IL129986A0 - Polypeptides encoded by a human lipase-like gene compositions and methods - Google Patents

Polypeptides encoded by a human lipase-like gene compositions and methods

Info

Publication number
IL129986A0
IL129986A0 IL12998697A IL12998697A IL129986A0 IL 129986 A0 IL129986 A0 IL 129986A0 IL 12998697 A IL12998697 A IL 12998697A IL 12998697 A IL12998697 A IL 12998697A IL 129986 A0 IL129986 A0 IL 129986A0
Authority
IL
Israel
Prior art keywords
methods
polypeptides encoded
human lipase
gene compositions
gene
Prior art date
Application number
IL12998697A
Other languages
English (en)
Original Assignee
Rhone Poulenc Rorer Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Pharma filed Critical Rhone Poulenc Rorer Pharma
Publication of IL129986A0 publication Critical patent/IL129986A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL12998697A 1996-12-06 1997-12-05 Polypeptides encoded by a human lipase-like gene compositions and methods IL129986A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3278396P 1996-12-06 1996-12-06
US3225496P 1996-12-06 1996-12-06
PCT/US1997/022331 WO1998024888A2 (en) 1996-12-06 1997-12-05 Polypeptides encoded by a human lipase-like gene, compositions and methods

Publications (1)

Publication Number Publication Date
IL129986A0 true IL129986A0 (en) 2000-02-29

Family

ID=26708180

Family Applications (2)

Application Number Title Priority Date Filing Date
IL12998697A IL129986A0 (en) 1996-12-06 1997-12-05 Polypeptides encoded by a human lipase-like gene compositions and methods
IL129986A IL129986A (en) 1996-12-06 1999-05-16 Polypeptides are encrypted by a lipase-like human gene, compounds and methods

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL129986A IL129986A (en) 1996-12-06 1999-05-16 Polypeptides are encrypted by a lipase-like human gene, compounds and methods

Country Status (22)

Country Link
US (4) US6395530B1 (xx)
EP (1) EP0948609B1 (xx)
JP (2) JP4615634B2 (xx)
KR (1) KR100516561B1 (xx)
CN (2) CN100497610C (xx)
AP (1) AP1313A (xx)
AT (1) ATE291080T1 (xx)
AU (1) AU750891B2 (xx)
BG (1) BG64798B1 (xx)
BR (1) BR9713847A (xx)
CA (1) CA2273823C (xx)
CZ (1) CZ299055B6 (xx)
DE (2) DE948609T1 (xx)
EA (1) EA003293B1 (xx)
ES (1) ES2239367T3 (xx)
HK (2) HK1024929A1 (xx)
IL (2) IL129986A0 (xx)
NO (1) NO326140B1 (xx)
OA (1) OA11057A (xx)
PL (1) PL191624B1 (xx)
SK (1) SK287687B6 (xx)
WO (1) WO1998024888A2 (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7008776B1 (en) * 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
EP0948609B1 (en) * 1996-12-06 2005-03-16 Aventis Pharmaceuticals Inc. Llg polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies
US7692067B2 (en) * 2002-09-18 2010-04-06 Mendel Biotechnology, Inc. Yield and stress tolerance in transgenic plants
CA2363486C (en) * 1999-03-26 2012-12-18 Michael Jaye Compositions and methods for effecting the levels of high density lipoprotein (hdl) cholesterol and apolipoprotein ai, very low density lipoprotein (vldl) cholesterol and low density lipoprotein (ldl) cholesterol
GB9920334D0 (en) 1999-08-28 1999-11-03 Glaxo Group Ltd Method
US6337187B1 (en) 1999-11-05 2002-01-08 Millennium Pharmaceuticals, Inc. 18891, a novel human lipase
AU1361601A (en) * 1999-11-05 2001-05-14 Millennium Pharmaceuticals, Inc. 18892, a novel human lipase
WO2002024898A2 (en) * 2000-09-25 2002-03-28 Millennium Pharmaceuticals, Inc. 47647, a human lipase and uses therefor
US7507808B2 (en) * 2002-12-12 2009-03-24 Isis Pharmaceuticals, Inc. Modulation of endothelial lipase expression
CN102250854B (zh) * 2011-07-01 2013-03-27 浙江商达环保有限公司 用于处理油脂污染物的脂肪酶、编码基因及其应用
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
MA41035A (fr) * 2014-08-19 2017-08-15 Shire Human Genetic Therapies Lipoprotéine lipase pour le traitement d'affections liées à une hypertriglycéridémie, y compris la pancréatite aiguë
TWI688575B (zh) * 2014-09-11 2020-03-21 日商塩野義製藥股份有限公司 阻礙血管內皮脂酶之酵素活性的人類化單株抗體

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691181A (en) * 1984-08-21 1997-11-25 Celltech Limited DNA encoding lipase from human gastric mucosal tissue
FR2573436B1 (fr) 1984-11-20 1989-02-17 Pasteur Institut Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
JP2764264B2 (ja) 1987-10-01 1998-06-11 株式会社ミドリ十字 線溶活性増強剤
US4944944A (en) * 1987-11-19 1990-07-31 Oklahoma Medical Research Foundation Dietary compositions and methods using bile salt-activated lipase
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5693622A (en) 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5364777A (en) 1992-04-03 1994-11-15 American Air Liquide Method of improving lipase activity using noble gases
HRP930935A2 (en) * 1992-06-11 1994-12-31 Astra Ab New dna sequences
DK88892D0 (da) 1992-07-06 1992-07-06 Novo Nordisk As Forbindelse
DE69334095T2 (de) 1992-07-17 2007-04-12 Dana-Farber Cancer Institute, Boston Verfahren zur intrazellulären Bindung von zielgerichteten Molekülen
US5998189A (en) * 1992-12-16 1999-12-07 Warner-Lambert Company Polypeptide derivatives of dog gastric lipase and pharmaceutical compositions containing same
ATE205531T1 (de) * 1993-03-05 2001-09-15 Univ Catholique Louvain Lo-cd2a antikörper und dessen verwendung zur inhibition von t-zell-aktivierung und -wachstum
FR2704556B1 (fr) 1993-04-30 1995-07-13 Rhone Poulenc Rorer Sa Virus recombinants et leur utilisation en thérapie génique.
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
FR2706486B1 (fr) 1993-06-16 1995-09-01 Rhone Poulenc Rorer Sa Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques.
AU7264694A (en) 1993-07-13 1995-02-13 Rhone-Poulenc Rorer S.A. Defective adenovirus vectors and use thereof in gene therapy
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
KR970701264A (ko) 1994-02-22 1997-03-17 안네 제케르 지질분해효소의 변이체 제조방법(a method of preparing a viriant of a lipolytic enzyme)
US5807746A (en) 1994-06-13 1998-09-15 Vanderbilt University Method for importing biologically active molecules into cells
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
ES2236738T3 (es) 1995-05-31 2005-07-16 Medzyme N.V. Composicion para mejorar la digestibilidad y la utilizacion de nutrientes.
EP0948609B1 (en) 1996-12-06 2005-03-16 Aventis Pharmaceuticals Inc. Llg polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies
US7008776B1 (en) 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
AU1941899A (en) 1997-12-19 1999-07-12 Progenitor, Inc. A lipase expressed in endothelial cells and methods for its use
US6337187B1 (en) * 1999-11-05 2002-01-08 Millennium Pharmaceuticals, Inc. 18891, a novel human lipase
US6558936B1 (en) * 1999-10-01 2003-05-06 Millennium Pharmaceuticals, Inc. Human lipase proteins, nucleic acids encoding them, and uses of both of these

Also Published As

Publication number Publication date
OA11057A (en) 2002-03-08
CN100497610C (zh) 2009-06-10
EP0948609B1 (en) 2005-03-16
NO992735D0 (no) 1999-06-04
BR9713847A (pt) 2000-02-29
US6395530B1 (en) 2002-05-28
US20030108538A1 (en) 2003-06-12
WO1998024888A2 (en) 1998-06-11
NO326140B1 (no) 2008-10-06
SK75399A3 (en) 2001-02-12
WO1998024888A3 (en) 1998-08-13
US7056720B2 (en) 2006-06-06
JP4615634B2 (ja) 2011-01-19
AP9901548A0 (en) 1999-06-30
NO992735L (no) 1999-08-05
CZ9902003A3 (cs) 2000-10-11
DE69732789D1 (de) 2005-04-21
CN1240000A (zh) 1999-12-29
HK1068636A1 (en) 2005-04-29
CN1167793C (zh) 2004-09-22
CA2273823C (en) 2007-06-05
ES2239367T3 (es) 2005-09-16
KR20000069336A (ko) 2000-11-25
KR100516561B1 (ko) 2005-09-22
CZ299055B6 (cs) 2008-04-09
CN1539849A (zh) 2004-10-27
JP5416053B2 (ja) 2014-02-12
US7579447B2 (en) 2009-08-25
ATE291080T1 (de) 2005-04-15
EP0948609A2 (en) 1999-10-13
EA003293B1 (ru) 2003-04-24
SK287687B6 (sk) 2011-06-06
DE948609T1 (de) 2000-03-09
US8343494B2 (en) 2013-01-01
US20070101451A1 (en) 2007-05-03
BG64798B1 (bg) 2006-04-28
AU750891B2 (en) 2002-08-01
PL191624B1 (pl) 2006-06-30
AU5690598A (en) 1998-06-29
JP2001505769A (ja) 2001-05-08
CA2273823A1 (en) 1998-06-11
JP2010284171A (ja) 2010-12-24
US20120114660A1 (en) 2012-05-10
HK1024929A1 (en) 2000-10-27
DE69732789T2 (de) 2005-08-11
BG103472A (en) 2001-01-31
AP1313A (en) 2004-10-04
IL129986A (en) 2006-07-05
EA199900522A1 (ru) 2000-02-28

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