MXPA03005989A - Receptores de sabor t1r y genes para su codificacion. - Google Patents

Receptores de sabor t1r y genes para su codificacion.

Info

Publication number
MXPA03005989A
MXPA03005989A MXPA03005989A MXPA03005989A MXPA03005989A MX PA03005989 A MXPA03005989 A MX PA03005989A MX PA03005989 A MXPA03005989 A MX PA03005989A MX PA03005989 A MXPA03005989 A MX PA03005989A MX PA03005989 A MXPA03005989 A MX PA03005989A
Authority
MX
Mexico
Prior art keywords
methods
taste
genes
receptors
mammal
Prior art date
Application number
MXPA03005989A
Other languages
English (en)
Inventor
Elliot Adler Jon
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of MXPA03005989A publication Critical patent/MXPA03005989A/es

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Physiology (AREA)
  • Theoretical Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se proporcionan receptores acoplados a proteinas G especificos de celulas del gusto en mamiferos recien identificados, y los genes y ADNc que codifican para tales receptores. Especificamente, se describen los receptores acoplados a proteinas G T1R activos en la senalizacion del gusto y los genes y ADNc que codifican para los mismos, junto con metodos para aislar tales genes y para aislar y expresar tales receptores. Tambien se describen metodos para representar la percepcion del gusto de un estimulo gustativo particular en un mamifero, asi como los metodos para generar moleculas novedosas o combinaciones de moleculas que inducen una percepcion de sabor determinada previamente en un mamifero asi como metodos para estimular uno o mas sabores. Ademas tambien se describen metodos para estimular o bloquear la percepcion del sabor en un mamifero. 20 5 10 124 Resumen Compuestos de formula general (1) . _= ' en la que R', R2, R3, R4, X, Y y A tienen los significados proporcionados en este doexmento) que son utiles en el tratamiento curativo y profilactico de una afeccion medica para 15 la que ss desea la inhibicion de una 3',5'-monoeos%ato ciclico de guanosina fosfodiecterasa (por ejemplo, la GMPc PDE5). r 37 RESUMEN Conectores electricos separables que son modificados para reducir la probabilidad de arqueo durante la operacion de desarme de un inserto aislador de entrada l 5 del conector acodado del cable de alimentacion. El inserto aislador de entrada se provee con ventilas para ventilar una cavidad formada entre el puno del codo y la porcion de resalto de transicion del inserto aislador de entrada con el aire ambiental para evitar una disminucion en la presion dentro de la region de conexion y evitar una disminucion en la resistencia dielectrica del aire ahi dentro, evitando de esta manera el arqueo. Las ventilas pueden proporcionarse directamente sobre la porcion del resalto de transicion del inserto, una banda indicadora de asentamiento del codo o sobre una cubierta interfacial del inserto aislador de entrada. Adicionalmente, la banda y la cubierta puede formarse de un color brillante contrastante que sirve para indicar si el conector de ruptura de carga se ensamblo de manera inapropiada. La cubierta reduce mas la friccion al ensamblar el 10 15 conector. -5- El objeto de sacar este modelo de utilidad es poder dejar al alcance de todas las iglesias la oporiunidad de poder ofrecer el servido de nichos, ya que coi? esie sistema podernos 5 iiisiafar casi eii cualquier parte del iemplo, en la actualidad es una necesidad ya que los ceineiiterios se ericuentran muy saiurados, el indice de seguridad en los cementerios cada vez es mas alto. Los cementerios lienden a ser lugares tetricos y poco higienicos, Por estas razones los templos deben destinar areas grandes para poner nichos, con nuestro modelo de uiilidad optirnizamos el espacio, es decir donde cabe u11 nicho de obra civil con nuestro sistema caben 2 o hasta 3 nichos en el mismo lugar. Ofreciendo una alta seguridad en el resguardo de cenizas y restos aridos. Y dandole una imagen de total calidez. _ . _ 5 RESUMEN Mejora A Pantifaja Reiiiodeladora De La Figura Femenina, que consiste en cubrir la zona de los gluteos proporcionando mayor seguridad, comodidad y confianza, sin perder 5 absolutamente ninguna de sus fuiiciones anteriores. Contando con una pieza nueva al modelo que cubre esta area con el material adecuado suave, resistente y ligero, sin que ocasione ningun dano al tejido, proporcionando con esto innumerables beneficios. 10 I.
MXPA03005989A 2001-01-03 2002-01-03 Receptores de sabor t1r y genes para su codificacion. MXPA03005989A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25922701P 2001-01-03 2001-01-03
US28454701P 2001-04-19 2001-04-19
PCT/US2002/000198 WO2002064631A2 (en) 2001-01-03 2002-01-03 T1r taste receptors and genes encoding same

Publications (1)

Publication Number Publication Date
MXPA03005989A true MXPA03005989A (es) 2004-05-04

Family

ID=26947173

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03005989A MXPA03005989A (es) 2001-01-03 2002-01-03 Receptores de sabor t1r y genes para su codificacion.

Country Status (15)

Country Link
US (16) US7241880B2 (es)
EP (2) EP1985630B1 (es)
JP (2) JP5411400B2 (es)
CN (2) CN1525981B (es)
AT (2) ATE407144T1 (es)
AU (2) AU2002251734B2 (es)
CA (1) CA2433514C (es)
DE (1) DE60228741D1 (es)
DK (2) DK1985630T3 (es)
ES (2) ES2385383T3 (es)
IL (1) IL156380A0 (es)
MX (1) MXPA03005989A (es)
NO (1) NO20033030L (es)
TW (1) TW201022287A (es)
WO (1) WO2002064631A2 (es)

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