IL137750A - Valve for aerosol container - Google Patents
Valve for aerosol containerInfo
- Publication number
- IL137750A IL137750A IL13775099A IL13775099A IL137750A IL 137750 A IL137750 A IL 137750A IL 13775099 A IL13775099 A IL 13775099A IL 13775099 A IL13775099 A IL 13775099A IL 137750 A IL137750 A IL 137750A
- Authority
- IL
- Israel
- Prior art keywords
- valve
- aerosol
- aerosol container
- container according
- metering chamber
- Prior art date
Links
- 239000000443 aerosol Substances 0.000 title claims abstract description 59
- 239000000203 mixture Substances 0.000 claims abstract description 69
- 239000003814 drug Substances 0.000 claims abstract description 61
- 238000009472 formulation Methods 0.000 claims abstract description 42
- 239000003380 propellant Substances 0.000 claims abstract description 28
- 229920002313 fluoropolymer Polymers 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 14
- 239000000725 suspension Substances 0.000 claims abstract description 12
- 239000001257 hydrogen Substances 0.000 claims abstract description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000004033 plastic Substances 0.000 claims abstract description 9
- 229920003023 plastic Polymers 0.000 claims abstract description 9
- 238000012546 transfer Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 229920006120 non-fluorinated polymer Polymers 0.000 claims abstract description 4
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000000576 coating method Methods 0.000 claims description 18
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims description 15
- 239000011248 coating agent Substances 0.000 claims description 14
- 229960000289 fluticasone propionate Drugs 0.000 claims description 12
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical group C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 12
- 229920000728 polyester Polymers 0.000 claims description 11
- -1 polychlorotrifluoroethylene Polymers 0.000 claims description 9
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 claims description 8
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 4
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 3
- 229960002052 salbutamol Drugs 0.000 claims description 3
- 229960004017 salmeterol Drugs 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 2
- 229950000210 beclometasone dipropionate Drugs 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000012453 solvate Substances 0.000 claims description 2
- 229920002493 poly(chlorotrifluoroethylene) Polymers 0.000 claims 2
- 239000005023 polychlorotrifluoroethylene (PCTFE) polymer Substances 0.000 claims 2
- 229920002620 polyvinyl fluoride Polymers 0.000 claims 2
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 32
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- 238000000151 deposition Methods 0.000 description 29
- 230000008021 deposition Effects 0.000 description 28
- 150000001241 acetals Chemical class 0.000 description 14
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- 239000004810 polytetrafluoroethylene Substances 0.000 description 10
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
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- 229910052731 fluorine Inorganic materials 0.000 description 7
- 239000011737 fluorine Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000004812 Fluorinated ethylene propylene Substances 0.000 description 6
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- HCDGVLDPFQMKDK-UHFFFAOYSA-N hexafluoropropylene Chemical group FC(F)=C(F)C(F)(F)F HCDGVLDPFQMKDK-UHFFFAOYSA-N 0.000 description 6
- 229920009441 perflouroethylene propylene Polymers 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 3
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000004411 aluminium Substances 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
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- 208000006673 asthma Diseases 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
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- 238000002360 preparation method Methods 0.000 description 3
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- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 2
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
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- 239000000168 bronchodilator agent Substances 0.000 description 2
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- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
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- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 150000005828 hydrofluoroalkanes Chemical class 0.000 description 2
- 238000002664 inhalation therapy Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
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- AKNNEGZIBPJZJG-MSOLQXFVSA-N (-)-noscapine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2[C@@H]1[C@@H]1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-MSOLQXFVSA-N 0.000 description 1
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- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 1
- 229960004666 glucagon Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 229960001361 ipratropium bromide Drugs 0.000 description 1
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 229960001317 isoprenaline Drugs 0.000 description 1
- 229940039009 isoproterenol Drugs 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- HNJJXZKZRAWDPF-UHFFFAOYSA-N methapyrilene Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CS1 HNJJXZKZRAWDPF-UHFFFAOYSA-N 0.000 description 1
- 229960001869 methapyrilene Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 238000010137 moulding (plastic) Methods 0.000 description 1
- PLPRGLOFPNJOTN-UHFFFAOYSA-N narcotine Natural products COc1ccc2C(OC(=O)c2c1OC)C3Cc4c(CN3C)cc5OCOc5c4OC PLPRGLOFPNJOTN-UHFFFAOYSA-N 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 229960004398 nedocromil Drugs 0.000 description 1
- RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 description 1
- 229960004708 noscapine Drugs 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 229960001802 phenylephrine Drugs 0.000 description 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
- 229960000395 phenylpropanolamine Drugs 0.000 description 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
- 229960005414 pirbuterol Drugs 0.000 description 1
- 229920000120 polyethyl acrylate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000012429 release testing Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 229960001457 rimiterol Drugs 0.000 description 1
- IYMMESGOJVNCKV-SKDRFNHKSA-N rimiterol Chemical compound C([C@@H]1[C@@H](O)C=2C=C(O)C(O)=CC=2)CCCN1 IYMMESGOJVNCKV-SKDRFNHKSA-N 0.000 description 1
- 229960005018 salmeterol xinafoate Drugs 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000012899 standard injection Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229950001669 tipredane Drugs 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
- B65D83/52—Metering valves; Metering devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49405—Valve or choke making
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49405—Valve or choke making
- Y10T29/4941—Valve stem or tire valve making
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49405—Valve or choke making
- Y10T29/49412—Valve or choke making with assembly, disassembly or composite article making
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Nozzles (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805938.9A GB9805938D0 (en) | 1998-03-19 | 1998-03-19 | Valve for aerosol container |
| PCT/EP1999/001757 WO1999047195A1 (en) | 1998-03-19 | 1999-03-17 | Valve for aerosol container |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL137750A0 IL137750A0 (en) | 2001-10-31 |
| IL137750A true IL137750A (en) | 2004-07-25 |
Family
ID=10828912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13775099A IL137750A (en) | 1998-03-19 | 1999-03-17 | Valve for aerosol container |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US6644306B1 (id) |
| EP (2) | EP1064040B1 (id) |
| JP (1) | JP2002506696A (id) |
| KR (1) | KR20010041914A (id) |
| CN (1) | CN1293580A (id) |
| AP (1) | AP2000001953A0 (id) |
| AT (1) | ATE302628T1 (id) |
| AU (1) | AU752739B2 (id) |
| BR (1) | BR9908766A (id) |
| CA (1) | CA2324524A1 (id) |
| DE (1) | DE69926870T2 (id) |
| EA (1) | EA002298B1 (id) |
| EE (1) | EE200000549A (id) |
| GB (1) | GB9805938D0 (id) |
| HR (1) | HRP20000610B1 (id) |
| HU (1) | HUP0101223A3 (id) |
| ID (1) | ID27903A (id) |
| IL (1) | IL137750A (id) |
| IS (1) | IS5597A (id) |
| NO (1) | NO20004642D0 (id) |
| NZ (1) | NZ506181A (id) |
| PL (1) | PL342972A1 (id) |
| SK (1) | SK13742000A3 (id) |
| TR (1) | TR200002663T2 (id) |
| WO (1) | WO1999047195A1 (id) |
| YU (1) | YU56000A (id) |
| ZA (1) | ZA200004377B (id) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9814717D0 (en) * | 1998-02-23 | 1998-09-02 | Bespak Plc | Improvements in drug delivery devices |
| GB9805938D0 (en) * | 1998-03-19 | 1998-05-13 | Glaxo Group Ltd | Valve for aerosol container |
| US6390291B1 (en) | 1998-12-18 | 2002-05-21 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
| US6315985B1 (en) | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
| GB9918573D0 (en) | 1999-08-07 | 1999-10-06 | Glaxo Group Ltd | Valve |
| GB9924780D0 (en) * | 1999-10-21 | 1999-12-22 | Glaxo Group Ltd | Medicament dispenser |
| GB9924808D0 (en) | 1999-10-21 | 1999-12-22 | Glaxo Group Ltd | Medicament dispenser |
| EP1259429A2 (en) * | 2000-03-01 | 2002-11-27 | Glaxo Group Limited | Metered dose inhaler |
| NZ522672A (en) * | 2000-05-23 | 2004-07-30 | Glaxo Group Ltd | Aerosol container for formulations of salmeterol xinafoate and preparation process thereof |
| US6553988B1 (en) * | 2000-06-09 | 2003-04-29 | Norton Healthcare, Inc. | Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber |
| AU2001270074A1 (en) * | 2000-06-22 | 2002-01-02 | Glaxo Group Limited | Method and package for storing a pressurized container containing a drug |
| GB0025092D0 (en) * | 2000-10-13 | 2000-11-29 | Glaxo Group Ltd | Medicament dispenser |
| AU2002222304B2 (en) * | 2000-12-22 | 2004-03-18 | Glaxo Group Limited | Metered dose inhaler for salmeterol xinafoate |
| GB0106046D0 (en) * | 2001-03-12 | 2001-05-02 | Glaxo Group Ltd | Canister |
| US20070089735A1 (en) * | 2001-06-26 | 2007-04-26 | Alan Langford | Aerosol actuator |
| GB0122725D0 (en) * | 2001-09-21 | 2001-11-14 | Glaxo Group Ltd | Drug dispensing components |
| GB0125380D0 (en) * | 2001-10-23 | 2001-12-12 | Glaxo Group Ltd | Medicament dispenser |
| FR2833584B1 (fr) * | 2001-12-13 | 2004-04-23 | Valois Sa | Valve de distribution de produit fluide et dispositif de distribution de produit fluide comportant une telle valve |
| GB0130857D0 (en) * | 2001-12-22 | 2002-02-06 | Glaxo Group Ltd | Medicament dispenser |
| US7258118B2 (en) | 2002-01-24 | 2007-08-21 | Sofotec Gmbh & Co, Kg | Pharmaceutical powder cartridge, and inhaler equipped with same |
| WO2004041340A2 (en) * | 2002-10-30 | 2004-05-21 | Nektar Therapeutics | Increased dosage metered dose inhaler |
| EP1615688A1 (en) * | 2003-04-22 | 2006-01-18 | Glaxo Group Limited | A medicament dispenser |
| US7571841B2 (en) * | 2004-04-19 | 2009-08-11 | Illinois Tool Works, Inc. | Interchangeable adapter for in-can and on-can fuel cells |
| US7392922B2 (en) | 2004-04-19 | 2008-07-01 | Illinois Tool Works Inc. | In-can fuel cell metering valve |
| US20060122560A1 (en) * | 2004-12-07 | 2006-06-08 | Robert Burgmeier | Medical devices and processes for preparing same |
| GB2417480B (en) * | 2004-12-15 | 2006-08-02 | Bespak Plc | Improvements in or relating to valves |
| EP1877238A1 (fr) * | 2005-04-04 | 2008-01-16 | Université de Liège | Nouveaux supports, en particulier pour 1 ' immunodetection molecules d'interet |
| KR20080035604A (ko) * | 2005-08-08 | 2008-04-23 | 노파르티스 아게 | 계량 흡입기용 단열식 캐니스터 |
| US7722819B2 (en) | 2005-10-11 | 2010-05-25 | Meadwestvaco Calmar, Inc. | Fragrance product, dispenser, and dispenser assembly |
| BRPI0617248B1 (pt) * | 2005-10-11 | 2020-11-17 | Westrock Dispensing Systems, Inc | produto de fragância |
| CA2634151A1 (en) * | 2005-12-21 | 2007-07-05 | Glaxo Group Limited | Aerosol canister employing a polymeric film having improved moisture barrier properties |
| US20100300437A1 (en) * | 2007-05-10 | 2010-12-02 | Sivigny Michael B | Manufacture of metered dose valve components |
| FR2918044B1 (fr) * | 2007-06-28 | 2012-01-20 | Valois Sas | Bague pour valve de distribution de produit fluide. |
| GB0719257D0 (en) * | 2007-10-04 | 2007-11-14 | 3M Innovative Properties Co | Metered dose dispenser |
| JP5104536B2 (ja) * | 2008-05-16 | 2012-12-19 | マックス株式会社 | 燃料充填容器及びガス燃焼式打込み工具 |
| WO2011121698A1 (ja) * | 2010-03-29 | 2011-10-06 | 日本たばこ産業株式会社 | エアロゾル吸引器のための液タンク |
| PL2627386T3 (pl) | 2010-10-12 | 2015-08-31 | Ivax Pharmaceuticals Ireland | Urządzenie rozpylające do nosa |
| CA2828884C (en) * | 2011-03-03 | 2021-04-27 | Impel Neuropharma, Inc. | Nasal drug delivery device |
| JP6645735B2 (ja) | 2011-05-09 | 2020-02-14 | インペル ニューロファーマ インコーポレイテッド | 鼻薬送達用ノズル |
| US11814239B2 (en) * | 2011-05-16 | 2023-11-14 | The Procter & Gamble Company | Heating of products in an aerosol dispenser and aerosol dispenser containing such heated products |
| KR101261813B1 (ko) * | 2011-07-27 | 2013-05-14 | (주)민진 | 불소고무밸브가 구비된 펌프식 화장품용기 |
| GB201121812D0 (en) | 2011-12-07 | 2012-02-01 | Teva Branded Pharmaceutical Prod R & D Inc | NAsal formulation |
| US9554982B2 (en) | 2012-09-14 | 2017-01-31 | The Procter & Gamble Company | Aerosol antiperspirant compositions, products and methods |
| US9662285B2 (en) | 2014-03-13 | 2017-05-30 | The Procter & Gamble Company | Aerosol antiperspirant compositions, products and methods |
| US9579265B2 (en) | 2014-03-13 | 2017-02-28 | The Procter & Gamble Company | Aerosol antiperspirant compositions, products and methods |
| GB201408229D0 (en) | 2014-05-09 | 2014-06-25 | Norton Waterford Ltd | Aerosol device |
| GB2535796A (en) * | 2015-02-27 | 2016-08-31 | 3M Innovative Properties Co | Improvements in or relating to metered dose inhalers |
| FR3035382B1 (fr) * | 2015-04-24 | 2019-10-18 | Nemera La Verpilliere | Valve doseuse perfectionnee de distribution d'un aerosol comprenant une tige de valve |
| US10166666B2 (en) * | 2015-11-25 | 2019-01-01 | Illinois Tool Works Inc. | Adapter for combustion tool fuel cells |
| FR3049275B1 (fr) * | 2016-03-23 | 2019-07-19 | Aptar France Sas | Valve doseuse et dispositif de distribution de produit fluide comportant une telle valve |
| FR3065891B1 (fr) * | 2017-05-05 | 2021-12-24 | Aptar France Sas | Valve doseuse et dispositif de distribution de produit fluide comportant une telle valve. |
| FR3114759B1 (fr) * | 2020-10-02 | 2022-09-23 | Aptar France Sas | Valve doseuse |
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| AT306895B (de) * | 1967-05-15 | 1973-04-25 | Minnesota Mining & Mfg | Mittel zur Behandlung von verletztem Körpergewebe |
| US3552608A (en) | 1968-11-12 | 1971-01-05 | Synectics Dev Corp | Pressurized container food valve |
| US3658214A (en) * | 1970-05-01 | 1972-04-25 | Walter C Beard | Metering valve for fluid dispenser |
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| NO134730L (id) * | 1971-07-19 | 1900-01-01 | ||
| JPS52106383A (en) * | 1976-03-04 | 1977-09-06 | Toyo Eazooru Kougiyou Kk | Adhesion preventing composites for adhesives |
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| US4649071A (en) * | 1984-04-28 | 1987-03-10 | Kabushiki Kaisha Toyota Chuo Kenkyusho | Composite material and process for producing the same |
| JPS61213221A (ja) | 1985-03-19 | 1986-09-22 | Japan Synthetic Rubber Co Ltd | プラズマ重合膜の製法 |
| US4718907A (en) * | 1985-06-20 | 1988-01-12 | Atrium Medical Corporation | Vascular prosthesis having fluorinated coating with varying F/C ratio |
| US5091204A (en) * | 1985-08-23 | 1992-02-25 | Weshington Research Foundation | Polymeric intraocular lens material having improved surface properties |
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| EP0293442A1 (en) | 1986-12-17 | 1988-12-07 | Microvol Limited | Pressurised metering dispenser |
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-
1998
- 1998-03-19 GB GBGB9805938.9A patent/GB9805938D0/en not_active Ceased
-
1999
- 1999-03-17 HR HR980304A patent/HRP20000610B1/xx not_active IP Right Cessation
- 1999-03-17 WO PCT/EP1999/001757 patent/WO1999047195A1/en not_active Ceased
- 1999-03-17 EA EA200000844A patent/EA002298B1/ru not_active IP Right Cessation
- 1999-03-17 SK SK1374-2000A patent/SK13742000A3/sk unknown
- 1999-03-17 EP EP99913267A patent/EP1064040B1/en not_active Expired - Lifetime
- 1999-03-17 EE EEP200000549A patent/EE200000549A/xx unknown
- 1999-03-17 JP JP2000536434A patent/JP2002506696A/ja active Pending
- 1999-03-17 NZ NZ506181A patent/NZ506181A/en unknown
- 1999-03-17 EP EP05076417A patent/EP1584344A1/en not_active Withdrawn
- 1999-03-17 TR TR2000/02663T patent/TR200002663T2/xx unknown
- 1999-03-17 AT AT99913267T patent/ATE302628T1/de not_active IP Right Cessation
- 1999-03-17 PL PL99342972A patent/PL342972A1/xx unknown
- 1999-03-17 AP APAP/P/2000/001953A patent/AP2000001953A0/en unknown
- 1999-03-17 HU HU0101223A patent/HUP0101223A3/hu unknown
- 1999-03-17 YU YU56000A patent/YU56000A/sh unknown
- 1999-03-17 CA CA002324524A patent/CA2324524A1/en not_active Abandoned
- 1999-03-17 BR BR9908766-9A patent/BR9908766A/pt active Search and Examination
- 1999-03-17 AU AU31457/99A patent/AU752739B2/en not_active Ceased
- 1999-03-17 KR KR1020007010221A patent/KR20010041914A/ko not_active Withdrawn
- 1999-03-17 ID IDW20002094A patent/ID27903A/id unknown
- 1999-03-17 DE DE69926870T patent/DE69926870T2/de not_active Expired - Lifetime
- 1999-03-17 IL IL13775099A patent/IL137750A/en not_active IP Right Cessation
- 1999-03-17 US US09/646,270 patent/US6644306B1/en not_active Expired - Fee Related
- 1999-03-17 CN CN99804167A patent/CN1293580A/zh active Pending
-
2000
- 2000-08-22 IS IS5597A patent/IS5597A/is unknown
- 2000-08-24 ZA ZA200004377A patent/ZA200004377B/xx unknown
- 2000-09-18 NO NO20004642A patent/NO20004642D0/no not_active Application Discontinuation
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2003
- 2003-09-11 US US10/662,008 patent/US20040055602A1/en not_active Abandoned
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2007
- 2007-12-14 US US11/956,408 patent/US20080098600A1/en not_active Abandoned
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