IL130536A0 - Novel compounds with analgesic effect - Google Patents

Novel compounds with analgesic effect

Info

Publication number
IL130536A0
IL130536A0 IL13053697A IL13053697A IL130536A0 IL 130536 A0 IL130536 A0 IL 130536A0 IL 13053697 A IL13053697 A IL 13053697A IL 13053697 A IL13053697 A IL 13053697A IL 130536 A0 IL130536 A0 IL 130536A0
Authority
IL
Israel
Prior art keywords
novel compounds
analgesic effect
analgesic
effect
novel
Prior art date
Application number
IL13053697A
Other languages
English (en)
Original Assignee
Astra Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Inc filed Critical Astra Pharma Inc
Publication of IL130536A0 publication Critical patent/IL130536A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
IL13053697A 1996-12-20 1997-12-09 Novel compounds with analgesic effect IL130536A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9604786A SE9604786D0 (sv) 1996-12-20 1996-12-20 New compounds
PCT/SE1997/002051 WO1998028270A1 (en) 1996-12-20 1997-12-09 Novel compounds with analgesic effect

Publications (1)

Publication Number Publication Date
IL130536A0 true IL130536A0 (en) 2000-06-01

Family

ID=20405139

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13053697A IL130536A0 (en) 1996-12-20 1997-12-09 Novel compounds with analgesic effect

Country Status (31)

Country Link
US (3) US6153626A (cs)
EP (2) EP0946510B1 (cs)
JP (1) JP2001507021A (cs)
KR (1) KR20000069600A (cs)
CN (2) CN1539824A (cs)
AR (1) AR010378A1 (cs)
AT (1) ATE266638T1 (cs)
AU (1) AU738002B2 (cs)
BR (1) BR9713785A (cs)
CA (1) CA2274117A1 (cs)
CZ (1) CZ220099A3 (cs)
DE (1) DE69729115T2 (cs)
DK (1) DK0946510T3 (cs)
EE (1) EE03966B1 (cs)
ES (1) ES2219783T3 (cs)
HU (1) HUP0000613A3 (cs)
ID (1) ID21662A (cs)
IL (1) IL130536A0 (cs)
IS (1) IS5078A (cs)
MY (1) MY132705A (cs)
NO (1) NO313632B1 (cs)
NZ (1) NZ336028A (cs)
PL (1) PL188945B1 (cs)
PT (1) PT946510E (cs)
RU (1) RU2193030C2 (cs)
SE (1) SE9604786D0 (cs)
SK (1) SK283300B6 (cs)
TR (1) TR199901411T2 (cs)
UA (1) UA54481C2 (cs)
WO (1) WO1998028270A1 (cs)
ZA (1) ZA9711049B (cs)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
AU2003220725B2 (en) * 1997-12-24 2006-06-01 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
DE69831876T2 (de) * 1997-12-24 2006-07-27 Ortho-Mcneil Pharmaceutical, Inc. (4)-[aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
CA2683097A1 (en) * 1998-03-10 1999-09-16 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904675D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
JP2003518119A (ja) * 1999-12-22 2003-06-03 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ４−［アリール（８−アザビシクロ［３．２．１］オクタン−３−イル）］アミノ安息香酸誘導体
AU2001232319B2 (en) * 2000-02-18 2005-01-13 Meiji Seika Kaisha, Ltd. Phenoxyalkylamine derivates useful as opioid delta receptor ligands
CA2402039A1 (en) 2000-03-03 2001-09-13 Ortho-Mcneil Pharmaceutical, Inc. 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
CA2404280A1 (en) 2000-03-24 2002-09-23 Meiji Seika Kaisha, Ltd. Diphenylalkylamine derivatives useful as opioid .delta. receptor agonists
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
AU2002234010A1 (en) 2000-12-14 2002-06-24 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
IL155995A0 (en) * 2000-12-15 2003-12-23 Astrazeneca Ab New process for the preparation of diaryl-4-amino-piperidinyl compounds
SE0101771D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101770D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
NZ539828A (en) 2001-05-18 2007-01-26 Astrazeneca Ab 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
ES2278065T3 (es) 2001-10-15 2007-08-01 Janssen Pharmaceutica N.V. Nuevos derivados de 4-fenil-4-(1h-imidazol-2-il)-piperidina sustituida y su uso como agonistas selectivos de opioides delta no peptidos.
EP1485364B1 (en) * 2002-03-13 2009-03-11 Janssen Pharmaceutica N.V. Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase
JP4828822B2 (ja) 2002-05-24 2011-11-30 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｃｃｒ９インヒビターおよびその使用方法
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
CA2500492C (en) 2002-11-18 2010-03-16 Solomon Ungashe Aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
CN1816524B (zh) * 2003-01-16 2012-06-27 阿卡蒂亚药品公司 用于神经退行性疾病的治疗的选择性五羟色胺2a/2c受体反向激动剂
BRPI0411998A (pt) * 2003-06-27 2006-09-05 Janssen Pharmaceutica Nv moduladores delta-opióides tricìclicos
EP1737853A1 (en) 2004-02-03 2007-01-03 Janssen Pharmaceutica N.V. 3-(diheteroarylmethylene)-8-azabicyclo¬3.2.1|octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo¬3.2.1|octane derivatives
HRP20120343T1 (hr) 2004-08-02 2012-05-31 Astrazeneca Ab Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba
EP1910353A1 (en) * 2004-08-05 2008-04-16 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
EA011674B1 (ru) * 2004-12-22 2009-04-28 Янссен Фармацевтика Н.В. ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ
JP2008525483A (ja) * 2004-12-22 2008-07-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
JP2008525481A (ja) * 2004-12-22 2008-07-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド・モジュレーター
KR20070104380A (ko) * 2005-01-06 2007-10-25 얀센 파마슈티카 엔.브이. 트리사이클릭 δ-오피오이드 조절제
TWI410406B (zh) * 2005-05-13 2013-10-01 Otsuka Pharma Co Ltd 吡咯烷化合物
CN101243079A (zh) * 2005-06-16 2008-08-13 詹森药业有限公司 三环阿片调节剂
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬

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US4091096A (en) * 1976-03-19 1978-05-23 Eli Lilly And Company Dinitroanilines for the control of phytopathogens
EG12406A (en) * 1976-08-12 1979-03-31 Janssen Pharmaceutica Nv Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
SE441448B (sv) * 1977-05-23 1985-10-07 Pfizer Sett att framstella hexahydro-gamma-karbolinforeningar
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3563964D1 (en) * 1984-10-16 1988-09-01 Synthelabo Piperidine derivatives, their preparation and their therapeutical application
KR940003491B1 (ko) 1989-08-10 1994-04-23 리히터 게데온 베기에스제티 기아르 알.티 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물
YU150489A (sh) 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
SE8904298D0 (sv) * 1989-12-21 1989-12-21 Astra Ab New compounds
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
DE69831876T2 (de) * 1997-12-24 2006-07-27 Ortho-Mcneil Pharmaceutical, Inc. (4)-[aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden
CA2683097A1 (en) 1998-03-10 1999-09-16 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides

Also Published As

Publication number Publication date
US20030055045A1 (en) 2003-03-20
BR9713785A (pt) 2000-02-08
ATE266638T1 (de) 2004-05-15
WO1998028270A1 (en) 1998-07-02
CN1154635C (zh) 2004-06-23
CN1241178A (zh) 2000-01-12
EP1428821A8 (en) 2005-01-26
NO993023D0 (no) 1999-06-18
HK1023996A1 (en) 2000-09-29
EP0946510B1 (en) 2004-05-12
CN1539824A (zh) 2004-10-27
ES2219783T3 (es) 2004-12-01
EE03966B1 (et) 2003-02-17
CZ220099A3 (cs) 1999-11-17
PT946510E (pt) 2004-08-31
DK0946510T3 (da) 2004-08-09
US6153626A (en) 2000-11-28
AU5351398A (en) 1998-07-17
NZ336028A (en) 2001-03-30
AR010378A1 (es) 2000-06-07
JP2001507021A (ja) 2001-05-29
PL188945B1 (pl) 2005-05-31
RU2193030C2 (ru) 2002-11-20
KR20000069600A (ko) 2000-11-25
ZA9711049B (en) 1998-06-22
PL334370A1 (en) 2000-02-28
ID21662A (id) 1999-07-08
HUP0000613A2 (hu) 2000-09-28
UA54481C2 (uk) 2003-03-17
HK1022910A1 (en) 2000-08-25
US6710179B2 (en) 2004-03-23
TR199901411T2 (xx) 1999-09-21
SK283300B6 (sk) 2003-05-02
SK76399A3 (en) 2000-01-18
CA2274117A1 (en) 1998-07-02
EP0946510A1 (en) 1999-10-06
SE9604786D0 (sv) 1996-12-20
NO993023L (no) 1999-08-12
HUP0000613A3 (en) 2002-10-28
EE9900261A (et) 2000-02-15
NO313632B1 (no) 2002-11-04
DE69729115T2 (de) 2005-04-28
EP1428821A1 (en) 2004-06-16
DE69729115D1 (de) 2004-06-17
MY132705A (en) 2007-10-31
IS5078A (is) 1999-06-11
US6399635B1 (en) 2002-06-04
AU738002B2 (en) 2001-09-06

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