IL141719A0 - Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors - Google Patents

Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors

Info

Publication number
IL141719A0
IL141719A0 IL14171999A IL14171999A IL141719A0 IL 141719 A0 IL141719 A0 IL 141719A0 IL 14171999 A IL14171999 A IL 14171999A IL 14171999 A IL14171999 A IL 14171999A IL 141719 A0 IL141719 A0 IL 141719A0
Authority
IL
Israel
Prior art keywords
optionally substituted
group
optionally
alkyl
hydroxy
Prior art date
Application number
IL14171999A
Other languages
English (en)
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of IL141719A0 publication Critical patent/IL141719A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL14171999A 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors IL141719A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI002319A IT1303272B1 (it) 1998-10-29 1998-10-29 Derivati triciclici inibitori della fosfodiesterasi 4
PCT/EP1999/007304 WO2000026218A1 (en) 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors

Publications (1)

Publication Number Publication Date
IL141719A0 true IL141719A0 (en) 2002-03-10

Family

ID=11380959

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14171999A IL141719A0 (en) 1998-10-29 1999-10-01 Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors

Country Status (10)

Country Link
US (1) US6525055B1 (xx)
EP (1) EP1124829B1 (xx)
JP (1) JP2002528549A (xx)
AT (1) ATE272638T1 (xx)
AU (1) AU766129B2 (xx)
CA (1) CA2345337A1 (xx)
DE (1) DE69919192D1 (xx)
IL (1) IL141719A0 (xx)
IT (1) IT1303272B1 (xx)
WO (1) WO2000026218A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224316A1 (en) 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
ES2372600T3 (es) * 2002-11-06 2012-01-24 Aska Pharmaceutical Co., Ltd. Derivado de pirazolonaftiridina.
WO2004063197A1 (en) * 2003-01-09 2004-07-29 Fujisawa Pharmaceutical Co., Ltd. Pyrrolopyridazine derivatives
CA2578368C (en) * 2004-09-02 2013-07-02 Altana Pharma Ag Triazolophthalazines
US7589205B2 (en) * 2004-09-08 2009-09-15 Nycomed Gmbh 3-thia-10-aza-phenanthrene derivatives
WO2006027344A2 (en) * 2004-09-08 2006-03-16 Altana Pharma Ag 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors
US7671050B2 (en) * 2005-01-05 2010-03-02 Nycomed Gmbh Triazolophthalazines
BRPI0606379A2 (pt) * 2005-01-05 2009-06-23 Nycomed Gmbh triazolftalazinas
ES2412481T3 (es) 2006-05-19 2013-07-11 Dart Neuroscience Llc Inhibidores de la fosfodiesterasa 4 para la rehabilitación motora
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
CA2682730A1 (en) * 2007-04-11 2008-10-23 Alcon Research, Ltd. Use of an inhibitor of tnf.alpha. plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
BR112012007091A2 (pt) * 2009-10-01 2016-04-19 Alcon Res Ltd composições de olopatadina e seus usos
GB2575490A (en) * 2018-07-12 2020-01-15 Recordati Ind Chimica E Farmaceutica Spa P2X3 receptor antagonists
CN113423435A (zh) 2018-12-28 2021-09-21 雷杰纳荣制药公司 使用花生四烯酸15-脂氧合酶(alox15)抑制剂治疗呼吸系统病症

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3704300A (en) * 1971-04-09 1972-11-28 Sandoz Ag Imidazo(2,1-a)phthalazines
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
ES2105920B1 (es) 1991-10-09 1998-07-01 Syntex Inc Procedimiento para preparar compuestos de benzo-y piridopiridazinona y piridazinationa.
TW211013B (xx) 1991-12-27 1993-08-11 Takeda Pharm Industry Co Ltd
CA2120997A1 (en) * 1993-04-12 1994-10-13 Akio Miyake Triazolopyridazine derivatives, their production and use
DE69533057T2 (de) * 1994-08-09 2005-06-16 Eisai Co., Ltd. Kondensierte pyridazinverbindungen
DE19617862A1 (de) * 1996-04-23 1997-10-30 Schering Ag Phthalazinderivate, deren Herstellung und Verwendung als Arzneimittel
WO1998004559A2 (en) * 1996-07-25 1998-02-05 Merck Sharp & Dohme Limited Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
WO1998007430A1 (fr) 1996-08-20 1998-02-26 Eisai Co., Ltd. Medicament contre les defaillances de l'erection, renfermant un compose a base de pyridazine fondue
BR9713338B1 (pt) * 1996-11-11 2009-12-01 benzonaftiridinas, medicamento, bem como seu uso como terapêuticos brÈnquicos.
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4

Also Published As

Publication number Publication date
EP1124829A1 (en) 2001-08-22
ITMI982319A1 (it) 2000-04-29
ATE272638T1 (de) 2004-08-15
AU6332499A (en) 2000-05-22
IT1303272B1 (it) 2000-11-06
CA2345337A1 (en) 2000-05-11
ITMI982319A0 (it) 1998-10-29
EP1124829B1 (en) 2004-08-04
JP2002528549A (ja) 2002-09-03
AU766129B2 (en) 2003-10-09
WO2000026218A1 (en) 2000-05-11
US6525055B1 (en) 2003-02-25
DE69919192D1 (de) 2004-09-09

Similar Documents

Publication Publication Date Title
IL141719A0 (en) Tricyclic phthalazine derivatives as phosphodiesterase 4 inhibitors
EA199900866A1 (ru) Пиразолопиримидиноны, которые ингибируют циклический гуанозин-3',5'-монофосфат-фосфодиэстеразу типа 5 (cgmp pde5), для лечения сексуального расстройства
EA200100061A1 (ru) Производные фталазина в качестве ингибиторов фосфодиэстеразы 4
WO2003106628A3 (en) BENZFIAZEPINE F1F0 ATP HYDROLASE MITOCHONDRIAL INHIBITORS AND METHODS OF INHIBITING F1F0 ATP HYDROLASE
MXPA02002720A (es) Nuevos compuestos de alfa-aminoacido-sulfonilo, un proceso para su preparacion y composiciones farmaceuticas que los comprenden.
YU48390B (sh) Novi derivati 2-anilinopirimidina, postupak za njihovo dobijanje i sredstva za uništavanje štetočina, koja sadrže ove derivate
BG102792A (en) Substituted derivatives of 4-hydroxyphenylalkane acids having antagonists activity to ppar-gama.
EA199700194A1 (ru) Производные пиразол-4-илбензоила и их применение в качестве гербицидов
CA2318579A1 (en) Nitrogen-containing heterocyclic compounds and medicaments containing the compounds
HUP0301688A2 (hu) Aminoalkoholszármazékok, eljárás az elżállításukra és ezeket tartalmazó gyógyszerkészítmények
DK70784D0 (da) Quinazolinyloxyalkylamidderivater
IT1263116B (it) Derivati basici dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso farmaceutico
HRP20000896B1 (en) Adenosine derivatives
NO20015446L (no) Kinolin-derivater som inhibitorer for MEK-enzymer
ATE120955T1 (de) Benzyliden-malononitril-derivate zur hemmung von proliferativen prozessen in säugetierzellen.
ATE251146T1 (de) Selektive thrombin-hemmer
IL98681A (en) Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives
EA200100062A1 (ru) Фталазиновые производные ингибиторов производных фосфодиэстеразы 4
HUP0303279A2 (hu) Indolo-pirrolo-karbazolok cukorszármazékai, mint topoizomeráz inhibitorok és ezeket tartalmazó gyógyszerkészítmények
KR970074779A (ko) 선택적 트롬빈 억제제로 유용한 방향족 아미딘 유도체
ES8504098A1 (es) Procedimiento para preparar agentes anti-psoriaticos naftalenicos
EA200100059A2 (ru) Новые бензолсульфонамидные производные, способ их получения и содержащие их фармацевтические композиции
CO5540322A2 (es) Nuevos derivados heterociclicos que comprenden un anillo de tetrahidroisoquinolina y uso farmaceutico de los mismos
EA200001165A1 (ru) Производные тетрагидрохинолина в качестве антагонистов глицина
AR001767A1 (es) Derivados de ciclolignanos utiles como inmunosupresores composiciones farmaceuticas que los contienen y procedimiento para preparar dichos derivados