IL151621A0 - Chimeric animal model susceptible to human hepatitis c virus infection - Google Patents
Chimeric animal model susceptible to human hepatitis c virus infectionInfo
- Publication number
- IL151621A0 IL151621A0 IL15162101A IL15162101A IL151621A0 IL 151621 A0 IL151621 A0 IL 151621A0 IL 15162101 A IL15162101 A IL 15162101A IL 15162101 A IL15162101 A IL 15162101A IL 151621 A0 IL151621 A0 IL 151621A0
- Authority
- IL
- Israel
- Prior art keywords
- human
- agents
- animal model
- virus infection
- human hepatitis
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title abstract 4
- 238000010171 animal model Methods 0.000 title abstract 2
- 208000010710 hepatitis C virus infection Diseases 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 210000004185 liver Anatomy 0.000 abstract 2
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- -1 e.g. Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003494 hepatotrophic effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/528,120 US6509514B1 (en) | 2000-03-17 | 2000-03-17 | Chimeric animal model susceptible to human hepatitis C virus infection |
PCT/CA2001/000350 WO2001067854A1 (en) | 2000-03-17 | 2001-03-16 | Chimeric animal model susceptible to human hepatitis c virus infection |
Publications (1)
Publication Number | Publication Date |
---|---|
IL151621A0 true IL151621A0 (en) | 2003-04-10 |
Family
ID=24104337
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15162101A IL151621A0 (en) | 2000-03-17 | 2001-03-16 | Chimeric animal model susceptible to human hepatitis c virus infection |
IL151621A IL151621A (en) | 2000-03-17 | 2002-09-04 | A chimeric animal model that is not resistant to infection and human hepatitis C virus |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL151621A IL151621A (en) | 2000-03-17 | 2002-09-04 | A chimeric animal model that is not resistant to infection and human hepatitis C virus |
Country Status (13)
Country | Link |
---|---|
US (6) | US6509514B1 (xx) |
EP (1) | EP1265480B1 (xx) |
JP (2) | JP4059672B2 (xx) |
KR (1) | KR100656795B1 (xx) |
AT (1) | ATE469547T1 (xx) |
AU (2) | AU4216301A (xx) |
CA (1) | CA2402117C (xx) |
DE (1) | DE60142281D1 (xx) |
DK (1) | DK1265480T3 (xx) |
ES (1) | ES2346636T3 (xx) |
IL (2) | IL151621A0 (xx) |
NZ (1) | NZ521119A (xx) |
WO (1) | WO2001067854A1 (xx) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6995299B2 (en) * | 1999-11-02 | 2006-02-07 | University Of Connecticut | Propagation of human hepatocytes in non-human animals |
US6509514B1 (en) * | 2000-03-17 | 2003-01-21 | Kmt Hepatech, Inc. | Chimeric animal model susceptible to human hepatitis C virus infection |
JPWO2002028174A1 (ja) * | 2000-10-03 | 2004-02-12 | 財団法人 東京都医学研究機構 | C型肝炎ウイルス感染方法 |
US20030096316A1 (en) * | 2001-11-21 | 2003-05-22 | Ingmar Wester | Use of apolipoprotein B as a single marker for evaluation of the risk or cardiovascular disease |
JP4334358B2 (ja) * | 2002-03-25 | 2009-09-30 | 財団法人 ひろしま産業振興機構 | 増殖性ヒト肝細胞を認識する抗体と、増殖性ヒト肝細胞および機能性ヒト肝細胞 |
EP1552740A1 (en) * | 2004-01-09 | 2005-07-13 | Institut Pasteur | Chimeric murine model comprising human hepatocytes - use for screening compounds |
EP1801582B1 (en) * | 2004-08-20 | 2010-03-17 | Sekisui Medical Co., Ltd. | Method of predicting the metabolism of drug in human liver and liver function |
AU2005277463A1 (en) * | 2004-08-20 | 2006-03-02 | Kmt Hepatech, Inc. | Malarial animal model having a chimeric human liver |
WO2006021896A2 (en) | 2004-08-27 | 2006-03-02 | Tripep Ab | Transgenic mouse models of hepatitis c virus (hcv) and identification of hcv therapeutics |
WO2006054755A1 (ja) * | 2004-11-16 | 2006-05-26 | Hiroshima Industrial Promotion Organization | 医薬候補物質のスクリーニング方法 |
US20060147429A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Facilitated cellular reconstitution of organs and tissues |
US20060148080A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Methods for supporting and producing human cells and tissues in non-human mammal hosts |
CA2615626A1 (en) * | 2005-07-18 | 2007-01-25 | Novartis Ag | Small animal model for hcv replication |
EP2158321B1 (en) * | 2007-06-05 | 2021-08-04 | Oregon Health & Science University | Method of expanding human hepatocytes in vivo |
WO2009105244A1 (en) * | 2008-02-21 | 2009-08-27 | The University Of North Carolina At Chapel Hill | Recombiant non-human mammalian model for hepatitis infection and immunopathogenesis |
CN101550425B (zh) * | 2008-03-31 | 2011-03-30 | 北京大学 | 一种可调控的肝损伤动物模型的制作方法及其专用载体 |
JP5710097B2 (ja) * | 2008-07-10 | 2015-04-30 | 株式会社バイオマーカーサイエンス | 動脈硬化改善・予防効果の評価方法、物質のスクリーニング方法、並びに、マーカーとしての使用 |
US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
CN101748123B (zh) * | 2008-11-27 | 2012-11-07 | 北京大学 | 可调控肝损伤动物模型的制作方法及其专用dna片段 |
WO2010082385A1 (ja) * | 2009-01-16 | 2010-07-22 | 財団法人実験動物中央研究所 | ヒト肝細胞が移植されたマウス |
JP5841322B2 (ja) | 2010-04-22 | 2016-01-13 | オレゴン ヘルス アンド サイエンス ユニバーシティ | フマリルアセト酢酸ヒドロラーゼ(fah)欠損性ブタおよびその使用 |
WO2012048170A2 (en) | 2010-10-06 | 2012-04-12 | Massachusetts Institute Of Technology | Humanized animals via tissue engineering and uses therefor |
EP2747551B1 (en) | 2011-08-26 | 2020-02-12 | Yecuris Corporation | Fumarylacetoacetate hydrolase (fah)-deficient and immunodeficient rats and uses thereof |
US9532554B2 (en) | 2011-09-30 | 2017-01-03 | Public University Corporation Yokohama City University | Method for inducing hepatocellular variation, and production method for chimeric non-human animal having humanized liver |
JP5883265B2 (ja) * | 2011-10-13 | 2016-03-09 | 株式会社フェニックスバイオ | ヒト肝細胞を担持するキメラ非ヒト動物 |
WO2013086019A1 (en) * | 2011-12-06 | 2013-06-13 | Massachusetts Institute Of Technology | Use of humanized mice to determine toxicity |
KR101708541B1 (ko) * | 2012-03-27 | 2017-02-20 | 가부시끼가이샤 트랜스제닉 | 인간화 마우스 |
JP5976380B2 (ja) | 2012-04-27 | 2016-08-23 | 公益財団法人東京都医学総合研究所 | ウロキナーゼ型プラスミノーゲンアクチベータートランスジェニックマウス |
EP2872155A4 (en) | 2012-07-10 | 2016-07-13 | Univ Pennsylvania | BIOMATERIALS TO IMPROVE THE INTEGRATION OF THE IMPLANT WITHIN THE HOST |
CN103088106A (zh) * | 2013-01-25 | 2013-05-08 | 中国水产科学研究院淡水渔业研究中心 | 用鱼原代肝细胞损伤模型筛选鱼类保肝药物的方法 |
US9566315B2 (en) | 2013-11-01 | 2017-02-14 | Oregon Health & Science University | Normalization of the enterohepatic circulation in animals with a chimeric humanized liver |
US10260111B1 (en) | 2014-01-20 | 2019-04-16 | Brett Eric Etchebarne | Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample |
WO2017062757A1 (en) | 2015-10-08 | 2017-04-13 | Massachusetts Institute Of Technology | In situ expansion of engineered devices for regeneration |
CN106047870B (zh) * | 2016-06-16 | 2019-01-08 | 中国医学科学院医学生物学研究所 | 树鼩mhc-drb1*1101基因序列及其应用 |
EP3474662A1 (en) | 2016-06-27 | 2019-05-01 | Baylor College of Medicine | Human liver chimeric non-human animal with deficient p450 oxidoreductase and methods of using same |
EP3583201B1 (en) | 2017-02-14 | 2024-01-17 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Methods of engineering human induced pluripotent stem cells to produce liver tissue |
EP3687288A4 (en) * | 2017-09-25 | 2021-06-30 | National University of Singapore | CHEMERICAL ANIMAL INCLUDING STABLE TRANSPLANTED BAT CELLS |
KR102362814B1 (ko) | 2020-06-04 | 2022-02-15 | 한국생명공학연구원 | 인간 간세포 이식용 동물모델 및 이를 이용한 항바이러스제 스크리닝 방법 |
Family Cites Families (25)
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US5476996A (en) * | 1988-06-14 | 1995-12-19 | Lidak Pharmaceuticals | Human immune system in non-human animal |
US5994617A (en) * | 1988-09-19 | 1999-11-30 | Hsc Research Development Corporation | Engraftment of immune-deficient mice with human cells |
US5849288A (en) | 1990-01-15 | 1998-12-15 | Yeda Research And Development Co. Ltd. | Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells |
EP0438053B1 (en) | 1990-01-15 | 1999-06-16 | Yeda Research And Development Company Limited | Durable engraftment and development of human hematopoietic lineages in normal mammals |
US5652373A (en) | 1990-01-15 | 1997-07-29 | Yeda Research And Development Co. Ltd. | Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems |
US5858328A (en) | 1991-06-04 | 1999-01-12 | Yeda Research And Development Co. Ltd. | Animal model for hepatitis virus infection |
US5804160A (en) | 1991-06-04 | 1998-09-08 | Yeda Research And Development Co. Ltd | Animal model for hepatitis virus infection |
US5849987A (en) | 1992-06-02 | 1998-12-15 | Yeda Research And Development Co. Ltd. | Animal model for hepatitis virus infection |
US5408038A (en) | 1991-10-09 | 1995-04-18 | The Scripps Research Institute | Nonnatural apolipoprotein B-100 peptides and apolipoprotein B-100-apolipoprotein A-I fusion peptides |
US5866757A (en) | 1992-06-02 | 1999-02-02 | Yeda Research And Development Co. Ltd. | Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems |
IL106368A0 (en) | 1992-07-24 | 1993-11-15 | Univ Pennsylvania | Non-native liver generation in an animal with impaired native liver function,by cell implantation |
WO1994027556A2 (en) | 1993-05-17 | 1994-12-08 | Yeda Research And Development Co. Ltd. | Animal model for hepatitis virus infection |
US5980886A (en) * | 1994-12-14 | 1999-11-09 | University Of Washington | Recombinant vectors for reconstitution of liver |
US6107027A (en) | 1994-12-14 | 2000-08-22 | University Of Washington | Ribozymes for treating hepatitis C |
WO1996039810A1 (en) | 1995-06-07 | 1996-12-19 | Novartis Ag | Human hepatocellular tissue in chimeric immunocompromised animals |
US5980866A (en) * | 1996-03-15 | 1999-11-09 | Juridical Foundation The Chemosero-Therapeutic Research Institute | Tissue adhesive suitable for spray application |
GB9705744D0 (en) | 1997-03-20 | 1997-05-07 | Davies Alison M | Methods for selecting cells and their uses |
US6034297A (en) * | 1997-09-26 | 2000-03-07 | Cedars-Sinai Medical Center | In vivo, animal model for expression of hepatitis C virus |
US6579682B1 (en) | 1998-03-10 | 2003-06-17 | The Regents Of University Of California | Methods and tools for identifying compounds which modulate atherosclerosis by impacting LDL-proteoglycan binding |
CA2343084A1 (en) | 1998-09-18 | 2000-03-30 | Albert Einstein College Of Medicine Of Yeshiva University | Upa/rag-2 mouse with mammalian repopulating hepatocytes for infection by hepadnaviruses |
US6864402B1 (en) * | 1998-09-18 | 2005-03-08 | Albert Einstein College Of Medicine Of Yeshiva University | Chronic hepatitis virus infection and clonal hepatocellular carcinoma in mouse repopulated livers |
US6249089B1 (en) * | 1998-10-09 | 2001-06-19 | Frederick Bruwer | Intelligent electrical device comprising microchip |
US6660905B1 (en) * | 1999-07-14 | 2003-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Mice comprising engrafted functional human hepatocytes |
US6525242B1 (en) | 1999-11-02 | 2003-02-25 | The University Of Connecticut | Propagation of human hepatocytes in non-human mammals |
US6509514B1 (en) | 2000-03-17 | 2003-01-21 | Kmt Hepatech, Inc. | Chimeric animal model susceptible to human hepatitis C virus infection |
-
2000
- 2000-03-17 US US09/528,120 patent/US6509514B1/en not_active Expired - Lifetime
-
2001
- 2001-03-16 JP JP2001566336A patent/JP4059672B2/ja not_active Expired - Fee Related
- 2001-03-16 KR KR1020027012249A patent/KR100656795B1/ko active IP Right Grant
- 2001-03-16 IL IL15162101A patent/IL151621A0/xx active IP Right Grant
- 2001-03-16 AT AT01914893T patent/ATE469547T1/de active
- 2001-03-16 DE DE60142281T patent/DE60142281D1/de not_active Expired - Lifetime
- 2001-03-16 NZ NZ521119A patent/NZ521119A/en not_active IP Right Cessation
- 2001-03-16 ES ES01914893T patent/ES2346636T3/es not_active Expired - Lifetime
- 2001-03-16 WO PCT/CA2001/000350 patent/WO2001067854A1/en active IP Right Grant
- 2001-03-16 EP EP01914893A patent/EP1265480B1/en not_active Expired - Lifetime
- 2001-03-16 AU AU4216301A patent/AU4216301A/xx active Pending
- 2001-03-16 DK DK01914893.1T patent/DK1265480T3/da active
- 2001-03-16 CA CA2402117A patent/CA2402117C/en not_active Expired - Fee Related
- 2001-03-16 AU AU2001242163A patent/AU2001242163B2/en not_active Ceased
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2002
- 2002-09-04 IL IL151621A patent/IL151621A/en not_active IP Right Cessation
- 2002-09-12 US US10/243,087 patent/US7161057B2/en not_active Expired - Lifetime
-
2006
- 2006-09-07 US US11/517,941 patent/US7498479B2/en not_active Expired - Fee Related
-
2007
- 2007-07-24 JP JP2007191518A patent/JP4436389B2/ja not_active Expired - Fee Related
-
2008
- 2008-12-11 US US12/333,002 patent/US7781642B2/en not_active Expired - Fee Related
-
2010
- 2010-07-20 US US12/840,188 patent/US8212106B2/en not_active Expired - Fee Related
-
2012
- 2012-05-30 US US13/484,073 patent/US8445745B2/en not_active Expired - Fee Related
Also Published As
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JP2008022853A (ja) | 2008-02-07 |
DK1265480T3 (da) | 2010-09-20 |
US7781642B2 (en) | 2010-08-24 |
US20070107069A1 (en) | 2007-05-10 |
US20090151012A1 (en) | 2009-06-11 |
US8445745B2 (en) | 2013-05-21 |
KR100656795B1 (ko) | 2006-12-12 |
CA2402117A1 (en) | 2001-09-20 |
US7498479B2 (en) | 2009-03-03 |
JP2003526348A (ja) | 2003-09-09 |
KR20030027883A (ko) | 2003-04-07 |
ES2346636T3 (es) | 2010-10-19 |
EP1265480B1 (en) | 2010-06-02 |
US20030115616A1 (en) | 2003-06-19 |
WO2001067854A1 (en) | 2001-09-20 |
DE60142281D1 (de) | 2010-07-15 |
IL151621A (en) | 2006-06-11 |
JP4059672B2 (ja) | 2008-03-12 |
US8212106B2 (en) | 2012-07-03 |
JP4436389B2 (ja) | 2010-03-24 |
EP1265480A1 (en) | 2002-12-18 |
ATE469547T1 (de) | 2010-06-15 |
US7161057B2 (en) | 2007-01-09 |
AU2001242163B2 (en) | 2005-06-23 |
CA2402117C (en) | 2012-01-17 |
US20110167507A1 (en) | 2011-07-07 |
US20120309032A1 (en) | 2012-12-06 |
AU4216301A (en) | 2001-09-24 |
US6509514B1 (en) | 2003-01-21 |
NZ521119A (en) | 2004-03-26 |
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