DE69826881D1 - Neue indolcarboxamide, pharmazeutische zusammensetzungen und methoden zur hemmung von calpain - Google Patents

Neue indolcarboxamide, pharmazeutische zusammensetzungen und methoden zur hemmung von calpain

Info

Publication number
DE69826881D1
DE69826881D1 DE69826881T DE69826881T DE69826881D1 DE 69826881 D1 DE69826881 D1 DE 69826881D1 DE 69826881 T DE69826881 T DE 69826881T DE 69826881 T DE69826881 T DE 69826881T DE 69826881 D1 DE69826881 D1 DE 69826881D1
Authority
DE
Germany
Prior art keywords
indolcarboxamides
new
methods
pharmaceutical compositions
inhibiting calpain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69826881T
Other languages
English (en)
Other versions
DE69826881T2 (de
Inventor
A Daines
Kin-Cheong Sham
P Mallamo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon LLC
SmithKline Beecham Corp
Original Assignee
Cephalon LLC
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon LLC, SmithKline Beecham Corp filed Critical Cephalon LLC
Application granted granted Critical
Publication of DE69826881D1 publication Critical patent/DE69826881D1/de
Publication of DE69826881T2 publication Critical patent/DE69826881T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69826881T 1997-03-14 1998-03-13 Neue indolcarboxamide, pharmazeutische zusammensetzungen und methoden zur hemmung von calpain Expired - Lifetime DE69826881T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4058997P 1997-03-14 1997-03-14
US40589P 1997-03-14
PCT/US1998/004873 WO1998041092A1 (en) 1997-03-14 1998-03-13 Novel indolecarboxamides, pharmaceutical compositions and methodsof inhibiting calpain

Publications (2)

Publication Number Publication Date
DE69826881D1 true DE69826881D1 (de) 2004-11-11
DE69826881T2 DE69826881T2 (de) 2005-12-01

Family

ID=21911807

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69826881T Expired - Lifetime DE69826881T2 (de) 1997-03-14 1998-03-13 Neue indolcarboxamide, pharmazeutische zusammensetzungen und methoden zur hemmung von calpain

Country Status (7)

Country Link
US (1) US6214856B1 (de)
EP (1) EP1018878B1 (de)
JP (1) JP4467648B2 (de)
CA (1) CA2284041C (de)
DE (1) DE69826881T2 (de)
ES (1) ES2230676T3 (de)
WO (1) WO1998041092A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19817459A1 (de) 1998-04-20 1999-10-21 Basf Ag Neue heterozyklische substituierte Amide, Herstellung und Anwendung
WO2000021550A2 (en) * 1998-10-13 2000-04-20 President And Fellows Of Harvard College Methods and compositions for treating neurodegenerative diseases
FR2890071B1 (fr) 2005-08-30 2007-11-09 Fournier Sa Sa Lab Nouveaux composes de l'indole
BR112014021498A2 (pt) * 2012-02-29 2017-07-18 Institute For Hepatitis And Virus Res composto, composição e método para tratar uma doença associada com formação de dna circular covalentemente fechado
WO2017156071A1 (en) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
US11292801B2 (en) 2016-07-05 2022-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
AU2017336523B2 (en) 2016-09-28 2022-07-21 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
CA3067063A1 (en) * 2017-06-23 2018-12-27 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0539503T3 (da) 1990-07-16 1996-05-13 Merrell Pharma Inc Excitatoriske aminosyreantagonister
CA2071621C (en) * 1991-06-19 1996-08-06 Ahihiko Hosoda Aldehyde derivatives
US5190968A (en) * 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis

Also Published As

Publication number Publication date
EP1018878A4 (de) 2001-01-10
DE69826881T2 (de) 2005-12-01
US6214856B1 (en) 2001-04-10
JP2001515508A (ja) 2001-09-18
CA2284041C (en) 2010-05-18
EP1018878B1 (de) 2004-10-06
CA2284041A1 (en) 1998-09-24
ES2230676T3 (es) 2005-05-01
WO1998041092A1 (en) 1998-09-24
EP1018878A1 (de) 2000-07-19
JP4467648B2 (ja) 2010-05-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition