DE60004087D1 - Verfahren und zwischenprodukte zur herstellung von imidazolinon alpha v integrin antagonisten - Google Patents

Verfahren und zwischenprodukte zur herstellung von imidazolinon alpha v integrin antagonisten

Info

Publication number
DE60004087D1
DE60004087D1 DE60004087T DE60004087T DE60004087D1 DE 60004087 D1 DE60004087 D1 DE 60004087D1 DE 60004087 T DE60004087 T DE 60004087T DE 60004087 T DE60004087 T DE 60004087T DE 60004087 D1 DE60004087 D1 DE 60004087D1
Authority
DE
Germany
Prior art keywords
alpha
intermediate products
integrin antagonists
imidazolinone
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60004087T
Other languages
English (en)
Other versions
DE60004087T2 (de
Inventor
S Jensen
Michael Palucki
R Rivera
M Wells
Yi Xiao
Yaling Wang
Chunhua Yang
Nobuyoshi Yasuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE60004087D1 publication Critical patent/DE60004087D1/de
Publication of DE60004087T2 publication Critical patent/DE60004087T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60004087T 1999-11-08 2000-11-03 Verfahren und zwischenprodukte zur herstellung von imidazolinon alpha v integrin antagonisten Expired - Lifetime DE60004087T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16397999P 1999-11-08 1999-11-08
US163979P 1999-11-08
PCT/US2000/030361 WO2001034602A2 (en) 1999-11-08 2000-11-03 Process and intermediates for the preparation of imidazolidinone alpha v integrin antagonists

Publications (2)

Publication Number Publication Date
DE60004087D1 true DE60004087D1 (de) 2003-08-28
DE60004087T2 DE60004087T2 (de) 2004-04-15

Family

ID=22592461

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60004087T Expired - Lifetime DE60004087T2 (de) 1999-11-08 2000-11-03 Verfahren und zwischenprodukte zur herstellung von imidazolinon alpha v integrin antagonisten

Country Status (20)

Country Link
EP (1) EP1230240B1 (de)
JP (1) JP2003513974A (de)
KR (1) KR20020048427A (de)
CN (1) CN1414966A (de)
AR (1) AR029407A1 (de)
AT (1) ATE245645T1 (de)
AU (1) AU777919B2 (de)
BR (1) BR0015384A (de)
CA (1) CA2389999A1 (de)
CZ (1) CZ20021508A3 (de)
DE (1) DE60004087T2 (de)
EA (1) EA200200548A1 (de)
ES (1) ES2202191T3 (de)
HU (1) HUP0203246A3 (de)
IL (1) IL149313A0 (de)
MX (1) MXPA02004547A (de)
PL (1) PL355011A1 (de)
SK (1) SK8012002A3 (de)
WO (1) WO2001034602A2 (de)
YU (1) YU32502A (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6916810B2 (en) * 2000-09-13 2005-07-12 Merck & Co., Inc. αν integrin receptor antagonists
CA2421652A1 (en) 2000-09-14 2002-03-21 Merck And Co., Inc. Alpha v integrin receptor antagonists
US6706885B2 (en) 2001-06-06 2004-03-16 Merck & Co., Inc. Process for preparing integrin antagonist intermediates
US6509347B2 (en) 2001-06-11 2003-01-21 Merck & Co., Inc. Crystalline forms of an integrin receptor antagonist
US6646130B2 (en) 2001-07-19 2003-11-11 Merck & Co., Inc. Process to chiral integrin antagonist beta-amino acid intermediate
TW200304439A (en) * 2002-01-29 2003-10-01 Merck & Co Inc Process for preparing integrin antagonist intermediate
EP1551401A4 (de) * 2002-09-20 2006-03-22 Merck & Co Inc Mannitol-formulierung f r einen integrin-rezeptor-antagonisten
SG186989A1 (en) 2010-07-14 2013-02-28 Novartis Ag Ip receptor agonist heterocyclic compounds
CN104053659B (zh) 2012-01-13 2016-11-09 诺华股份有限公司 用于治疗肺动脉高压(pah)及相关病症的作为ip 受体激动剂的稠合的吡咯类
WO2014125413A1 (en) 2013-02-13 2014-08-21 Novartis Ag Ip receptor agonist heterocyclic compounds
GB201305668D0 (en) * 2013-03-28 2013-05-15 Glaxosmithkline Ip Dev Ltd Avs6 Integrin Antagonists
JP6215335B2 (ja) 2013-09-24 2017-10-18 富士フイルム株式会社 新規な含窒素化合物もしくはその塩またはそれらと金属との錯体
AU2014338549B2 (en) 2013-10-25 2017-05-25 Novartis Ag Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417002D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
ES2756748T3 (es) * 2014-10-03 2020-04-27 Novartis Ag Uso de derivados de piridilo bicíclicos de anillo fusionado como inhibidores de fgfr4
GB201604681D0 (en) * 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
GB201604680D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
WO2017189828A1 (en) * 2016-04-27 2017-11-02 Scifluor Life Sciences, Inc. Nonanoic and decanoic acid derivatives and uses thereof
LT3538528T (lt) * 2016-11-08 2021-03-10 Bristol-Myers Squibb Company Pirolo amidai, kaip alfa v integrino inhibitoriai

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1040111E (pt) * 1997-12-17 2005-10-31 Merck & Co Inc Antagonistas do receptor da integrina

Also Published As

Publication number Publication date
ES2202191T3 (es) 2004-04-01
CN1414966A (zh) 2003-04-30
KR20020048427A (ko) 2002-06-22
DE60004087T2 (de) 2004-04-15
YU32502A (sh) 2004-12-31
JP2003513974A (ja) 2003-04-15
IL149313A0 (en) 2002-11-10
AR029407A1 (es) 2003-06-25
WO2001034602A3 (en) 2002-01-17
CA2389999A1 (en) 2001-05-17
HUP0203246A2 (hu) 2003-01-28
AU1461401A (en) 2001-06-06
PL355011A1 (en) 2004-03-22
HUP0203246A3 (en) 2003-12-29
EP1230240B1 (de) 2003-07-23
SK8012002A3 (en) 2002-10-08
ATE245645T1 (de) 2003-08-15
WO2001034602A2 (en) 2001-05-17
EP1230240A2 (de) 2002-08-14
CZ20021508A3 (cs) 2002-10-16
BR0015384A (pt) 2002-10-08
MXPA02004547A (es) 2002-09-02
EA200200548A1 (ru) 2002-10-31
AU777919B2 (en) 2004-11-04

Similar Documents

Publication Publication Date Title
ATE245645T1 (de) Verfahren und zwischenprodukte zur herstellung von imidazolinon alpha v integrin antagonisten
ATE348098T1 (de) Verfahren und zwischenprodukte zur herstellung von antikrebsmitteln
DE69938197D1 (de) Vliesstoff hoher festigkeit und verfahren zu seiner herstellung
ATE265164T1 (de) Verfahren und vorrichtung zur herstellung von borstenwaren und danach hergestellte borstenwaren
DE60027698D1 (de) Lasttragendes osteoimplantat und verfahren zu seiner herstellung
DE60023023D1 (de) Zirkoniumdioxidsol und verfahren zu seiner herstellung
DE60013027D1 (de) Bauteil und Verfahren zu seiner Herstellung
DE69936398D1 (de) Polyesterbehälter und verfahren zu seiner herstellung
DE59912579D1 (de) Verfahren und Vorrichtung zur Herstellung von Packungen
ATE446697T1 (de) Verfahren zur herstellung von borstenwaren sowie borstenware
DE60045897D1 (de) Verfahren zur herstellung von polyolefinprodukten
DE69815545D1 (de) Mehrschichtiger kunststoffbehälter und verfahren zu seiner herstellung
DE60042806D1 (de) Verfahren und Vorrichtung zur Herstellung von in Längsrichtung angeordneten Vliesstoffen
ATE372570T1 (de) Umgossener transponder und verfahren zu dessen herstellung
DE60002630D1 (de) Verfahren und Vorrichtung zur Herstellung von Verpackungen
DE50006193D1 (de) Verfahren zur herstellung von otoplastiken und otoplastik
ATE236549T1 (de) Verfahren zur herstellung von borstenwaren und danach hergestellte borstenwaren
DE50002380D1 (de) Verfahren und arbeitsmaschine zur herstellung von bodenflächen
DE50010110D1 (de) Verfahren zur herstellung von plattenförmigen produkten
DE60027952D1 (de) Infrarotdetektor und Verfahren zu seiner Herstellung
DE59813228D1 (de) Kunststoffbehälter und verfahren zu seiner herstellung
DE69813312D1 (de) Verfahren zur herstellung von cyclopropylethyn sowie zwischenprodukte zur herstellung von cyclopropylethyn
DE60018389D1 (de) Senkrecht detektierendes fluxgate-mikromagnetometer und verfahren zu seiner herstellung
DE60026765D1 (de) Vorrichtung und Verfahren zur Herstellung von Etiketten
DE59908270D1 (de) Verfahren und vorrichtung zur herstellung von bürsten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK & CO., INC., RAHWAY, N.J., US

8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US