IL149313A0 - Process and intermediates for the preparation of imidazolidinone alpha v integrin antagonists - Google Patents

Process and intermediates for the preparation of imidazolidinone alpha v integrin antagonists

Info

Publication number
IL149313A0
IL149313A0 IL14931300A IL14931300A IL149313A0 IL 149313 A0 IL149313 A0 IL 149313A0 IL 14931300 A IL14931300 A IL 14931300A IL 14931300 A IL14931300 A IL 14931300A IL 149313 A0 IL149313 A0 IL 149313A0
Authority
IL
Israel
Prior art keywords
imidazolidinone
intermediates
alpha
preparation
integrin antagonists
Prior art date
Application number
IL14931300A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL149313A0 publication Critical patent/IL149313A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL14931300A 1999-11-08 2000-11-03 Process and intermediates for the preparation of imidazolidinone alpha v integrin antagonists IL149313A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16397999P 1999-11-08 1999-11-08
PCT/US2000/030361 WO2001034602A2 (en) 1999-11-08 2000-11-03 Process and intermediates for the preparation of imidazolidinone alpha v integrin antagonists

Publications (1)

Publication Number Publication Date
IL149313A0 true IL149313A0 (en) 2002-11-10

Family

ID=22592461

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14931300A IL149313A0 (en) 1999-11-08 2000-11-03 Process and intermediates for the preparation of imidazolidinone alpha v integrin antagonists

Country Status (20)

Country Link
EP (1) EP1230240B1 (ja)
JP (1) JP2003513974A (ja)
KR (1) KR20020048427A (ja)
CN (1) CN1414966A (ja)
AR (1) AR029407A1 (ja)
AT (1) ATE245645T1 (ja)
AU (1) AU777919B2 (ja)
BR (1) BR0015384A (ja)
CA (1) CA2389999A1 (ja)
CZ (1) CZ20021508A3 (ja)
DE (1) DE60004087T2 (ja)
EA (1) EA200200548A1 (ja)
ES (1) ES2202191T3 (ja)
HU (1) HUP0203246A3 (ja)
IL (1) IL149313A0 (ja)
MX (1) MXPA02004547A (ja)
PL (1) PL355011A1 (ja)
SK (1) SK8012002A3 (ja)
WO (1) WO2001034602A2 (ja)
YU (1) YU32502A (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1322310A4 (en) * 2000-09-13 2004-09-15 Merck & Co Inc ALPHA V INTEGRIN RECEPTOR ANTAGONISTS
EP1319002A1 (en) 2000-09-14 2003-06-18 Merck & Co., Inc. Alpha v integrin receptor antagonists
US6706885B2 (en) 2001-06-06 2004-03-16 Merck & Co., Inc. Process for preparing integrin antagonist intermediates
US6509347B2 (en) 2001-06-11 2003-01-21 Merck & Co., Inc. Crystalline forms of an integrin receptor antagonist
US6646130B2 (en) 2001-07-19 2003-11-11 Merck & Co., Inc. Process to chiral integrin antagonist beta-amino acid intermediate
AR038189A1 (es) * 2002-01-29 2005-01-05 Merck & Co Inc Proceso para la preparacion de intermediarios de antagonistas de integrina
AU2003267216A1 (en) * 2002-09-20 2004-04-08 Merck & Co., Inc. Mannitol formulation for integrin receptor antagonist
MX2013000537A (es) 2010-07-14 2013-01-29 Novartis Ag Compuestos heterociclicos agonistas del receptor ip.
ES2565826T3 (es) 2012-01-13 2016-04-07 Novartis Ag Pirroles fusionados como agonistas del receptor IP para el tratamiento de hipertensión arterial pulmonar (PAH) y trastornos relacionados
JP2016507582A (ja) 2013-02-13 2016-03-10 ノバルティス アーゲー Ｉｐ受容体アゴニスト複素環式化合物
GB201305668D0 (en) * 2013-03-28 2013-05-15 Glaxosmithkline Ip Dev Ltd Avs6 Integrin Antagonists
PT3929196T (pt) 2013-09-24 2023-09-11 Fujifilm Corp Composição farmacêutica de um novo composto contendo azoto ou seu sal, ou seu complexo de metal
PL3060563T3 (pl) * 2013-10-25 2018-10-31 Novartis Ag Pierścienio-skondensowane bicykliczne pochodne pirydylowe jako inhibitory fgfr4
GB201417002D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
ES2756748T3 (es) * 2014-10-03 2020-04-27 Novartis Ag Uso de derivados de piridilo bicíclicos de anillo fusionado como inhibidores de fgfr4
GB201604681D0 (en) * 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
GB201604680D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
US10118929B2 (en) 2016-04-27 2018-11-06 Scifluor Life Sciences, Inc. Nonanoic and decanoic acid derivatives and uses thereof
BR112019009293A2 (pt) * 2016-11-08 2019-07-30 Bristol-Myers Squibb Company pirrol amidas como inibidores de integrina alfa v

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA003095B1 (ru) * 1997-12-17 2002-12-26 Мерк Энд Ко., Инк. Антагонисты рецепторов интегринов

Also Published As

Publication number Publication date
WO2001034602A3 (en) 2002-01-17
EA200200548A1 (ru) 2002-10-31
AU777919B2 (en) 2004-11-04
BR0015384A (pt) 2002-10-08
AR029407A1 (es) 2003-06-25
MXPA02004547A (es) 2002-09-02
WO2001034602A2 (en) 2001-05-17
YU32502A (sh) 2004-12-31
SK8012002A3 (en) 2002-10-08
ES2202191T3 (es) 2004-04-01
EP1230240B1 (en) 2003-07-23
DE60004087D1 (de) 2003-08-28
PL355011A1 (en) 2004-03-22
KR20020048427A (ko) 2002-06-22
HUP0203246A2 (hu) 2003-01-28
CZ20021508A3 (cs) 2002-10-16
AU1461401A (en) 2001-06-06
DE60004087T2 (de) 2004-04-15
JP2003513974A (ja) 2003-04-15
ATE245645T1 (de) 2003-08-15
CA2389999A1 (en) 2001-05-17
CN1414966A (zh) 2003-04-30
HUP0203246A3 (en) 2003-12-29
EP1230240A2 (en) 2002-08-14

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