IL147868A0 - Antibacterial heterobicyclic substituted phenyl oxazolidinones - Google Patents

Antibacterial heterobicyclic substituted phenyl oxazolidinones

Info

Publication number
IL147868A0
IL147868A0 IL14786800A IL14786800A IL147868A0 IL 147868 A0 IL147868 A0 IL 147868A0 IL 14786800 A IL14786800 A IL 14786800A IL 14786800 A IL14786800 A IL 14786800A IL 147868 A0 IL147868 A0 IL 147868A0
Authority
IL
Israel
Prior art keywords
antibacterial
substituted phenyl
phenyl oxazolidinones
heterobicyclic
heterobicyclic substituted
Prior art date
Application number
IL14786800A
Other languages
English (en)
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of IL147868A0 publication Critical patent/IL147868A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL14786800A 1999-08-12 2000-08-02 Antibacterial heterobicyclic substituted phenyl oxazolidinones IL147868A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14862199P 1999-08-12 1999-08-12
PCT/US2000/021093 WO2001042242A1 (en) 1999-08-12 2000-08-02 Antibacterial heterobicyclic substituted phenyl oxazolidinones

Publications (1)

Publication Number Publication Date
IL147868A0 true IL147868A0 (en) 2002-08-14

Family

ID=22526580

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14786800A IL147868A0 (en) 1999-08-12 2000-08-02 Antibacterial heterobicyclic substituted phenyl oxazolidinones

Country Status (23)

Country Link
US (2) US6413981B1 (de)
EP (1) EP1206469B1 (de)
JP (1) JP2003516404A (de)
KR (1) KR100463634B1 (de)
CN (1) CN1330647C (de)
AR (1) AR025225A1 (de)
AT (1) ATE260276T1 (de)
AU (1) AU783088B2 (de)
BR (1) BR0013237A (de)
CA (1) CA2378183C (de)
CZ (1) CZ2002882A3 (de)
DE (1) DE60008545T2 (de)
DK (1) DK1206469T3 (de)
ES (1) ES2215713T3 (de)
HU (1) HUP0202447A3 (de)
IL (1) IL147868A0 (de)
MX (1) MXPA02001559A (de)
MY (1) MY125359A (de)
PL (1) PL198558B1 (de)
PT (1) PT1206469E (de)
RU (1) RU2278117C2 (de)
TW (1) TW593313B (de)
WO (1) WO2001042242A1 (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
ATE321024T1 (de) * 2000-10-17 2006-04-15 Pharmacia & Upjohn Co Llc Verfahren zur herstellung von oxazolidinonverbindungen
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
WO2003093247A2 (en) * 2002-04-30 2003-11-13 Orchid Chemicals & Pharmaceuticals Ltd Antibacterial agents
WO2003106454A1 (en) * 2002-06-12 2003-12-24 Orchid Chemicals & Pharmaceuticals Ltd 1h-isoquinoline-oxazolidinone derivaties and their use as antibacterial agents
WO2004026848A1 (en) 2002-09-20 2004-04-01 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
EP2716647A3 (de) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Makrocyclische Verbindungen Und Verfahren Zu Deren Herstellung Und Anwendung
EP1685841A1 (de) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prophylaxe und Behandlung von thrombolischen Erkrankungen
JP5395432B2 (ja) 2005-08-24 2014-01-22 リブ−エックス ファーマシューティカルズ,インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
EP1934237A2 (de) 2005-08-24 2008-06-25 Rib-X Pharmaceuticals, Inc. Triazolverbindungen und verfahren zu deren herstellung und anwendung
CA2624310C (en) 2005-10-04 2014-01-07 Bayer Healthcare Ag Polymorphic form of 5-chloro-n-({5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
JP4012239B2 (ja) * 2006-01-11 2007-11-21 生化学工業株式会社 オキサゾロン誘導体
US7776855B2 (en) * 2006-07-27 2010-08-17 Janssen Pharmaceutica N.V. Antimicrobial oxazolidinone prodrugs
WO2008045473A1 (en) * 2006-10-11 2008-04-17 Transform Pharmaceuticals, Inc. Novel crystal of n-[[(5s)-3-[4-(2,6-dihydro-2-methylpyrolo[3,4-c] pyrazol-5(4h)-yl)-3-fluoropheny]-2-oxo-5-oxazolidinyl]methyl] acetamide
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
MY148847A (en) * 2006-11-10 2013-06-14 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives
CN101084901B (zh) * 2007-06-22 2011-12-21 复旦大学 一种葡萄球菌抑制剂
US8218847B2 (en) 2008-06-06 2012-07-10 Superdimension, Ltd. Hybrid registration method
SG10201702946RA (en) 2008-10-10 2017-05-30 Merck Sharp & Dohme Methods for preparing oxazolidinones and compositions containing them
CN102439006A (zh) 2009-02-03 2012-05-02 特留斯治疗学公司 (r)-3-(4-(2-(2-甲基四唑-5-基)吡啶-5-基)-3-氟苯基)-5-羟甲基噁唑烷-2-酮二氢磷酸酯的晶型
CN103030634B (zh) * 2011-09-30 2015-07-15 山东轩竹医药科技有限公司 含有并环的噁唑烷酮类抗菌素
EP2766373B1 (de) * 2011-10-11 2016-08-17 Council of Scientific & Industrial Research Sila-analoga von oxazolidinon-derivaten und ihre herstellung
US9603668B2 (en) 2014-07-02 2017-03-28 Covidien Lp Dynamic 3D lung map view for tool navigation inside the lung
US9633431B2 (en) 2014-07-02 2017-04-25 Covidien Lp Fluoroscopic pose estimation
US9986983B2 (en) 2014-10-31 2018-06-05 Covidien Lp Computed tomography enhanced fluoroscopic system, device, and method of utilizing the same
MX2017006319A (es) 2014-11-14 2017-08-10 Melinta Therapeutics Inc Método para tratar, prevenir o reducir el riesgo de infección cutánea.
WO2016201370A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
US10702226B2 (en) 2015-08-06 2020-07-07 Covidien Lp System and method for local three dimensional volume reconstruction using a standard fluoroscope
US10674982B2 (en) 2015-08-06 2020-06-09 Covidien Lp System and method for local three dimensional volume reconstruction using a standard fluoroscope
US10716525B2 (en) 2015-08-06 2020-07-21 Covidien Lp System and method for navigating to target and performing procedure on target utilizing fluoroscopic-based local three dimensional volume reconstruction
US10575754B2 (en) 2015-09-23 2020-03-03 Covidien Lp Catheter having a sensor and an extended working channel
AU2016361478B2 (en) 2015-11-25 2020-09-10 Dana-Farber Cancer Institute, Inc. Bivalent bromodomain inhibitors and uses thereof
JP2019508422A (ja) * 2016-02-16 2019-03-28 イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム・リミテッドYissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. シアノバクテリアおよび植物の増殖を阻害するための非タンパク質性フェニルアラニン類似体
CN109415367B (zh) 2016-06-29 2021-04-16 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的新的二氢吡咯并嘧啶类化合物
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
US11529190B2 (en) 2017-01-30 2022-12-20 Covidien Lp Enhanced ablation and visualization techniques for percutaneous surgical procedures
US11793579B2 (en) 2017-02-22 2023-10-24 Covidien Lp Integration of multiple data sources for localization and navigation
US10699448B2 (en) 2017-06-29 2020-06-30 Covidien Lp System and method for identifying, marking and navigating to a target using real time two dimensional fluoroscopic data
US10893843B2 (en) 2017-10-10 2021-01-19 Covidien Lp System and method for identifying and marking a target in a fluoroscopic three-dimensional reconstruction
US10930064B2 (en) 2018-02-08 2021-02-23 Covidien Lp Imaging reconstruction system and method
US10905498B2 (en) 2018-02-08 2021-02-02 Covidien Lp System and method for catheter detection in fluoroscopic images and updating displayed position of catheter
US10893842B2 (en) 2018-02-08 2021-01-19 Covidien Lp System and method for pose estimation of an imaging device and for determining the location of a medical device with respect to a target
US10872449B2 (en) 2018-05-02 2020-12-22 Covidien Lp System and method for constructing virtual radial ultrasound images from CT data and performing a surgical navigation procedure using virtual ultrasound images
KR20210038632A (ko) 2018-07-25 2021-04-07 카딜라 핼쓰캐어 리미티드 포유류 감염 치료를 위한 신규 화합물
US11071591B2 (en) 2018-07-26 2021-07-27 Covidien Lp Modeling a collapsed lung using CT data
US11705238B2 (en) 2018-07-26 2023-07-18 Covidien Lp Systems and methods for providing assistance during surgery
US11944388B2 (en) 2018-09-28 2024-04-02 Covidien Lp Systems and methods for magnetic interference correction
US11877806B2 (en) 2018-12-06 2024-01-23 Covidien Lp Deformable registration of computer-generated airway models to airway trees
US11045075B2 (en) 2018-12-10 2021-06-29 Covidien Lp System and method for generating a three-dimensional model of a surgical site
US11617493B2 (en) 2018-12-13 2023-04-04 Covidien Lp Thoracic imaging, distance measuring, surgical awareness, and notification system and method
US11801113B2 (en) 2018-12-13 2023-10-31 Covidien Lp Thoracic imaging, distance measuring, and notification system and method
US11357593B2 (en) 2019-01-10 2022-06-14 Covidien Lp Endoscopic imaging with augmented parallax
US11625825B2 (en) 2019-01-30 2023-04-11 Covidien Lp Method for displaying tumor location within endoscopic images
US11564751B2 (en) 2019-02-01 2023-01-31 Covidien Lp Systems and methods for visualizing navigation of medical devices relative to targets
US11925333B2 (en) 2019-02-01 2024-03-12 Covidien Lp System for fluoroscopic tracking of a catheter to update the relative position of a target and the catheter in a 3D model of a luminal network
US11744643B2 (en) 2019-02-04 2023-09-05 Covidien Lp Systems and methods facilitating pre-operative prediction of post-operative tissue function
US11819285B2 (en) 2019-04-05 2023-11-21 Covidien Lp Magnetic interference detection systems and methods
US11975157B2 (en) 2019-04-12 2024-05-07 Covidien Lp Method of manufacturing an elongated catheter having multiple sensors for three-dimensional location of the catheter
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections
US11269173B2 (en) 2019-08-19 2022-03-08 Covidien Lp Systems and methods for displaying medical video images and/or medical 3D models
US11864935B2 (en) 2019-09-09 2024-01-09 Covidien Lp Systems and methods for pose estimation of a fluoroscopic imaging device and for three-dimensional imaging of body structures
US11931111B2 (en) 2019-09-09 2024-03-19 Covidien Lp Systems and methods for providing surgical guidance
US11627924B2 (en) 2019-09-24 2023-04-18 Covidien Lp Systems and methods for image-guided navigation of percutaneously-inserted devices
US11380060B2 (en) 2020-01-24 2022-07-05 Covidien Lp System and method for linking a segmentation graph to volumetric data
US11847730B2 (en) 2020-01-24 2023-12-19 Covidien Lp Orientation detection in fluoroscopic images
US11922581B2 (en) 2020-05-08 2024-03-05 Coviden Lp Systems and methods of controlling an operating room display using an augmented reality headset
US11701492B2 (en) 2020-06-04 2023-07-18 Covidien Lp Active distal tip drive
US12008760B2 (en) 2020-07-24 2024-06-11 Covidien Lp Systems and methods for estimating the movement of a target using a universal deformation model for anatomic tissue
US11950950B2 (en) 2020-07-24 2024-04-09 Covidien Lp Zoom detection and fluoroscope movement detection for target overlay

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100257418B1 (ko) 1991-11-01 2000-05-15 로렌스 티. 마이젠헬더 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
ES2193201T3 (es) * 1994-11-15 2003-11-01 Upjohn Co Agentes antibacterianos tipo oxazolidonas sustituidas con oxazina y tiazina biciclica.
BR9607017A (pt) 1995-02-03 1997-10-28 Upjohn Co Composto e uso do mesmo
US6124334A (en) 1995-02-03 2000-09-26 Pharmacia & Upjohn Company Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
US6090820A (en) 1995-05-11 2000-07-18 Pharmacia & Upjohn Company Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones
MX9703040A (es) 1995-09-12 1997-07-31 Upjohn Co Antimicrobianos de feniloxazolidinona.
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
RU2176643C2 (ru) 1996-04-11 2001-12-10 Фармация Энд Апджон Компани Способ получения 5-гидроксиметил замещенных оксазолидинонов, способ получения 5-аминометил замещенных оксазолидиноновых аминов, оксазолидинонсульфонат
WO1998054161A1 (en) 1997-05-30 1998-12-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
DE19736973A1 (de) * 1997-08-25 1999-03-04 Basf Ag Formmassen auf der Basis von Polyarylenethern und Polyamiden
JPH11322729A (ja) 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体

Also Published As

Publication number Publication date
PL354200A1 (en) 2003-12-29
ES2215713T3 (es) 2004-10-16
MY125359A (en) 2006-07-31
HUP0202447A2 (en) 2002-10-28
CZ2002882A3 (cs) 2002-06-12
TW593313B (en) 2004-06-21
DE60008545T2 (de) 2004-12-23
PL198558B1 (pl) 2008-06-30
WO2001042242A1 (en) 2001-06-14
RU2278117C2 (ru) 2006-06-20
RU2002103379A (ru) 2003-09-20
ATE260276T1 (de) 2004-03-15
CA2378183A1 (en) 2001-06-14
DE60008545D1 (de) 2004-04-01
EP1206469B1 (de) 2004-02-25
AU6892800A (en) 2001-06-18
DK1206469T3 (da) 2004-05-10
CA2378183C (en) 2009-10-20
CN1414964A (zh) 2003-04-30
KR100463634B1 (ko) 2004-12-30
AU783088B2 (en) 2005-09-22
HUP0202447A3 (en) 2003-10-28
AR025225A1 (es) 2002-11-13
US6413981B1 (en) 2002-07-02
MXPA02001559A (es) 2003-10-14
PT1206469E (pt) 2004-06-30
CN1330647C (zh) 2007-08-08
US20030171366A1 (en) 2003-09-11
KR20020016652A (ko) 2002-03-04
EP1206469A1 (de) 2002-05-22
BR0013237A (pt) 2003-07-15
JP2003516404A (ja) 2003-05-13

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