IL129427A0 - Preparation of biologically active molecules - Google Patents

Preparation of biologically active molecules

Info

Publication number
IL129427A0
IL129427A0 IL12942799A IL12942799A IL129427A0 IL 129427 A0 IL129427 A0 IL 129427A0 IL 12942799 A IL12942799 A IL 12942799A IL 12942799 A IL12942799 A IL 12942799A IL 129427 A0 IL129427 A0 IL 129427A0
Authority
IL
Israel
Prior art keywords
preparation
biologically active
active molecules
molecules
biologically
Prior art date
Application number
IL12942799A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL12942799A priority Critical patent/IL129427A0/xx
Publication of IL129427A0 publication Critical patent/IL129427A0/xx
Priority to ARP000101692A priority patent/AR023468A1/es
Priority to MXPA01010487A priority patent/MXPA01010487A/es
Priority to DE60028022T priority patent/DE60028022T2/de
Priority to ES00919108T priority patent/ES2259287T3/es
Priority to EP00919108A priority patent/EP1169460B1/en
Priority to IL14584200A priority patent/IL145842A0/xx
Priority to EA200101078A priority patent/EA006825B1/ru
Priority to DK00919108T priority patent/DK1169460T3/da
Priority to CA002368994A priority patent/CA2368994C/en
Priority to AU39851/00A priority patent/AU781342B2/en
Priority to AT00919108T priority patent/ATE326536T1/de
Priority to PCT/IL2000/000220 priority patent/WO2000061768A2/en
Priority to CNB008080577A priority patent/CN1324140C/zh
Priority to EEP200100530A priority patent/EE05591B1/xx
Priority to US09/958,914 priority patent/US7098002B1/en
Priority to SI200030860T priority patent/SI1169460T1/sl
Priority to BR0009782-9A priority patent/BR0009782A/pt
Priority to KR1020017012973A priority patent/KR100682185B1/ko
Priority to PT00919108T priority patent/PT1169460E/pt
Priority to UA2001117751A priority patent/UA73940C2/uk
Priority to JP2000611691A priority patent/JP4822587B2/ja
Priority to IL145842A priority patent/IL145842A/en
Priority to ZA200108364A priority patent/ZA200108364B/en
Priority to NO20014966A priority patent/NO329525B1/no
Priority to HK02105972A priority patent/HK1044351A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
IL12942799A 1999-04-13 1999-04-13 Preparation of biologically active molecules IL129427A0 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
IL12942799A IL129427A0 (en) 1999-04-13 1999-04-13 Preparation of biologically active molecules
ARP000101692A AR023468A1 (es) 1999-04-13 2000-04-12 Metodo para la produccion de citosina biologicamente activa a partir de su precursor biologicamente inactivo y cadn que codifica un precursor mutado de dicha citosina.
JP2000611691A JP4822587B2 (ja) 1999-04-13 2000-04-13 生物学的活性分子の製造
PCT/IL2000/000220 WO2000061768A2 (en) 1999-04-13 2000-04-13 Preparation of biologically active molecules
CNB008080577A CN1324140C (zh) 1999-04-13 2000-04-13 生物活性分子的制备
ES00919108T ES2259287T3 (es) 1999-04-13 2000-04-13 Preparacion de moleculas biologicamente activas.
EP00919108A EP1169460B1 (en) 1999-04-13 2000-04-13 Preparation of biologically active molecules
IL14584200A IL145842A0 (en) 1999-04-13 2000-04-13 Preparation of biologically active molecules
EA200101078A EA006825B1 (ru) 1999-04-13 2000-04-13 Способы получения биологически активных молекул
DK00919108T DK1169460T3 (da) 1999-04-13 2000-04-13 Fremstilling af biologisk aktive molekyler
CA002368994A CA2368994C (en) 1999-04-13 2000-04-13 Preparation of biologically active molecules
AU39851/00A AU781342B2 (en) 1999-04-13 2000-04-13 Preparation of biologically active molecules
AT00919108T ATE326536T1 (de) 1999-04-13 2000-04-13 Herstellung von biologisch aktiven molekülen
MXPA01010487A MXPA01010487A (es) 1999-04-13 2000-04-13 Preparacion de moleculas biologicamente activas.
DE60028022T DE60028022T2 (de) 1999-04-13 2000-04-13 Herstellung von biologisch aktiven molekülen
EEP200100530A EE05591B1 (et) 1999-04-13 2000-04-13 Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA
US09/958,914 US7098002B1 (en) 1999-04-13 2000-04-13 Preparation of biologically active molecules
SI200030860T SI1169460T1 (sl) 1999-04-13 2000-04-13 Priprava biolosko aktivnih molekul
BR0009782-9A BR0009782A (pt) 1999-04-13 2000-04-13 Preparo de moléculas biologicamente ativas
KR1020017012973A KR100682185B1 (ko) 1999-04-13 2000-04-13 생물학적 활성분자의 제조
PT00919108T PT1169460E (pt) 1999-04-13 2000-04-13 Preparacao de moleculas biologicamente activas.
UA2001117751A UA73940C2 (uk) 1999-04-13 2000-04-13 Спосіб одержання біологічно активної молекули
IL145842A IL145842A (en) 1999-04-13 2001-10-10 Preparation of molecules with biological activity
ZA200108364A ZA200108364B (en) 1999-04-13 2001-10-11 Preparation of biologically active molecules.
NO20014966A NO329525B1 (no) 1999-04-13 2001-10-12 Fremgangsmate for fremstilling av et biologisk aktivt cytokin og et cDNA
HK02105972A HK1044351A1 (en) 1999-04-13 2002-08-15 Preparation of biologically active molecules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL12942799A IL129427A0 (en) 1999-04-13 1999-04-13 Preparation of biologically active molecules

Publications (1)

Publication Number Publication Date
IL129427A0 true IL129427A0 (en) 2000-02-17

Family

ID=11072700

Family Applications (3)

Application Number Title Priority Date Filing Date
IL12942799A IL129427A0 (en) 1999-04-13 1999-04-13 Preparation of biologically active molecules
IL14584200A IL145842A0 (en) 1999-04-13 2000-04-13 Preparation of biologically active molecules
IL145842A IL145842A (en) 1999-04-13 2001-10-10 Preparation of molecules with biological activity

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL14584200A IL145842A0 (en) 1999-04-13 2000-04-13 Preparation of biologically active molecules
IL145842A IL145842A (en) 1999-04-13 2001-10-10 Preparation of molecules with biological activity

Country Status (24)

Country Link
US (1) US7098002B1 (pt)
EP (1) EP1169460B1 (pt)
JP (1) JP4822587B2 (pt)
KR (1) KR100682185B1 (pt)
CN (1) CN1324140C (pt)
AR (1) AR023468A1 (pt)
AT (1) ATE326536T1 (pt)
AU (1) AU781342B2 (pt)
BR (1) BR0009782A (pt)
CA (1) CA2368994C (pt)
DE (1) DE60028022T2 (pt)
DK (1) DK1169460T3 (pt)
EA (1) EA006825B1 (pt)
EE (1) EE05591B1 (pt)
ES (1) ES2259287T3 (pt)
HK (1) HK1044351A1 (pt)
IL (3) IL129427A0 (pt)
MX (1) MXPA01010487A (pt)
NO (1) NO329525B1 (pt)
PT (1) PT1169460E (pt)
SI (1) SI1169460T1 (pt)
UA (1) UA73940C2 (pt)
WO (1) WO2000061768A2 (pt)
ZA (1) ZA200108364B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029232A2 (en) * 1999-10-20 2001-04-26 Scios Inc. Functional cloning of genes encoding proteins/enzymes involved in proteolytic cleavage
US7273722B2 (en) 2000-11-29 2007-09-25 Allergan, Inc. Neurotoxins with enhanced target specificity
SI1392830T1 (sl) 2001-03-08 2006-06-30 Ares Trading Sa Mutanti interlevkina-18, njihova proizvodnja in uporaba
IL142246A0 (en) * 2001-03-26 2002-03-10 Applied Research Systems Method and kit for quantitation of polypeptides
WO2003068802A2 (en) 2002-02-11 2003-08-21 Zymogenetics, Inc. Materials and methods for preparing dimeric growth factors
WO2004074488A1 (en) * 2003-02-21 2004-09-02 Biotecnol S.A. Use of caspase enzymes for maturation of engineered recombinant polypeptide fusions
US7824885B2 (en) * 2003-08-06 2010-11-02 University Of Maryland, College Park Engineered proteases for affinity purification and processing of fusion proteins
JP2007512008A (ja) * 2003-11-24 2007-05-17 ノボ　ノルディスク　アクティーゼルスカブ 融合タンパク質及び該タンパク質の切断方法
CA2558811A1 (en) 2004-03-08 2005-09-22 Zymogenetics, Inc. Dimeric fusion proteins and materials and methods for producing them
WO2008008082A2 (en) * 2005-09-19 2008-01-17 Allergan, Inc. Clostridial toxin activatable clostridial toxins
EP2014676B1 (en) * 2006-04-20 2012-03-07 Kringle Pharma Inc. Hgf precursor protein mutant and activated form thereof
DE102007008596B4 (de) * 2007-02-15 2010-09-02 Friedrich-Schiller-Universität Jena Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
CA3128656A1 (en) 2007-08-22 2009-02-26 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
WO2009044988A1 (en) * 2007-10-01 2009-04-09 Korea Research Institute Of Bioscience And Biotechnology Method for large scale preparation of procaspases, which can be artificially activated, in e. coli expression system and their activation
DE102009043743B4 (de) 2009-03-13 2016-10-13 Friedrich-Schiller-Universität Jena Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
RU2636046C2 (ru) 2009-01-12 2017-11-17 Сайтомкс Терапьютикс, Инк Композиции модифицированных антител, способы их получения и применения
EP2398494A4 (en) 2009-02-23 2015-10-28 Cytomx Therapeutics Inc Proproteins and their methods of use
CN103923897B (zh) * 2013-01-11 2016-06-01 中国人民解放军军事医学科学院生物工程研究所 caspase重组酶原及其编码基因与应用
CN103388001B (zh) * 2013-07-16 2016-01-20 中国人民解放军第四军医大学 一种含凝血酶切割位点gst膜型表达载体及转染阳性细胞的方法
EP3083977B1 (en) 2013-12-20 2018-02-28 F. Hoffmann-La Roche AG Improved recombinant polypeptide production methods
KR20230048162A (ko) 2015-03-30 2023-04-10 그린라이트 바이오사이언시스, 아이엔씨. 리보핵산의 무세포 생산
IL302486A (en) 2015-06-24 2023-06-01 Hoffmann La Roche Antibodies against the transnephrine receptor with adapted affinity
PE20231655A1 (es) 2015-10-02 2023-10-17 Hoffmann La Roche Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
WO2017176963A1 (en) 2016-04-06 2017-10-12 Greenlight Biosciences, Inc. Cell-free production of ribonucleic acid
MX2020003841A (es) 2017-10-11 2020-11-06 Greenlight Biosciences Inc Métodos y composiciones para la producción de nucleósido trifosfatos y ácidos ribonucleicos.
KR20200080749A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법
EP4013857A1 (en) * 2019-08-13 2022-06-22 King's College London Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the il-1 superfamily

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AU659412B2 (en) * 1990-06-25 1995-05-18 Osi Pharmaceuticals, Inc. Tissue-derived tumor growth inhibitors
EP0533350B1 (en) * 1991-08-16 1999-05-26 Merck & Co. Inc. DNA encoding precursor interleukin 1B converting enzyme
JP3404038B2 (ja) 1991-12-31 2003-05-06 ザイモジェネティクス，インコーポレイティド トロンビンの製造方法
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JP4059941B2 (ja) * 1996-08-26 2008-03-12 社団法人芝蘭会 Ｒｈｏ標的タンパク質ｐ１４０ｍＤｉａ
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
JPH10327872A (ja) * 1997-05-30 1998-12-15 Otsuka Pharmaceut Co Ltd Ｂｃｌ−２相互作用蛋白遺伝子ｂｉｓ
CA2295957C (en) 1997-08-07 2009-09-22 Toray Industries, Inc. Canine interleukin 18, canine interleukin 1.beta. converting enzyme, dna sequences encoding these, interleukin 18 production method and canine immune disease remedy

Also Published As

Publication number Publication date
EP1169460B1 (en) 2006-05-17
SI1169460T1 (sl) 2006-08-31
MXPA01010487A (es) 2002-05-06
ZA200108364B (en) 2002-10-11
WO2000061768A3 (en) 2001-02-08
CN1324140C (zh) 2007-07-04
ATE326536T1 (de) 2006-06-15
JP2002541813A (ja) 2002-12-10
BR0009782A (pt) 2002-01-08
CN1353761A (zh) 2002-06-12
NO20014966D0 (no) 2001-10-12
HK1044351A1 (en) 2002-10-18
EA200101078A1 (ru) 2002-04-25
IL145842A (en) 2008-06-05
UA73940C2 (uk) 2005-10-17
IL145842A0 (en) 2002-07-25
CA2368994C (en) 2010-03-09
KR100682185B1 (ko) 2007-02-12
CA2368994A1 (en) 2000-10-19
PT1169460E (pt) 2006-07-31
DK1169460T3 (da) 2006-09-18
EP1169460A2 (en) 2002-01-09
US7098002B1 (en) 2006-08-29
DE60028022D1 (de) 2006-06-22
JP4822587B2 (ja) 2011-11-24
AR023468A1 (es) 2002-09-04
NO329525B1 (no) 2010-11-01
EA006825B1 (ru) 2006-04-28
AU3985100A (en) 2000-11-14
AU781342B2 (en) 2005-05-19
KR20020007365A (ko) 2002-01-26
ES2259287T3 (es) 2006-10-01
NO20014966L (no) 2001-12-11
DE60028022T2 (de) 2006-09-28
EE200100530A (et) 2002-12-16
EE05591B1 (et) 2012-10-15
WO2000061768A2 (en) 2000-10-19

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