IL153594A0 - Amino alcohol derivatives and pharmaceutical compositions containing the same - Google Patents

Amino alcohol derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL153594A0
IL153594A0 IL15359401A IL15359401A IL153594A0 IL 153594 A0 IL153594 A0 IL 153594A0 IL 15359401 A IL15359401 A IL 15359401A IL 15359401 A IL15359401 A IL 15359401A IL 153594 A0 IL153594 A0 IL 153594A0
Authority
IL
Israel
Prior art keywords
group
hydrogen atom
same
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL15359401A
Other languages
English (en)
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of IL153594A0 publication Critical patent/IL153594A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/008—Preparation of nitrogen-containing organic compounds containing a N-O bond, e.g. nitro (-NO2), nitroso (-NO)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL15359401A 2000-07-13 2001-07-10 Amino alcohol derivatives and pharmaceutical compositions containing the same IL153594A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2000212246 2000-07-13
JP2000241744 2000-08-09
JP2000283218 2000-09-19
PCT/JP2001/005988 WO2002006268A1 (fr) 2000-07-13 2001-07-10 Derives d'alcool amino

Publications (1)

Publication Number Publication Date
IL153594A0 true IL153594A0 (en) 2003-07-06

Family

ID=27344040

Family Applications (3)

Application Number Title Priority Date Filing Date
IL15359401A IL153594A0 (en) 2000-07-13 2001-07-10 Amino alcohol derivatives and pharmaceutical compositions containing the same
IL153594A IL153594A (en) 2000-07-13 2002-12-22 History of Amino Alcohol and Pharmaceutical Preparations Containing Them
IL174664A IL174664A0 (en) 2000-07-13 2006-03-30 Optically active amino alcohol derivatives and processes for the preparation thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL153594A IL153594A (en) 2000-07-13 2002-12-22 History of Amino Alcohol and Pharmaceutical Preparations Containing Them
IL174664A IL174664A0 (en) 2000-07-13 2006-03-30 Optically active amino alcohol derivatives and processes for the preparation thereof

Country Status (20)

Country Link
US (2) US6723745B2 (xx)
EP (1) EP1300405B1 (xx)
KR (1) KR100812578B1 (xx)
CN (2) CN1328387C (xx)
AT (1) ATE360011T1 (xx)
AU (2) AU6950301A (xx)
BR (1) BR0112484A (xx)
CA (1) CA2415678A1 (xx)
CZ (1) CZ200350A3 (xx)
DE (1) DE60127961D1 (xx)
HK (1) HK1051680A1 (xx)
HU (1) HUP0301688A3 (xx)
IL (3) IL153594A0 (xx)
MX (1) MXPA03000397A (xx)
NO (1) NO20030120L (xx)
NZ (2) NZ523554A (xx)
PL (1) PL359411A1 (xx)
SK (1) SK152003A3 (xx)
TW (1) TWI301833B (xx)
WO (1) WO2002006268A1 (xx)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
CN1328387C (zh) * 2000-07-13 2007-07-25 三共株式会社 氨基醇衍生物
WO2002029001A2 (en) 2000-10-03 2002-04-11 University Of Virginian Patent Foundation Novel lysophosphatidic acid receptor agonists and antagonists
CA2437358A1 (en) 2001-01-30 2002-08-22 University Of Virginia Patent Foundation Agonists and antagonists of sphingosine-1-phosphate receptors
PL367348A1 (en) * 2001-03-26 2005-02-21 Novartis Ag 2-amino-propanol derivatives
CA2473461C (en) * 2002-01-11 2011-11-01 Sankyo Company, Limited Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these
EP1478641A1 (en) * 2002-01-24 2004-11-24 Eli Lilly And Company Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine
MXPA04011384A (es) 2002-05-16 2005-02-14 Novartis Ag Uso de agentes de union del receptor edg en cancer.
SE0202280D0 (sv) * 2002-07-19 2002-07-19 Astrazeneca Ab Novel compounds
SE0202279D0 (sv) * 2002-07-19 2002-07-19 Astrazeneca Ab Novel comppounds
US7482491B2 (en) 2002-09-19 2009-01-27 Kyorin Pharmaceutical Co., Ltd. Amino alcohol derivative, addition salt thereof, and immunosuppressant
PL408347A1 (pl) 2002-09-24 2014-08-18 Novartis Ag Kombinacja, zastosowanie kombinacji oraz zastosowanie agonisty receptora S1P
US7452911B2 (en) 2002-10-31 2008-11-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
EP1558181B1 (en) 2002-11-07 2015-08-26 ConforMIS, Inc. Methods for determining meniscal size and shape and for devising treatment
RU2358716C2 (ru) 2003-04-08 2009-06-20 Новартис Аг Органические соединения
WO2005005383A1 (ja) * 2003-07-11 2005-01-20 Sankyo Company, Limited アミノアルコール化合物
WO2005014525A2 (en) * 2003-08-12 2005-02-17 Mitsubishi Pharma Corporation Bi-aryl compound having immunosuppressive activity
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
GB0329498D0 (en) 2003-12-19 2004-01-28 Novartis Ag Organic compounds
DE102004004719A1 (de) * 2004-01-29 2005-08-18 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen
KR101182619B1 (ko) 2004-02-24 2012-09-18 상꾜 가부시키가이샤 아미노 알코올 화합물
US7521473B2 (en) 2004-02-25 2009-04-21 Wyeth Inhibitors of protein tyrosine phosphatase 1B
BRPI0510627A (pt) 2004-05-03 2007-10-30 Novartis Ag combinações que compreendem um agonista do receptor s1p e um inibidor da jak3 quinase
WO2005115150A2 (en) 2004-05-06 2005-12-08 University Of Virginia Patent Foundation Novel lysophosphatidic acid receptor selective antagonists
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006009092A1 (ja) * 2004-07-16 2006-01-26 Kyorin Pharmaceutical Co., Ltd. 効果的な医薬の使用法及び副作用発現の防御に関する方法
TW200611687A (en) * 2004-07-29 2006-04-16 Sankyo Co Pharmaceutical compositions used for immunosuppressant
KR101174930B1 (ko) 2004-07-30 2012-08-17 노파르티스 아게 ２-아미노-１,３-프로판디올 화합물의 화합물 제제
US7119211B2 (en) * 2004-09-23 2006-10-10 Yamakawa Chemical Industry Co., Ltd. Process for preparing optically active 3-(methylamino)-1-(2-thienyl) propan-1-ol and intermediates for preparation
EP1806338B1 (en) * 2004-10-12 2016-01-20 Kyorin Pharmaceutical Co., Ltd. Process for producing 2-amino-2-[2-[4-(3-benzyloxy-phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride and hydrates thereof. and intermediates the production thereof
BRPI0518674A2 (pt) 2004-11-29 2008-12-02 Novartis Ag regime de dosagem de um agonista de receptor s1p
GB0504544D0 (en) 2005-03-04 2005-04-13 Novartis Ag Organic compounds
GB0519274D0 (en) * 2005-09-21 2005-11-02 Arakis Ltd The treatment of neurodegenerative diseases
CN101277687B (zh) * 2005-10-07 2012-07-18 杏林制药株式会社 以2-氨基-1,3-丙二醇衍生物作为有效成分的肝脏疾病治疗剂及肝脏疾病治疗方法
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
UA100666C2 (xx) 2006-04-11 2013-01-25 Новартіс Аг Інгібітори нсv/віл та їх застосування$ингибиторы нсv/вич и их применение
GB0612721D0 (en) 2006-06-27 2006-08-09 Novartis Ag Organic compounds
TW200815600A (en) 2006-08-04 2008-04-01 Daiichi Sankyo Co Ltd An enzyme for phosphorizing a medicine
MX2009001457A (es) * 2006-08-08 2009-02-19 Kyorin Seiyaku Kk Derivados de aminoalcohol e inmunosupresores que contienen lo mismo como ingrediente activo.
SG174028A1 (en) * 2006-08-08 2011-09-29 Kyorin Seiyaku Kk Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient
EP2086514A2 (en) 2006-09-26 2009-08-12 Novartis Ag Pharmaceutical compositions comprising an s1p modulator
TW200906389A (en) * 2007-05-25 2009-02-16 Daiichi Sankyo Co Ltd Pharmaceutical composition comprising of therapeutic or prophylactic agents for hepatitis
AU2008310846C1 (en) 2007-10-12 2022-10-06 Novartis Ag Compositions comprising sphingosine 1 phosphate (S1P) receptor modulators
TW200946105A (en) 2008-02-07 2009-11-16 Kyorin Seiyaku Kk Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient
EP2292594A4 (en) * 2008-05-19 2014-10-15 Kyorin Seiyaku Kk PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINOALCOOL DERIVATIVE
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
WO2012048235A1 (en) 2010-10-08 2012-04-12 Novartis Ag Vitamin e formulations of sulfamide ns3 inhibitors
WO2013109991A1 (en) * 2012-01-20 2013-07-25 Acucela Inc. Substituted heterocyclic compounds for disease treatment
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2817494A1 (de) * 1977-05-03 1978-11-09 Continental Pharma Aminoalkohol-derivat
US4638070A (en) * 1978-12-21 1987-01-20 Continental Pharma Heterocyclic amino-alcohol derivatives
JPS55124742A (en) * 1979-03-20 1980-09-26 Kyowa Hakko Kogyo Co Ltd Novel aminoalcohol derivative
JPS60132934A (ja) * 1983-11-21 1985-07-16 Nippon Shinyaku Co Ltd ブタノ−ル誘導体
GB8405112D0 (en) * 1984-02-28 1984-04-04 Akzo Nv Anti-arrhythmic amino-alcohols
US5250546A (en) * 1984-09-28 1993-10-05 Nippon Chemiphar Co., Ltd. Amino-alcohol derivatives and processes for their preparation
FR2585708B1 (fr) * 1985-07-31 1989-07-07 Sanofi Sa Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
IL86740A (en) * 1987-06-30 1992-11-15 Tanabe Seiyaku Co Thiphene derivatives,their preparation and pharmaceutical compositions containing them
JPH02256612A (ja) * 1988-12-22 1990-10-17 Tanabe Seiyaku Co Ltd 消化管機能調整剤
JP2747849B2 (ja) * 1990-08-24 1998-05-06 大鵬薬品工業株式会社 ２’―デオキシヌクレオシド類の選択的アシル化方法
ATE141950T1 (de) * 1990-12-24 1996-09-15 Hoechst Ag Verfahren zur acylierung von alkoholen mit einem immobilisierten pseudomonas-lipase
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
WO1993015405A1 (en) * 1992-01-29 1993-08-05 Sci-Clone, Inc. Carcinoma associated antigen (sk1) monoclonal antibodies against sk1, methods of producing these antibodies and use therfor
ES2126658T3 (es) 1992-10-21 1999-04-01 Yoshitomi Pharmaceutical Compuesto de 2-amino-1,3-propanodiol e inmunosupresor.
USRE36718E (en) * 1993-06-29 2000-05-30 Kaneka Corporation Optically active aminoalcohol derivatives and method of producing same
WO1996006068A1 (fr) * 1994-08-22 1996-02-29 Yoshitomi Pharmaceutical Industries, Ltd. Compose benzenique et son utilisation medicale
US5948820A (en) * 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof
DE69506900T2 (de) * 1994-10-12 1999-07-22 Du Pont Enzymatisches verfahren zur herstellung von chiralen alpha-tertiären carbonsäureestern
JPH09124564A (ja) * 1995-11-06 1997-05-13 Nikko Rika Kk 光学活性体混合物ならびにその製造方法
NO965193L (no) * 1995-12-08 1997-06-09 Seikagaku Kogyo Kk Seikagaku C Aminalkoholderivat og fremgangsmåte for fremstilling derav
DK0904348T3 (da) * 1996-05-30 2005-02-14 Lonza Ag Fremgangsmåde til fremstilling af aminoalkoholer og derivater deraf
JP4045364B2 (ja) 1997-04-04 2008-02-13 田辺三菱製薬株式会社 ２−アミノプロパン−１，３−ジオール化合物、その医薬としての用途およびその合成中間体
US6214823B1 (en) * 1997-10-17 2001-04-10 Merck & Co., Inc. Benzodiazepine derivatives as antiarrhythmic agents
CN1328387C (zh) * 2000-07-13 2007-07-25 三共株式会社 氨基醇衍生物
JP2004507552A (ja) * 2000-08-31 2004-03-11 メルク　エンド　カムパニー　インコーポレーテッド 免疫調節剤としてのリン酸誘導体
US20040058894A1 (en) * 2002-01-18 2004-03-25 Doherty George A. Selective S1P1/Edg1 receptor agonists

Also Published As

Publication number Publication date
CZ200350A3 (cs) 2003-05-14
IL174664A0 (en) 2006-08-20
BR0112484A (pt) 2003-09-23
CA2415678A1 (en) 2003-01-10
AU6950301A (en) 2002-01-30
EP1300405A1 (en) 2003-04-09
HUP0301688A2 (hu) 2003-09-29
PL359411A1 (en) 2004-08-23
IL153594A (en) 2008-04-13
ATE360011T1 (de) 2007-05-15
CN1328387C (zh) 2007-07-25
CN1680563A (zh) 2005-10-12
HK1051680A1 (en) 2003-08-15
HUP0301688A3 (en) 2006-05-29
CN1494540A (zh) 2004-05-05
KR100812578B1 (ko) 2008-03-13
NO20030120D0 (no) 2003-01-10
DE60127961D1 (de) 2007-05-31
US6964976B2 (en) 2005-11-15
US20030236297A1 (en) 2003-12-25
EP1300405A4 (en) 2004-04-21
NZ523554A (en) 2004-12-24
AU2001269503B2 (en) 2005-02-17
NO20030120L (no) 2003-03-11
US20040132784A1 (en) 2004-07-08
SK152003A3 (en) 2004-07-07
MXPA03000397A (es) 2003-05-27
KR20030047988A (ko) 2003-06-18
US6723745B2 (en) 2004-04-20
CN1267429C (zh) 2006-08-02
TWI301833B (en) 2008-10-11
WO2002006268A1 (fr) 2002-01-24
NZ533997A (en) 2005-11-25
EP1300405B1 (en) 2007-04-18

Similar Documents

Publication Publication Date Title
IL153594A0 (en) Amino alcohol derivatives and pharmaceutical compositions containing the same
AU2212392A (en) Novel alkoxy substituted taxanes and pharmaceutical compositions containing them
TW200611687A (en) Pharmaceutical compositions used for immunosuppressant
IL150650A0 (en) Piperidine derivatives and pharmaceutical compositions containing the same
EP0870765A4 (xx)
EP1254659A4 (en) STABLE EMULSION PREPARATIONS
RS49850B (sr) Derivati 1,4-benzotiazepin-1,1-dioksida supstituisani radikalima šećera, postupak za njihovu proizvodnju, lekovi koji sadrže ova jedinjenja i njihova primena
DE60014104D1 (de) Bicyclonucleosid-analoga
AU2212492A (en) Novel substituted taxanes and pharmaceutical compositions containing them
WO2008108386A1 (ja) 医薬組成物
UA89672C2 (xx) Фенілсульфонілкарбаміди$фенилсульфонилкарбамиды
MX2010013275A (es) Compuesto novedoso de uracilo o su sal que tiene actividad inhibidora de desoxiuridin trifosfatasa de humano.
IL136100A0 (en) Biphenylamidine derivatives, prodrugs thereof and pharmaceutical compositions containing the same
EP0997462A4 (en) NOVEL NAPHTHYRIDINE DERIVATIVES OR THEIR SALTS
ATE223411T1 (de) 1-methylcarbapenem-derivate
WO1998053790A3 (en) Compounds that inhibit the binding of vascular endothelial growth factor to its receptors
MXPA04001171A (es) Compuestos policiclicos condensados.
BG101942A (en) Analogues of arginine having inhibiting activity on no-synthetase
DE60221250D1 (de) Bis(5-aryl-2-pyridyl)derivate
HUT76477A (en) Thiazolo[3,2-a]azepine derivatives, process for the preparation thereof and pharmaceutical compositions containing them
MXPA04002474A (es) Inhibicion de produccion de exoproteina usando composiciones aromaticas.
WO2003014089A8 (en) Aminotetrahydroisoquinoline derivatives as analgesics

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed