DK1476012T3 - Transgene mus, der udtrykker PRKAG3 - Google Patents
Transgene mus, der udtrykker PRKAG3Info
- Publication number
- DK1476012T3 DK1476012T3 DK03734810.9T DK03734810T DK1476012T3 DK 1476012 T3 DK1476012 T3 DK 1476012T3 DK 03734810 T DK03734810 T DK 03734810T DK 1476012 T3 DK1476012 T3 DK 1476012T3
- Authority
- DK
- Denmark
- Prior art keywords
- prkag3
- transgenic mice
- mice expressing
- human animals
- transgenic non
- Prior art date
Links
- 102100024628 5'-AMP-activated protein kinase subunit gamma-3 Human genes 0.000 title 1
- 101000760977 Homo sapiens 5'-AMP-activated protein kinase subunit gamma-3 Proteins 0.000 title 1
- 241000699660 Mus musculus Species 0.000 title 1
- 238000011830 transgenic mouse model Methods 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 101100191376 Dictyostelium discoideum prkag gene Proteins 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000037149 energy metabolism Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35343002P | 2002-02-01 | 2002-02-01 | |
PCT/IB2003/000912 WO2003063586A1 (en) | 2002-02-01 | 2003-01-31 | Transgenic animals expressing prkag3 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1476012T3 true DK1476012T3 (da) | 2010-05-31 |
Family
ID=27663211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03734810.9T DK1476012T3 (da) | 2002-02-01 | 2003-01-31 | Transgene mus, der udtrykker PRKAG3 |
Country Status (8)
Country | Link |
---|---|
US (2) | US7214850B2 (da) |
EP (1) | EP1476012B1 (da) |
AT (1) | ATE458403T1 (da) |
AU (1) | AU2003209552B2 (da) |
CA (1) | CA2474007A1 (da) |
DE (1) | DE60331416D1 (da) |
DK (1) | DK1476012T3 (da) |
WO (1) | WO2003063586A1 (da) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA02002613A (es) * | 1999-09-10 | 2003-10-14 | Agronomique Inst Nat Rech | Variantes de la cadena gamma de ampk, secuencias de adn que codifican las mismas, y usos de las mismas. |
AU2003207884B2 (en) | 2002-02-01 | 2008-07-31 | Arexis Ab | Variants of the alpha 1 subunit of human AMPK |
JP6282642B2 (ja) | 2012-06-27 | 2018-02-21 | メタノミクス ヘルス ゲーエムベーハー | 糖尿病薬を同定する方法 |
CN102978202A (zh) * | 2012-10-10 | 2013-03-20 | 中国农业科学院北京畜牧兽医研究所 | 一种肌肉特异表达猪igf1基因的过表达载体 |
US10683552B2 (en) | 2014-11-25 | 2020-06-16 | Presidents And Fellows Of Harvard College | Clonal haematopoiesis |
US11168369B2 (en) | 2014-11-25 | 2021-11-09 | The Brigham And Women's Hospital, Inc. | Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease |
CN112795641A (zh) * | 2021-02-09 | 2021-05-14 | 复旦大学附属中山医院 | Scn5a中电压感受器突变位点r225q在扩心病基因检测中的应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4873191A (en) * | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5580722A (en) * | 1989-07-18 | 1996-12-03 | Oncogene Science, Inc. | Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease |
AUPN745096A0 (en) | 1996-01-08 | 1996-02-01 | St. Vincent's Institute Of Medical Research | Novel amp activated protein kinase |
MXPA02002613A (es) | 1999-09-10 | 2003-10-14 | Agronomique Inst Nat Rech | Variantes de la cadena gamma de ampk, secuencias de adn que codifican las mismas, y usos de las mismas. |
US20020142310A1 (en) | 2000-04-07 | 2002-10-03 | Leif Andersson | Variants of the human AMP-activated protein kinase gamma 3 subunit |
AU2003207884B2 (en) | 2002-02-01 | 2008-07-31 | Arexis Ab | Variants of the alpha 1 subunit of human AMPK |
US20050155091A1 (en) | 2002-02-01 | 2005-07-14 | Thomas Svensson | Prkag3 gene promoter and uses thereof |
-
2003
- 2003-01-31 CA CA002474007A patent/CA2474007A1/en not_active Abandoned
- 2003-01-31 WO PCT/IB2003/000912 patent/WO2003063586A1/en not_active Application Discontinuation
- 2003-01-31 DK DK03734810.9T patent/DK1476012T3/da active
- 2003-01-31 US US10/503,175 patent/US7214850B2/en not_active Expired - Fee Related
- 2003-01-31 EP EP03734810A patent/EP1476012B1/en not_active Expired - Lifetime
- 2003-01-31 DE DE60331416T patent/DE60331416D1/de not_active Expired - Lifetime
- 2003-01-31 AT AT03734810T patent/ATE458403T1/de not_active IP Right Cessation
- 2003-01-31 AU AU2003209552A patent/AU2003209552B2/en not_active Ceased
-
2007
- 2007-05-04 US US11/744,590 patent/US7858369B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7858369B2 (en) | 2010-12-28 |
WO2003063586A1 (en) | 2003-08-07 |
EP1476012A1 (en) | 2004-11-17 |
AU2003209552B2 (en) | 2007-09-27 |
CA2474007A1 (en) | 2003-08-07 |
US20080050767A1 (en) | 2008-02-28 |
DE60331416D1 (de) | 2010-04-08 |
US20050172348A1 (en) | 2005-08-04 |
US7214850B2 (en) | 2007-05-08 |
EP1476012B1 (en) | 2010-02-24 |
ATE458403T1 (de) | 2010-03-15 |
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