IL137750A - Valve for aerosol container - Google Patents
Valve for aerosol containerInfo
- Publication number
- IL137750A IL137750A IL13775099A IL13775099A IL137750A IL 137750 A IL137750 A IL 137750A IL 13775099 A IL13775099 A IL 13775099A IL 13775099 A IL13775099 A IL 13775099A IL 137750 A IL137750 A IL 137750A
- Authority
- IL
- Israel
- Prior art keywords
- valve
- aerosol
- aerosol container
- container according
- metering chamber
- Prior art date
Links
- 239000000443 aerosol Substances 0.000 title claims abstract description 59
- 239000000203 mixture Substances 0.000 claims abstract description 69
- 239000003814 drug Substances 0.000 claims abstract description 61
- 238000009472 formulation Methods 0.000 claims abstract description 42
- 239000003380 propellant Substances 0.000 claims abstract description 28
- 229920002313 fluoropolymer Polymers 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 14
- 239000000725 suspension Substances 0.000 claims abstract description 12
- 239000001257 hydrogen Substances 0.000 claims abstract description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000004033 plastic Substances 0.000 claims abstract description 9
- 229920003023 plastic Polymers 0.000 claims abstract description 9
- 238000012546 transfer Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 229920006120 non-fluorinated polymer Polymers 0.000 claims abstract description 4
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000000576 coating method Methods 0.000 claims description 18
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims description 15
- 239000011248 coating agent Substances 0.000 claims description 14
- 229960000289 fluticasone propionate Drugs 0.000 claims description 12
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical group C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 12
- 229920000728 polyester Polymers 0.000 claims description 11
- -1 polychlorotrifluoroethylene Polymers 0.000 claims description 9
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 claims description 8
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 4
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 3
- 229960002052 salbutamol Drugs 0.000 claims description 3
- 229960004017 salmeterol Drugs 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 2
- 229950000210 beclometasone dipropionate Drugs 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000012453 solvate Substances 0.000 claims description 2
- 229920002493 poly(chlorotrifluoroethylene) Polymers 0.000 claims 2
- 239000005023 polychlorotrifluoroethylene (PCTFE) polymer Substances 0.000 claims 2
- 229920002620 polyvinyl fluoride Polymers 0.000 claims 2
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 32
- 229920000642 polymer Polymers 0.000 description 31
- 238000000151 deposition Methods 0.000 description 29
- 230000008021 deposition Effects 0.000 description 28
- 150000001241 acetals Chemical class 0.000 description 14
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- 239000004810 polytetrafluoroethylene Substances 0.000 description 10
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 229910052731 fluorine Inorganic materials 0.000 description 7
- 239000011737 fluorine Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000004812 Fluorinated ethylene propylene Substances 0.000 description 6
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- HCDGVLDPFQMKDK-UHFFFAOYSA-N hexafluoropropylene Chemical group FC(F)=C(F)C(F)(F)F HCDGVLDPFQMKDK-UHFFFAOYSA-N 0.000 description 6
- 229920009441 perflouroethylene propylene Polymers 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 229920000840 ethylene tetrafluoroethylene copolymer Polymers 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 229940071648 metered dose inhaler Drugs 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 3
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000004411 aluminium Substances 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000008249 pharmaceutical aerosol Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 2
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229940124630 bronchodilator Drugs 0.000 description 2
- 239000000168 bronchodilator agent Substances 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229960002714 fluticasone Drugs 0.000 description 2
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 150000005828 hydrofluoroalkanes Chemical class 0.000 description 2
- 238000002664 inhalation therapy Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 229920006324 polyoxymethylene Polymers 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 1
- AKNNEGZIBPJZJG-MSOLQXFVSA-N (-)-noscapine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2[C@@H]1[C@@H]1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-MSOLQXFVSA-N 0.000 description 1
- WRRSFOZOETZUPG-FFHNEAJVSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;hydrate Chemical compound O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC WRRSFOZOETZUPG-FFHNEAJVSA-N 0.000 description 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- KHXKESCWFMPTFT-UHFFFAOYSA-N 1,1,1,2,2,3,3-heptafluoro-3-(1,2,2-trifluoroethenoxy)propane Chemical compound FC(F)=C(F)OC(F)(F)C(F)(F)C(F)(F)F KHXKESCWFMPTFT-UHFFFAOYSA-N 0.000 description 1
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 1
- WXGNWUVNYMJENI-UHFFFAOYSA-N 1,1,2,2-tetrafluoroethane Chemical compound FC(F)C(F)F WXGNWUVNYMJENI-UHFFFAOYSA-N 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 1
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- IJVCSMSMFSCRME-KBQPJGBKSA-N Dihydromorphine Chemical compound O([C@H]1[C@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-KBQPJGBKSA-N 0.000 description 1
- 102400000321 Glucagon Human genes 0.000 description 1
- 108060003199 Glucagon Proteins 0.000 description 1
- 229920005240 HOSTAFORM® C 9021 TF Polymers 0.000 description 1
- 229920005176 Hostaform® Polymers 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- 229920001774 Perfluoroether Polymers 0.000 description 1
- VQDBNKDJNJQRDG-UHFFFAOYSA-N Pirbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=N1 VQDBNKDJNJQRDG-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- DXEXNWDGDYUITL-FXSSSKFRSA-N Tipredane Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@@](SC)(SCC)[C@@]1(C)C[C@@H]2O DXEXNWDGDYUITL-FXSSSKFRSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- AKNNEGZIBPJZJG-UHFFFAOYSA-N alpha-noscapine Natural products CN1CCC2=CC=3OCOC=3C(OC)=C2C1C1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-UHFFFAOYSA-N 0.000 description 1
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 description 1
- 229960002576 amiloride Drugs 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000003434 antitussive agent Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 229940092705 beclomethasone Drugs 0.000 description 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
- 229960004217 benzyl alcohol Drugs 0.000 description 1
- 229960004436 budesonide Drugs 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229960004126 codeine Drugs 0.000 description 1
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Natural products C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 229960000265 cromoglicic acid Drugs 0.000 description 1
- 229940109248 cromoglycate Drugs 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 description 1
- 229960004943 ergotamine Drugs 0.000 description 1
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 description 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 1
- 229960001022 fenoterol Drugs 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229960000676 flunisolide Drugs 0.000 description 1
- 238000003682 fluorination reaction Methods 0.000 description 1
- 229960002848 formoterol Drugs 0.000 description 1
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 1
- 229960004666 glucagon Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 229960001361 ipratropium bromide Drugs 0.000 description 1
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 229960001317 isoprenaline Drugs 0.000 description 1
- 229940039009 isoproterenol Drugs 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- HNJJXZKZRAWDPF-UHFFFAOYSA-N methapyrilene Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CS1 HNJJXZKZRAWDPF-UHFFFAOYSA-N 0.000 description 1
- 229960001869 methapyrilene Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 238000010137 moulding (plastic) Methods 0.000 description 1
- PLPRGLOFPNJOTN-UHFFFAOYSA-N narcotine Natural products COc1ccc2C(OC(=O)c2c1OC)C3Cc4c(CN3C)cc5OCOc5c4OC PLPRGLOFPNJOTN-UHFFFAOYSA-N 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 229960004398 nedocromil Drugs 0.000 description 1
- RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 description 1
- 229960004708 noscapine Drugs 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 229960001802 phenylephrine Drugs 0.000 description 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
- 229960000395 phenylpropanolamine Drugs 0.000 description 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
- 229960005414 pirbuterol Drugs 0.000 description 1
- 229920000120 polyethyl acrylate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000012429 release testing Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 229960001457 rimiterol Drugs 0.000 description 1
- IYMMESGOJVNCKV-SKDRFNHKSA-N rimiterol Chemical compound C([C@@H]1[C@@H](O)C=2C=C(O)C(O)=CC=2)CCCN1 IYMMESGOJVNCKV-SKDRFNHKSA-N 0.000 description 1
- 229960005018 salmeterol xinafoate Drugs 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000012899 standard injection Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229950001669 tipredane Drugs 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
- B65D83/52—Metering valves; Metering devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49405—Valve or choke making
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49405—Valve or choke making
- Y10T29/4941—Valve stem or tire valve making
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49405—Valve or choke making
- Y10T29/49412—Valve or choke making with assembly, disassembly or composite article making
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Nozzles (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805938.9A GB9805938D0 (en) | 1998-03-19 | 1998-03-19 | Valve for aerosol container |
| PCT/EP1999/001757 WO1999047195A1 (en) | 1998-03-19 | 1999-03-17 | Valve for aerosol container |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL137750A0 IL137750A0 (en) | 2001-10-31 |
| IL137750A true IL137750A (en) | 2004-07-25 |
Family
ID=10828912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13775099A IL137750A (en) | 1998-03-19 | 1999-03-17 | Valve for aerosol container |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US6644306B1 (is) |
| EP (2) | EP1064040B1 (is) |
| JP (1) | JP2002506696A (is) |
| KR (1) | KR20010041914A (is) |
| CN (1) | CN1293580A (is) |
| AP (1) | AP2000001953A0 (is) |
| AT (1) | ATE302628T1 (is) |
| AU (1) | AU752739B2 (is) |
| BR (1) | BR9908766A (is) |
| CA (1) | CA2324524A1 (is) |
| DE (1) | DE69926870T2 (is) |
| EA (1) | EA002298B1 (is) |
| EE (1) | EE200000549A (is) |
| GB (1) | GB9805938D0 (is) |
| HR (1) | HRP20000610B1 (is) |
| HU (1) | HUP0101223A3 (is) |
| ID (1) | ID27903A (is) |
| IL (1) | IL137750A (is) |
| IS (1) | IS5597A (is) |
| NO (1) | NO20004642D0 (is) |
| NZ (1) | NZ506181A (is) |
| PL (1) | PL342972A1 (is) |
| SK (1) | SK13742000A3 (is) |
| TR (1) | TR200002663T2 (is) |
| WO (1) | WO1999047195A1 (is) |
| YU (1) | YU56000A (is) |
| ZA (1) | ZA200004377B (is) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9814717D0 (en) * | 1998-02-23 | 1998-09-02 | Bespak Plc | Improvements in drug delivery devices |
| GB9805938D0 (en) * | 1998-03-19 | 1998-05-13 | Glaxo Group Ltd | Valve for aerosol container |
| US6390291B1 (en) | 1998-12-18 | 2002-05-21 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
| US6315985B1 (en) | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
| GB9918573D0 (en) | 1999-08-07 | 1999-10-06 | Glaxo Group Ltd | Valve |
| GB9924780D0 (en) * | 1999-10-21 | 1999-12-22 | Glaxo Group Ltd | Medicament dispenser |
| GB9924808D0 (en) | 1999-10-21 | 1999-12-22 | Glaxo Group Ltd | Medicament dispenser |
| EP1259429A2 (en) * | 2000-03-01 | 2002-11-27 | Glaxo Group Limited | Metered dose inhaler |
| NZ522672A (en) * | 2000-05-23 | 2004-07-30 | Glaxo Group Ltd | Aerosol container for formulations of salmeterol xinafoate and preparation process thereof |
| US6553988B1 (en) * | 2000-06-09 | 2003-04-29 | Norton Healthcare, Inc. | Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber |
| AU2001270074A1 (en) * | 2000-06-22 | 2002-01-02 | Glaxo Group Limited | Method and package for storing a pressurized container containing a drug |
| GB0025092D0 (en) * | 2000-10-13 | 2000-11-29 | Glaxo Group Ltd | Medicament dispenser |
| AU2002222304B2 (en) * | 2000-12-22 | 2004-03-18 | Glaxo Group Limited | Metered dose inhaler for salmeterol xinafoate |
| GB0106046D0 (en) * | 2001-03-12 | 2001-05-02 | Glaxo Group Ltd | Canister |
| US20070089735A1 (en) * | 2001-06-26 | 2007-04-26 | Alan Langford | Aerosol actuator |
| GB0122725D0 (en) * | 2001-09-21 | 2001-11-14 | Glaxo Group Ltd | Drug dispensing components |
| GB0125380D0 (en) * | 2001-10-23 | 2001-12-12 | Glaxo Group Ltd | Medicament dispenser |
| FR2833584B1 (fr) * | 2001-12-13 | 2004-04-23 | Valois Sa | Valve de distribution de produit fluide et dispositif de distribution de produit fluide comportant une telle valve |
| GB0130857D0 (en) * | 2001-12-22 | 2002-02-06 | Glaxo Group Ltd | Medicament dispenser |
| US7258118B2 (en) | 2002-01-24 | 2007-08-21 | Sofotec Gmbh & Co, Kg | Pharmaceutical powder cartridge, and inhaler equipped with same |
| WO2004041340A2 (en) * | 2002-10-30 | 2004-05-21 | Nektar Therapeutics | Increased dosage metered dose inhaler |
| EP1615688A1 (en) * | 2003-04-22 | 2006-01-18 | Glaxo Group Limited | A medicament dispenser |
| US7571841B2 (en) * | 2004-04-19 | 2009-08-11 | Illinois Tool Works, Inc. | Interchangeable adapter for in-can and on-can fuel cells |
| US7392922B2 (en) | 2004-04-19 | 2008-07-01 | Illinois Tool Works Inc. | In-can fuel cell metering valve |
| US20060122560A1 (en) * | 2004-12-07 | 2006-06-08 | Robert Burgmeier | Medical devices and processes for preparing same |
| GB2417480B (en) * | 2004-12-15 | 2006-08-02 | Bespak Plc | Improvements in or relating to valves |
| EP1877238A1 (fr) * | 2005-04-04 | 2008-01-16 | Université de Liège | Nouveaux supports, en particulier pour 1 ' immunodetection molecules d'interet |
| KR20080035604A (ko) * | 2005-08-08 | 2008-04-23 | 노파르티스 아게 | 계량 흡입기용 단열식 캐니스터 |
| US7722819B2 (en) | 2005-10-11 | 2010-05-25 | Meadwestvaco Calmar, Inc. | Fragrance product, dispenser, and dispenser assembly |
| BRPI0617248B1 (pt) * | 2005-10-11 | 2020-11-17 | Westrock Dispensing Systems, Inc | produto de fragância |
| CA2634151A1 (en) * | 2005-12-21 | 2007-07-05 | Glaxo Group Limited | Aerosol canister employing a polymeric film having improved moisture barrier properties |
| US20100300437A1 (en) * | 2007-05-10 | 2010-12-02 | Sivigny Michael B | Manufacture of metered dose valve components |
| FR2918044B1 (fr) * | 2007-06-28 | 2012-01-20 | Valois Sas | Bague pour valve de distribution de produit fluide. |
| GB0719257D0 (en) * | 2007-10-04 | 2007-11-14 | 3M Innovative Properties Co | Metered dose dispenser |
| JP5104536B2 (ja) * | 2008-05-16 | 2012-12-19 | マックス株式会社 | 燃料充填容器及びガス燃焼式打込み工具 |
| WO2011121698A1 (ja) * | 2010-03-29 | 2011-10-06 | 日本たばこ産業株式会社 | エアロゾル吸引器のための液タンク |
| PL2627386T3 (pl) | 2010-10-12 | 2015-08-31 | Ivax Pharmaceuticals Ireland | Urządzenie rozpylające do nosa |
| CA2828884C (en) * | 2011-03-03 | 2021-04-27 | Impel Neuropharma, Inc. | Nasal drug delivery device |
| JP6645735B2 (ja) | 2011-05-09 | 2020-02-14 | インペル ニューロファーマ インコーポレイテッド | 鼻薬送達用ノズル |
| US11814239B2 (en) * | 2011-05-16 | 2023-11-14 | The Procter & Gamble Company | Heating of products in an aerosol dispenser and aerosol dispenser containing such heated products |
| KR101261813B1 (ko) * | 2011-07-27 | 2013-05-14 | (주)민진 | 불소고무밸브가 구비된 펌프식 화장품용기 |
| GB201121812D0 (en) | 2011-12-07 | 2012-02-01 | Teva Branded Pharmaceutical Prod R & D Inc | NAsal formulation |
| US9554982B2 (en) | 2012-09-14 | 2017-01-31 | The Procter & Gamble Company | Aerosol antiperspirant compositions, products and methods |
| US9662285B2 (en) | 2014-03-13 | 2017-05-30 | The Procter & Gamble Company | Aerosol antiperspirant compositions, products and methods |
| US9579265B2 (en) | 2014-03-13 | 2017-02-28 | The Procter & Gamble Company | Aerosol antiperspirant compositions, products and methods |
| GB201408229D0 (en) | 2014-05-09 | 2014-06-25 | Norton Waterford Ltd | Aerosol device |
| GB2535796A (en) * | 2015-02-27 | 2016-08-31 | 3M Innovative Properties Co | Improvements in or relating to metered dose inhalers |
| FR3035382B1 (fr) * | 2015-04-24 | 2019-10-18 | Nemera La Verpilliere | Valve doseuse perfectionnee de distribution d'un aerosol comprenant une tige de valve |
| US10166666B2 (en) * | 2015-11-25 | 2019-01-01 | Illinois Tool Works Inc. | Adapter for combustion tool fuel cells |
| FR3049275B1 (fr) * | 2016-03-23 | 2019-07-19 | Aptar France Sas | Valve doseuse et dispositif de distribution de produit fluide comportant une telle valve |
| FR3065891B1 (fr) * | 2017-05-05 | 2021-12-24 | Aptar France Sas | Valve doseuse et dispositif de distribution de produit fluide comportant une telle valve. |
| FR3114759B1 (fr) * | 2020-10-02 | 2022-09-23 | Aptar France Sas | Valve doseuse |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2886217A (en) * | 1957-05-20 | 1959-05-12 | Riker Laboratories Inc | Dispensing device |
| US3272442A (en) * | 1964-01-16 | 1966-09-13 | Union Carbide Corp | Aerosol valve |
| AT306895B (de) * | 1967-05-15 | 1973-04-25 | Minnesota Mining & Mfg | Mittel zur Behandlung von verletztem Körpergewebe |
| US3552608A (en) | 1968-11-12 | 1971-01-05 | Synectics Dev Corp | Pressurized container food valve |
| US3658214A (en) * | 1970-05-01 | 1972-04-25 | Walter C Beard | Metering valve for fluid dispenser |
| US3709410A (en) | 1970-07-30 | 1973-01-09 | Barr Stalfort Co | Aerosol valve with differential flow control rate |
| NO134730L (is) * | 1971-07-19 | 1900-01-01 | ||
| JPS52106383A (en) * | 1976-03-04 | 1977-09-06 | Toyo Eazooru Kougiyou Kk | Adhesion preventing composites for adhesives |
| US4252848A (en) * | 1977-04-11 | 1981-02-24 | Rca Corporation | Perfluorinated polymer thin films |
| US4418846A (en) | 1980-01-04 | 1983-12-06 | American Cyanamid Company | Aerosol dispensing system |
| US4656083A (en) * | 1983-08-01 | 1987-04-07 | Washington Research Foundation | Plasma gas discharge treatment for improving the biocompatibility of biomaterials |
| US4649071A (en) * | 1984-04-28 | 1987-03-10 | Kabushiki Kaisha Toyota Chuo Kenkyusho | Composite material and process for producing the same |
| JPS61213221A (ja) | 1985-03-19 | 1986-09-22 | Japan Synthetic Rubber Co Ltd | プラズマ重合膜の製法 |
| US4718907A (en) * | 1985-06-20 | 1988-01-12 | Atrium Medical Corporation | Vascular prosthesis having fluorinated coating with varying F/C ratio |
| US5091204A (en) * | 1985-08-23 | 1992-02-25 | Weshington Research Foundation | Polymeric intraocular lens material having improved surface properties |
| US4666083A (en) * | 1985-11-21 | 1987-05-19 | Fluidyne Corporation | Process and apparatus for generating particulate containing fluid jets |
| EP0293442A1 (en) | 1986-12-17 | 1988-12-07 | Microvol Limited | Pressurised metering dispenser |
| FR2615172B1 (fr) | 1987-05-11 | 1989-08-18 | Valois | Valve aerosol doseuse utilisable en position inversee |
| FR2615124B1 (fr) | 1987-05-12 | 1989-11-24 | Valois | Valve aerosol doseuse a propulseur, utilisable en position inversee |
| FR2615173B1 (fr) | 1987-05-13 | 1989-08-18 | Valois | Valve doseuse pour liquide charge d'un propulseur liquide ou gaz liquefie, utilisable en position inversee |
| US4961966A (en) * | 1988-05-25 | 1990-10-09 | The United States Of America As Represented By The Administrator Of The Environmental Protection Agency | Fluorocarbon coating method |
| US4902318A (en) * | 1988-05-25 | 1990-02-20 | The United States Of America As Represented By The Administrator Of The Environmental Protection Agency | Inlet apparatus for gas-aerosol sampling |
| FR2634534B1 (fr) | 1988-07-04 | 1990-10-12 | Valois Sa | Valve doseuse pour aerosols |
| US5073175A (en) * | 1988-08-09 | 1991-12-17 | Air Products And Chemicals, Inc. | Fluorooxidized polymeric membranes for gas separation and process for preparing them |
| IE62780B1 (en) * | 1988-09-10 | 1995-02-22 | Fisons Plc | Inhalation devices with a reduced risk of blockage |
| US5147075A (en) | 1988-10-03 | 1992-09-15 | Falcon Safety Products Incorporated | Actuating mechanism for pressurized fluid containers and nozzle assembly |
| GB8825632D0 (en) * | 1988-11-02 | 1988-12-07 | Bespak Plc | Dispensing apparatus for pressurised dispensing containers |
| GB8828477D0 (en) | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| US5176132A (en) * | 1989-05-31 | 1993-01-05 | Fisons Plc | Medicament inhalation device and formulation |
| US5027986A (en) | 1989-06-09 | 1991-07-02 | Heinzel Irving Charles | Actuating valve for aerosol foam product |
| US5200173A (en) * | 1989-08-30 | 1993-04-06 | Revlon Consumer Products Corporation | Molded cosmetic products containing uniform ultra glossy wet look surface finish |
| GB8921222D0 (en) | 1989-09-20 | 1989-11-08 | Riker Laboratories Inc | Medicinal aerosol formulations |
| IL97065A (en) | 1990-02-02 | 1994-01-25 | Fisons Plc | Repellent preparations for aerosol |
| DE4003272A1 (de) | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
| AU654813B2 (en) | 1990-03-23 | 1994-11-24 | Minnesota Mining And Manufacturing Company | The use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations |
| US5126123A (en) * | 1990-06-28 | 1992-06-30 | Glaxo, Inc. | Aerosol drug formulations |
| CA2085884C (en) | 1990-06-29 | 2001-12-04 | Asit Somani | Pressurized hydrofluorocarbon aerosol compositions |
| US5522879A (en) * | 1991-11-12 | 1996-06-04 | Ethicon, Inc. | Piezoelectric biomedical device |
| FR2670139B1 (fr) | 1992-01-15 | 1993-12-24 | Valois | Valve doseuse utilisable en position inversee. |
| US6325192B1 (en) * | 1992-11-25 | 2001-12-04 | Luk Lamellen Und Kupplungsbau | Self-adjusting friction clutch |
| JPH06220286A (ja) | 1993-01-22 | 1994-08-09 | Mitsubishi Cable Ind Ltd | しゅう動材 |
| DE69701051T2 (de) * | 1993-04-30 | 2000-08-31 | Minnesota Mining And Mfg. Co., Saint Paul | Abdichtung an Aerosolbehältern |
| JP2803017B2 (ja) * | 1993-06-07 | 1998-09-24 | 工業技術院長 | 抗血栓性医用材料及び医療用具並びにこれらの製造方法、製造装置及びプラズマ処理装置 |
| US5657456A (en) * | 1993-06-18 | 1997-08-12 | Digital Equipment Corporation | Semiconductor process power supply voltage and temperature compensated integrated system bus driver rise and fall time |
| ES2119219T5 (es) | 1993-07-15 | 2011-05-11 | Minnesota Mining And Manufacturing Company | Cierres estancos para uso en un dispositivo para suministrar un aerosol. |
| US6596260B1 (en) * | 1993-08-27 | 2003-07-22 | Novartis Corporation | Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol |
| US5421492A (en) * | 1993-11-02 | 1995-06-06 | Glaxo Inc. | Metered aerosol dispensing apparatus and method of use thereof |
| US5575311A (en) * | 1995-01-13 | 1996-11-19 | Furon Company | Three-way poppet valve apparatus |
| EP0870699A3 (en) | 1995-03-10 | 1998-10-21 | Minnesota Mining And Manufacturing Company | Aerosol valves |
| US6014970A (en) * | 1998-06-11 | 2000-01-18 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
| GB9507768D0 (en) | 1995-04-13 | 1995-05-31 | Glaxo Group Ltd | Method of apparatus |
| AP791A (en) * | 1995-04-14 | 1999-12-17 | Glaxo Wellcome Inc | Metered dose inhaler for albuterol. |
| MX9707864A (es) * | 1995-04-14 | 1997-11-29 | Glaxo Wellcome Inc | Inhalador de dosis medida por salmeterol. |
| MX9707862A (es) * | 1995-04-14 | 1997-11-29 | Glaxo Wellcome Inc | Inhalador de dosis medida para el propionato de fluticasona. |
| KR19980703850A (ko) * | 1995-04-14 | 1998-12-05 | 그레이엄브레레톤 | 베클로메타손 디프로피오네이트용 계량 흡입기 |
| FR2733758B1 (fr) * | 1995-05-04 | 1997-07-18 | Stelumi Sa | Procede et traitement d'un element de conditionnement, notamment a usage medical ou pharmaceutique ; element de conditionnement ainsi traite |
| GB9517998D0 (en) | 1995-09-04 | 1995-11-08 | Bioglan Lab Ltd | Compositions and device for their administration |
| FR2740527B1 (fr) | 1995-10-31 | 1998-01-02 | Valois | Tige de soupape a faibles frottements |
| US5871010A (en) * | 1996-06-10 | 1999-02-16 | Sarnoff Corporation | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
| US5857456A (en) * | 1996-06-10 | 1999-01-12 | Sarnoff Corporation | Inhaler apparatus with an electronic means for enhanced release of dry powders |
| US5921447A (en) | 1997-02-13 | 1999-07-13 | Glaxo Wellcome Inc. | Flow-through metered aerosol dispensing apparatus and method of use thereof |
| GB2329939A (en) * | 1997-06-26 | 1999-04-07 | Glaxo Group Ltd | Self-lubricating valve stem for aerosol containers |
| GB2332712A (en) | 1997-07-29 | 1999-06-30 | Glaxo Group Ltd | Valve for aerosol container |
| DE19835273A1 (de) * | 1997-09-03 | 1999-03-04 | Bespak Plc | Dosierventil für einen Druck-Abgabe-Behälter |
| GB2328932B (en) | 1997-09-03 | 1999-10-13 | Bespak Plc | Improvements in or relating to metering valves for pressurised dispensing containers |
| ATE415993T1 (de) | 1998-02-23 | 2008-12-15 | Bespak Plc | Abgabevorrichtungen für artzneimittel |
| GB9805938D0 (en) * | 1998-03-19 | 1998-05-13 | Glaxo Group Ltd | Valve for aerosol container |
| US6089258A (en) * | 1999-03-17 | 2000-07-18 | Oasis Corporation | Float valve assembly for a water purification system |
| US6070575A (en) * | 1998-11-16 | 2000-06-06 | Aradigm Corporation | Aerosol-forming porous membrane with certain pore structure |
| GB0025092D0 (en) * | 2000-10-13 | 2000-11-29 | Glaxo Group Ltd | Medicament dispenser |
| GB0122725D0 (en) * | 2001-09-21 | 2001-11-14 | Glaxo Group Ltd | Drug dispensing components |
| US6596290B2 (en) * | 2001-10-02 | 2003-07-22 | Kimberly-Clark Worldwide, Inc. | Inhibition of exoprotein production in non-absorbent articles using isoprenoid compositions |
| GB0125380D0 (en) * | 2001-10-23 | 2001-12-12 | Glaxo Group Ltd | Medicament dispenser |
-
1998
- 1998-03-19 GB GBGB9805938.9A patent/GB9805938D0/en not_active Ceased
-
1999
- 1999-03-17 HR HR980304A patent/HRP20000610B1/xx not_active IP Right Cessation
- 1999-03-17 WO PCT/EP1999/001757 patent/WO1999047195A1/en not_active Ceased
- 1999-03-17 EA EA200000844A patent/EA002298B1/ru not_active IP Right Cessation
- 1999-03-17 SK SK1374-2000A patent/SK13742000A3/sk unknown
- 1999-03-17 EP EP99913267A patent/EP1064040B1/en not_active Expired - Lifetime
- 1999-03-17 EE EEP200000549A patent/EE200000549A/xx unknown
- 1999-03-17 JP JP2000536434A patent/JP2002506696A/ja active Pending
- 1999-03-17 NZ NZ506181A patent/NZ506181A/en unknown
- 1999-03-17 EP EP05076417A patent/EP1584344A1/en not_active Withdrawn
- 1999-03-17 TR TR2000/02663T patent/TR200002663T2/xx unknown
- 1999-03-17 AT AT99913267T patent/ATE302628T1/de not_active IP Right Cessation
- 1999-03-17 PL PL99342972A patent/PL342972A1/xx unknown
- 1999-03-17 AP APAP/P/2000/001953A patent/AP2000001953A0/en unknown
- 1999-03-17 HU HU0101223A patent/HUP0101223A3/hu unknown
- 1999-03-17 YU YU56000A patent/YU56000A/sh unknown
- 1999-03-17 CA CA002324524A patent/CA2324524A1/en not_active Abandoned
- 1999-03-17 BR BR9908766-9A patent/BR9908766A/pt active Search and Examination
- 1999-03-17 AU AU31457/99A patent/AU752739B2/en not_active Ceased
- 1999-03-17 KR KR1020007010221A patent/KR20010041914A/ko not_active Withdrawn
- 1999-03-17 ID IDW20002094A patent/ID27903A/id unknown
- 1999-03-17 DE DE69926870T patent/DE69926870T2/de not_active Expired - Lifetime
- 1999-03-17 IL IL13775099A patent/IL137750A/en not_active IP Right Cessation
- 1999-03-17 US US09/646,270 patent/US6644306B1/en not_active Expired - Fee Related
- 1999-03-17 CN CN99804167A patent/CN1293580A/zh active Pending
-
2000
- 2000-08-22 IS IS5597A patent/IS5597A/is unknown
- 2000-08-24 ZA ZA200004377A patent/ZA200004377B/xx unknown
- 2000-09-18 NO NO20004642A patent/NO20004642D0/no not_active Application Discontinuation
-
2003
- 2003-09-11 US US10/662,008 patent/US20040055602A1/en not_active Abandoned
-
2007
- 2007-12-14 US US11/956,408 patent/US20080098600A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1064040B1 (en) | Valve for aerosol container | |
| US7387121B2 (en) | Valve for aerosol container | |
| CA2361954C (en) | Metered dose inhaler for albuterol | |
| CA2217948C (en) | Metered dose inhaler for fluticasone propionate | |
| US6524555B1 (en) | Metered dose inhaler for salmeterol | |
| RS56000B1 (sr) | Prečišćavanje stafilokokus aureus tip 5 i tip 8 kapsuliranih saharida | |
| CA2218179A1 (en) | Metered dose inhaler for beclomethasone dipropionate | |
| US6345740B1 (en) | Valve for aerosol container | |
| US20050002869A1 (en) | Metered dose inhaler having internal surfaces coated with fluorocarbon polymer | |
| HK1084057A (en) | Valve for aerosol container | |
| MXPA00008726A (en) | Valve for aerosol container | |
| CZ20003367A3 (cs) | Ventil pro kontejner na aerosol, kontejner na aerosol a inhalační zařízení s tímto ventilem | |
| HK1026407B (en) | Aerosol container comprising a valve |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |