IL139710A - Benzamide derivatives for the treatment of diseases mediated by cytokines - Google Patents

Benzamide derivatives for the treatment of diseases mediated by cytokines

Info

Publication number
IL139710A
IL139710A IL13971099A IL13971099A IL139710A IL 139710 A IL139710 A IL 139710A IL 13971099 A IL13971099 A IL 13971099A IL 13971099 A IL13971099 A IL 13971099A IL 139710 A IL139710 A IL 139710A
Authority
IL
Israel
Prior art keywords
cytokines
treatment
diseases mediated
benzamide derivatives
6alkoxy
Prior art date
Application number
IL13971099A
Other languages
English (en)
Other versions
IL139710A0 (en
Original Assignee
Astazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9810356.7A external-priority patent/GB9810356D0/en
Priority claimed from GBGB9905970.1A external-priority patent/GB9905970D0/en
Application filed by Astazeneca Ab filed Critical Astazeneca Ab
Publication of IL139710A0 publication Critical patent/IL139710A0/xx
Publication of IL139710A publication Critical patent/IL139710A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL13971099A 1998-05-15 1999-05-11 Benzamide derivatives for the treatment of diseases mediated by cytokines IL139710A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9810356.7A GB9810356D0 (en) 1998-05-15 1998-05-15 Amide derivatives
GBGB9905970.1A GB9905970D0 (en) 1999-03-17 1999-03-17 Amide derivatives
PCT/GB1999/001491 WO1999059960A1 (en) 1998-05-15 1999-05-11 Benzamide derivatives for the treatment of diseases mediated by cytokines

Publications (2)

Publication Number Publication Date
IL139710A0 IL139710A0 (en) 2002-02-10
IL139710A true IL139710A (en) 2005-07-25

Family

ID=26313677

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13971099A IL139710A (en) 1998-05-15 1999-05-11 Benzamide derivatives for the treatment of diseases mediated by cytokines

Country Status (23)

Country Link
US (1) US6465455B1 (ko)
EP (1) EP1077930B1 (ko)
JP (1) JP2003505337A (ko)
KR (1) KR100628284B1 (ko)
CN (1) CN1188389C (ko)
AT (1) ATE282023T1 (ko)
AU (1) AU748397B2 (ko)
BR (1) BR9910467A (ko)
CA (1) CA2328699A1 (ko)
DE (1) DE69921804T2 (ko)
ES (1) ES2230853T3 (ko)
HK (1) HK1033753A1 (ko)
HU (1) HUP0102367A3 (ko)
ID (1) ID27285A (ko)
IL (1) IL139710A (ko)
NO (1) NO20005766L (ko)
NZ (1) NZ507143A (ko)
PL (1) PL197181B1 (ko)
PT (1) PT1077930E (ko)
RU (1) RU2205823C2 (ko)
SK (1) SK286247B6 (ko)
TR (1) TR200003355T2 (ko)
WO (1) WO1999059960A1 (ko)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772432B2 (en) 1991-09-19 2010-08-10 Astrazeneca Ab Amidobenzamide derivatives which are useful as cytokine inhibitors
GB9816837D0 (en) 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
EP1017378B1 (en) 1997-09-23 2002-12-11 AstraZeneca AB Amide derivatives for the treatment of diseases mediated by cytokines
TR200003355T2 (tr) 1998-05-15 2001-03-21 Astrazeneca Ab Sitokinin sebep olduğu hastalıkların tedavisinde benzamid türevlerinin kullanılması
NZ507144A (en) 1998-05-15 2002-10-25 Astrazeneca Ab Benzamide derivatives useful for the treatment of diseases mediated by cytokines
US6432949B1 (en) 1998-08-04 2002-08-13 Astrazeneca Ab Amide derivatives useful as inhibitors of the production of cytokines
ATE266399T1 (de) 1998-08-20 2004-05-15 Smithkline Beecham Corp Neue substituierte triazolverbindungen
WO2000018738A1 (en) 1998-09-25 2000-04-06 Astrazeneca Ab Benzamide derivatives and their use as cytokine inhibitors
CZ300293B6 (cs) 1999-03-17 2009-04-15 Astrazeneca Ab Nové amidové deriváty, zpusob jejich prípravy a farmaceutická kompozice, která je obsahuje
CZ20013276A3 (cs) * 1999-03-17 2001-12-12 Astrazeneca Ab Nové amidové deriváty, způsob jejich přípravy a farmaceutická kompozice, která je obsahuje
GB9906566D0 (en) 1999-03-23 1999-05-19 Zeneca Ltd Chemical compounds
GB9924092D0 (en) 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives
ATE281439T1 (de) 1999-11-23 2004-11-15 Smithkline Beecham Corp 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
US6943161B2 (en) 1999-12-28 2005-09-13 Pharmacopela Drug Discovery, Inc. Pyrimidine and triazine kinase inhibitors
JP4224566B2 (ja) * 2000-12-18 2009-02-18 株式会社医薬分子設計研究所 炎症性サイトカイン産生遊離抑制剤
US7320991B2 (en) 2001-02-27 2008-01-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health Analogs of thalidomide as potential angiogenesis inhibitors
AU2003242098B2 (en) * 2002-06-10 2008-11-20 Institute Of Medicinal Molecular Design, Inc Inhibitors against activation of NFkappaB
AU2003281198A1 (en) * 2002-07-04 2004-01-23 Mitsui Chemicals, Inc. m-PHENYLENEDIAMINE DERIVATIVE
EP1707205A2 (en) 2002-07-09 2006-10-04 Boehringer Ingelheim Pharma GmbH & Co. KG Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
CA2538864C (en) 2003-09-17 2013-05-07 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Thalidomide analogs as tnf-alpha modulators
GB0324790D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
ES2380236T3 (es) 2005-10-28 2012-05-09 Takeda Pharmaceutical Company Limited Compuesto de amida heterocíclica y uso del mismo
CA2629814C (en) * 2005-11-14 2013-12-31 Genentech, Inc. Bisamide inhibitors of hedgehog signaling
EP2004614B1 (en) 2006-04-13 2016-10-19 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Tetrahalogenated compounds useful as inhibitors of angiogenesis
US7671058B2 (en) * 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
WO2008089034A2 (en) * 2007-01-11 2008-07-24 Kemia, Inc. Cytokine inhibitors
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds
CN104326937B (zh) * 2014-09-03 2016-08-24 天津市肿瘤研究所 抗肿瘤化合物及其医药用途
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療

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US1909960A (en) 1929-08-06 1933-05-23 Du Pont Intermediate for azo dyes
DE2812252A1 (de) 1978-03-21 1979-10-04 Bayer Ag 1,2,4-triazol-blockierte polyisocyanate als vernetzer fuer lackbindemittel
US4524168A (en) 1981-11-18 1985-06-18 Ciba-Geigy Corporation Process for the mass coloration of polymers
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AU2552492A (en) 1991-08-23 1993-03-16 United States of America as represented by The Secretary Department of Health and Human Services, The Raf protein kinase therapeutics
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WO1997005878A1 (en) 1995-08-10 1997-02-20 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
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WO1998006715A1 (en) * 1996-08-09 1998-02-19 Smithkline Beecham Corporation Novel piperazine containing compounds
GB9623833D0 (en) 1996-11-16 1997-01-08 Zeneca Ltd Chemical compound
EP1017378B1 (en) * 1997-09-23 2002-12-11 AstraZeneca AB Amide derivatives for the treatment of diseases mediated by cytokines
GB9809347D0 (en) 1998-05-05 1998-07-01 Reckitt & Colmann Prod Ltd Compositions
NZ507144A (en) 1998-05-15 2002-10-25 Astrazeneca Ab Benzamide derivatives useful for the treatment of diseases mediated by cytokines
TR200003355T2 (tr) 1998-05-15 2001-03-21 Astrazeneca Ab Sitokinin sebep olduğu hastalıkların tedavisinde benzamid türevlerinin kullanılması
US6432949B1 (en) 1998-08-04 2002-08-13 Astrazeneca Ab Amide derivatives useful as inhibitors of the production of cytokines
WO2000018738A1 (en) 1998-09-25 2000-04-06 Astrazeneca Ab Benzamide derivatives and their use as cytokine inhibitors
CA2341374A1 (en) 1998-10-01 2000-04-13 Astrazeneca Ab Quinoline and quinazoline derivatives and their use as inhibitors of cytokine mediated diseases
CZ20013276A3 (cs) 1999-03-17 2001-12-12 Astrazeneca Ab Nové amidové deriváty, způsob jejich přípravy a farmaceutická kompozice, která je obsahuje
CZ300293B6 (cs) 1999-03-17 2009-04-15 Astrazeneca Ab Nové amidové deriváty, zpusob jejich prípravy a farmaceutická kompozice, která je obsahuje
GB9924092D0 (en) 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives

Also Published As

Publication number Publication date
CA2328699A1 (en) 1999-11-25
TR200003355T2 (tr) 2001-03-21
DE69921804T2 (de) 2005-10-27
US6465455B1 (en) 2002-10-15
RU2205823C2 (ru) 2003-06-10
HK1033753A1 (en) 2001-09-21
EP1077930B1 (en) 2004-11-10
IL139710A0 (en) 2002-02-10
KR20010043547A (ko) 2001-05-25
JP2003505337A (ja) 2003-02-12
NO20005766L (no) 2001-01-12
SK17172000A3 (sk) 2001-04-09
ES2230853T3 (es) 2005-05-01
NO20005766D0 (no) 2000-11-14
ATE282023T1 (de) 2004-11-15
BR9910467A (pt) 2001-01-09
AU748397B2 (en) 2002-06-06
NZ507143A (en) 2003-08-29
PL197181B1 (pl) 2008-03-31
PT1077930E (pt) 2005-03-31
KR100628284B1 (ko) 2006-09-27
ID27285A (id) 2001-03-22
HUP0102367A2 (hu) 2001-10-28
CN1188389C (zh) 2005-02-09
PL344185A1 (en) 2001-10-08
AU3839299A (en) 1999-12-06
HUP0102367A3 (en) 2002-11-28
WO1999059960A1 (en) 1999-11-25
DE69921804D1 (de) 2004-12-16
SK286247B6 (sk) 2008-06-06
EP1077930A1 (en) 2001-02-28
CN1359371A (zh) 2002-07-17

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