IL145187A0 - Echinocandin/carbohydrate complexes - Google Patents

Echinocandin/carbohydrate complexes

Info

Publication number
IL145187A0
IL145187A0 IL14518700A IL14518700A IL145187A0 IL 145187 A0 IL145187 A0 IL 145187A0 IL 14518700 A IL14518700 A IL 14518700A IL 14518700 A IL14518700 A IL 14518700A IL 145187 A0 IL145187 A0 IL 145187A0
Authority
IL
Israel
Prior art keywords
echinocandin
complex
carbohydrate
carbohydrate complexes
treatments
Prior art date
Application number
IL14518700A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL145187A0 publication Critical patent/IL145187A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
IL14518700A 1999-03-03 2000-03-02 Echinocandin/carbohydrate complexes IL145187A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12269299P 1999-03-03 1999-03-03
PCT/US2000/005508 WO2000052037A1 (en) 1999-03-03 2000-03-02 Echinocandin/carbohydrate complexes

Publications (1)

Publication Number Publication Date
IL145187A0 true IL145187A0 (en) 2002-06-30

Family

ID=22404173

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14518700A IL145187A0 (en) 1999-03-03 2000-03-02 Echinocandin/carbohydrate complexes

Country Status (18)

Country Link
US (3) US7041637B2 (de)
EP (1) EP1157030B1 (de)
JP (1) JP4272359B2 (de)
KR (1) KR20020003864A (de)
CN (1) CN1345333A (de)
AT (1) ATE248187T1 (de)
AU (1) AU772633B2 (de)
BR (1) BR0008712A (de)
CA (1) CA2362016A1 (de)
DE (1) DE60004793T2 (de)
DK (1) DK1157030T3 (de)
ES (1) ES2204548T3 (de)
HK (1) HK1040088B (de)
IL (1) IL145187A0 (de)
PT (1) PT1157030E (de)
RU (1) RU2001126723A (de)
WO (1) WO2000052037A1 (de)
ZA (1) ZA200108004B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
AU766091B2 (en) 1998-12-09 2003-10-09 Eli Lilly And Company Purification of echinocandin cyclopeptide compounds
KR100613136B1 (ko) 1999-03-03 2006-08-17 일라이 릴리 앤드 캄파니 미셀-형성 계면활성제를 함유하는 에키노칸딘 제약학적조제물
CN1345230A (zh) 1999-03-03 2002-04-17 伊莱利利公司 口服ecb药物制剂和药物组合物的制备方法
WO2000052037A1 (en) * 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin/carbohydrate complexes
PT1155034E (pt) 1999-03-03 2007-01-31 Lilly Co Eli Formação e permuta aniónica de sais de amónio internos cristalinos de equinocandina b
US6482847B2 (en) * 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
JP2005053782A (ja) * 2001-08-31 2005-03-03 Fujisawa Pharmaceut Co Ltd 環状リポペプチド化合物の新規結晶
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
RU2284832C2 (ru) * 2004-08-30 2006-10-10 Николай Александрович Киселев Антимикробная композиция для перорального введения
BRPI0708585B1 (pt) * 2006-03-07 2017-02-21 Aquanova Ag solubilizado livre de agente de estabilização, processo para a preparação e uso do mesmo
NZ572226A (en) 2006-04-18 2011-05-27 Ekr Therapeutics Inc Pre-mixed, ready-to-use IV bolus compositions comprising nicardipine and methods of use
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
CN102614492B (zh) * 2011-01-31 2013-12-11 上海天伟生物制药有限公司 一种含有棘白菌素类抗真菌剂米卡芬净的液体药用组合物
CN102614491B (zh) * 2011-01-31 2014-04-16 上海天伟生物制药有限公司 一种含有棘白菌素类抗真菌剂米卡芬净的药用组合物及其制备方法和用途
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
PL3058958T3 (pl) 2015-02-23 2019-02-28 Selectchemie Ag Kompozycja anidulafunginy
CN110339341A (zh) * 2018-04-03 2019-10-18 江苏恒瑞医药股份有限公司 一种达托霉素或其盐的组合物
CA3113071A1 (en) * 2018-10-11 2020-04-16 Imbria Pharmaceuticals, Inc. Tca cycle intermediates and methods of use thereof
CN109574811B (zh) * 2018-11-22 2021-12-24 中山大学 一种阿尼芬净侧链中间体对戊氧基三联苯甲酸的制备方法

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US161176A (en) * 1875-03-23 Improvement in heaters for cheese-vats
US54981A (en) * 1866-05-22 Improvement in nail-machines
US151474A (en) * 1874-06-02 Improvement in corn-shellers
US3293482A (en) 1962-06-21 1966-12-20 Rca Corp Plural output traveling wave tube
JPS5134916B2 (de) 1974-03-06 1976-09-29
DE2803581A1 (de) 1978-01-27 1979-08-02 Sandoz Ag Derivate des tetrahydro-echinocandin b
US4320052A (en) 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293483A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4299763A (en) 1979-12-13 1981-11-10 Eli Lilly And Company A-30912B Nucleus
US4293482A (en) 1979-12-13 1981-10-06 Eli Lilly And Company A-30912A Nucleus
US4293489A (en) 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
CA1183127A (en) 1979-12-13 1985-02-26 Manuel Debono Process for the preparation of derivatives of cyclic peptide nuclei
CA1170598A (en) 1979-12-13 1984-07-10 Bernard J. Abbott Process for the preparation of cyclic peptide nuclei
US4304716A (en) 1979-12-13 1981-12-08 Eli Lilly And Company S 31794/F-1 Nucleus
US4348384A (en) 1980-10-17 1982-09-07 Dainippon Pharmaceutical Co., Ltd. Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
US4393489A (en) * 1981-03-30 1983-07-12 Rca Corporation Audio processor for single, channel, matrixed two-channel and un-matrixed two-channel signals
US5141674A (en) 1984-03-08 1992-08-25 Phares Pharmaceutical Research N.V. Methods of preparing pro-liposome dispersions and aerosols
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
US5166135A (en) 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
AU617541B2 (en) 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US4927831A (en) 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5202309A (en) 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
JPH03240727A (ja) 1990-02-15 1991-10-28 Toyo Jozo Co Ltd ニューモシスチス・カリニ肺炎治療剤
CA2037957A1 (en) 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
US5049546A (en) 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
IE910892A1 (en) 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
US5310726A (en) 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
IL97347A0 (en) 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5386009A (en) 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5330973A (en) 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IL98349A (en) 1990-06-07 1995-05-26 Lilly Co Eli Diphylase lipopeptide
IE912046A1 (en) 1990-06-18 1991-12-18 Fujisawa Pharmaceutical Co New polypeptide compound and a process for preparation¹thereof
US5198421A (en) 1991-04-26 1993-03-30 Merck & Co., Inc. Phosphorylated cyclic lipopeptide
EP0486011A3 (en) 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii
US5369093A (en) 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
US5233023A (en) 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
JPH05271097A (ja) 1991-10-07 1993-10-19 Asahi Chem Ind Co Ltd アクレアシン類の可溶化剤および医薬組成物
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
NZ299314A (en) 1992-03-19 2001-09-28 Lilly Co Eli Cyclic peptide for inhibiting parasitic and antifungal activity
US5965525A (en) 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
DE69232220D1 (de) * 1992-09-22 2002-01-03 Takeo Takayanagi Kohlenhydrate-Komplexe zur Vernichtung von Krebszellen
JPH06172205A (ja) 1992-12-11 1994-06-21 Asahi Chem Ind Co Ltd アクレアシン類含有脂肪乳剤
US6268338B1 (en) 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
JPH09500103A (ja) 1993-05-04 1997-01-07 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルアミノアルキルエーテル
IS1796B (is) 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US5541160A (en) 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US5646111A (en) 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5618787A (en) 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5786325A (en) 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5629290A (en) 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5652213A (en) 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
GB9515182D0 (en) 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
US5629289A (en) 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
FR2740686B1 (fr) 1995-11-03 1998-01-16 Sanofi Sa Formulation pharmaceutique lyophilisee stable
US5693611A (en) 1996-02-01 1997-12-02 Eli Lilly And Company Cyclic peptide antifungal agents
CA2244238A1 (en) 1996-02-01 1997-08-07 Eli Lilly And Company Cyclic peptide antifungal agents
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5696084A (en) 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
WO1998029098A1 (en) 1996-12-31 1998-07-09 Inhale Therapeutic Systems, Inc. Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes
CA2301184A1 (en) 1997-08-04 1999-02-11 Eli Lilly And Company Cyclic peptide antifungal agents
US5972996A (en) 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
EP0931834A3 (de) 1997-12-23 2002-06-26 Eli Lilly And Company Echinocandin-bindungsdomäne von 1,3-Beta-glukan Synthase
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
US6284282B1 (en) 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
US6423345B2 (en) 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US6451349B1 (en) 1998-08-19 2002-09-17 Quadrant Healthcare (Uk) Limited Spray-drying process for the preparation of microparticles
ES2233070T3 (es) 1998-08-20 2005-06-01 ELI LILLY & COMPANY Sintesis de analogos peptidicos ciclicos modificados en el anillo.
ATE267210T1 (de) 1998-08-28 2004-06-15 Lilly Co Eli Reversible borkomplexe von 1,2-(cis)-diol zyklischen peptiden
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
AU766091B2 (en) 1998-12-09 2003-10-09 Eli Lilly And Company Purification of echinocandin cyclopeptide compounds
CA2354055A1 (en) 1998-12-16 2000-06-22 Eli Lilly And Company Cyclic peptide antifungal agents having a sugar substituent
AU767357B2 (en) 1998-12-16 2003-11-06 Eli Lilly And Company Cyclic peptide antifungal agents
US20030104048A1 (en) 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
KR100613136B1 (ko) 1999-03-03 2006-08-17 일라이 릴리 앤드 캄파니 미셀-형성 계면활성제를 함유하는 에키노칸딘 제약학적조제물
PT1155034E (pt) 1999-03-03 2007-01-31 Lilly Co Eli Formação e permuta aniónica de sais de amónio internos cristalinos de equinocandina b
WO2000052037A1 (en) * 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin/carbohydrate complexes
CN1345230A (zh) 1999-03-03 2002-04-17 伊莱利利公司 口服ecb药物制剂和药物组合物的制备方法
US6258821B1 (en) 1999-04-26 2001-07-10 Medimmune Oncology, Inc. Compositions comprising trimetrexate and methods of their synthesis and use
WO2003018051A1 (en) 2001-08-27 2003-03-06 Vic Jira Anti-fungal composition
US6991800B2 (en) 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products

Also Published As

Publication number Publication date
CA2362016A1 (en) 2000-09-08
US8022033B2 (en) 2011-09-20
EP1157030A1 (de) 2001-11-28
WO2000052037A8 (en) 2001-03-22
US20020160942A1 (en) 2002-10-31
CN1345333A (zh) 2002-04-17
HK1040088A1 (en) 2002-05-24
AU772633B2 (en) 2004-05-06
JP2002539090A (ja) 2002-11-19
DE60004793T2 (de) 2004-07-01
DE60004793D1 (de) 2003-10-02
US7041637B2 (en) 2006-05-09
KR20020003864A (ko) 2002-01-15
US20090258820A1 (en) 2009-10-15
EP1157030B1 (de) 2003-08-27
ZA200108004B (en) 2003-06-25
DK1157030T3 (da) 2003-12-22
ES2204548T3 (es) 2004-05-01
JP4272359B2 (ja) 2009-06-03
WO2000052037A1 (en) 2000-09-08
AU3863500A (en) 2000-09-21
BR0008712A (pt) 2001-12-26
ATE248187T1 (de) 2003-09-15
RU2001126723A (ru) 2003-09-27
US20060111277A1 (en) 2006-05-25
US7550428B2 (en) 2009-06-23
HK1040088B (zh) 2004-04-16
PT1157030E (pt) 2004-01-30

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