IL155160A0 - Aminopyridinyl-, aminoguanidinyl-and alkoxyguanidinyl- substituted phenyl acetamide derivatives and pharmaceutical compositions containing the same - Google Patents

Aminopyridinyl-, aminoguanidinyl-and alkoxyguanidinyl- substituted phenyl acetamide derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL155160A0
IL155160A0 IL15516001A IL15516001A IL155160A0 IL 155160 A0 IL155160 A0 IL 155160A0 IL 15516001 A IL15516001 A IL 15516001A IL 15516001 A IL15516001 A IL 15516001A IL 155160 A0 IL155160 A0 IL 155160A0
Authority
IL
Israel
Prior art keywords
blood
sup
compounds
inhibiting
formation
Prior art date
Application number
IL15516001A
Other languages
English (en)
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Publication of IL155160A0 publication Critical patent/IL155160A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
IL15516001A 2000-10-06 2001-10-05 Aminopyridinyl-, aminoguanidinyl-and alkoxyguanidinyl- substituted phenyl acetamide derivatives and pharmaceutical compositions containing the same IL155160A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23813200P 2000-10-06 2000-10-06
PCT/US2001/031249 WO2002028825A2 (en) 2000-10-06 2001-10-05 Aminopyridinyl-, aminoguanidinyl- and alkoxyguanidinyl- substituted phenyl acetamides as protease inhibitors

Publications (1)

Publication Number Publication Date
IL155160A0 true IL155160A0 (en) 2003-10-31

Family

ID=22896640

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15516001A IL155160A0 (en) 2000-10-06 2001-10-05 Aminopyridinyl-, aminoguanidinyl-and alkoxyguanidinyl- substituted phenyl acetamide derivatives and pharmaceutical compositions containing the same

Country Status (26)

Country Link
US (3) US6521663B2 (xx)
EP (1) EP1324981B1 (xx)
JP (1) JP4256160B2 (xx)
KR (1) KR20030045103A (xx)
CN (1) CN1315803C (xx)
AT (1) ATE337299T1 (xx)
AU (2) AU2002211464B2 (xx)
BR (1) BR0114263A (xx)
CA (1) CA2423883A1 (xx)
CY (1) CY1106243T1 (xx)
DE (1) DE60122546T2 (xx)
DK (1) DK1324981T3 (xx)
ES (1) ES2269474T3 (xx)
HK (1) HK1058032A1 (xx)
HR (1) HRP20030252A2 (xx)
HU (1) HUP0303149A3 (xx)
IL (1) IL155160A0 (xx)
MX (1) MXPA03002998A (xx)
NO (1) NO20031390L (xx)
NZ (1) NZ525438A (xx)
PL (1) PL361185A1 (xx)
PT (1) PT1324981E (xx)
RU (1) RU2003113205A (xx)
UA (1) UA75093C2 (xx)
WO (1) WO2002028825A2 (xx)
ZA (1) ZA200303091B (xx)

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US7914705B2 (en) * 2005-01-10 2011-03-29 Robert Eliot Sisson Flowable electrical conductive liquid
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CN101243069A (zh) * 2005-06-17 2008-08-13 阿斯利康(瑞典)有限公司 凝血酶抑制剂2-氧代-1,2,5,6-四氢吡啶衍生物
RU2008144571A (ru) 2006-04-12 2010-05-20 Мерк энд Ко., Инк. (US) Пиридиламидные антагонисты кальциевых каналов т-типа
RU2353619C2 (ru) * 2007-06-28 2009-04-27 Общество С Ограниченной Ответственностью "Бионика" Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции
RU2354647C2 (ru) * 2007-06-28 2009-05-10 Общество С Ограниченной Ответственностью "Бионика" Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе
CN101665465B (zh) * 2007-09-19 2011-09-07 复旦大学 一种含胍基杂环化合物凝血酶抑制剂及其制备方法
RU2010120671A (ru) * 2007-10-24 2011-11-27 Мерк Шарп Энд Домэ Корп. (Us) Гетероциклические фениламидные антагонисты кальциевых каналов т-типа
US10299714B2 (en) 2010-12-02 2019-05-28 Becton, Dickinson And Company Blood collection devices containing blood stabilization agent including variegin or analog thereof and/or a polysulfated disaccharide
EP2658580A4 (en) 2010-12-31 2014-07-23 Corridor Pharmaceuticals Inc ARGINE STARTER AND USE METHOD
EP2709446A2 (en) 2011-05-17 2014-03-26 Velico Medical, Inc. Platelet storage using a sialidase inhibitor
US9788539B2 (en) 2011-05-17 2017-10-17 Velico Medical, Inc. Platelet protection solution having beta-galactosidase and sialidase inhibitors
EP2903430A1 (en) 2012-10-05 2015-08-12 Velico Medical, Inc. Platelet additive solution having a beta-galactosidase inhibitor
RU2524647C1 (ru) * 2012-12-25 2014-07-27 Государственное Бюджетное Учреждение Санкт-Петербургский Научно-Исследовательский Институт Скорой Помощи Им. И.И. Джанелидзе" Способ лечения синдрома эндогенной интоксикации, обусловленного гиперпротеолизом
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Also Published As

Publication number Publication date
EP1324981A2 (en) 2003-07-09
CA2423883A1 (en) 2002-04-11
JP4256160B2 (ja) 2009-04-22
MXPA03002998A (es) 2004-02-12
HRP20030252A2 (en) 2005-10-31
WO2002028825A3 (en) 2002-06-13
PL361185A1 (en) 2004-09-20
US20050159457A1 (en) 2005-07-21
ZA200303091B (en) 2004-07-22
DE60122546T2 (de) 2007-09-13
RU2003113205A (ru) 2004-11-10
US20020061872A1 (en) 2002-05-23
BR0114263A (pt) 2004-03-02
DK1324981T3 (da) 2006-12-04
NO20031390D0 (no) 2003-03-26
NZ525438A (en) 2004-09-24
US6900231B2 (en) 2005-05-31
DE60122546D1 (en) 2006-10-05
PT1324981E (pt) 2006-12-29
ES2269474T3 (es) 2007-04-01
NO20031390L (no) 2003-06-03
AU2002211464B2 (en) 2006-06-22
CN1568307A (zh) 2005-01-19
ATE337299T1 (de) 2006-09-15
UA75093C2 (en) 2006-03-15
AU1146402A (en) 2002-04-15
CY1106243T1 (el) 2011-06-08
EP1324981B1 (en) 2006-08-23
US6521663B2 (en) 2003-02-18
US20030073833A1 (en) 2003-04-17
KR20030045103A (ko) 2003-06-09
CN1315803C (zh) 2007-05-16
HUP0303149A2 (hu) 2004-01-28
JP2004510759A (ja) 2004-04-08
HUP0303149A3 (en) 2009-05-28
WO2002028825A2 (en) 2002-04-11
HK1058032A1 (en) 2004-04-30

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