IL142983A0 - Nucleosides with anti-hepatisis b virus activity - Google Patents
Nucleosides with anti-hepatisis b virus activityInfo
- Publication number
- IL142983A0 IL142983A0 IL14298399A IL14298399A IL142983A0 IL 142983 A0 IL142983 A0 IL 142983A0 IL 14298399 A IL14298399 A IL 14298399A IL 14298399 A IL14298399 A IL 14298399A IL 142983 A0 IL142983 A0 IL 142983A0
- Authority
- IL
- Israel
- Prior art keywords
- hepatisis
- nucleosides
- acyl
- virus activity
- virus
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 125000003835 nucleoside group Chemical group 0.000 title 1
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000001177 diphosphate Substances 0.000 abstract 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
- 235000011180 diphosphates Nutrition 0.000 abstract 1
- 229960004413 flucytosine Drugs 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000001226 triphosphate Substances 0.000 abstract 1
- 235000011178 triphosphate Nutrition 0.000 abstract 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10711698P | 1998-11-05 | 1998-11-05 | |
| US11565399P | 1999-01-13 | 1999-01-13 | |
| PCT/US1999/026157 WO2000026225A2 (en) | 1998-11-05 | 1999-11-05 | Nucleosides with anti-hepatitis b virus activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL142983A0 true IL142983A0 (en) | 2002-04-21 |
Family
ID=26804401
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14298399A IL142983A0 (en) | 1998-11-05 | 1999-11-05 | Nucleosides with anti-hepatisis b virus activity |
| IL142983A IL142983A (en) | 1998-11-05 | 2001-05-04 | History of ß - L - (2 'or 3') - Azido - 2 ', 3' - Dioxy - 5 - Fluorocytocine with antiviral activity and hepatitis preparations containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL142983A IL142983A (en) | 1998-11-05 | 2001-05-04 | History of ß - L - (2 'or 3') - Azido - 2 ', 3' - Dioxy - 5 - Fluorocytocine with antiviral activity and hepatitis preparations containing them |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6458773B1 (enExample) |
| EP (1) | EP1124839B1 (enExample) |
| JP (2) | JP2002528554A (enExample) |
| KR (1) | KR100618028B1 (enExample) |
| CN (1) | CN1216893C (enExample) |
| AT (1) | ATE315574T1 (enExample) |
| AU (1) | AU774720B2 (enExample) |
| BR (1) | BR9915555A (enExample) |
| CA (1) | CA2348470C (enExample) |
| DE (1) | DE69929460D1 (enExample) |
| IL (2) | IL142983A0 (enExample) |
| MX (1) | MXPA01004504A (enExample) |
| WO (1) | WO2000026225A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2787199A (en) * | 1998-02-25 | 1999-09-15 | Emory University | 2'-fluoronucleosides |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| JP5230052B2 (ja) * | 2000-05-26 | 2013-07-10 | イデニクス（ケイマン）リミテツド | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
| EP1387850A2 (en) | 2001-05-18 | 2004-02-11 | Rakesh Kumar | Antiviral nucleosides |
| US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| AP2005003213A0 (en) | 2002-06-28 | 2005-03-31 | Univ Cagliari | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections. |
| US20040067877A1 (en) | 2002-08-01 | 2004-04-08 | Schinazi Raymond F. | 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections |
| BR0315795A (pt) * | 2002-10-31 | 2005-09-13 | Metabasis Therapeutics Inc | Pró-medicamentos de monofosfato de citarabina |
| US7824851B2 (en) | 2002-11-15 | 2010-11-02 | Idenix Pharmaceuticals, Inc. | 2′-branched nucleosides and Flaviviridae mutation |
| MXPA05006230A (es) | 2002-12-12 | 2005-09-20 | Idenix Cayman Ltd | Proceso para la produccion de nucleosidos ramificados-2'. |
| ES2422290T3 (es) | 2005-12-23 | 2013-09-10 | Idenix Pharmaceuticals Inc | Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados |
| AU2015217221A1 (en) | 2014-02-13 | 2016-08-11 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| JP2017520545A (ja) | 2014-07-02 | 2017-07-27 | リガンド・ファーマシューティカルズ・インコーポレイテッド | プロドラッグ化合物およびそれらの使用 |
| CA3087932A1 (en) | 2018-01-09 | 2019-07-18 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681933A (en) | 1986-05-01 | 1987-07-21 | University Of Georgia Research Foundation, Inc. | 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents |
| US5084445A (en) | 1986-05-01 | 1992-01-28 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxy-5-methylcytidine |
| US4916122A (en) | 1987-01-28 | 1990-04-10 | University Of Georgia Research Foundation, Inc. | 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition |
| US5077279A (en) | 1986-05-01 | 1991-12-31 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition |
| US4841039A (en) | 1986-05-01 | 1989-06-20 | Emory University | 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents |
| US5190926A (en) | 1987-01-28 | 1993-03-02 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents |
| NZ228645A (en) | 1988-04-11 | 1991-09-25 | Iaf Biochem Int | 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections |
| US5041449A (en) | 1988-04-11 | 1991-08-20 | Iaf Biochem International, Inc. | 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections |
| US5047407A (en) | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
| DD293498A5 (de) * | 1989-07-20 | 1991-09-05 | Zi Fuer Molekularbiologie Der Adw,De | Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier |
| US5204466A (en) | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| DE4224737A1 (de) | 1992-07-27 | 1994-02-03 | Herbert Prof Dr Schott | Neue Cytosinnucleosidanaloga, Verfahren zu ihrer Herstellung und ihre Verwendung |
| FR2709754B1 (fr) | 1993-09-10 | 1995-12-01 | Centre Nat Rech Scient | Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale. |
| WO1995007086A1 (en) | 1993-09-10 | 1995-03-16 | Emory University | Nucleosides with anti-hepatitis b virus activity |
| DE4418690A1 (de) | 1994-05-28 | 1996-01-11 | Boehringer Mannheim Gmbh | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
| US5559101A (en) | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
| US5703058A (en) | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
| DK0831852T3 (da) | 1995-06-07 | 2007-03-19 | Univ Emory | Nukleosider med anti-hepatitis B-virusaktivitet |
| BR9610120A (pt) | 1995-09-07 | 1999-12-21 | Univ Georgia Res Found | Composição farmacêutica e processo para aumentar a meia vida de um medicamento em um indivìduo e para melhorar uma condição patológica em um paciente. |
| CN1268140A (zh) | 1996-10-16 | 2000-09-27 | Icn药品公司 | 单环l－核苷、类似物及其应用 |
-
1999
- 1999-11-05 EP EP99958793A patent/EP1124839B1/en not_active Expired - Lifetime
- 1999-11-05 AT AT99958793T patent/ATE315574T1/de not_active IP Right Cessation
- 1999-11-05 US US09/435,261 patent/US6458773B1/en not_active Expired - Lifetime
- 1999-11-05 CA CA002348470A patent/CA2348470C/en not_active Expired - Fee Related
- 1999-11-05 BR BR9915555-9A patent/BR9915555A/pt not_active IP Right Cessation
- 1999-11-05 JP JP2000579613A patent/JP2002528554A/ja not_active Withdrawn
- 1999-11-05 IL IL14298399A patent/IL142983A0/xx active IP Right Grant
- 1999-11-05 CN CN998141895A patent/CN1216893C/zh not_active Expired - Fee Related
- 1999-11-05 WO PCT/US1999/026157 patent/WO2000026225A2/en not_active Ceased
- 1999-11-05 KR KR1020017005679A patent/KR100618028B1/ko not_active Expired - Fee Related
- 1999-11-05 DE DE69929460T patent/DE69929460D1/de not_active Expired - Lifetime
- 1999-11-05 MX MXPA01004504A patent/MXPA01004504A/es not_active IP Right Cessation
- 1999-11-05 AU AU16085/00A patent/AU774720B2/en not_active Ceased
-
2001
- 2001-05-04 IL IL142983A patent/IL142983A/en not_active IP Right Cessation
-
2011
- 2011-06-22 JP JP2011138647A patent/JP2011246469A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1329618A (zh) | 2002-01-02 |
| JP2002528554A (ja) | 2002-09-03 |
| AU1608500A (en) | 2000-05-22 |
| EP1124839A2 (en) | 2001-08-22 |
| ATE315574T1 (de) | 2006-02-15 |
| JP2011246469A (ja) | 2011-12-08 |
| WO2000026225A3 (en) | 2000-10-05 |
| KR20020013474A (ko) | 2002-02-20 |
| WO2000026225A2 (en) | 2000-05-11 |
| KR100618028B1 (ko) | 2006-08-30 |
| IL142983A (en) | 2006-07-05 |
| CA2348470C (en) | 2007-06-05 |
| CN1216893C (zh) | 2005-08-31 |
| MXPA01004504A (es) | 2005-04-19 |
| HK1036069A1 (en) | 2001-12-21 |
| EP1124839B1 (en) | 2006-01-11 |
| DE69929460D1 (de) | 2006-04-06 |
| BR9915555A (pt) | 2002-01-15 |
| CA2348470A1 (en) | 2000-05-11 |
| AU774720B2 (en) | 2004-07-08 |
| US6458773B1 (en) | 2002-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |