IL136734A0 - Alpha-aminoamide derivatives useful as analgesic agents - Google Patents

Alpha-aminoamide derivatives useful as analgesic agents

Info

Publication number
IL136734A0
IL136734A0 IL13673498A IL13673498A IL136734A0 IL 136734 A0 IL136734 A0 IL 136734A0 IL 13673498 A IL13673498 A IL 13673498A IL 13673498 A IL13673498 A IL 13673498A IL 136734 A0 IL136734 A0 IL 136734A0
Authority
IL
Israel
Prior art keywords
sub
hydrogen
alkyl
integer
present
Prior art date
Application number
IL13673498A
Other languages
English (en)
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10824342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL136734(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of IL136734A0 publication Critical patent/IL136734A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
IL13673498A 1997-12-31 1998-12-12 Alpha-aminoamide derivatives useful as analgesic agents IL136734A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9727523.4A GB9727523D0 (en) 1997-12-31 1997-12-31 Alpha-aminoamide derivatives useful as analgesic agents
PCT/EP1998/008157 WO1999035125A1 (en) 1997-12-31 1998-12-12 Alpha-aminoamide derivatives useful as analgesic agents

Publications (1)

Publication Number Publication Date
IL136734A0 true IL136734A0 (en) 2001-06-14

Family

ID=10824342

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13673498A IL136734A0 (en) 1997-12-31 1998-12-12 Alpha-aminoamide derivatives useful as analgesic agents
IL136734A IL136734A (en) 1997-12-31 2000-06-13 Alpha-aminoamide derivatives are effective as analgesics

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL136734A IL136734A (en) 1997-12-31 2000-06-13 Alpha-aminoamide derivatives are effective as analgesics

Country Status (19)

Country Link
US (2) US6306903B1 (hu)
EP (1) EP1045830B1 (hu)
JP (1) JP4410930B2 (hu)
KR (1) KR100525587B1 (hu)
AT (1) ATE238273T1 (hu)
BR (1) BR9814548A (hu)
CA (1) CA2316902C (hu)
DE (1) DE69813896T2 (hu)
DK (1) DK1045830T3 (hu)
EA (1) EA002763B1 (hu)
ES (1) ES2194392T3 (hu)
GB (1) GB9727523D0 (hu)
HK (1) HK1028020A1 (hu)
HU (1) HU228995B1 (hu)
IL (2) IL136734A0 (hu)
NO (1) NO327453B1 (hu)
NZ (1) NZ505440A (hu)
PT (1) PT1045830E (hu)
WO (1) WO1999035125A1 (hu)

Families Citing this family (32)

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Publication number Priority date Publication date Assignee Title
CA2310664C (en) 1997-11-21 2008-03-11 Euro-Celtique S.A. Substituted 2-aminoacetamides and the use thereof
AU2002215053A1 (en) * 2000-11-27 2002-06-24 Pharmacia Italia S.P.A. Phenylacetamido- pyrazole derivatives and their use as antitumor agents
NZ531586A (en) * 2001-09-03 2005-09-30 Newron Pharm Spa Pharmaceutical composition comprising gabapentin or an analogue thereof and an alpha-aminoamide and its analgesic use
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
WO2004087125A1 (en) * 2003-04-02 2004-10-14 Ionix Pharmaceuticals Limited Amino acid derivatives as inhibitors of mammalian sodium channels
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
WO2005000309A2 (en) * 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
KR101233711B1 (ko) * 2003-08-25 2013-02-18 뉴론 파마슈티칼즈 에스. 피. 에이. 항염증제로서 유용한 알파-아미노아미드 유도체
EP1524267A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Substituted benzylaminoalkylene heterocycles
EP1533302A1 (en) * 2003-11-21 2005-05-25 Newron Pharmaceuticals S.p.A. Histidine derivatives
EP1533298A1 (en) * 2003-11-21 2005-05-25 Newron Pharmaceuticals S.p.A. 3-aminopyrrolidone derivatives
EP1535908A1 (en) * 2003-11-24 2005-06-01 Newron Pharmaceuticals S.p.A. N-acyl-N'-benzyl-alkylendiamino drivatives
EP1533295A1 (en) 2003-11-24 2005-05-25 Newron Pharmaceuticals S.p.A. Cyclopentyl Derivatives
EP1557166A1 (en) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
PT1809271E (pt) * 2004-09-10 2010-08-30 Newron Pharm Spa Utilização de (halogenobenziloxi)benzilamino-propanamidas para o fabrico de medicamentos activos como moduladores selectivos dos canais de sódio e/ou de cálcio
TW200730494A (en) * 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
ATE472529T1 (de) * 2005-10-10 2010-07-15 Glaxo Group Ltd Prolinamidderivate als natriumkanalmodulatoren
RS54522B1 (en) * 2005-12-22 2016-06-30 Newron Pharmaceuticals S.P.A. 2-Phenylethylamino Derivatives as Modulators of Calcium and (or Sodium) Channels
EP1870097A1 (en) * 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
DK2474521T3 (en) 2006-06-19 2016-10-31 Newron Pharm Spa High-purity 2- [4- (3- and 2-fluorobenzyloxy) benzylamino] propanamides for use as pharmaceuticals and pharmaceutical formulations thus
ES2655704T3 (es) 2007-06-15 2018-02-21 Newron Pharmaceuticals S.P.A. Derivados de 2-[2-(fenil)etilamino]alcanoamida sustituidos y su uso como moduladores de canales de calcio y/o sodio
SI2229351T1 (en) 2007-12-11 2018-02-28 Newron Pharmaceuticals S.P.A. PROCEDURE FOR PREPARATION OF 2- (4- (3-OR 2-FLUOROBENYLOXYL) BENZYLAMINO) PROPANAMIDES WITH A HIGH PURITY Purity
EP2314569A1 (en) 2009-10-22 2011-04-27 Merck Patent GmbH Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof
NZ602648A (en) 2010-04-27 2014-10-31 Newron Pharm Spa Process for the production of ralfinamide methanesulfonate salts or their r-enantiomers
WO2014037480A1 (en) 2012-09-10 2014-03-13 F. Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
KR101705718B1 (ko) * 2013-12-30 2017-02-14 이화여자대학교 산학협력단 신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물
ES2912881T3 (es) 2014-12-23 2022-05-30 Convergence Pharmaceuticals Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
CN107522654B (zh) * 2016-06-21 2020-09-01 中国人民解放军军事医学科学院毒物药物研究所 新的α-氨基酰胺衍生物及其医药用途
EP3691634A4 (en) 2017-10-05 2021-03-31 Biogen Inc. PROCESS FOR THE PREPARATION OF PYRROLIDINE ALPHA-CARBOXAMIDE DERIVATIVES

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CA2310664C (en) 1997-11-21 2008-03-11 Euro-Celtique S.A. Substituted 2-aminoacetamides and the use thereof
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NZ531586A (en) 2001-09-03 2005-09-30 Newron Pharm Spa Pharmaceutical composition comprising gabapentin or an analogue thereof and an alpha-aminoamide and its analgesic use
EP1438956A1 (en) 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders

Also Published As

Publication number Publication date
EA002763B1 (ru) 2002-08-29
DE69813896T2 (de) 2003-11-06
JP4410930B2 (ja) 2010-02-10
EP1045830A1 (en) 2000-10-25
HUP0100870A3 (en) 2002-11-28
NO20003399L (no) 2000-08-02
KR100525587B1 (ko) 2005-11-03
WO1999035125A1 (en) 1999-07-15
KR20010033706A (ko) 2001-04-25
BR9814548A (pt) 2000-10-10
ES2194392T3 (es) 2003-11-16
PT1045830E (pt) 2003-08-29
NO20003399D0 (no) 2000-06-29
IL136734A (en) 2007-03-08
ATE238273T1 (de) 2003-05-15
DK1045830T3 (da) 2003-08-04
DE69813896D1 (de) 2003-05-28
CA2316902C (en) 2006-06-06
EP1045830B1 (en) 2003-04-23
HU228995B1 (en) 2013-07-29
USRE40259E1 (en) 2008-04-22
NO327453B1 (no) 2009-07-06
HK1028020A1 (en) 2001-02-02
US6306903B1 (en) 2001-10-23
EA200000731A1 (ru) 2001-02-26
GB9727523D0 (en) 1998-02-25
CA2316902A1 (en) 1999-07-15
HUP0100870A2 (hu) 2001-07-30
JP2002508302A (ja) 2002-03-19
NZ505440A (en) 2002-02-01

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