AU1941899A - A lipase expressed in endothelial cells and methods for its use - Google Patents

A lipase expressed in endothelial cells and methods for its use

Info

Publication number
AU1941899A
AU1941899A AU19418/99A AU1941899A AU1941899A AU 1941899 A AU1941899 A AU 1941899A AU 19418/99 A AU19418/99 A AU 19418/99A AU 1941899 A AU1941899 A AU 1941899A AU 1941899 A AU1941899 A AU 1941899A
Authority
AU
Australia
Prior art keywords
methods
endothelial cells
lipase expressed
lipase
expressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU19418/99A
Inventor
Joseph A. Cioffi
Ken-Ichi Hirata
Thomas Quertermous
Thomas Zupancic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Progenitor Inc
Vanderbilt University
Original Assignee
Progenitor Inc
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progenitor Inc, Vanderbilt University filed Critical Progenitor Inc
Publication of AU1941899A publication Critical patent/AU1941899A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
AU19418/99A 1997-12-19 1998-12-21 A lipase expressed in endothelial cells and methods for its use Abandoned AU1941899A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6833697P 1997-12-19 1997-12-19
US60068336 1997-12-19
PCT/US1998/027335 WO1999032611A1 (en) 1997-12-19 1998-12-21 A lipase expressed in endothelial cells and methods for its use

Publications (1)

Publication Number Publication Date
AU1941899A true AU1941899A (en) 1999-07-12

Family

ID=22081910

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19418/99A Abandoned AU1941899A (en) 1997-12-19 1998-12-21 A lipase expressed in endothelial cells and methods for its use

Country Status (2)

Country Link
AU (1) AU1941899A (en)
WO (1) WO1999032611A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU776684B2 (en) * 1999-03-26 2004-09-16 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI, very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100516561B1 (en) 1996-12-06 2005-09-22 아벤티스 파마슈티칼스 인크. Polypeptides encoded by a human lipase-like gene, compositions and methods
US7008776B1 (en) 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
JP2005533505A (en) * 2002-07-19 2005-11-10 ファルマシア コーポレイション Antisense regulation of endothelial lipase expression
EP2760828B1 (en) 2011-09-27 2015-10-21 Bristol-Myers Squibb Company Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
EP2760829B1 (en) 2011-09-27 2016-05-18 Bristol-Myers Squibb Company Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
WO2013048928A1 (en) 2011-09-27 2013-04-04 Bristol-Myers Squibb Company Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
EP2760840B1 (en) 2011-09-30 2015-08-12 Bristol-Myers Squibb Company Quinolinone carboxamide inhibitors of endothelial lipase
WO2013049104A1 (en) 2011-09-30 2013-04-04 Bristol-Myers Squibb Company Pyridinedione carboxamide inhibitors of endothelial lipase
US8933235B2 (en) 2011-09-30 2015-01-13 Bristol-Myers Squibb Company Pyridinedione carboxamide inhibitors of endothelial lipase
WO2013151923A1 (en) 2012-04-03 2013-10-10 Bristol-Myers Squibb Company Pyrimidinone carboxamides as inhibitors of endothelial lipase
EP2844643B1 (en) 2012-04-03 2016-11-30 Bristol-Myers Squibb Company Pyrimidinedione carboxamide inhibitors of endothelial lipase
US8680090B2 (en) 2012-07-09 2014-03-25 Bristol-Myers Squibb Company Sulfonyl containing benzothiazole inhibitors of endothelial lipase
US9139578B2 (en) 2012-07-09 2015-09-22 Bristol-Myers Squibb Company Amide or urea containing benzothiazole inhibitors of endothelial lipase
AR093281A1 (en) 2012-07-19 2015-05-27 Bristol Myers Squibb Co BENZOTIAZOLES LINKED TO AMIDA, UREA OR SULFONAMIDE AS INHIBITORS OF THE ENDOTELIAL LIPASE
EP2895483A1 (en) 2012-09-11 2015-07-22 Bristol-Myers Squibb Company Ketone linked benzothiazole inhibitors of endothelial lipase
RU2662673C2 (en) 2013-03-14 2018-07-26 Сионоги Энд Ко., Лтд. Monoclonal antibody inhibiting enzymatic activity of endothelial lipase
WO2015105749A1 (en) 2014-01-07 2015-07-16 Bristol-Myers Squibb Company Sulfone amide linked benzothiazole inhibitors of endothelial lipase
TWI688575B (en) 2014-09-11 2020-03-21 日商塩野義製藥股份有限公司 Humanized monoclonal antibody, inhibiting the enzymatic activity of vascular endothelial lipase
US10597370B2 (en) 2016-06-06 2020-03-24 Bristol-Myers Squibb Company 2-(benzothiazol-2-yl)-2-cyano-acetamide derivatives and their use as endothelial lipase inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU776684B2 (en) * 1999-03-26 2004-09-16 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI, very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol

Also Published As

Publication number Publication date
WO1999032611A1 (en) 1999-07-01

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase