ES2095186A1 - Derivados de epi-epibatidina. - Google Patents

Derivados de epi-epibatidina.

Info

Publication number
ES2095186A1
ES2095186A1 ES09402520A ES9402520A ES2095186A1 ES 2095186 A1 ES2095186 A1 ES 2095186A1 ES 09402520 A ES09402520 A ES 09402520A ES 9402520 A ES9402520 A ES 9402520A ES 2095186 A1 ES2095186 A1 ES 2095186A1
Authority
ES
Spain
Prior art keywords
alkyl
epi
epibatidine
aryl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09402520A
Other languages
English (en)
Other versions
ES2095186B1 (es
Inventor
Csaba Szantay
Zsuzsanna Balogh
Istvan Moldvai
Eszter Temesvari
Attila Mandi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9303507A external-priority patent/HUT69389A/hu
Priority claimed from HU9303506A external-priority patent/HUT69382A/hu
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES2095186A1 publication Critical patent/ES2095186A1/es
Application granted granted Critical
Publication of ES2095186B1 publication Critical patent/ES2095186B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

DERIVADOS DE EPI-EPIBATIDINA. LOS COMPUESTOS DE FORMULA GENERAL XVII *FIG* DONDE R REPRESENTA UN ALQUILO INFERIOR, ALQUENILO INFERIOR, ALQUINILO INFERIOR, CICLOALQUILO INFERIOR, ARILO, HETEROARILO, ARILO-ALQUILO INFERIOR O HETEROARILO-ALQUILO INFERIOR, PUDIENDO ESTAR DICHOS GRUPOS OPCIONALMENTE SUSTITUIDOS POR UNO O MAS SUSTITUYENTES DE ALQUILO INFERIOR, ALQUENILO INFERIOR, ALQUINILO INFERIOR, CICLOALQUILO INFERIOR, ARILO, HETEROARILO, ARILO-ALQUILO INFERIOR, HETEROARILO-ALQUILO INFERIOR, HIDROXILO, ALCOXILO INFERIOR, FENOXILO, HALOGENO, HALOGENO-ALQUILO INFERIOR, AMINO-, AMINO- MONO O DISUSTITUIDO Y/O SULFONAMIDO.
ES09402520A 1993-12-09 1994-12-09 Derivados de epi-epibatidina. Expired - Lifetime ES2095186B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9303507A HUT69389A (en) 1993-12-09 1993-12-09 Amino-ciklohexane-derivatives and process for their production
HU9303506A HUT69382A (en) 1993-12-09 1993-12-09 7-azabicyclo [2.2.1]heptane derivatives and pharmaceutical compositions containing the same and process for the production thereof

Publications (2)

Publication Number Publication Date
ES2095186A1 true ES2095186A1 (es) 1997-02-01
ES2095186B1 ES2095186B1 (es) 1997-09-01

Family

ID=26318171

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09402520A Expired - Lifetime ES2095186B1 (es) 1993-12-09 1994-12-09 Derivados de epi-epibatidina.

Country Status (15)

Country Link
EP (1) EP0657455A1 (es)
JP (1) JPH07291974A (es)
KR (1) KR950017996A (es)
CN (1) CN1112118A (es)
BE (1) BE1008622A3 (es)
BG (1) BG99253A (es)
CA (1) CA2137611A1 (es)
CZ (1) CZ308494A3 (es)
ES (1) ES2095186B1 (es)
FR (1) FR2713641B1 (es)
GR (1) GR1002598B (es)
HR (1) HRP940980A2 (es)
IT (1) ITMI942483A1 (es)
PL (1) PL306204A1 (es)
YU (1) YU71994A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT69381A (en) * 1993-12-09 1995-09-28 Egyt Gyogyszervegyeszeti Gyar Process for producing (2-chloro pyridyl)-7-azabicyclo [2.2.1.]heptane
FR2713641B1 (fr) * 1993-12-09 1997-04-11 Egyt Gyogyszervegyeszeti Gyar Dérivés de l'épi-épibatidine.
AU708112B2 (en) * 1994-08-25 1999-07-29 University Of Virginia 7-azabicyclo{2.2.1}-heptane and -heptene derivatives as cholinergic receptor ligands
EP0955301A3 (en) * 1998-04-27 2001-04-18 Pfizer Products Inc. 7-aza-bicyclo[2.2.1]-heptane derivatives, their preparation and use according to their affinity for neuronal nicotinic acetylcholine receptors
TW200626138A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
US7884125B2 (en) 2008-04-30 2011-02-08 Universiteit Gent Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
US8389561B2 (en) 2008-04-30 2013-03-05 Universiteit Gent Substituted 7-azabicyclo[2.2.1]heptyl derivatives useful for making pharmaceutical compositions
US8809365B2 (en) 2009-11-04 2014-08-19 Universiteit Gent 1-substituted 2-azabicyclo [3.1.1] heptyl derivatives useful as nicotinic acetylcholine receptor modulators for treating neurologic disorders
CN101863892B (zh) * 2010-06-13 2012-05-09 华东理工大学 地棘蛙素及其类似物的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018037A1 (en) * 1992-03-03 1993-09-16 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Epibatidine and derivatives, compositions and methods of treating pain

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU646432B2 (en) * 1990-02-02 1994-02-24 Schering Corporation 4,5-cycloalkano-3-benzazepin-7-ol-derivatives and their use
AU695682B2 (en) * 1993-04-01 1998-08-20 University Of Virginia 7-azabicyclo-(2.2.1)-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
FR2713641B1 (fr) * 1993-12-09 1997-04-11 Egyt Gyogyszervegyeszeti Gyar Dérivés de l'épi-épibatidine.
EP0664293A1 (en) * 1993-12-24 1995-07-26 Duphar International Research B.V 2-Phenyl-7-azabicycloheptanes and 6-phenyl-8-azabicyclo

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018037A1 (en) * 1992-03-03 1993-09-16 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Epibatidine and derivatives, compositions and methods of treating pain

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
C. SZANTAY et al. "A practical route to epibatidine" TETRAHEDRON LETTERS., Vol. 35, n‘ 19, 9 Mayo 1994, OXFORD GB, pßginas 3171-3174 * CAS RN 152377-48-5, 156489-42-8, 156489-43-9, 156489-44-0 * *
D.F. HUANG et al. "A versatile total synthesis of epibatidine and analogs" TETRAHEDRON LETTERS., Vol. 34, n‘ 28, 1993, OXFORD GB, pßginas 4477-4480 *
J.S. BINDRA et al. "2-Substituted octahydrophenanthridines." INDIAN JOURNAL OF CHEMISTRY, Vol. 5, n‘ 7, 1967, pßginas 344-346 * Compuestos II,VII: CAS RN 18123-22-3, 18123-28-9 * *
M.E. LEWELLYN et al. "Formation of a cyclohexane ring by condensation of a nitro ketone and an aldehyde." JOURNAL OF ORGANIC CHEMISTRY., Vol. 39, n‘ 10, 1974, EASTON US, pßginas 1407-1410 * 3-(2-furyl)-4-nitrocyclohexanone: CAS RN 51004-08-1 * *
N.L. DRAKE et al. "Polycyclic compounds containing nitrogen. II. hydroindoles." JOURNAL OF ORGANIC CHEMISTRY., Vol. 23, 1958, EASTON US, pßginas 794-796 * 3-(2-ethoxyethyl)-4-nitrocyclohexanone: CAS RN 99189-98-7 * *
R.W. ABEN et al. "Synthesis of endo-2-phenyl-7-azabicyclo(2.2.1)heptane via high pressure Diels-Alder reaction of pyrroles." TETRAHEDRON LETTERS., Vol. 35, n‘ 8, 21 Febrero 1994, OXFORD GB, pßginas 1299-1300 * CAS RN 155053-30-8 * *
S.Y. KO et al. "The total synthesis of epibatidine" JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, n‘ 15, 17 Agosto 1994, LETCHWORTH GB, pßginas 1775-1776 * Compuesto 10 * *
T. LI et al. "The analgesic effect of epibatidine and isomers." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 3, n‘ 12, 1993, OXFORD, pßginas 2759-2764 *

Also Published As

Publication number Publication date
YU71994A (sh) 1997-12-05
ITMI942483A0 (it) 1994-12-09
BE1008622A3 (fr) 1996-06-04
FR2713641A1 (fr) 1995-06-16
CN1112118A (zh) 1995-11-22
ITMI942483A1 (it) 1995-06-09
CA2137611A1 (en) 1995-06-10
FR2713641B1 (fr) 1997-04-11
EP0657455A1 (en) 1995-06-14
HRP940980A2 (en) 1997-06-30
KR950017996A (ko) 1995-07-22
CZ308494A3 (en) 1995-07-12
JPH07291974A (ja) 1995-11-07
ES2095186B1 (es) 1997-09-01
PL306204A1 (en) 1995-06-12
BG99253A (en) 1995-09-29
GR1002598B (el) 1997-02-12

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