DE948609T1 - Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden - Google Patents

Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden

Info

Publication number
DE948609T1
DE948609T1 DE0948609T DE97953093T DE948609T1 DE 948609 T1 DE948609 T1 DE 948609T1 DE 0948609 T DE0948609 T DE 0948609T DE 97953093 T DE97953093 T DE 97953093T DE 948609 T1 DE948609 T1 DE 948609T1
Authority
DE
Germany
Prior art keywords
humanem
lipase
gene
compositions
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0948609T
Other languages
English (en)
Inventor
Michael Jaye
Kim-Anh Doan
John KRAWIEC
Kevin Lynch
Dilip Amin
Victoria South
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Rhone Poulenc Rorer Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Pharmaceuticals Inc filed Critical Rhone Poulenc Rorer Pharmaceuticals Inc
Publication of DE948609T1 publication Critical patent/DE948609T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE0948609T 1996-12-06 1997-12-05 Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden Pending DE948609T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3278396P 1996-12-06 1996-12-06
US3225496P 1996-12-06 1996-12-06
PCT/US1997/022331 WO1998024888A2 (en) 1996-12-06 1997-12-05 Polypeptides encoded by a human lipase-like gene, compositions and methods

Publications (1)

Publication Number Publication Date
DE948609T1 true DE948609T1 (de) 2000-03-09

Family

ID=26708180

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69732789T Expired - Lifetime DE69732789T2 (de) 1996-12-06 1997-12-05 Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden
DE0948609T Pending DE948609T1 (de) 1996-12-06 1997-12-05 Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69732789T Expired - Lifetime DE69732789T2 (de) 1996-12-06 1997-12-05 Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden

Country Status (22)

Country Link
US (4) US6395530B1 (de)
EP (1) EP0948609B1 (de)
JP (2) JP4615634B2 (de)
KR (1) KR100516561B1 (de)
CN (2) CN100497610C (de)
AP (1) AP1313A (de)
AT (1) ATE291080T1 (de)
AU (1) AU750891B2 (de)
BG (1) BG64798B1 (de)
BR (1) BR9713847A (de)
CA (1) CA2273823C (de)
CZ (1) CZ299055B6 (de)
DE (2) DE69732789T2 (de)
EA (1) EA003293B1 (de)
ES (1) ES2239367T3 (de)
HK (2) HK1024929A1 (de)
IL (2) IL129986A0 (de)
NO (1) NO326140B1 (de)
OA (1) OA11057A (de)
PL (1) PL191624B1 (de)
SK (1) SK287687B6 (de)
WO (1) WO1998024888A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7008776B1 (en) * 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
CZ299055B6 (cs) * 1996-12-06 2008-04-09 Aventis Pharmaceuticals Inc. Izolovaný polypeptid kódovaný genem podobným genupro lipázu, prostredek mající fosfolipázovou úcinnost, farmaceutický prostredek, izolovaný imunizacní peptid a nukleová kyselina, biologicky aktivní prostredek, vektor, rekombinantní bunka, prostredek
US7692067B2 (en) * 2002-09-18 2010-04-06 Mendel Biotechnology, Inc. Yield and stress tolerance in transgenic plants
WO2000057837A2 (en) * 1999-03-26 2000-10-05 Aventis Pharmaceuticals Products Inc. Compositions and methods for effecting the levels of cholesterol
GB9920334D0 (en) 1999-08-28 1999-11-03 Glaxo Group Ltd Method
US6337187B1 (en) * 1999-11-05 2002-01-08 Millennium Pharmaceuticals, Inc. 18891, a novel human lipase
AU1361601A (en) * 1999-11-05 2001-05-14 Millennium Pharmaceuticals, Inc. 18892, a novel human lipase
WO2002024898A2 (en) * 2000-09-25 2002-03-28 Millennium Pharmaceuticals, Inc. 47647, a human lipase and uses therefor
US7507808B2 (en) * 2002-12-12 2009-03-24 Isis Pharmaceuticals, Inc. Modulation of endothelial lipase expression
CN102250854B (zh) * 2011-07-01 2013-03-27 浙江商达环保有限公司 用于处理油脂污染物的脂肪酶、编码基因及其应用
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
MA41035A (fr) * 2014-08-19 2017-08-15 Shire Human Genetic Therapies Lipoprotéine lipase pour le traitement d'affections liées à une hypertriglycéridémie, y compris la pancréatite aiguë
TWI688575B (zh) * 2014-09-11 2020-03-21 日商塩野義製藥股份有限公司 阻礙血管內皮脂酶之酵素活性的人類化單株抗體

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691181A (en) * 1984-08-21 1997-11-25 Celltech Limited DNA encoding lipase from human gastric mucosal tissue
FR2573436B1 (fr) 1984-11-20 1989-02-17 Pasteur Institut Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
JP2764264B2 (ja) 1987-10-01 1998-06-11 株式会社ミドリ十字 線溶活性増強剤
US4944944A (en) * 1987-11-19 1990-07-31 Oklahoma Medical Research Foundation Dietary compositions and methods using bile salt-activated lipase
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5693622A (en) 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5364777A (en) 1992-04-03 1994-11-15 American Air Liquide Method of improving lipase activity using noble gases
US5616483A (en) * 1992-06-11 1997-04-01 Aktiebolaget Astra Genomic DNA sequences encoding human BSSL/CEL
DK88892D0 (da) 1992-07-06 1992-07-06 Novo Nordisk As Forbindelse
DE69334095T2 (de) 1992-07-17 2007-04-12 Dana-Farber Cancer Institute, Boston Verfahren zur intrazellulären Bindung von zielgerichteten Molekülen
US5998189A (en) * 1992-12-16 1999-12-07 Warner-Lambert Company Polypeptide derivatives of dog gastric lipase and pharmaceutical compositions containing same
DK0687300T3 (da) * 1993-03-05 2001-12-31 Univ Catholique Louvain LO-CD2a-antistof og anvendelser deraf til inhibering af T-celle-aktivering og -proliferation
FR2704556B1 (fr) 1993-04-30 1995-07-13 Rhone Poulenc Rorer Sa Virus recombinants et leur utilisation en thérapie génique.
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
FR2706486B1 (fr) 1993-06-16 1995-09-01 Rhone Poulenc Rorer Sa Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques.
SK282843B6 (sk) 1993-07-13 2002-12-03 Rhone-Poulenc Rorer S. A. Defektný rekombinantný adenovírus a farmaceutický prostriedok s jeho obsahom
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
AU1806795A (en) 1994-02-22 1995-09-04 Novo Nordisk A/S A method of preparing a variant of a lipolytic enzyme
US5807746A (en) 1994-06-13 1998-09-15 Vanderbilt University Method for importing biologically active molecules into cells
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
ES2236738T3 (es) 1995-05-31 2005-07-16 Medzyme N.V. Composicion para mejorar la digestibilidad y la utilizacion de nutrientes.
US7008776B1 (en) 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
CZ299055B6 (cs) 1996-12-06 2008-04-09 Aventis Pharmaceuticals Inc. Izolovaný polypeptid kódovaný genem podobným genupro lipázu, prostredek mající fosfolipázovou úcinnost, farmaceutický prostredek, izolovaný imunizacní peptid a nukleová kyselina, biologicky aktivní prostredek, vektor, rekombinantní bunka, prostredek
WO1999032611A1 (en) 1997-12-19 1999-07-01 Progenitor, Inc. A lipase expressed in endothelial cells and methods for its use
US6337187B1 (en) * 1999-11-05 2002-01-08 Millennium Pharmaceuticals, Inc. 18891, a novel human lipase
US6558936B1 (en) * 1999-10-01 2003-05-06 Millennium Pharmaceuticals, Inc. Human lipase proteins, nucleic acids encoding them, and uses of both of these

Also Published As

Publication number Publication date
EA199900522A1 (ru) 2000-02-28
EP0948609B1 (de) 2005-03-16
WO1998024888A3 (en) 1998-08-13
DE69732789D1 (de) 2005-04-21
HK1024929A1 (en) 2000-10-27
IL129986A (en) 2006-07-05
JP2010284171A (ja) 2010-12-24
CN1240000A (zh) 1999-12-29
WO1998024888A2 (en) 1998-06-11
AU5690598A (en) 1998-06-29
US20030108538A1 (en) 2003-06-12
KR100516561B1 (ko) 2005-09-22
US6395530B1 (en) 2002-05-28
US20120114660A1 (en) 2012-05-10
CZ9902003A3 (cs) 2000-10-11
BG64798B1 (bg) 2006-04-28
JP5416053B2 (ja) 2014-02-12
US7579447B2 (en) 2009-08-25
US20070101451A1 (en) 2007-05-03
KR20000069336A (ko) 2000-11-25
JP4615634B2 (ja) 2011-01-19
NO992735L (no) 1999-08-05
CA2273823A1 (en) 1998-06-11
SK287687B6 (sk) 2011-06-06
AP1313A (en) 2004-10-04
CZ299055B6 (cs) 2008-04-09
EA003293B1 (ru) 2003-04-24
US8343494B2 (en) 2013-01-01
PL191624B1 (pl) 2006-06-30
AU750891B2 (en) 2002-08-01
ES2239367T3 (es) 2005-09-16
AP9901548A0 (en) 1999-06-30
CN1167793C (zh) 2004-09-22
CA2273823C (en) 2007-06-05
CN1539849A (zh) 2004-10-27
NO992735D0 (no) 1999-06-04
BR9713847A (pt) 2000-02-29
HK1068636A1 (en) 2005-04-29
OA11057A (en) 2002-03-08
EP0948609A2 (de) 1999-10-13
US7056720B2 (en) 2006-06-06
DE69732789T2 (de) 2005-08-11
SK75399A3 (en) 2001-02-12
IL129986A0 (en) 2000-02-29
BG103472A (en) 2001-01-31
NO326140B1 (no) 2008-10-06
CN100497610C (zh) 2009-06-10
JP2001505769A (ja) 2001-05-08
ATE291080T1 (de) 2005-04-15

Similar Documents

Publication Publication Date Title
DK1149905T3 (da) Fremgangsmåder og præparat til polypeptidteknologi
TR199600357A2 (tr) Rekombinant simanlik (Ob) proteinleri.
NO20002800D0 (no) Cyklosporinholdig mikroemulsjon, forkonsentratsammensetning
DE69602638D1 (de) Naphthylverbindungen, Zwischenprodukte, Zusammensetzungen und Methoden
ATE378375T1 (de) Methoden und zusammensetzungen zum wirksameren abfangen von sauerstoff
ATE390486T1 (de) Modifizierte vitamin k-abhängige polypeptide
DE948609T1 (de) Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden
NO995182L (no) Pattedyrcytokinlignende faktor 7
DE59710609D1 (de) Mittel zur Herstellung von Leder
DK0977812T3 (da) Asfaltsammensætninger og fremgangsmåder til fremstilling deraf
EP1004674A4 (de) Menschliches adamts-1 protein, gen , welches für dieses kodiert, pharmazeutische zusammensetzung und verfahrem zur immunologischen bestimmung von menschlichen adamts-1 proteinen
DE69714475D1 (de) Neue (alpha-aminophosphino) peptide, verfahren zu ihrer herstellung und ihre therapeutische verwendung
DE69720335D1 (de) Recombinante Fructosyl-Aminosäure-Oxidase
WO1998057983A3 (en) Mammalian neuro-growth factor like protein
DE69634489D1 (de) Adenovirus dodekahedrischer proteinkomplex, dieser enthaltende zusammensetzung und verwendungen davon
DE897420T1 (de) Zusammensetzung zum entschichten von photolack
ATE385805T1 (de) Neue peptide
DK0874822T3 (da) Ny fremgangsmåde til fremstilling
DE69002558D1 (de) Zusammensetzungen und methoden zur verhinderung von inkrustierungen.
DE69826881D1 (de) Neue indolcarboxamide, pharmazeutische zusammensetzungen und methoden zur hemmung von calpain
DE69717045T2 (de) Aminocarbamate von Polyalkylphenoxyalkanolen, und die selben enthaltende Brennstoffzusammensetzungen
DE69841861D1 (de) E immunomodulatoren und entsprechende methoden
IL135987A0 (en) Lysozyme analogous proteins and peptides, processes for the preparation thereof and compositions and methods utilizing the same
FI990157A0 (fi) Immunoterapeuttisina aineina käyttökelpoisia polypeptidejä sekä polypeptidivalmistuksen menetelmiä
WO1997039102A3 (en) Secreted proteins