AR038189A1 - Proceso para la preparacion de intermediarios de antagonistas de integrina - Google Patents
Proceso para la preparacion de intermediarios de antagonistas de integrinaInfo
- Publication number
- AR038189A1 AR038189A1 ARP030100156A ARP030100156A AR038189A1 AR 038189 A1 AR038189 A1 AR 038189A1 AR P030100156 A ARP030100156 A AR P030100156A AR P030100156 A ARP030100156 A AR P030100156A AR 038189 A1 AR038189 A1 AR 038189A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- integrine
- intermediaries
- antagonist
- structural formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Proceso para la preparación de 2,5-di-(3-aminopropil)piridina, de fórmula estructural (1) que es útil en la síntesis de antagonistas del receptor de integrina alfa v beta 3. Además se proporcionan intermediarios útiles obtenidos del proceso. Reivindicación 1: un proceso para la preparación del compuesto de fórmula estructural (1) que comprende la etapa de hidrogenar el compuesto de la fórmula estructural (2).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35260102P | 2002-01-29 | 2002-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR038189A1 true AR038189A1 (es) | 2005-01-05 |
Family
ID=27663113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030100156A AR038189A1 (es) | 2002-01-29 | 2003-01-20 | Proceso para la preparacion de intermediarios de antagonistas de integrina |
Country Status (4)
Country | Link |
---|---|
US (1) | US6914144B2 (es) |
AR (1) | AR038189A1 (es) |
TW (1) | TW200304439A (es) |
WO (1) | WO2003064390A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8372399B2 (en) * | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
US8636995B2 (en) * | 2006-08-31 | 2014-01-28 | Cardiac Pacemakers, Inc. | Methods and devices to regulate stem cell homing |
US20080058922A1 (en) * | 2006-08-31 | 2008-03-06 | Cardiac Pacemakers, Inc. | Methods and devices employing vap-1 inhibitors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19741876A1 (de) | 1997-09-23 | 1999-03-25 | Basf Ag | Verfahren zur selektiven Herstellung racemischer Metallocenkomplexe |
US6017926A (en) | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
EP1230240B1 (en) * | 1999-11-08 | 2003-07-23 | Merck & Co., Inc. | Process and intermediates for the preparation of imidazolidinone alpha v integrin antagonists |
GB2356630A (en) * | 1999-11-10 | 2001-05-30 | Merck & Co Inc | Intermediates used in the preparation of tetrahydronaphthyridine |
JP4787447B2 (ja) * | 2000-01-20 | 2011-10-05 | メルク・シャープ・エンド・ドーム・コーポレイション | αvインテグリン受容体拮抗薬 |
-
2003
- 2003-01-20 AR ARP030100156A patent/AR038189A1/es unknown
- 2003-01-20 TW TW092101118A patent/TW200304439A/zh unknown
- 2003-01-24 WO PCT/US2003/002191 patent/WO2003064390A1/en not_active Application Discontinuation
- 2003-01-29 US US10/353,612 patent/US6914144B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2003064390A1 (en) | 2003-08-07 |
US6914144B2 (en) | 2005-07-05 |
TW200304439A (en) | 2003-10-01 |
US20030176707A1 (en) | 2003-09-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP066773A (es) | Intermediarios de quinolina como inhibidores de receptores de tirosina quinasas y la síntesis de los mismos | |
AR064165A1 (es) | Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento | |
ITMI20050801A1 (it) | Procedimento per la preparazione di telmisartan | |
EA200700365A1 (ru) | Производные индол-2-карбоксамидина как антагонисты nmda рецептора | |
AR006545A1 (es) | Compuestos sustitutos de las catecolaminas, utiles como antagonistas beta3, composiciones farmaceuticas que los contienen y compuestos intermediarios deaplicacion exclusiva en la preparacion de dichos compuestos | |
NO20060195L (no) | Kinolylamidderivater som CCR-5-antagonister | |
GT200500296A (es) | Sintesis asimetrica de derivados del dehidrobenzofurano | |
ATE439345T1 (de) | Zwischenprodukte für die herstellung von harnstoffderivaten mit muskarinrezeptor- antagonistischer aktivität | |
UY26974A1 (es) | Agonistas del receptor beta3 adrenérgico y usos de los mismos | |
CR8475A (es) | Fenilalanina-amidas sustituidas por benzoilo | |
WO2005030712A3 (en) | Thrombin receptor antagonists | |
WO2004048345A3 (en) | 2,5-diketopiperazines for the treatment of obesity | |
MA27991A1 (fr) | Derives d'aminoquinoline et leur utilisation comme ligands d'adenosine a3 | |
EA200500536A1 (ru) | Антагонисты рецептора pgd2 для лечения воспалительных заболеваний | |
SMAP200600024A (it) | 2,6-Biseteroaril-4-amminopirimidine come antagonisti del recettore dell'adenosia | |
DE602005021258D1 (de) | Biphenylverbindungen geeignet für die Synthese von Muscarinrezeptorantagonisten | |
UY29919A1 (es) | Derivados sustituidos de 3,4-dihidroisoquinolin-1-amino-trifluoroacetato, sus composiciones farmacéuticas y aplicaciones | |
EA200600621A1 (ru) | Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств | |
ATE386740T1 (de) | Beta-3 adrenergische agonisten | |
BR0206595A (pt) | Composto, composição farmacêutica, e uso de um composto | |
EA200400454A1 (ru) | Мускариновые агонисты | |
PA8782901A1 (es) | "nuevos compuestos ligandos del receptor de la adenosina a3" | |
ECSP045291A (es) | Preparación de ácido n1-(2'-piridil)-1,2-propanodiamino sulfámico y su uso en la síntesis de piperazinas biológicamente activas | |
ECSP088878A (es) | Proceso para la preparación de indazolil ureas que inhiben receptores de vanilloides del subtipo 1 (vr1) | |
AR038189A1 (es) | Proceso para la preparacion de intermediarios de antagonistas de integrina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |