CA2008213A1 - Methode de fragmentation de certains anticorps monoclonaux - Google Patents

Methode de fragmentation de certains anticorps monoclonaux

Info

Publication number
CA2008213A1
CA2008213A1 CA002008213A CA2008213A CA2008213A1 CA 2008213 A1 CA2008213 A1 CA 2008213A1 CA 002008213 A CA002008213 A CA 002008213A CA 2008213 A CA2008213 A CA 2008213A CA 2008213 A1 CA2008213 A1 CA 2008213A1
Authority
CA
Canada
Prior art keywords
fragments
antibody
chymopapain
digestion
monoclonal antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002008213A
Other languages
English (en)
Inventor
David A. Hilborn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2008213A1 publication Critical patent/CA2008213A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002008213A 1989-02-21 1990-01-22 Methode de fragmentation de certains anticorps monoclonaux Abandoned CA2008213A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31283289A 1989-02-21 1989-02-21
US312,832 1989-02-21

Publications (1)

Publication Number Publication Date
CA2008213A1 true CA2008213A1 (fr) 1990-08-21

Family

ID=23213210

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002008213A Abandoned CA2008213A1 (fr) 1989-02-21 1990-01-22 Methode de fragmentation de certains anticorps monoclonaux

Country Status (4)

Country Link
EP (1) EP0460014A1 (fr)
JP (1) JPH03505283A (fr)
CA (1) CA2008213A1 (fr)
WO (1) WO1990010082A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001510483A (ja) 1997-06-13 2001-07-31 ジェネンテク，インコーポレイテッド タンパク質の回収

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2311333C2 (de) * 1972-03-13 1982-10-21 Cutter Laboratories, Inc., 94710 Berkeley, Calif. Verfahren zur Herstellung eines intravenös injizierbaren modifizierten Immunserumglobulins
NZ194363A (en) * 1979-12-26 1982-12-21 Gamma Biologicals Inc Producing anti-serum
ATE162308T1 (de) * 1987-07-15 1998-01-15 Us Health Monoklonale antikörper der zweiten generation mit bindungsspezifität für tag-72 und menschliche karzinome sowie methoden zu ihrer anwendung

Also Published As

Publication number Publication date
JPH03505283A (ja) 1991-11-21
WO1990010082A1 (fr) 1990-09-07
EP0460014A1 (fr) 1991-12-11

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead