IL132838A - Protein recovery by chromatography followed by filtration upon a charged layer - Google Patents

Protein recovery by chromatography followed by filtration upon a charged layer

Info

Publication number
IL132838A
IL132838A IL13283898A IL13283898A IL132838A IL 132838 A IL132838 A IL 132838A IL 13283898 A IL13283898 A IL 13283898A IL 13283898 A IL13283898 A IL 13283898A IL 132838 A IL132838 A IL 132838A
Authority
IL
Israel
Prior art keywords
polypeptide
antibody
reagent
pepsin
composition
Prior art date
Application number
IL13283898A
Other languages
English (en)
Other versions
IL132838A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21968517&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL132838(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL132838A0 publication Critical patent/IL132838A0/xx
Publication of IL132838A publication Critical patent/IL132838A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL13283898A 1997-06-13 1998-06-12 Protein recovery by chromatography followed by filtration upon a charged layer IL132838A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5095197P 1997-06-13 1997-06-13
PCT/US1998/012334 WO1998056808A1 (fr) 1997-06-13 1998-06-12 Recuperation de proteine par chromatographie suivie d'une filtration sur une couche chargee

Publications (2)

Publication Number Publication Date
IL132838A0 IL132838A0 (en) 2001-03-19
IL132838A true IL132838A (en) 2004-08-31

Family

ID=21968517

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13283898A IL132838A (en) 1997-06-13 1998-06-12 Protein recovery by chromatography followed by filtration upon a charged layer

Country Status (12)

Country Link
US (4) US6121428A (fr)
EP (1) EP0998486B2 (fr)
JP (1) JP2001510483A (fr)
AT (1) ATE361930T1 (fr)
AU (1) AU735883C (fr)
CA (1) CA2289665C (fr)
DE (1) DE69837760T3 (fr)
DK (1) DK0998486T4 (fr)
ES (1) ES2287976T3 (fr)
IL (1) IL132838A (fr)
PT (1) PT998486E (fr)
WO (1) WO1998056808A1 (fr)

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DK0998486T4 (da) * 1997-06-13 2012-05-14 Genentech Inc Proteinoprensning ved kromatografi efterfulgt af filtrering på en ladet fase
CA2399020A1 (fr) * 2000-02-22 2001-08-30 Applied Research Systems Ars Holding N.V. Procede de purification de hcg et hcg recombinee purifiee par cette methode
WO2002018583A2 (fr) 2000-09-01 2002-03-07 The Center For Blood Research, Inc. Polypeptides modifiés stabilisés dans une conformation souhaitée et procédés de production correspondants
WO2002060377A2 (fr) * 2000-12-15 2002-08-08 The Johns Hopkins University Separation, identification et analyse quantitative de melanges de proteines
US20040067599A1 (en) * 2001-12-14 2004-04-08 Katz Joseph L. Separation identification and quantitation of protein mixtures
AU2002359816B2 (en) * 2001-12-21 2006-07-13 Immunex Corporation Methods for purifying protein
US20050271639A1 (en) * 2002-08-22 2005-12-08 Penn Marc S Genetically engineered cells for therapeutic applications
PT1539798E (pt) 2002-09-06 2011-02-23 Genentech Inc Processo para extracção de proteínas
ZA200504990B (en) * 2003-01-09 2006-08-30 Genentech Inc Purification of polypeptides
GB0304576D0 (en) 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
CN100526453C (zh) * 2005-05-20 2009-08-12 麦克奥迪实业集团有限公司 激光显微切割后细胞收集方法
CA2622180C (fr) 2005-09-20 2012-03-20 John O. Hui Methode pour generer des fragments d'anticorps f(ab')2
US7662930B2 (en) 2005-12-06 2010-02-16 Amgen Inc. Polishing steps used in multi-step protein purification processes
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8163886B2 (en) 2006-12-21 2012-04-24 Emd Millipore Corporation Purification of proteins
ES2520044T3 (es) * 2007-03-30 2014-11-11 The Cleveland Clinic Foundation SDF-1 para su uso en el tratamiento de trastornos vasculares periféricos isquémicos
MX2009012786A (es) 2007-06-01 2009-12-10 Hoffmann La Roche Purificacion de inmunoglobulina.
WO2009079451A2 (fr) 2007-12-14 2009-06-25 The Cleveland Clinic Foundation Compositions et procédés pour favoriser la guérison d'une plaie
US20100190963A1 (en) 2008-12-16 2010-07-29 Millipore Corporation Stirred Tank Reactor And Method
CN102264392A (zh) 2008-12-22 2011-11-30 弗·哈夫曼-拉罗切有限公司 免疫球蛋白纯化
WO2011026041A2 (fr) 2009-08-28 2011-03-03 The Cleveland Clinic Foundation Administration de sdf-1 en vue du traitement de tissus ischémiques
NZ598381A (en) * 2009-09-10 2013-10-25 Lonza Biologics Plc Method and system for polypeptide purification
ES2754210T3 (es) 2010-05-17 2020-04-16 Emd Millipore Corp Polímeros sensibles a estímulos para la purificación de biomoléculas
CN104093743B (zh) 2011-11-23 2018-04-24 医学免疫有限责任公司 特异于her3的结合分子及其用途
WO2015048008A2 (fr) 2013-09-24 2015-04-02 Medimmune, Llc Molécules de liaison spécifiques de her3 et utilisation desdites molécules
WO2015157634A1 (fr) 2014-04-11 2015-10-15 Kolltan Pharmaceuticals, Inc. Anticorps anti-erbb et leurs méthodes d'utilisation

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CA1044537A (fr) * 1973-05-09 1978-12-19 Amf Incorporated Milleux de filtration
FR2413974A1 (fr) * 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
CA1148872A (fr) * 1979-04-06 1983-06-28 Eugene A. Ostreicher Filtre a base de silice cationique, colloidale, minerale
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
SE451843B (sv) * 1983-05-09 1987-11-02 Gambro Lundia Ab Forfarande for utvinning av en forening
US4604208A (en) * 1983-12-29 1986-08-05 Chaokang Chu Liquid filtration using an anionic microporous membrane
US4849352A (en) * 1984-10-09 1989-07-18 Sullivan John B Antibody purification process
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
CA1339946C (fr) * 1987-03-31 1998-07-07 Michael J. Griffith Methode d'ultrapurification pour les polypeptides
US4983722A (en) † 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
US5115101A (en) * 1988-06-08 1992-05-19 Miles Inc. Removal of protein A from antibody preparations
CA2008213A1 (fr) 1989-02-21 1990-08-21 David A. Hilborn Methode de fragmentation de certains anticorps monoclonaux
US4981591A (en) * 1989-04-07 1991-01-01 Cuno, Incorporated Cationic charge modified filter media
DE3920358A1 (de) * 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
ES2096590T3 (es) * 1989-06-29 1997-03-16 Medarex Inc Reactivos biespecificos para la terapia del sida.
GB9014932D0 (en) 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
CA2102511A1 (fr) * 1991-05-14 1992-11-15 Paul J. Higgins Anticorps heteroconjugues pour le traitement de l'infection a vih
WO1993008829A1 (fr) * 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions induisant la destruction de cellules infectees par l'hiv
AU3178993A (en) * 1991-11-25 1993-06-28 Enzon, Inc. Multivalent antigen-binding proteins
US5932448A (en) * 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
DE69333807T2 (de) * 1992-02-06 2006-02-02 Chiron Corp., Emeryville Marker für krebs und biosynthetisches bindeprotein dafür
CA2140280A1 (fr) * 1992-08-17 1994-03-03 Avi J. Ashkenazi Immunoadhesines bispecifiques
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5534615A (en) * 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5731168A (en) * 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6121022A (en) * 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
JP3505283B2 (ja) 1995-08-01 2004-03-08 日本ファイリング株式会社 電動台車の荷位置制御装置
DK0998486T4 (da) * 1997-06-13 2012-05-14 Genentech Inc Proteinoprensning ved kromatografi efterfulgt af filtrering på en ladet fase

Also Published As

Publication number Publication date
DK0998486T3 (da) 2007-09-10
US20040138426A1 (en) 2004-07-15
IL132838A0 (en) 2001-03-19
AU7838898A (en) 1998-12-30
WO1998056808A1 (fr) 1998-12-17
AU735883C (en) 2002-02-07
DE69837760T2 (de) 2008-02-28
DK0998486T4 (da) 2012-05-14
CA2289665C (fr) 2005-08-09
PT998486E (pt) 2007-08-21
ES2287976T3 (es) 2007-12-16
EP0998486B1 (fr) 2007-05-09
US6322997B1 (en) 2001-11-27
US6716598B2 (en) 2004-04-06
AU735883B2 (en) 2001-07-19
US6121428A (en) 2000-09-19
EP0998486A1 (fr) 2000-05-10
DE69837760D1 (de) 2007-06-21
CA2289665A1 (fr) 1998-12-17
JP2001510483A (ja) 2001-07-31
US20020058324A1 (en) 2002-05-16
DE69837760T3 (de) 2012-06-21
EP0998486B2 (fr) 2012-02-01
ATE361930T1 (de) 2007-06-15

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EP1308455A2 (fr) Composition d'anticorps anti-HER2
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CA2753381A1 (fr) Purification de proteines par chromatographie par echange d'ions

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