI429404B (zh) | 2008-03-03 | 2014-03-11 | Senomyx Inc | 異山梨醇衍生物及彼等作為風味改良劑、促味劑及促味增強劑之用途 |
RU2618868C2 (ru) | 2008-05-27 | 2017-05-11 | Дако Денмарк А/С | Композиции и способы определения хромосомных аберраций с новыми буферами для гибридизации |
MX2011001155A (es) | 2008-07-31 | 2011-07-29 | Senomyx Inc | Composiciones que comprenden mejoradores del dulzor, y métodos para prepararlas. |
WO2010014666A2 (en) | 2008-07-31 | 2010-02-04 | Senomyx, Inc. | Processes and intermediates for making sweet taste enhancers |
EP2391711B1 (en) * | 2009-02-02 | 2015-04-08 | Chromocell Corporation | Novel cell lines and methods |
EP2401396B1 (en) | 2009-02-26 | 2016-11-23 | Dako Denmark A/S | Methods for performing a stringent wash step in hybridization applications |
CA2781907C (en) * | 2009-12-02 | 2019-07-16 | Dako Denmark A/S | Compositions and methods for performing hybridizations with no denaturation |
MY175079A (en) | 2010-04-02 | 2020-06-04 | Firmenich Incorporated | Sweet flavor modifier |
SG184962A1 (en) | 2010-05-07 | 2012-11-29 | Givaudan Sa | Methods to identify modulators of tas2r4s receptors |
SG184960A1 (en) | 2010-05-07 | 2012-11-29 | Givaudan Sa | Methods to identify modulators |
EP2603098A4 (en) | 2010-08-12 | 2018-01-17 | Senomyx, Inc. | Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
WO2012149088A1 (en) | 2011-04-29 | 2012-11-01 | Kraft Foods Global Brands Llc | Encapsulated acid, method for the preparation thereof, and chewing gum comprising same |
EP2742350B1 (en) | 2011-08-08 | 2019-10-30 | The Coca-Cola Company | Cell lines comprising endogenous taste receptors and their uses |
MY179876A (en) | 2011-08-12 | 2020-11-18 | Firmenich Incorporated | Sweet flavor modifier |
US10662465B2 (en) | 2011-09-30 | 2020-05-26 | Agilent Technologies, Inc. | Hybridization compositions and methods using formamide |
US11118226B2 (en) | 2011-10-21 | 2021-09-14 | Agilent Technologies, Inc. | Hybridization compositions and methods |
US9404080B2 (en) | 2012-04-25 | 2016-08-02 | B.R.A.I.N. Biotechnology Research And Information Network Ag | Human taste cells capable of continuous proliferation |
US10314492B2 (en) | 2013-05-23 | 2019-06-11 | Medibotics Llc | Wearable spectroscopic sensor to measure food consumption based on interaction between light and the human body |
US9442100B2 (en) | 2013-12-18 | 2016-09-13 | Medibotics Llc | Caloric intake measuring system using spectroscopic and 3D imaging analysis |
US9042596B2 (en) | 2012-06-14 | 2015-05-26 | Medibotics Llc | Willpower watch (TM)—a wearable food consumption monitor |
US9536449B2 (en) | 2013-05-23 | 2017-01-03 | Medibotics Llc | Smart watch and food utensil for monitoring food consumption |
US9254099B2 (en) | 2013-05-23 | 2016-02-09 | Medibotics Llc | Smart watch and food-imaging member for monitoring food consumption |
US9456916B2 (en) | 2013-03-12 | 2016-10-04 | Medibotics Llc | Device for selectively reducing absorption of unhealthy food |
BR112015002380B1 (pt) | 2012-08-06 | 2021-09-28 | Firmenich Incorporated | Composto, composições ingeríveis, processos para aumentar o sabor doce de composição e formulação flavorizante concentrada |
JO3155B1 (ar) | 2013-02-19 | 2017-09-20 | Senomyx Inc | معدِّل نكهة حلوة |
US9011365B2 (en) | 2013-03-12 | 2015-04-21 | Medibotics Llc | Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food |
US9067070B2 (en) | 2013-03-12 | 2015-06-30 | Medibotics Llc | Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type |
US9804157B1 (en) | 2013-03-15 | 2017-10-31 | Senomyx, Inc. | Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives |
US9529385B2 (en) | 2013-05-23 | 2016-12-27 | Medibotics Llc | Smart watch and human-to-computer interface for monitoring food consumption |
JP6755640B2 (ja) | 2014-03-28 | 2020-09-16 | 味の素株式会社 | 甘味受容体キメラタンパク質及びその利用 |
JP6339432B2 (ja) * | 2014-07-16 | 2018-06-06 | オリンパス株式会社 | 細胞観察情報処理システム、細胞観察情報処理方法、細胞観察情報処理プログラム |
MX2017005931A (es) | 2014-11-07 | 2017-06-30 | Senomyx Inc | Acidos 4-amino-5- (ciclohexiloxi) quinolina-3-carboxilicos sustituidos como modificadores del sabor dulce. |
JP6383704B2 (ja) * | 2015-07-02 | 2018-08-29 | 日立オートモティブシステムズ株式会社 | 電池制御装置 |
WO2017030862A1 (en) * | 2015-08-20 | 2017-02-23 | Monell Chemical Senses Center | Method of modulating fat taste perception |
CN107513505A (zh) * | 2017-10-17 | 2017-12-26 | 北京理工大学 | 一种高效检测甜味强度的工程化酵母生物系统及其应用 |
CN108611324A (zh) * | 2018-05-07 | 2018-10-02 | 云南中烟工业有限责任公司 | 一种稳定共表达重组人源甜味受体蛋白的真核细胞系及其制备方法 |
MX2021001193A (es) | 2018-08-07 | 2021-04-28 | Firmenich Incorporated | 2,2-dioxidos de 4-amino-1h-benzo[c][1,2,6]tiadiazina 5-sustituidos y formulaciones y usos de los mismos. |
WO2021150686A1 (en) | 2020-01-22 | 2021-07-29 | Firmenich Incorporated | High-sensitivity detection of gpcr activity and uses thereof |
WO2023243495A1 (ja) * | 2022-06-16 | 2023-12-21 | 花王株式会社 | Gタンパク質共役型受容体の解析方法 |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US243770A (en) | 1881-07-05 | Holder for grinding tools | ||
JPS5825980B2 (ja) | 1976-02-12 | 1983-05-31 | ヤマサ醤油株式会社 | サイクリックヌクレオチドの定量法 |
US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
DE69034135T3 (de) | 1989-12-22 | 2012-08-23 | Laboratoires Serono S.A. | DNS-Konstrukten zur Aktivierung und Veränderung der Expression von endogenen Genen |
WO1991012650A1 (fr) | 1990-02-09 | 1991-08-22 | Asulab S.A. | Micromoteur electrostatique a champ radial realise par microfabrication photolithographique et procede de realisation d'un tel micromoteur |
AU8066591A (en) * | 1990-05-14 | 1991-12-10 | Duke University | Cloned genes encoding the d1 dopamine receptor |
IE66205B1 (en) | 1990-06-14 | 1995-12-13 | Paul A Bartlett | Polypeptide analogs |
US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
WO1992017585A1 (en) | 1991-04-05 | 1992-10-15 | The Trustees Of Columbia University In The City Of New York | Odorant receptors ans uses thereof |
US6008011A (en) * | 1991-10-31 | 1999-12-28 | Whitehead Institute For Biomedical Research | TGF-β type II receptor cDNAs |
US6270989B1 (en) | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
PT101031B (pt) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
US5968817A (en) * | 1993-03-15 | 1999-10-19 | The Scripps Research Institute | DNA encoding serotonin receptors |
US6664107B1 (en) | 1993-05-26 | 2003-12-16 | Ontario Cancer Institute, University Health Network | CD45 disrupted nucleic acid |
US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
US6228610B1 (en) * | 1993-09-20 | 2001-05-08 | Novartis Corporation | Human metabotropic glutamate receptor subtypes (hmR4, hmR6, hmR7) and related DNA compounds |
IL108205A0 (en) | 1993-12-28 | 1994-04-12 | Yeda Res & Dev | Olfactory genes and receptors |
US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
US5691188A (en) | 1994-02-14 | 1997-11-25 | American Cyanamid Company | Transformed yeast cells expressing heterologous G-protein coupled receptor |
US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
US5716835A (en) * | 1994-05-05 | 1998-02-10 | Allergan, Inc. | Nucleic acid encoding a novel human EP prostaglandin receptor |
US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
EP0831854A4 (en) | 1995-06-06 | 2001-01-24 | Isis Pharmaceuticals Inc | OLIGONUCLEOTIDS WITH PHOSPHOROTHIOATE BINDINGS OF HIGH CHIRAL PURITY |
EP2258726A1 (en) | 1995-06-14 | 2010-12-08 | The Regents of the University of California | High affinity human antibodies to c-erbB-2 |
US5985662A (en) | 1995-07-13 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense inhibition of hepatitis B virus replication |
AU1118197A (en) | 1995-11-09 | 1997-05-29 | Johns Hopkins University School Of Medicine, The | Novel sperm receptors |
US5874243A (en) | 1997-03-28 | 1999-02-23 | Smithkline Beecham Corporation | OLRCC15 receptor |
US5993778A (en) * | 1997-05-07 | 1999-11-30 | Firestein; Stuart J. | Functional expression of, and assay for, functional cellular receptors in vivo |
FR2780405B1 (fr) | 1998-06-25 | 2001-12-28 | Centre Nat Rech Scient | Nouveaux recepteurs olfactifs et leurs utilisations |
KR100643622B1 (ko) | 1998-07-28 | 2006-11-10 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 감각 정보 전달과 관련된 g-단백질 커플링된 수용체를암호화하는 핵산 |
US7402400B2 (en) | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
KR20010085308A (ko) * | 1998-07-28 | 2001-09-07 | 린다 에스. 스티븐슨 | 감각 정보전달에 관여하는 단백질 암호 핵산 |
JP2002521049A (ja) | 1998-07-28 | 2002-07-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 感覚伝達に関与するgタンパク質共役型レセプターをコードする核酸 |
DE19839359C2 (de) * | 1998-08-28 | 2000-07-27 | Jost Werke Ag | Stützvorrichtung |
JP4139565B2 (ja) | 1998-10-29 | 2008-08-27 | 株式会社荏原製作所 | Pfc系ガス回収方法及び装置 |
US6106555A (en) | 1998-12-15 | 2000-08-22 | Av Healing Llc | Method for tissue fixation |
WO2000038536A2 (en) * | 1998-12-23 | 2000-07-06 | Mount Sinai School Of Medicine Of New York University | Inhibitors of the bitter taste response |
US6439990B1 (en) * | 1999-05-02 | 2002-08-27 | Hitec Co., Ltd. | Method and apparatus for manufacturing chain-like food products such as sausages or the like |
EP1214343A2 (en) * | 1999-09-10 | 2002-06-19 | The Regents Of The University Of California | T2r taste receptor family |
US6558910B2 (en) * | 1999-09-10 | 2003-05-06 | The Regents Of The University Of California | SF, a novel family of taste receptors |
US20030036089A1 (en) * | 1999-12-20 | 2003-02-20 | Applera Corporation | Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof |
EP2143796A3 (en) | 2000-02-29 | 2010-03-17 | Millennium Pharmaceuticals, Inc. | 1983, 52881, 2398, 45449, 50289, and 52872, G protein-coupled receptors and uses therefor |
TW201006846A (en) | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
US6608176B2 (en) * | 2000-03-31 | 2003-08-19 | University Of Miami | Taste receptor for umami (monosodium glutamate) taste |
CA2403003A1 (en) * | 2000-04-07 | 2001-10-18 | Senomyx, Inc. | T2r taste receptors and genes encoding same |
AU2001255681A1 (en) * | 2000-04-28 | 2001-11-12 | The Monell Chemical Senses Center | Gene and sequence variation associated with sensing carbohydrate compounds and other sweeteners |
WO2001098323A2 (en) * | 2000-06-16 | 2001-12-27 | Incyte Genomics, Inc. | G-protein coupled receptors |
AU2002213409A1 (en) | 2000-10-30 | 2002-05-15 | Senomyx, Inc. | Galphaqproetin variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors |
TW201022287A (en) * | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
US7368285B2 (en) | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
US6955887B2 (en) * | 2001-03-30 | 2005-10-18 | Senomyx, Inc. | Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling |
US20080244761A1 (en) | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
US7301009B2 (en) | 2001-06-26 | 2007-11-27 | Senomyx, Inc. | Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli |
US7763431B1 (en) | 2001-03-07 | 2010-07-27 | Senomyx, Inc. | Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste |
US7309577B2 (en) * | 2001-03-07 | 2007-12-18 | Senomyx, Inc. | Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste |
EP1412750B1 (en) | 2001-06-26 | 2012-05-23 | Senomyx, Inc. | T1r2-t1r3 hetero-oligomeric sweet taste receptors and cell lines that express said receptors and use thereof for identification of sweet taste compounds |
DK2327985T3 (en) | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
WO2003004992A2 (en) | 2001-07-03 | 2003-01-16 | The Regents Of The University Of California | Mammalian sweet and amino acid heterodimeric taste receptors |
US7022488B2 (en) * | 2003-02-03 | 2006-04-04 | Senomyx, Inc. | Functional coupling of T1Rs and T2Rs by Gi proteins, and cells-based assays for the identification of T1R and T2R modulators |
AU2002336571A1 (en) | 2001-09-18 | 2003-04-01 | Irm, Llc | Sweet taste receptors |
US7208290B2 (en) * | 2001-12-14 | 2007-04-24 | Senomyx, Inc. | Methods of co-expressing umami taste receptors and chimeric Gα15 variants |
FR2852463B1 (fr) * | 2003-03-11 | 2005-05-06 | Convertisseur tension/tension | |
US7906627B2 (en) | 2003-08-06 | 2011-03-15 | Senomyx, Inc. | Chimeric human sweet-umami and umami-sweet taste receptors |
RU2006106920A (ru) | 2003-08-06 | 2007-09-20 | Синомикс Инк. (Us) | Гетеро-олигомерные вкусовые рецепторы t1r, клеточные линии, которые экспрессируют указанные рецепторы и вкусовые соединения |
US20050106571A1 (en) * | 2003-10-02 | 2005-05-19 | The Regents Of The University Of California | Mammalian T1R3 sweet taste receptors |
US20060045953A1 (en) | 2004-08-06 | 2006-03-02 | Catherine Tachdjian | Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers |
US7303866B2 (en) * | 2004-10-19 | 2007-12-04 | Thanos D. Halazonetis | Methods of identifying an agent that modulates an interaction between 53BP1 and histone H3, and uses thereof |
US7435522B2 (en) * | 2005-03-31 | 2008-10-14 | Xerox Corporation | Carrier compositions |
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