IL142952A - Process for enzyme-catalyzed production of 1,2 diacylated phospholipids - Google Patents
Process for enzyme-catalyzed production of 1,2 diacylated phospholipidsInfo
- Publication number
- IL142952A IL142952A IL14295201A IL14295201A IL142952A IL 142952 A IL142952 A IL 142952A IL 14295201 A IL14295201 A IL 14295201A IL 14295201 A IL14295201 A IL 14295201A IL 142952 A IL142952 A IL 142952A
- Authority
- IL
- Israel
- Prior art keywords
- sub
- glycerophospholipid
- carboxylic acid
- fatty acid
- desired carboxylic
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 150000003904 phospholipids Chemical class 0.000 title abstract 2
- 239000008777 Glycerylphosphorylcholine Substances 0.000 abstract 4
- SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 abstract 4
- 229960004956 glycerylphosphorylcholine Drugs 0.000 abstract 4
- 150000001735 carboxylic acids Chemical class 0.000 abstract 3
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 3
- 229930195729 fatty acid Natural products 0.000 abstract 3
- 239000000194 fatty acid Substances 0.000 abstract 3
- 150000004665 fatty acids Chemical class 0.000 abstract 3
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000015439 Phospholipases Human genes 0.000 abstract 2
- 108010064785 Phospholipases Proteins 0.000 abstract 2
- 230000010933 acylation Effects 0.000 abstract 2
- 238000005917 acylation reaction Methods 0.000 abstract 2
- 230000032050 esterification Effects 0.000 abstract 2
- 238000005886 esterification reaction Methods 0.000 abstract 2
- 150000002327 glycerophospholipids Chemical class 0.000 abstract 2
- 238000005809 transesterification reaction Methods 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6481—Phosphoglycerides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL14295201A IL142952A (en) | 2001-05-03 | 2001-05-03 | Process for enzyme-catalyzed production of 1,2 diacylated phospholipids |
| AU2002258129A AU2002258129A1 (en) | 2001-05-03 | 2002-05-02 | Process for the production of phospholipids |
| JP2002587619A JP4216082B2 (ja) | 2001-05-03 | 2002-05-02 | リン脂質の製造方法 |
| AT02728001T ATE520786T1 (de) | 2001-05-03 | 2002-05-02 | Verfahren zur herstellung von phospholipiden |
| PCT/IL2002/000344 WO2002090560A2 (en) | 2001-05-03 | 2002-05-02 | Process for the production of phospholipids |
| EP02728001A EP1412511B1 (de) | 2001-05-03 | 2002-05-02 | Verfahren zur herstellung von phospholipiden |
| US10/700,320 US7034168B2 (en) | 2001-05-03 | 2003-11-03 | Process for the production of phospholipids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL14295201A IL142952A (en) | 2001-05-03 | 2001-05-03 | Process for enzyme-catalyzed production of 1,2 diacylated phospholipids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL142952A0 IL142952A0 (en) | 2002-04-21 |
| IL142952A true IL142952A (en) | 2005-12-18 |
Family
ID=11075371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14295201A IL142952A (en) | 2001-05-03 | 2001-05-03 | Process for enzyme-catalyzed production of 1,2 diacylated phospholipids |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7034168B2 (de) |
| EP (1) | EP1412511B1 (de) |
| JP (1) | JP4216082B2 (de) |
| AT (1) | ATE520786T1 (de) |
| AU (1) | AU2002258129A1 (de) |
| IL (1) | IL142952A (de) |
| WO (1) | WO2002090560A2 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006270921A1 (en) * | 2005-07-19 | 2007-01-25 | Asahi Kasei Pharma Corporation | Novel phospholipid processing agent |
| IL183084A0 (en) * | 2007-05-09 | 2007-09-20 | Trans Biodisel Ltd | Modified-immobilized enzymes of high tolerance to hydrophilic substrates in organic media |
| US8846338B2 (en) | 2008-08-07 | 2014-09-30 | Lipogen Ltd. | Processes for the preparation of phosphatides |
| ES2468799T3 (es) * | 2009-07-06 | 2014-06-17 | Kaneka Corporation | Procedimiento para producir fosfol�pido |
| US20130295171A1 (en) | 2009-07-23 | 2013-11-07 | U.S NUTRACEUTICALS, LLC d/b/a Valensa International | Krill oil and reacted astaxanthin composition and associated method |
| WO2011050474A1 (en) | 2009-10-29 | 2011-05-05 | Acasti Pharma, Inc. | Concentrated therapeutic phospholipid compositions |
| US8663704B2 (en) | 2010-04-30 | 2014-03-04 | U.S. Nutraceuticals, LLC | Composition and method to improve blood lipid profiles and optionally reduce low density lipoprotein (LDL) per-oxidation in humans |
| WO2011137160A2 (en) * | 2010-04-30 | 2011-11-03 | U.S. Nutraceuticals, Llc D/B/A Valensa International | Composition and method to improve blood lipid profiles and optionally reduce low density lipoprotein (ldl) per-oxidation in humans |
| US9763897B2 (en) | 2010-04-30 | 2017-09-19 | U.S. Nutraceuticals, LLC | Therapeutic astaxanthin and phospholipid composition and associated method |
| CN103140587B (zh) | 2010-09-30 | 2016-06-22 | 国立大学法人东京海洋大学 | 含2-酰基-溶血磷脂酰丝氨酸的组合物及其制造方法 |
| WO2013136183A2 (en) | 2012-03-12 | 2013-09-19 | Innolipid, As | Oxidixable fatty acid composition delivery form |
| AU2013319911B2 (en) | 2012-09-19 | 2016-07-07 | Aker Biomarine Antarctic As | Omega-3 phospholipid supplements for females |
| AU2014229540A1 (en) | 2013-03-14 | 2015-10-08 | Aker Biomarine Antarctic As | Omega- 3 phospholipid supplements for improved brain maturity |
| DK4242305T3 (en) * | 2014-05-20 | 2026-03-23 | Bunge Loders Croklaan B V | Process for immobilization of a lipase |
| CZ308596B6 (cs) * | 2017-04-03 | 2020-12-23 | Ústav molekulární genetiky AV ČR, v. v. i. | Deriváty fosfolipidů a jejich použití jako léčiva |
| PL232663B1 (pl) * | 2017-06-30 | 2019-07-31 | Univ Przyrodniczy We Wroclawiu | Fosfatydylocholiny oraz sposób ich otrzymywania |
| PL232298B1 (pl) * | 2017-06-30 | 2019-06-28 | Univ Przyrodniczy We Wroclawiu | Sposób otrzymywania fosfatydylocholiny zawierającej ibuprofen w pozycji sn-1 |
| CN112067735A (zh) * | 2020-08-31 | 2020-12-11 | 陕西科技大学 | 一种卵磷脂脂肪酸位置分布的分析方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5191213A (en) * | 1975-02-04 | 1976-08-10 | Jiashiru ll3** guriserohosuhorirukorinruino seizoho | |
| WO1991000918A1 (en) * | 1989-07-12 | 1991-01-24 | Berol Nobel Ab | A METHOD FOR THE PREPARATION OF A PHOSPHOLIPID WITH A CARBOXYLIC ACID RESIDUE IN THE 2-POSITION AND A PHOSPHOLIPID WITH AN φ-3-FATTY ACID RESIDUE IN THE 2-POSITION |
| ES2180541T5 (es) * | 1992-06-16 | 2008-12-01 | Sankyo Lifetech Company Limited | Nueva fosfolipasa a1, procedimiento para su preparacion y uso de la misma. |
| FR2698269B1 (fr) * | 1992-11-24 | 1995-01-06 | Inst Nat Sante Rech Med | Nouveaux médicaments à base d'acides gras insaturés, utilisables notamment comme antiagrégants plaquettaires et/ou comme transporteurs privilégiés vers le cerveau. |
| US6268187B1 (en) * | 1997-07-24 | 2001-07-31 | Doosan Corporation | Process for preparing lysophospholipid using enzyme |
| WO1999015689A1 (en) * | 1997-09-24 | 1999-04-01 | Enzymothec Ltd. | Surfactant-lipase complex immobilized on insoluble matrix |
| IL129086A0 (en) | 1999-03-22 | 2000-02-17 | Enzymotec Ltd | Surfactant-lipase complex immobilized on insoluble matrix |
| JP4412427B2 (ja) * | 1999-03-29 | 2010-02-10 | 日油株式会社 | 混合酸型１，２−ジアシル−３−グリセロリン脂質の製造方法 |
-
2001
- 2001-05-03 IL IL14295201A patent/IL142952A/xx active IP Right Grant
-
2002
- 2002-05-02 EP EP02728001A patent/EP1412511B1/de not_active Expired - Lifetime
- 2002-05-02 AU AU2002258129A patent/AU2002258129A1/en not_active Abandoned
- 2002-05-02 WO PCT/IL2002/000344 patent/WO2002090560A2/en not_active Ceased
- 2002-05-02 AT AT02728001T patent/ATE520786T1/de not_active IP Right Cessation
- 2002-05-02 JP JP2002587619A patent/JP4216082B2/ja not_active Expired - Fee Related
-
2003
- 2003-11-03 US US10/700,320 patent/US7034168B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002090560A2 (en) | 2002-11-14 |
| WO2002090560A3 (en) | 2004-02-19 |
| US7034168B2 (en) | 2006-04-25 |
| IL142952A0 (en) | 2002-04-21 |
| EP1412511A2 (de) | 2004-04-28 |
| JP4216082B2 (ja) | 2009-01-28 |
| US20040171126A1 (en) | 2004-09-02 |
| JP2004532857A (ja) | 2004-10-28 |
| ATE520786T1 (de) | 2011-09-15 |
| EP1412511B1 (de) | 2011-08-17 |
| AU2002258129A1 (en) | 2002-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |