DE60331416D1 - Transgene mäuse, die prkag3 exprimieren - Google Patents

Transgene mäuse, die prkag3 exprimieren

Info

Publication number
DE60331416D1
DE60331416D1 DE60331416T DE60331416T DE60331416D1 DE 60331416 D1 DE60331416 D1 DE 60331416D1 DE 60331416 T DE60331416 T DE 60331416T DE 60331416 T DE60331416 T DE 60331416T DE 60331416 D1 DE60331416 D1 DE 60331416D1
Authority
DE
Germany
Prior art keywords
prkag3
transgenic mice
mice expressing
human animals
transgenic non
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60331416T
Other languages
English (en)
Inventor
Leif Andersson
Stefan Marklund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arexis AB
Original Assignee
Arexis AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arexis AB filed Critical Arexis AB
Application granted granted Critical
Publication of DE60331416D1 publication Critical patent/DE60331416D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60331416T 2002-02-01 2003-01-31 Transgene mäuse, die prkag3 exprimieren Expired - Lifetime DE60331416D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35343002P 2002-02-01 2002-02-01
PCT/IB2003/000912 WO2003063586A1 (en) 2002-02-01 2003-01-31 Transgenic animals expressing prkag3

Publications (1)

Publication Number Publication Date
DE60331416D1 true DE60331416D1 (de) 2010-04-08

Family

ID=27663211

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60331416T Expired - Lifetime DE60331416D1 (de) 2002-02-01 2003-01-31 Transgene mäuse, die prkag3 exprimieren

Country Status (8)

Country Link
US (2) US7214850B2 (de)
EP (1) EP1476012B1 (de)
AT (1) ATE458403T1 (de)
AU (1) AU2003209552B2 (de)
CA (1) CA2474007A1 (de)
DE (1) DE60331416D1 (de)
DK (1) DK1476012T3 (de)
WO (1) WO2003063586A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE293167T1 (de) * 1999-09-10 2005-04-15 Arexis Ab Ampk-gamma variante, dafür kodierende dna sequenzen, und deren verwendung
AU2003207884B2 (en) 2002-02-01 2008-07-31 Arexis Ab Variants of the alpha 1 subunit of human AMPK
EP2867669B1 (de) 2012-06-27 2016-12-21 Metanomics Health GmbH Verfahren zur Identifizierung von Diabetes-Arzneimitteln
CN102978202A (zh) * 2012-10-10 2013-03-20 中国农业科学院北京畜牧兽医研究所 一种肌肉特异表达猪igf1基因的过表达载体
WO2016085876A1 (en) 2014-11-25 2016-06-02 The Broad Institute Inc. Clonal haematopoiesis
EP3224381B1 (de) 2014-11-25 2019-09-04 The Brigham and Women's Hospital, Inc. Verfahren zur identifizierung von personen mit einer prädisposition für eine kardiometabolische krankheit oder davon betroffenen personen
CN112795641A (zh) * 2021-02-09 2021-05-14 复旦大学附属中山医院 Scn5a中电压感受器突变位点r225q在扩心病基因检测中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873191A (en) * 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5580722A (en) * 1989-07-18 1996-12-03 Oncogene Science, Inc. Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease
AUPN745096A0 (en) 1996-01-08 1996-02-01 St. Vincent's Institute Of Medical Research Novel amp activated protein kinase
ATE293167T1 (de) 1999-09-10 2005-04-15 Arexis Ab Ampk-gamma variante, dafür kodierende dna sequenzen, und deren verwendung
US20020142310A1 (en) 2000-04-07 2002-10-03 Leif Andersson Variants of the human AMP-activated protein kinase gamma 3 subunit
AU2003207884B2 (en) * 2002-02-01 2008-07-31 Arexis Ab Variants of the alpha 1 subunit of human AMPK
EP1474520A2 (de) * 2002-02-01 2004-11-10 Arexis AB Prkag3-genpromotor und verwendungen davon

Also Published As

Publication number Publication date
US7214850B2 (en) 2007-05-08
AU2003209552B2 (en) 2007-09-27
ATE458403T1 (de) 2010-03-15
EP1476012A1 (de) 2004-11-17
EP1476012B1 (de) 2010-02-24
DK1476012T3 (da) 2010-05-31
US20050172348A1 (en) 2005-08-04
CA2474007A1 (en) 2003-08-07
US20080050767A1 (en) 2008-02-28
US7858369B2 (en) 2010-12-28
WO2003063586A1 (en) 2003-08-07

Similar Documents

Publication Publication Date Title
MX2007007602A (es) Agonistas del peptido 1 similar al glucagon, composiciones, metodos y usos.
TW200602491A (en) Human GLP-1 mimetibodies, compositions, methods and uses
ATE401787T1 (de) Menschliches cd20 exprimierende transgene mäuse
DE502005008790D1 (de) Substituierte phenylaminopyrimidine
EP2336338A3 (de) Transgene, nicht-menschliche Tiere für pharmakologische und toxikologische Untersuchungen
MX2009006066A (es) Tratamiento de cerdos con el antigeno pcv.
WO2008155133A3 (en) Fusion protein comprising a caspase domain and a nuclear hormone receptor binding domain and methods and uses thereof
UA101301C2 (ru) ВЫДЕЛЕННОЕ АНТИТЕЛО ПРОТИВ IL-23pl 9 И ЕГО ПРИМЕНЕНИЕ
ZA200604322B (en) Method to reduce odor of excreta from companion animals
WO2005081687A3 (en) Human hinge core mimetibodies, compositions, methods and uses
WO2008080042A3 (en) Use of long-acting glp-1 receptor agonists to improve insulin sensitivity and lipid profiles
ZA202006503B (en) Non-human animal models of ditra disease and uses thereof
ATE458403T1 (de) Transgene mäuse, die prkag3 exprimieren
WO2007076319A3 (en) Human glp-1 mimetibodies and compositions for treating obesity and related disorders, methods and uses
EP1406917A4 (de) Humanalbumintiermodelle für die bewertung von arzneimitteln und für toxikologie- und immunogenitätsuntersuchungen
JP2005523891A5 (de)
WO2009142724A3 (en) Novel gpr101 transgenic mice and methods of use thereof
MX2007011975A (es) Mimeticuerpos de peptido similar a glucagon-1 humanos, composiciones, metodos y usos.
AU2002368482A1 (en) Melusin, a muscle specific protein, as a drug target for prevention and treatment of heart failure
Broughton Time, gentlemen, please.
AU2006100025A4 (en) Australian Wildlife Carer
ITRM20040455A1 (it) Uso di una composizione comprendente cuoio per il trattamento del mal dell'esca e marciume radicale di tutte le piante.
NO20052774D0 (no) Topiske preparater og bruk av disse for behandling av vannlevende dyr utsatt for desinfeksjon og vaksinasjon.
MX2009006696A (es) Tratamiento de diabetes con al menos un anticuerpo especifico del receptor del factor de crecimiento epidermico o uin derivado de este.
JP2003093504A (ja) 動物型輸液注入装置

Legal Events

Date Code Title Description
8364 No opposition during term of opposition