IL144964A0 - Methods of treatment of mitochondrial disorders - Google Patents
Methods of treatment of mitochondrial disordersInfo
- Publication number
- IL144964A0 IL144964A0 IL14496400A IL14496400A IL144964A0 IL 144964 A0 IL144964 A0 IL 144964A0 IL 14496400 A IL14496400 A IL 14496400A IL 14496400 A IL14496400 A IL 14496400A IL 144964 A0 IL144964 A0 IL 144964A0
- Authority
- IL
- Israel
- Prior art keywords
- methods
- mitochondrial disorders
- treatment
- mitochondrial
- disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12158899P | 1999-02-23 | 1999-02-23 | |
PCT/US2000/004663 WO2000050043A1 (en) | 1999-02-23 | 2000-02-23 | Methods of treatment of mitochondrial disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
IL144964A0 true IL144964A0 (en) | 2002-06-30 |
Family
ID=22397641
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14496400A IL144964A0 (en) | 1999-02-23 | 2000-02-23 | Methods of treatment of mitochondrial disorders |
IL144964A IL144964A (en) | 1999-02-23 | 2001-08-19 | Medicines to treat deficiencies of pyrimidine synthesis pathways, containing 2 ', 3', 5 'triacetylauridine |
IL180528A IL180528A (en) | 1999-02-23 | 2007-01-03 | Pharmaceuticals containing certain uridine derivatives |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL144964A IL144964A (en) | 1999-02-23 | 2001-08-19 | Medicines to treat deficiencies of pyrimidine synthesis pathways, containing 2 ', 3', 5 'triacetylauridine |
IL180528A IL180528A (en) | 1999-02-23 | 2007-01-03 | Pharmaceuticals containing certain uridine derivatives |
Country Status (20)
Country | Link |
---|---|
US (2) | US7638501B1 (ru) |
EP (2) | EP1808177B1 (ru) |
JP (1) | JP4776780B2 (ru) |
KR (2) | KR100758712B1 (ru) |
CN (2) | CN100379426C (ru) |
AT (1) | ATE381935T1 (ru) |
AU (1) | AU776437B2 (ru) |
BR (1) | BR0008447A (ru) |
CA (1) | CA2362925C (ru) |
DE (1) | DE60037578T2 (ru) |
DK (1) | DK1171137T3 (ru) |
ES (1) | ES2298130T3 (ru) |
HU (1) | HU230191B1 (ru) |
IL (3) | IL144964A0 (ru) |
MX (1) | MXPA01008549A (ru) |
NZ (1) | NZ513926A (ru) |
PT (1) | PT1171137E (ru) |
RU (2) | RU2268732C2 (ru) |
WO (1) | WO2000050043A1 (ru) |
ZA (1) | ZA200107727B (ru) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6306909B1 (en) | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
US8518882B2 (en) * | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
US20050203053A1 (en) * | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
US8314064B2 (en) * | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
US8143234B2 (en) * | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
DK1870103T3 (da) * | 1998-07-31 | 2010-01-11 | Massachusetts Inst Technology | Anvendelse af uridin i kombination med cholin i behandling af hukommelsesforsstyrrelse |
US7807654B2 (en) | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
US7915233B1 (en) | 1998-08-31 | 2011-03-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
DE60037578T2 (de) | 1999-02-23 | 2009-01-08 | The Regents Of The University Of California, Oakland | Verwendung von triacetyluridin zur behandlung von mitochondrialen erkrankungen |
US6727231B1 (en) * | 2000-10-12 | 2004-04-27 | Repligen Corporation | Uridine therapy for patients with elevated purine levels |
DE10110355A1 (de) * | 2001-03-03 | 2002-09-12 | Ulrich Walker | Bekämpfung von Nebenwirkungen |
CA2444148A1 (en) * | 2001-04-11 | 2002-10-24 | Queen's University At Kingston | Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents |
AU2002302272B2 (en) * | 2001-05-29 | 2008-05-22 | The University Of British Columbia | Pharmacological applications of mitochondrial DNA assays |
JP2004182705A (ja) * | 2002-10-11 | 2004-07-02 | Yasutoshi Koga | ミトコンドリア機能異常に起因する疾患における臨床症状発現の予防・治療用組成物 |
KR20050092424A (ko) * | 2003-01-17 | 2005-09-21 | 씨브이 쎄러퓨틱스, 인코포레이티드 | 심혈관 질환의 치료에 유용한 치환된 헤테로고리 화합물 |
DK1888059T3 (en) | 2005-06-01 | 2015-03-30 | Edison Pharmaceuticals Inc | Redox-active therapeutic products for the treatment of mitochondrial diseases and other conditions as well as modulation of energy biomarkers |
US7432305B2 (en) | 2005-09-15 | 2008-10-07 | Edison Pharmaceuticals, Inc. | Tail variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
JP5374162B2 (ja) | 2006-02-22 | 2013-12-25 | エジソン ファーマシューティカルズ, インコーポレイテッド | ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節 |
US8748405B2 (en) | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
CN105510850A (zh) | 2007-11-02 | 2016-04-20 | 麻省理工学院 | 尿苷饮食添加顺应性方法及其用途 |
CN101612110B (zh) * | 2008-06-23 | 2012-07-25 | 欣凯医药化工中间体(上海)有限公司 | 三乙酰尿苷缓释制剂及其制备方法 |
WO2010030607A1 (en) | 2008-09-10 | 2010-03-18 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
ES2640485T3 (es) * | 2011-08-12 | 2017-11-03 | Universitätsklinikum Freiburg | Uridina y análogos de uridina para el uso en el tratamiento de la enfermedad pulmonar obstructiva crónica |
WO2015106255A1 (en) | 2014-01-13 | 2015-07-16 | City Of Hope | Multivalent oligonucleotide assemblies |
WO2016028894A1 (en) * | 2014-08-19 | 2016-02-25 | Wellstat Therapeutics Corportion | Treatment of glycosylation deficiency diseases |
FR3027804A1 (fr) * | 2014-10-31 | 2016-05-06 | Centre Nat Rech Scient | Utilisation d'un inhibiteur de transcriptase inverse dans la prevention et le traitement des maladies degeneratives |
US10675293B2 (en) | 2015-05-29 | 2020-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | Nucleoside agents for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
MX2017015566A (es) * | 2015-06-05 | 2018-08-15 | Fundacio Hospital Univ Vall Dhebron Institut De Recerca | Tratamiento de enfermedades mitocondriales. |
RU2721492C2 (ru) * | 2015-06-17 | 2020-05-19 | Зе Трастис Оф Коламбия Юниверсити Ин Зе Сити Оф Нью-Йорк | Дезоксинуклеозидная терапия заболеваний, вызванных несбалансированными пулами нуклеотидов, в том числе синдромов истощения митохондриальной днк |
EP3389646A1 (en) | 2015-12-17 | 2018-10-24 | BioElectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
KR101981843B1 (ko) | 2016-09-13 | 2019-05-23 | 울산대학교 산학협력단 | 일산화탄소 또는 일산화탄소 공급체를 유효성분으로 함유하는 미토콘드리아 기능 개선용 조성물 |
CA3094324A1 (en) | 2018-03-26 | 2019-10-03 | Clear Creek Bio, Inc. | Compositions and methods for inhibiting dihydroorotate dehydrogenase |
JP2022546611A (ja) * | 2019-09-05 | 2022-11-04 | ミトレインボー セラピューティクス,インコーポレーテッド | ミトコンドリアdna枯渇障害の処置 |
KR102290596B1 (ko) * | 2020-09-10 | 2021-08-19 | 주식회사 파이안바이오테크놀로지 | 분리된 미토콘드리아를 포함하는 주사용 조성물 및 이의 용도 |
EP3970713A1 (en) | 2020-09-16 | 2022-03-23 | GV Squared S.r.l. | Pharmaceutical composition comprising uridine and pyruvate for regulating the profileration, activity and survival of immune cells |
CN113116900B (zh) * | 2021-04-14 | 2022-07-08 | 兰州大学 | 一类核苷类似物在制备预防和/或治疗脑血管疾病药物中的应用 |
BE1030026B1 (fr) * | 2022-06-14 | 2023-07-07 | Dendrogenix | Composés dérivés de stérols et composition pharmaceutique les comprenant pour leur utilisation dans la prévention, l’amélioration et/ou le traitement d’une pathologie liée à un déficit mitochondrial |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5356690A (en) * | 1976-09-30 | 1978-05-23 | Rikagaku Kenkyusho | Purin compund sugar derivatives and their preparation |
US6348451B1 (en) | 1987-10-28 | 2002-02-19 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
US6060459A (en) | 1987-10-28 | 2000-05-09 | Pro-Neuron, Inc. | Enhancing blood cell count with oxypurine nucleosides |
US5691320A (en) | 1987-10-28 | 1997-11-25 | Pro-Neuron, Inc. | Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis |
CA1321994C (en) * | 1987-10-28 | 1993-09-07 | Reid Von Borstel | Acylated uridine and cytidine and uses thereof |
US5736531A (en) | 1987-10-28 | 1998-04-07 | Pro-Neuron, Inc. | Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides |
US6020322A (en) | 1993-11-09 | 2000-02-01 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
US5470838A (en) | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
US6329350B1 (en) | 1987-10-28 | 2001-12-11 | Pro-Neuron, Inc. | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
ATE142221T1 (de) | 1987-10-28 | 1996-09-15 | Pro Neuron Inc | Acyl deoxyribonukleosid-derivate und deren verwendungen |
US5968914A (en) | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US6743782B1 (en) | 1987-10-28 | 2004-06-01 | Wellstat Therapeutics Corporation | Acyl deoxyribonucleoside derivatives and uses thereof |
IT1219667B (it) | 1988-06-21 | 1990-05-24 | Polifarma Spa | Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico |
IT1241984B (it) | 1990-06-13 | 1994-02-02 | Polifarma Spa | Impiego di uridina nel trattamento farmacologico delle complicazioni periferiche del diabete |
US5981601A (en) * | 1992-05-28 | 1999-11-09 | Centre For Molecular Biology And Medicine | Method for enhancing cellular bioenergy |
US5567689A (en) | 1993-08-13 | 1996-10-22 | The Uab Research Foundation | Methods for increasing uridine levels with L-nucleosides |
US5852000A (en) | 1993-08-25 | 1998-12-22 | Otsuka Pharmaceutical Factory, Inc. | Cardiac rehabilitation agent |
BR9507241A (pt) * | 1994-03-30 | 1997-09-16 | Mitokor | Processos para detectar a presença de doença de alzheimer e de origem mitocondrial em um indivíduo e as mutações genéticas que provocam doença de alzheimer para inibir a transcrição ou tradução de genes e de um ou mais ácidos nucleicos codificando oxidase de citocromo c mutante para introduzir seletivamente uma molécula conjugada em mitocôndrias para construir uma linhagem de células para avaliar um composto para utilidade em potencial no diagnóstico de distúrbios no tratamento de um distúrbio eno diagnóstico ou tratamento de diabetes mellitus para preparar um animal cibrido e para determinar a presença de uma doença humana de origem mitoconddrial sequências de nucleotideos isoladas sonda kit composição terapêutica ribozima linhagem de cêlulas e animal cibrido |
JP3808121B2 (ja) * | 1995-01-09 | 2006-08-09 | 日本メジフィジックス株式会社 | 低酸素症またはミトコンドリア機能障害診断剤 |
US5962459A (en) | 1996-05-28 | 1999-10-05 | Polifarma S.P.A. | Therapeutic active agent for treatment of neuron degenerative diseases |
JPH10273469A (ja) * | 1997-02-03 | 1998-10-13 | Takeda Chem Ind Ltd | 2環性キノン誘導体、製造法および剤 |
US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
US7807654B2 (en) | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
DE60037578T2 (de) | 1999-02-23 | 2009-01-08 | The Regents Of The University Of California, Oakland | Verwendung von triacetyluridin zur behandlung von mitochondrialen erkrankungen |
-
2000
- 2000-02-23 DE DE60037578T patent/DE60037578T2/de not_active Expired - Lifetime
- 2000-02-23 CA CA2362925A patent/CA2362925C/en not_active Expired - Fee Related
- 2000-02-23 RU RU2001125913/14A patent/RU2268732C2/ru not_active IP Right Cessation
- 2000-02-23 MX MXPA01008549A patent/MXPA01008549A/es active IP Right Grant
- 2000-02-23 US US09/889,251 patent/US7638501B1/en not_active Expired - Fee Related
- 2000-02-23 PT PT00910321T patent/PT1171137E/pt unknown
- 2000-02-23 RU RU2005121711/14A patent/RU2394580C2/ru not_active IP Right Cessation
- 2000-02-23 CN CNB2004100784053A patent/CN100379426C/zh not_active Expired - Fee Related
- 2000-02-23 IL IL14496400A patent/IL144964A0/xx unknown
- 2000-02-23 HU HU0400914A patent/HU230191B1/hu not_active IP Right Cessation
- 2000-02-23 KR KR1020017010801A patent/KR100758712B1/ko not_active IP Right Cessation
- 2000-02-23 EP EP07008953.7A patent/EP1808177B1/en not_active Expired - Lifetime
- 2000-02-23 ES ES00910321T patent/ES2298130T3/es not_active Expired - Lifetime
- 2000-02-23 BR BR0008447-6A patent/BR0008447A/pt not_active Application Discontinuation
- 2000-02-23 DK DK00910321T patent/DK1171137T3/da active
- 2000-02-23 JP JP2000600654A patent/JP4776780B2/ja not_active Expired - Lifetime
- 2000-02-23 CN CNB008041032A patent/CN1191835C/zh not_active Expired - Fee Related
- 2000-02-23 WO PCT/US2000/004663 patent/WO2000050043A1/en active IP Right Grant
- 2000-02-23 KR KR1020077012846A patent/KR100879559B1/ko not_active IP Right Cessation
- 2000-02-23 NZ NZ513926A patent/NZ513926A/en not_active IP Right Cessation
- 2000-02-23 EP EP00910321A patent/EP1171137B1/en not_active Expired - Lifetime
- 2000-02-23 AU AU32434/00A patent/AU776437B2/en not_active Ceased
- 2000-02-23 AT AT00910321T patent/ATE381935T1/de active
-
2001
- 2001-08-19 IL IL144964A patent/IL144964A/en not_active IP Right Cessation
- 2001-09-19 ZA ZA200107727A patent/ZA200107727B/en unknown
-
2007
- 2007-01-03 IL IL180528A patent/IL180528A/en not_active IP Right Cessation
-
2009
- 2009-12-21 US US12/643,920 patent/US8748408B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL144964A0 (en) | Methods of treatment of mitochondrial disorders | |
FR13C0062I1 (ru) | ||
ATE225341T1 (de) | In 6-position durch thio substituierte paclitaxele | |
AU2003272285A8 (en) | Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine h4 receptor ligands | |
BR0007527A (pt) | Fenilfenantridinas com atividade inibitória depde-iv | |
BR0008176A (pt) | Derivados anti-convulsivantes úteis no tratamento de cefaléias em cacho | |
BRPI0415699A (pt) | uso de oligossacarìdeo ácido e de oligossacarìdeo neutro, e, composições alimentìcia e lìquida | |
TW200503719A (en) | Pyridino [1,2-a] pyrimidin-4-one compounds as anticancer agents | |
ZA200108530B (en) | 4,5,6,7-tetrahydroindazole derivatives as antitumor agents. | |
MY145074A (en) | Thiazolidin-4-one derivatives | |
YU60900A (sh) | Novi kristalni oblici antivirusnog benzimidazolskog jedinjenja | |
AU2158601A (en) | Antiviral agent for use in treatment of cancer | |
ATE439363T1 (de) | Imidazo 2,1-b -1,3,4-thiadiazole sulfonamides | |
DK1220852T3 (da) | Substituerede diazepaner | |
MY133107A (en) | Use of pyrimidine derivatives for the prophylaxis and therapy of cerebral ischemia | |
WO2002030354A3 (en) | Uridine therapy for patients with elevated purine levels | |
NO933722L (no) | Pyrimidin-derivater for forbedring av antitumor-aktivitet | |
WO2001057042A3 (de) | 4-pyridyl- und 2,4-pyrimidinyl-substituierte pyrrolderivate und ihre anwendung in der pharmazie | |
BR0101245B1 (pt) | barra de direção ajustável com travamento longitudinal. | |
YU58600A (sh) | Oblik vi 5,6-dihloro-2-(izopropilamino)-1-(beta-l-ribofuranozil)-1h-benzimidazola | |
AU2003227593A1 (en) | New analogs of nitrobenzylthioinosine | |
ZA200105473B (en) | Utilisation of 2-substituted 1,2-benzisothiazole derivatives and 3-substituted tetrahydropyridopyrimidinone derivatives for the prophylaxis and therapy of cerebral ischaemia. | |
MXPA02003731A (es) | Derivados novedosos de acido fusidico. | |
WO2001004090A3 (en) | Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods | |
MXPA02005649A (es) | Nuevas combinaciones terapeuticas de (s)-2 -(bencilamino -metil)-2, 3, 8, 9-tetrahidro-7h -1, 4-dioxino(2-3 -e]indol-8 -ona y agentes neurolepticos para el tratamiento o prevencion de trastornos psicoticos. |