IL126453A0 - New triazolopurines method of preparing them and their use as drugs - Google Patents
New triazolopurines method of preparing them and their use as drugsInfo
- Publication number
- IL126453A0 IL126453A0 IL12645397A IL12645397A IL126453A0 IL 126453 A0 IL126453 A0 IL 126453A0 IL 12645397 A IL12645397 A IL 12645397A IL 12645397 A IL12645397 A IL 12645397A IL 126453 A0 IL126453 A0 IL 126453A0
- Authority
- IL
- Israel
- Prior art keywords
- optionally substituted
- alkyl
- alkenyl
- alkynyl
- cycloalkyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 19
- 125000003342 alkenyl group Chemical group 0.000 abstract 14
- 125000000304 alkynyl group Chemical group 0.000 abstract 11
- -1 benzylsulphonyl Chemical group 0.000 abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19629378A DE19629378A1 (de) | 1996-07-20 | 1996-07-20 | Neue Triazolopurine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP1997/003841 WO1998003511A1 (de) | 1996-07-20 | 1997-07-17 | Neue triazolopurine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| CA002242097A CA2242097C (en) | 1996-07-20 | 1998-06-26 | Imidazotriazolopyrimidines, process for preparing them and their use as pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL126453A0 true IL126453A0 (en) | 1999-08-17 |
Family
ID=32963000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12645397A IL126453A0 (en) | 1996-07-20 | 1997-07-17 | New triazolopurines method of preparing them and their use as drugs |
Country Status (25)
| Country | Link |
|---|---|
| EP (2) | EP0978517A3 (cs) |
| JP (1) | JP3020281B2 (cs) |
| CN (1) | CN1219936A (cs) |
| AT (1) | ATE191913T1 (cs) |
| AU (1) | AU3695597A (cs) |
| BG (1) | BG102707A (cs) |
| BR (1) | BR9710747A (cs) |
| CA (1) | CA2256736A1 (cs) |
| CZ (1) | CZ265498A3 (cs) |
| DE (2) | DE19629378A1 (cs) |
| DK (1) | DK0880524T3 (cs) |
| EE (1) | EE9800451A (cs) |
| ES (1) | ES2147453T3 (cs) |
| GR (1) | GR3033842T3 (cs) |
| HR (1) | HRP970395A2 (cs) |
| HU (1) | HUP9902311A3 (cs) |
| ID (1) | ID19106A (cs) |
| IL (1) | IL126453A0 (cs) |
| NO (1) | NO983860L (cs) |
| PL (1) | PL328824A1 (cs) |
| PT (1) | PT880524E (cs) |
| SK (1) | SK114498A3 (cs) |
| TR (1) | TR199801659T2 (cs) |
| WO (1) | WO1998003511A1 (cs) |
| ZA (1) | ZA976331B (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19826843A1 (de) * | 1998-06-16 | 1999-12-23 | Boehringer Ingelheim Pharma | Neue Imidazotriazolopyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US6492377B1 (en) | 1998-06-25 | 2002-12-10 | Boehringer Ingelheim Pharma Kg | Imidazotriazolopyrimidines with adenosine-antagonistic activity |
| WO2000012511A1 (de) * | 1998-08-27 | 2000-03-09 | Boehringer Ingelheim Pharma Kg | Imidazotriazolopyrimidine |
| WO2004075846A2 (en) | 2003-02-25 | 2004-09-10 | Bristol-Myers Squibb Company | Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same |
| US7071333B2 (en) | 2003-07-30 | 2006-07-04 | Bristol-Myers Squibb Company | Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same |
| MX2009000170A (es) * | 2006-06-23 | 2009-01-23 | Incyte Corp | Derivados de purinona como agonistas de hm74a. |
| CR20230030A (es) | 2018-02-27 | 2023-03-10 | Incyte Corp | Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b (divisional 2020-0441) |
| CA3100731A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| CN117304191A (zh) | 2018-07-05 | 2023-12-29 | 因赛特公司 | 作为a2a/a2b抑制剂的稠合吡嗪衍生物 |
| CA3120862C (en) | 2018-11-30 | 2024-05-07 | Merck Sharp & Dohme Corp. | 9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| CN112778311B (zh) * | 2019-11-01 | 2024-06-04 | 上海翰森生物医药科技有限公司 | 含氮并环类衍生物抑制剂、其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA902282B (en) * | 1989-03-29 | 1990-12-28 | Merrell Dow Pharma | Selective adenosine receptor compounds |
| IT1264901B1 (it) * | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| JPH083169A (ja) * | 1994-06-15 | 1996-01-09 | Yamasa Shoyu Co Ltd | ４−メチル−１Ｈ−［１，２，４］トリアゾロ［１，５−ａ］プリン−９（４Ｈ）−オン類 |
-
1996
- 1996-07-20 DE DE19629378A patent/DE19629378A1/de not_active Withdrawn
-
1997
- 1997-07-17 AT AT97933683T patent/ATE191913T1/de active
- 1997-07-17 TR TR1998/01659T patent/TR199801659T2/xx unknown
- 1997-07-17 EP EP99119410A patent/EP0978517A3/de not_active Withdrawn
- 1997-07-17 ZA ZA976331A patent/ZA976331B/xx unknown
- 1997-07-17 BR BR9710747A patent/BR9710747A/pt unknown
- 1997-07-17 PT PT97933683T patent/PT880524E/pt unknown
- 1997-07-17 IL IL12645397A patent/IL126453A0/xx unknown
- 1997-07-17 SK SK1144-98A patent/SK114498A3/sk unknown
- 1997-07-17 ES ES97933683T patent/ES2147453T3/es not_active Expired - Lifetime
- 1997-07-17 CN CN97194506A patent/CN1219936A/zh active Pending
- 1997-07-17 CZ CZ982654A patent/CZ265498A3/cs unknown
- 1997-07-17 DE DE59701467T patent/DE59701467D1/de not_active Expired - Lifetime
- 1997-07-17 EP EP97933683A patent/EP0880524B1/de not_active Expired - Lifetime
- 1997-07-17 PL PL97328824A patent/PL328824A1/xx unknown
- 1997-07-17 HU HU9902311A patent/HUP9902311A3/hu unknown
- 1997-07-17 DK DK97933683T patent/DK0880524T3/da active
- 1997-07-17 AU AU36955/97A patent/AU3695597A/en not_active Abandoned
- 1997-07-17 JP JP10505626A patent/JP3020281B2/ja not_active Expired - Fee Related
- 1997-07-17 WO PCT/EP1997/003841 patent/WO1998003511A1/de not_active Ceased
- 1997-07-17 EE EE9800451A patent/EE9800451A/xx unknown
- 1997-07-17 CA CA002256736A patent/CA2256736A1/en not_active Abandoned
- 1997-07-18 HR HR19629378.2A patent/HRP970395A2/hr not_active Application Discontinuation
- 1997-07-18 ID IDP972495A patent/ID19106A/id unknown
-
1998
- 1998-08-20 BG BG102707A patent/BG102707A/xx unknown
- 1998-08-21 NO NO983860A patent/NO983860L/no not_active Application Discontinuation
-
2000
- 2000-06-30 GR GR20000401543T patent/GR3033842T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0978517A3 (de) | 2003-11-12 |
| SK114498A3 (en) | 1999-02-11 |
| JP3020281B2 (ja) | 2000-03-15 |
| EP0978517A2 (de) | 2000-02-09 |
| DE59701467D1 (de) | 2000-05-25 |
| CZ265498A3 (cs) | 1998-12-16 |
| PT880524E (pt) | 2000-07-31 |
| HRP970395A2 (en) | 1998-08-31 |
| GR3033842T3 (en) | 2000-10-31 |
| ATE191913T1 (de) | 2000-05-15 |
| ID19106A (id) | 1998-06-18 |
| DK0880524T3 (da) | 2000-07-17 |
| TR199801659T2 (xx) | 1998-12-21 |
| AU3695597A (en) | 1998-02-10 |
| HUP9902311A2 (hu) | 1999-10-28 |
| JP2000501420A (ja) | 2000-02-08 |
| PL328824A1 (en) | 1999-02-15 |
| NO983860D0 (no) | 1998-08-21 |
| EP0880524B1 (de) | 2000-04-19 |
| BG102707A (bg) | 1999-09-30 |
| ES2147453T3 (es) | 2000-09-01 |
| CA2256736A1 (en) | 1998-01-29 |
| EP0880524A1 (de) | 1998-12-02 |
| BR9710747A (pt) | 1999-08-17 |
| HUP9902311A3 (en) | 2000-06-28 |
| ZA976331B (en) | 1999-01-25 |
| CN1219936A (zh) | 1999-06-16 |
| WO1998003511A1 (de) | 1998-01-29 |
| NO983860L (no) | 1998-10-21 |
| EE9800451A (et) | 1999-06-15 |
| DE19629378A1 (de) | 1998-01-29 |
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