AR038189A1 - PROCESS FOR THE PREPARATION OF INTEGRINE ANTAGONIST INTERMEDIARIES - Google Patents

PROCESS FOR THE PREPARATION OF INTEGRINE ANTAGONIST INTERMEDIARIES

Info

Publication number
AR038189A1
AR038189A1 ARP030100156A ARP030100156A AR038189A1 AR 038189 A1 AR038189 A1 AR 038189A1 AR P030100156 A ARP030100156 A AR P030100156A AR P030100156 A ARP030100156 A AR P030100156A AR 038189 A1 AR038189 A1 AR 038189A1
Authority
AR
Argentina
Prior art keywords
preparation
integrine
intermediaries
antagonist
structural formula
Prior art date
Application number
ARP030100156A
Other languages
Spanish (es)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR038189A1 publication Critical patent/AR038189A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Abstract

Proceso para la preparación de 2,5-di-(3-aminopropil)piridina, de fórmula estructural (1) que es útil en la síntesis de antagonistas del receptor de integrina alfa v beta 3. Además se proporcionan intermediarios útiles obtenidos del proceso. Reivindicación 1: un proceso para la preparación del compuesto de fórmula estructural (1) que comprende la etapa de hidrogenar el compuesto de la fórmula estructural (2).Process for the preparation of 2,5-di- (3-aminopropyl) pyridine, of structural formula (1) which is useful in the synthesis of alpha v beta 3 integrin receptor antagonists. Also useful intermediates obtained from the process are provided. Claim 1: A process for the preparation of the compound of structural formula (1) comprising the step of hydrogenating the compound of the structural formula (2).

ARP030100156A 2002-01-29 2003-01-20 PROCESS FOR THE PREPARATION OF INTEGRINE ANTAGONIST INTERMEDIARIES AR038189A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35260102P 2002-01-29 2002-01-29

Publications (1)

Publication Number Publication Date
AR038189A1 true AR038189A1 (en) 2005-01-05

Family

ID=27663113

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030100156A AR038189A1 (en) 2002-01-29 2003-01-20 PROCESS FOR THE PREPARATION OF INTEGRINE ANTAGONIST INTERMEDIARIES

Country Status (4)

Country Link
US (1) US6914144B2 (en)
AR (1) AR038189A1 (en)
TW (1) TW200304439A (en)
WO (1) WO2003064390A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080058922A1 (en) * 2006-08-31 2008-03-06 Cardiac Pacemakers, Inc. Methods and devices employing vap-1 inhibitors
US8372399B2 (en) * 2006-08-31 2013-02-12 Cardiac Pacemakers, Inc. Bispecific antibodies and agents to enhance stem cell homing
US8636995B2 (en) * 2006-08-31 2014-01-28 Cardiac Pacemakers, Inc. Methods and devices to regulate stem cell homing

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19741876A1 (en) 1997-09-23 1999-03-25 Basf Ag Selective preparation of racemic metallocene complexes, used as catalysts
US6017926A (en) 1997-12-17 2000-01-25 Merck & Co., Inc. Integrin receptor antagonists
CN1414966A (en) * 1999-11-08 2003-04-30 麦克公司 Process and intermediates for preparation of imidazolidinone alpha U protein antagonists
GB2356630A (en) * 1999-11-10 2001-05-30 Merck & Co Inc Intermediates used in the preparation of tetrahydronaphthyridine
JP4787447B2 (en) * 2000-01-20 2011-10-05 メルク・シャープ・エンド・ドーム・コーポレイション αv integrin receptor antagonist

Also Published As

Publication number Publication date
US6914144B2 (en) 2005-07-05
TW200304439A (en) 2003-10-01
US20030176707A1 (en) 2003-09-18
WO2003064390A1 (en) 2003-08-07

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