IL129188A - תהליך פיקטט-שפנגלר לסינטזת טטראהידרואיזוקוונולינים ותרכובות הטרוציקליות קרובות - Google Patents
תהליך פיקטט-שפנגלר לסינטזת טטראהידרואיזוקוונולינים ותרכובות הטרוציקליות קרובותInfo
- Publication number
- IL129188A IL129188A IL12918897A IL12918897A IL129188A IL 129188 A IL129188 A IL 129188A IL 12918897 A IL12918897 A IL 12918897A IL 12918897 A IL12918897 A IL 12918897A IL 129188 A IL129188 A IL 129188A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- compound created
- created
- alkyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72258896A | 1996-09-27 | 1996-09-27 | |
| PCT/US1997/013672 WO1998013351A1 (en) | 1996-09-27 | 1997-08-04 | Pictet-spengler reaction for the synthesis of tetrahydroisoquinolines and related heterocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL129188A0 IL129188A0 (en) | 2000-02-17 |
| IL129188A true IL129188A (he) | 2004-03-28 |
Family
ID=24902494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12918897A IL129188A (he) | 1996-09-27 | 1997-08-04 | תהליך פיקטט-שפנגלר לסינטזת טטראהידרואיזוקוונולינים ותרכובות הטרוציקליות קרובות |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0929527B1 (he) |
| JP (1) | JP2001510449A (he) |
| KR (1) | KR100445953B1 (he) |
| CN (1) | CN1101811C (he) |
| AR (1) | AR009364A1 (he) |
| AT (1) | ATE280761T1 (he) |
| AU (1) | AU711358B2 (he) |
| BR (1) | BR9712143B1 (he) |
| CA (1) | CA2266357C (he) |
| DE (1) | DE69731392T2 (he) |
| DK (1) | DK0929527T3 (he) |
| ES (1) | ES2230618T3 (he) |
| HK (1) | HK1022311A1 (he) |
| HU (1) | HUP9904161A3 (he) |
| IL (1) | IL129188A (he) |
| NO (1) | NO312761B1 (he) |
| NZ (1) | NZ334491A (he) |
| PT (1) | PT929527E (he) |
| SI (1) | SI0929527T1 (he) |
| TW (1) | TW434224B (he) |
| WO (1) | WO1998013351A1 (he) |
| ZA (1) | ZA978560B (he) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100503571C (zh) * | 2006-07-12 | 2009-06-24 | 中国药科大学 | 四氢异喹啉类衍生物、其制备方法及其医药用途 |
| EP2420237A1 (en) | 2010-08-11 | 2012-02-22 | Ville Takio | Fluorinated derivatives of endogenous isoquinolines for use in the treatment of diseases mediated through endogenous isoquinoline pathways |
| CN103694170B (zh) * | 2013-04-01 | 2016-04-06 | 常州夏青化工有限公司 | 6,7-二氟-1-甲基-1,2,3,4-四氢异喹啉盐酸盐的合成方法 |
| CN110590795B (zh) * | 2019-10-10 | 2021-01-22 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 一类多并杂环螺羟吲哚类化合物的合成方法 |
| FI130627B (en) | 2021-03-31 | 2023-12-18 | Equinorm Ltd | NEW HETEROCYCLIC COMPOUNDS AND THEIR USE |
| CN113214252B (zh) * | 2021-05-28 | 2022-02-11 | 常州大学 | 6-苯基-7-(吡啶-2-基)-7H-吲哚并[2,3-c]喹啉化合物的合成方法 |
-
1997
- 1997-08-04 DK DK97936381T patent/DK0929527T3/da active
- 1997-08-04 WO PCT/US1997/013672 patent/WO1998013351A1/en active IP Right Grant
- 1997-08-04 HU HU9904161A patent/HUP9904161A3/hu unknown
- 1997-08-04 EP EP97936381A patent/EP0929527B1/en not_active Expired - Lifetime
- 1997-08-04 IL IL12918897A patent/IL129188A/he not_active IP Right Cessation
- 1997-08-04 KR KR10-1999-7002580A patent/KR100445953B1/ko not_active IP Right Cessation
- 1997-08-04 BR BRPI9712143-6A patent/BR9712143B1/pt not_active IP Right Cessation
- 1997-08-04 JP JP51562398A patent/JP2001510449A/ja not_active Ceased
- 1997-08-04 CN CN97198263A patent/CN1101811C/zh not_active Expired - Fee Related
- 1997-08-04 CA CA002266357A patent/CA2266357C/en not_active Expired - Fee Related
- 1997-08-04 ES ES97936381T patent/ES2230618T3/es not_active Expired - Lifetime
- 1997-08-04 SI SI9730683T patent/SI0929527T1/xx unknown
- 1997-08-04 PT PT97936381T patent/PT929527E/pt unknown
- 1997-08-04 NZ NZ334491A patent/NZ334491A/xx unknown
- 1997-08-04 DE DE69731392T patent/DE69731392T2/de not_active Expired - Fee Related
- 1997-08-04 AT AT97936381T patent/ATE280761T1/de not_active IP Right Cessation
- 1997-08-04 AU AU39063/97A patent/AU711358B2/en not_active Ceased
- 1997-09-17 AR ARP970104243A patent/AR009364A1/es active IP Right Grant
- 1997-09-23 ZA ZA9708560A patent/ZA978560B/xx unknown
- 1997-09-23 TW TW086113858A patent/TW434224B/zh not_active IP Right Cessation
-
1999
- 1999-03-26 NO NO19991495A patent/NO312761B1/no not_active IP Right Cessation
-
2000
- 2000-02-28 HK HK00101202A patent/HK1022311A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA978560B (en) | 1998-03-27 |
| HUP9904161A2 (hu) | 2000-05-28 |
| JP2001510449A (ja) | 2001-07-31 |
| ATE280761T1 (de) | 2004-11-15 |
| NZ334491A (en) | 2000-04-28 |
| TW434224B (en) | 2001-05-16 |
| CN1231660A (zh) | 1999-10-13 |
| DE69731392T2 (de) | 2006-02-09 |
| KR20000048638A (ko) | 2000-07-25 |
| ES2230618T3 (es) | 2005-05-01 |
| DE69731392D1 (de) | 2004-12-02 |
| EP0929527B1 (en) | 2004-10-27 |
| DK0929527T3 (da) | 2005-02-14 |
| NO991495D0 (no) | 1999-03-26 |
| BR9712143A (pt) | 1999-08-31 |
| AR009364A1 (es) | 2000-04-12 |
| AU3906397A (en) | 1998-04-17 |
| NO312761B1 (no) | 2002-07-01 |
| CA2266357C (en) | 2003-07-29 |
| CN1101811C (zh) | 2003-02-19 |
| HUP9904161A3 (en) | 2001-01-29 |
| SI0929527T1 (en) | 2005-02-28 |
| IL129188A0 (en) | 2000-02-17 |
| KR100445953B1 (ko) | 2004-08-25 |
| NO991495L (no) | 1999-03-26 |
| HK1022311A1 (en) | 2000-08-04 |
| WO1998013351A1 (en) | 1998-04-02 |
| CA2266357A1 (en) | 1998-04-02 |
| EP0929527A1 (en) | 1999-07-21 |
| AU711358B2 (en) | 1999-10-14 |
| PT929527E (pt) | 2005-01-31 |
| BR9712143B1 (pt) | 2009-05-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004137288A (ja) | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン | |
| Celerier et al. | Lactim ether chemistry. Cyclic. beta.-enamino ester synthesis | |
| CA2266357C (en) | Pictet-spengler reaction for the synthesis of tetrahydroisoquinolines and related heterocyclic compounds | |
| Kupchan et al. | Intramolecular nonphenol oxidative coupling of phenethylisoquinolines | |
| US5808071A (en) | Pictet-Spengler reaction for the synthesis of tetrahydroisoquinolines and related heterocyclic compounds | |
| US4309542A (en) | Process for the O-methylation of hydroxyaporphines | |
| Ajao et al. | The preparation and oxidative dimerisation of 2‐acetyl‐7‐hydroxy‐1, 2, 3, 4‐tetrahydroisoquinoline. A new approach to tetrahydroisoquinoline synthesis | |
| Cortés et al. | Synthesis and spectral properties of 6, 7‐dimethoxy‐1‐[(ortho; and para‐R)‐phenyl]‐3, 4‐dihydroisoquinoline | |
| MXPA99002943A (en) | Pictet-spengler reaction for the synthesis of tetrahydroisoquinolines and related heterocyclic compounds | |
| US3726924A (en) | Method for the preparation of tris (dimethylamino) methane | |
| Adesomoju et al. | Total synthesis of leucoxylonine | |
| Heaney et al. | The synthesis of 2-arylmethyltetrahydroisoquinolines from bis (aminol) ethers involving two iminium salt intermediates | |
| US4501891A (en) | Method of forming a solution of papavrine carbanion | |
| Clarke et al. | Central nervous system active compounds. XIII. The use of aminomethylene phthalides in the synthesis of phthalideisoquinoline alkaloids | |
| Toda et al. | A novel synthesis of 1, 2, 3, 4-tetrahydroquinolines via pummerer-type reaction of N-aryl-N-[(phenylsulfinyl) propyl] formamide | |
| Suau et al. | N-Benzylisoquinoline alkaloids from Ceratocapnos heterocarpa | |
| HARA et al. | Studies on Tetrahydroisoquinolines. XXVI.: A Biomimetic Synthesis of 5-Oxygenated 1, 2, 3, 4-Tetrahydroisoquinolines | |
| HARA et al. | Studies on Tetrahydroisoquinolines. XIX. Synthesis of (±)-Isothebaine,(±)-1-Hydroxy-2, 9-dimethoxy-,(±)-1-Hydroxy-2, 10-dimethoxy-, and (±)-2, 10-Dimethoxy-aporphines,(±)-2, 6-Dimethoxyhomomorphinandienone, and (±)-1-Hydroxy-2, 10-dimethoxyhomoaporphine | |
| Meese et al. | Synthesis of deuterated 1, 2, 3, 4‐tetrahydroisoquinolines | |
| Lap et al. | Synthetic studies on potential metabolites of carcinogenic aza aromatic hydrocarbons. Part II. Non‐k‐region oxidised and reduced derivatives of 7‐methylbenz [c] acridine | |
| Coşkun et al. | Reactivity of Benzylic Acylammonium Chlorides. A Novel Method for the Synthesis of N-Phenacylamides | |
| US3966740A (en) | 2-Methyl-3-phenyl-1,2,3,7,8,8a-hexahydro-1H-cyclopent[i,j]-isoquinoline hydrobromide | |
| Atanes et al. | Synthesis of 7-substituted dehydronoraporphines, with some biogenetic considerations | |
| Jirkovsky et al. | Synthesis of 1, 3, 4, 6, 7, 11b‐hexahydro‐9, 10‐dimethoxy‐11b‐methyl [1, 4] thiazino [3, 4‐a] isoquinoline derivatives | |
| Takeya et al. | An Approach for General Synthesis of Biphenyl Neolignans by the Reaction of 1-Oxaspiro [4.5] deca-6, 9-diene-2, 8-dione with the Grignard Reagent and Synthesis of Magnaldehyde B |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |