DE69824582D1 - Chinolin- und naphthalincarboxamide, pharmazeutische zubereitungen und verfahren zur hemmung von calpain - Google Patents

Chinolin- und naphthalincarboxamide, pharmazeutische zubereitungen und verfahren zur hemmung von calpain

Info

Publication number
DE69824582D1
DE69824582D1 DE69824582T DE69824582T DE69824582D1 DE 69824582 D1 DE69824582 D1 DE 69824582D1 DE 69824582 T DE69824582 T DE 69824582T DE 69824582 T DE69824582 T DE 69824582T DE 69824582 D1 DE69824582 D1 DE 69824582D1
Authority
DE
Germany
Prior art keywords
chinoline
naphthaline
carboxamides
pharmaceutical preparations
inhibiting calpain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69824582T
Other languages
English (en)
Other versions
DE69824582T2 (de
Inventor
A Daines
D Kingsbury
Israil Pendrak
P Mallamo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon LLC
SmithKline Beecham Corp
Original Assignee
Cephalon LLC
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon LLC, SmithKline Beecham Corp filed Critical Cephalon LLC
Publication of DE69824582D1 publication Critical patent/DE69824582D1/de
Application granted granted Critical
Publication of DE69824582T2 publication Critical patent/DE69824582T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69824582T 1997-03-14 1998-03-13 Neuartige Chinolin- und Naphthalincarboxamide, pharmazeutische Zusammensetzungen und Verfahren zum Inhibieren von Calpain Expired - Lifetime DE69824582T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4058397P 1997-03-14 1997-03-14
US40583P 1997-03-14
PCT/US1998/004874 WO1998041506A1 (en) 1997-03-14 1998-03-13 Novel quinoline- and naphthalenecarboxamides, pharmaceutical compositions and methods of inhibiting calpain

Publications (2)

Publication Number Publication Date
DE69824582D1 true DE69824582D1 (de) 2004-07-22
DE69824582T2 DE69824582T2 (de) 2005-07-07

Family

ID=21911774

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824582T Expired - Lifetime DE69824582T2 (de) 1997-03-14 1998-03-13 Neuartige Chinolin- und Naphthalincarboxamide, pharmazeutische Zusammensetzungen und Verfahren zum Inhibieren von Calpain

Country Status (7)

Country Link
US (1) US6100267A (de)
EP (2) EP0983243B1 (de)
JP (1) JP4444375B2 (de)
CA (1) CA2284035A1 (de)
DE (1) DE69824582T2 (de)
ES (1) ES2222576T3 (de)
WO (1) WO1998041506A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083944A (en) * 1997-10-07 2000-07-04 Cephalon, Inc. Quinoline-containing α-ketoamide cysteine and serine protease inhibitors
DE19817459A1 (de) * 1998-04-20 1999-10-21 Basf Ag Neue heterozyklische substituierte Amide, Herstellung und Anwendung
WO1999054305A1 (de) * 1998-04-20 1999-10-28 Basf Aktiengesellschaft Heterocyclisch substituierte amide als calpainhemmer
AU4802500A (en) 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
AU2003209297A1 (en) * 2002-01-18 2003-09-02 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
FI20045395A (fi) * 2004-10-21 2006-04-22 Elmomed Ltd Oy Ravintoainelisä ja sen käyttö
US7592330B2 (en) * 2005-08-08 2009-09-22 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
CN104003918A (zh) * 2011-09-23 2014-08-27 中南大学 一种二芳基硫醚化合物、制备方法及其抗肿瘤应用
US10590084B2 (en) 2016-03-09 2020-03-17 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
WO2018009417A1 (en) 2016-07-05 2018-01-11 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
US10934261B2 (en) * 2016-09-28 2021-03-02 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
CA3067063A1 (en) * 2017-06-23 2018-12-27 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6399057A (ja) * 1986-06-27 1988-04-30 Nippon Shinyaku Co Ltd グリシン誘導体
CA2111930A1 (en) * 1992-12-25 1994-06-26 Ryoichi Ando Aminoketone derivatives
PT940391E (pt) * 1994-05-27 2004-12-31 Glaxosmithkline Spa Derivados de quinolina como antagonistas do receptor de taquicinina nk3
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina
AR004735A1 (es) * 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

Also Published As

Publication number Publication date
EP1491533A2 (de) 2004-12-29
EP0983243A4 (de) 2002-01-16
JP2001515509A (ja) 2001-09-18
US6100267A (en) 2000-08-08
JP4444375B2 (ja) 2010-03-31
WO1998041506A1 (en) 1998-09-24
DE69824582T2 (de) 2005-07-07
EP1491533A3 (de) 2005-01-19
CA2284035A1 (en) 1998-09-24
EP0983243A1 (de) 2000-03-08
ES2222576T3 (es) 2005-02-01
EP0983243B1 (de) 2004-06-16

Similar Documents

Publication Publication Date Title
DE69824312D1 (de) Verfahren und gerät zur beendigung von tachyarrhythmien
DE69814199T2 (de) Verfahren und System zur Eingabe von Zeichen
DE69811735D1 (de) Heterocyclische verbindungen zur hemmung der magensäureproduktion, verfahren zu ihrer herstellung und pharmazeutische zubereitungen davon
DE69820014D1 (de) Knotenloses nähsystem und verfahren
DE69834401D1 (de) Businterfacesystem und verfahren
DE60122786D1 (de) System und verfahren zum kommentieren von medizinischen patienteninformationen
DE69710095D1 (de) Pharmazeutische zubereitung zur behandlung von diabetes
DE69724235D1 (de) Computersystem und Verfahren zum Schutz von Software
DE69816789D1 (de) Verfahren und system zur gestengesteuerten optionsauswahl
DE69817251D1 (de) System und Verfahren zur Abscheidung von Schichten
DE69902251T2 (de) System und verfahren zum definieren von ortbestimmungsdiensten
DE69819264D1 (de) Verfahren und Einrichtung zur Granulierung
DE69821302D1 (de) System zur Handhabung von Verbindungen, bestehend aus Gefässen und Trägern
DE69828571D1 (de) Blutfiltersatz und zugehöriges Verfahren zur Gewinnung von Blutkomponenten
DE60120620D1 (de) Netzwerkspielsystem und Verfahren zur Bereitstellung von Netzwerkspiel
DE69703993T2 (de) Einbügelbarer Einlagestoff und Verfahren zu dessen Herstellung
DE69824582D1 (de) Chinolin- und naphthalincarboxamide, pharmazeutische zubereitungen und verfahren zur hemmung von calpain
DE69815163D1 (de) Verfahren und Vorrichtung zur Abscheidung von Titanschichten
DE50112123D1 (de) Retard-zubereitungen von chinolon-antibiotika und verfahren zu ihrer herstellung
DE69720972D1 (de) Computersystem und Verfahren zum Schutz von Software
DE69720971T2 (de) Computersystem und Verfahren zum Schutz von Software
DE69714504D1 (de) Benzothiopene, diese enthaltende Zubereitungen und Verfahren
ATE264837T1 (de) N-guanidinalkylamide, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate
DE69621681T2 (de) Sicherheitssystem und Verfahren dafür
DE69837890D1 (de) System und verfahren zum zentralen verwalten von schaltfunktionen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition