IL143903A - A medicinal product containing pancovinone for the treatment or prevention of memory impairments - Google Patents
A medicinal product containing pancovinone for the treatment or prevention of memory impairmentsInfo
- Publication number
- IL143903A IL143903A IL14390300A IL14390300A IL143903A IL 143903 A IL143903 A IL 143903A IL 14390300 A IL14390300 A IL 14390300A IL 14390300 A IL14390300 A IL 14390300A IL 143903 A IL143903 A IL 143903A
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical composition
- phanquinone
- memory
- memory impairment
- suffering
- Prior art date
Links
- VLPADTBFADIFKG-UHFFFAOYSA-N phanquone Chemical compound C1=CN=C2C(=O)C(=O)C3=NC=CC=C3C2=C1 VLPADTBFADIFKG-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 229960003606 phanquinone Drugs 0.000 title claims abstract description 41
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 33
- 206010027175 memory impairment Diseases 0.000 title claims abstract description 28
- 230000002265 prevention Effects 0.000 title claims description 10
- 208000024827 Alzheimer disease Diseases 0.000 claims abstract description 7
- 239000003937 drug carrier Substances 0.000 claims abstract description 7
- 230000028252 learning or memory Effects 0.000 claims abstract 5
- 230000015654 memory Effects 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000007911 parenteral administration Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 25
- 239000000470 constituent Substances 0.000 description 11
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- 150000001875 compounds Chemical class 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 229920002261 Corn starch Polymers 0.000 description 5
- 235000019759 Maize starch Nutrition 0.000 description 5
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- 206010012289 Dementia Diseases 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 230000006403 short-term memory Effects 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- -1 2-benzyl-2-propyl Chemical group 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000001828 Gelatine Substances 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 239000004141 Sodium laurylsulphate Substances 0.000 description 2
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- ZZWKZQDOSJAGGF-VRSYWUPDSA-N [(1s,2e,7s,10e,12r,13r,15s)-12-hydroxy-7-methyl-9-oxo-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-15-yl] 2-(dimethylamino)acetate Chemical compound O[C@@H]1\C=C\C(=O)O[C@@H](C)CCC\C=C\[C@@H]2C[C@H](OC(=O)CN(C)C)C[C@H]21 ZZWKZQDOSJAGGF-VRSYWUPDSA-N 0.000 description 2
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- KRKRAOXTGDJWNI-UHFFFAOYSA-N (2R,4S)-4-Methyl glutamic acid Natural products OC(=O)C(C)CC(N)C(O)=O KRKRAOXTGDJWNI-UHFFFAOYSA-N 0.000 description 1
- ZYFTZMADDQMCNB-UHFFFAOYSA-N 2-aminoethyl carbamate Chemical class NCCOC(N)=O ZYFTZMADDQMCNB-UHFFFAOYSA-N 0.000 description 1
- OUHPEQFMFIKJQZ-UHFFFAOYSA-N 3-aminopropyl carbamate Chemical compound NCCCOC(N)=O OUHPEQFMFIKJQZ-UHFFFAOYSA-N 0.000 description 1
- RITPLLYUVXGBFT-UHFFFAOYSA-N 4-methyl-1,2-oxazole-5-carboxylic acid Chemical compound CC=1C=NOC=1C(O)=O RITPLLYUVXGBFT-UHFFFAOYSA-N 0.000 description 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 1
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- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 description 1
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 description 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
- 102000000079 Kainic Acid Receptors Human genes 0.000 description 1
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- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
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- YKRSWMGPYKJOBF-UHFFFAOYSA-N [1-(4-chlorophenyl)-2-methylpropan-2-yl] 2-amino-3-methylbutanoate Chemical compound CC(C)C(N)C(=O)OC(C)(C)CC1=CC=C(Cl)C=C1 YKRSWMGPYKJOBF-UHFFFAOYSA-N 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
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- JZMJDSHXVKJFKW-UHFFFAOYSA-N methyl sulfate Chemical compound COS(O)(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-N 0.000 description 1
- ONOUXANYVOEFTK-UHFFFAOYSA-N methyl sulfate;trimethyl-[4-(octadecanoylamino)phenyl]azanium Chemical compound COS([O-])(=O)=O.CCCCCCCCCCCCCCCCCC(=O)NC1=CC=C([N+](C)(C)C)C=C1 ONOUXANYVOEFTK-UHFFFAOYSA-N 0.000 description 1
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- XEZLAJRZQNKEOJ-UHFFFAOYSA-N n-pentylhydroxylamine Chemical class CCCCCNO XEZLAJRZQNKEOJ-UHFFFAOYSA-N 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229940112042 peripherally acting choline derivative muscle relaxants Drugs 0.000 description 1
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- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
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- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 150000003235 pyrrolidines Chemical class 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
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- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR99100005 | 1999-01-07 | ||
| PCT/IB2000/000011 WO2000040244A1 (en) | 1999-01-07 | 2000-01-06 | Use of phanquinone for the treatment or prevention of memory impairment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL143903A0 IL143903A0 (en) | 2002-04-21 |
| IL143903A true IL143903A (en) | 2004-02-08 |
Family
ID=10943706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14390300A IL143903A (en) | 1999-01-07 | 2000-01-06 | A medicinal product containing pancovinone for the treatment or prevention of memory impairments |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7030136B2 (pt) |
| EP (1) | EP1140090B1 (pt) |
| JP (1) | JP2002534386A (pt) |
| AR (1) | AR022215A1 (pt) |
| AT (1) | ATE285235T1 (pt) |
| AU (1) | AU1792200A (pt) |
| BR (1) | BR0008241A (pt) |
| CA (1) | CA2358487C (pt) |
| DE (1) | DE60016892T2 (pt) |
| DK (1) | DK1140090T3 (pt) |
| ES (1) | ES2234559T3 (pt) |
| HK (1) | HK1042039B (pt) |
| IL (1) | IL143903A (pt) |
| PT (1) | PT1140090E (pt) |
| SI (1) | SI1140090T1 (pt) |
| TR (1) | TR200101892T2 (pt) |
| WO (1) | WO2000040244A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999009981A1 (en) | 1997-08-21 | 1999-03-04 | P.N. Gerolymatos S.A. | Use of phanquinone for the treatment of alzheimer's disease |
| AU2001250573A1 (en) * | 2000-04-28 | 2001-11-12 | Michel Xilinas | Treatment of pathological conditions influenced by the action of matrix metalloproteinases (mmps) using phanquinone |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1472257A (en) | 1973-09-10 | 1977-05-04 | Christiaens Sa A | Derivative of 4-hydroxy-5-azacoumarin |
| AU618520B2 (en) * | 1986-12-17 | 1992-01-02 | Glaxo Group Limited | Medicaments |
| US5091391A (en) | 1990-08-16 | 1992-02-25 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of resisting neurodegenerative disorders |
| US5705401A (en) | 1991-11-12 | 1998-01-06 | The University Of Melbourne | Method of assaying for alzheimer's disease |
| US5866597A (en) * | 1993-03-19 | 1999-02-02 | Glaxo Wellcome Inc. | Use of triazine compounds for the treatment of memory and learning disorders |
| US5792774A (en) * | 1996-02-21 | 1998-08-11 | Chiroscience Limited | Quinolones and their therapeutic use |
| WO1997046526A1 (en) | 1996-06-07 | 1997-12-11 | Eisai Co., Ltd. | Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production |
| CZ295118B6 (cs) | 1996-08-13 | 2005-05-18 | P. N. Gerolymatos S. A. | Farmaceutický prostředek |
| EP1007048A4 (en) | 1997-03-11 | 2004-09-22 | Gen Hospital Corp | IDENTIFICATION OF AGENTS USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE |
| WO1999009981A1 (en) * | 1997-08-21 | 1999-03-04 | P.N. Gerolymatos S.A. | Use of phanquinone for the treatment of alzheimer's disease |
| US5980914A (en) | 1997-08-22 | 1999-11-09 | P.N. Gerolymatos S.A. | Clioquinol for the treatment of Parkinson's disease |
| US5994323A (en) | 1997-12-31 | 1999-11-30 | P.N. Gerolymatos S.A. | Pharmaceutical compositions comprising clioquinol in combination with vitamin B12 and therapeutic and prophylactic uses thereof |
-
2000
- 2000-01-06 EP EP00900025A patent/EP1140090B1/en not_active Expired - Lifetime
- 2000-01-06 DK DK00900025T patent/DK1140090T3/da active
- 2000-01-06 BR BR0008241-4A patent/BR0008241A/pt not_active Application Discontinuation
- 2000-01-06 AT AT00900025T patent/ATE285235T1/de not_active IP Right Cessation
- 2000-01-06 PT PT00900025T patent/PT1140090E/pt unknown
- 2000-01-06 JP JP2000592001A patent/JP2002534386A/ja active Pending
- 2000-01-06 DE DE60016892T patent/DE60016892T2/de not_active Expired - Fee Related
- 2000-01-06 AU AU17922/00A patent/AU1792200A/en not_active Abandoned
- 2000-01-06 SI SI200030621T patent/SI1140090T1/xx unknown
- 2000-01-06 AR ARP000100046A patent/AR022215A1/es unknown
- 2000-01-06 CA CA002358487A patent/CA2358487C/en not_active Expired - Fee Related
- 2000-01-06 TR TR2001/01892T patent/TR200101892T2/xx unknown
- 2000-01-06 WO PCT/IB2000/000011 patent/WO2000040244A1/en not_active Application Discontinuation
- 2000-01-06 IL IL14390300A patent/IL143903A/en not_active IP Right Cessation
- 2000-01-06 ES ES00900025T patent/ES2234559T3/es not_active Expired - Lifetime
-
2002
- 2002-03-15 US US10/098,922 patent/US7030136B2/en not_active Expired - Fee Related
- 2002-04-10 HK HK02102678.3A patent/HK1042039B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002534386A (ja) | 2002-10-15 |
| CA2358487C (en) | 2008-11-18 |
| HK1042039A1 (en) | 2002-08-02 |
| CA2358487A1 (en) | 2000-07-13 |
| TR200101892T2 (tr) | 2001-11-21 |
| US7030136B2 (en) | 2006-04-18 |
| WO2000040244A1 (en) | 2000-07-13 |
| ATE285235T1 (de) | 2005-01-15 |
| HK1042039B (zh) | 2005-07-29 |
| DK1140090T3 (da) | 2005-04-18 |
| DE60016892T2 (de) | 2005-12-15 |
| PT1140090E (pt) | 2005-05-31 |
| AR022215A1 (es) | 2002-09-04 |
| IL143903A0 (en) | 2002-04-21 |
| ES2234559T3 (es) | 2005-07-01 |
| AU1792200A (en) | 2000-07-24 |
| DE60016892D1 (de) | 2005-01-27 |
| EP1140090B1 (en) | 2004-12-22 |
| EP1140090A1 (en) | 2001-10-10 |
| US20030055078A1 (en) | 2003-03-20 |
| SI1140090T1 (en) | 2005-06-30 |
| BR0008241A (pt) | 2001-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |