IL125928A - The use of soluble ligands that react with CTLA4, B7, CD40, gp39 and / or CD28 for the preparation of pharmaceutical preparations - Google Patents
The use of soluble ligands that react with CTLA4, B7, CD40, gp39 and / or CD28 for the preparation of pharmaceutical preparationsInfo
- Publication number
- IL125928A IL125928A IL12592897A IL12592897A IL125928A IL 125928 A IL125928 A IL 125928A IL 12592897 A IL12592897 A IL 12592897A IL 12592897 A IL12592897 A IL 12592897A IL 125928 A IL125928 A IL 125928A
- Authority
- IL
- Israel
- Prior art keywords
- antigen
- ctla4
- soluble
- binding
- positive cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1375196P | 1996-03-20 | 1996-03-20 | |
PCT/US1997/004248 WO1997034633A1 (en) | 1996-03-20 | 1997-03-20 | Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith |
Publications (2)
Publication Number | Publication Date |
---|---|
IL125928A0 IL125928A0 (en) | 1999-04-11 |
IL125928A true IL125928A (en) | 2002-11-10 |
Family
ID=21761563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12592897A IL125928A (en) | 1996-03-20 | 1997-03-20 | The use of soluble ligands that react with CTLA4, B7, CD40, gp39 and / or CD28 for the preparation of pharmaceutical preparations |
Country Status (13)
Country | Link |
---|---|
US (4) | US5916560A (pt) |
EP (1) | EP0892643B2 (pt) |
JP (1) | JP4751493B2 (pt) |
AT (1) | ATE219376T1 (pt) |
AU (1) | AU710998B2 (pt) |
CA (1) | CA2246352C (pt) |
DE (1) | DE69713499T3 (pt) |
DK (1) | DK0892643T4 (pt) |
ES (1) | ES2177967T5 (pt) |
IL (1) | IL125928A (pt) |
NO (1) | NO326922B1 (pt) |
PT (1) | PT892643E (pt) |
WO (1) | WO1997034633A1 (pt) |
Families Citing this family (68)
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US6887471B1 (en) * | 1991-06-27 | 2005-05-03 | Bristol-Myers Squibb Company | Method to inhibit T cell interactions with soluble B7 |
US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
US5397703A (en) * | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
US6340459B1 (en) | 1995-12-01 | 2002-01-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients |
PT892643E (pt) * | 1996-03-20 | 2002-09-30 | Univ Emory | Metodos para inibir uma resposta imunitaria bloqueando os circuitos de gp39/cd40 e ctla4/cd28/b7 e composicoes utilizaveis para o efeito |
ATE356634T1 (de) * | 1997-01-10 | 2007-04-15 | Biogen Idec Inc | Verfahren zur therapeutischen verabreichung von anti-cd40l-mitteln |
ZA98533B (en) * | 1997-01-31 | 1999-07-22 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof. |
US20030219863A1 (en) * | 1997-01-31 | 2003-11-27 | Bristol-Myers Squibb Company | Soluble CTLA4 mutant molecules and uses thereof |
BR9809641A (pt) * | 1997-05-17 | 2000-07-11 | Biogen Inc | Uso de um interruptor de ligação cd40:cd154 para evitar respostas imunes inadaptadas, particularmente rejeição a enxerto |
WO1998056417A1 (en) * | 1997-06-11 | 1998-12-17 | The United States Of America, Represented By The Secretary Of The U.S. Department Of The Navy | Composition and method to prevent graft rejection and other counter-adaptive t lymphocyte mediated immune responses |
CA2294154A1 (en) * | 1997-06-20 | 1998-12-30 | Biogen, Inc. | Cd154 blockade therapy for pancreatic islet tissue transplantation |
US6955811B2 (en) * | 1997-11-07 | 2005-10-18 | Trillium Therapeutics Inc. | Methods of inhibiting immune response suppression by administering antibodies to OX-2 |
US7223729B2 (en) * | 1997-11-07 | 2007-05-29 | Trillium Therapeutics Inc. | Methods of treating allergy by administering a CD200 protein |
CA2308765C (en) | 1997-11-07 | 2010-10-12 | Transplantation Technologies Inc. | The use of an ox-2 protein or nucleic acid in immunomodulation |
AU746825B2 (en) * | 1998-02-04 | 2002-05-02 | Brigham And Women's Hospital | Costimulatory blockade and mixed chimerism in allotransplantation |
US6841347B1 (en) | 1998-02-05 | 2005-01-11 | The General Hospital Corporation | In vivo construction of DNA libraries |
GB9809280D0 (en) * | 1998-04-30 | 1998-07-01 | Rpms Technology Ltd | Immunosupression |
HUP0103107A2 (hu) * | 1998-07-30 | 2001-11-28 | Regents Of The University Of Minnesota | Allogénikus és xenogénikus T-sejtek ex vivo kezelése gp39 antagonistákkal |
CZ20011021A3 (cs) * | 1998-09-21 | 2001-10-17 | Genetics Institute, Inc. | Způsoby tlumení imunitní odpovědi na terapeutické proteiny |
WO2000039294A1 (en) * | 1998-12-24 | 2000-07-06 | Novartis Ag | Porcine cells incapable of expressing cd40 antigen, for xenotransplantation |
EP1181050A4 (en) | 1999-04-30 | 2005-05-18 | Jolla Inst Allergy Immunolog | METHODS FOR PREVENTING THE REACTIVATION OF LATENT VIRUSES AND CONTROLLING VIRUS REPLICATION |
DK1176981T3 (da) | 1999-05-07 | 2006-04-10 | Genentech Inc | Behandling af autoimmune sygdomme med antagonister som binder til B celleoverflademarkörer |
EP1221973B1 (en) * | 1999-10-04 | 2007-05-30 | Novartis Vaccines and Diagnostics, Inc. | CD40 antagonist for treating psoriasis |
US20020028178A1 (en) * | 2000-07-12 | 2002-03-07 | Nabil Hanna | Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
EP1248645B1 (en) * | 2000-01-03 | 2007-04-18 | Tr Associates, L.L.C. | Novel chimeric proteins and their use |
WO2001068134A2 (en) * | 2000-03-14 | 2001-09-20 | Genetics Institute, Inc. | Therapies that improve graft survival, using antibodies against a b7 antigen |
US6797263B2 (en) | 2000-05-12 | 2004-09-28 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for achieving immune suppression |
US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
WO2001095928A2 (en) * | 2000-06-09 | 2001-12-20 | Bristol-Myers Squibb Company | Methods for regulating a cell-mediated immune response by blocking lymphocytic signals and by blocking lfa-1 mediated adhesion |
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US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
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US20030211107A1 (en) * | 2002-01-31 | 2003-11-13 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
US20020159996A1 (en) * | 2001-01-31 | 2002-10-31 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
WO2002083162A1 (en) * | 2001-04-13 | 2002-10-24 | University Of Chicago | Use of a cd8+ t cell inhibitory agent in the presence of a cd4+ t cell inhibitory agent for inhibition of transplant rejection |
US20040058445A1 (en) * | 2001-04-26 | 2004-03-25 | Ledbetter Jeffrey Alan | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB |
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US20030180292A1 (en) * | 2002-03-14 | 2003-09-25 | Idec Pharmaceuticals | Treatment of B cell malignancies using anti-CD40L antibodies in combination with anti-CD20 antibodies and/or chemotherapeutics and radiotherapy |
US20030219436A1 (en) * | 2002-03-15 | 2003-11-27 | Ledbetter Jeffrey A. | Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein |
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MXPA06001225A (es) * | 2003-08-04 | 2006-04-11 | Bristol Myers Squibb Co | Metodos de tratamiento de enfermedad cardiovascular usando una molecula soluble de ctla4. |
US20070009517A1 (en) * | 2003-08-25 | 2007-01-11 | Mark De Boer | Method of inducing immune tolerance |
PT2298815E (pt) * | 2005-07-25 | 2015-07-16 | Emergent Product Dev Seattle | Moléculas de ligaçao especificas para cd37 e especificas para cd20 |
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DK2699601T3 (en) | 2011-04-21 | 2018-04-23 | Bristol Myers Squibb Co | ANTIBODY POLYPEPTIDES ANTAGONIZING CD40 |
EP3113796A1 (en) | 2014-03-07 | 2017-01-11 | Bristol-Myers Squibb Company | Method of using antibody polypeptides that antagonize cd40 to treat ibd |
KR102656470B1 (ko) | 2014-12-10 | 2024-04-09 | 리전츠 오브 더 유니버스티 오브 미네소타 | 질환을 치료하기 위한 유전적으로 변형된 세포, 조직 및 장기 |
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US5872154A (en) * | 1995-02-24 | 1999-02-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant adenovirus |
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JPH11510685A (ja) * | 1995-06-05 | 1999-09-21 | ザ ユニバーシティ オブ ワシントン | 可溶性ctla4分子を用いる関心とする遺伝子の発現を延長する方法 |
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-
1997
- 1997-03-20 PT PT97916037T patent/PT892643E/pt unknown
- 1997-03-20 AT AT97916037T patent/ATE219376T1/de active
- 1997-03-20 DK DK97916037T patent/DK0892643T4/da active
- 1997-03-20 WO PCT/US1997/004248 patent/WO1997034633A1/en active IP Right Grant
- 1997-03-20 JP JP53360197A patent/JP4751493B2/ja not_active Expired - Lifetime
- 1997-03-20 EP EP97916037A patent/EP0892643B2/en not_active Expired - Lifetime
- 1997-03-20 IL IL12592897A patent/IL125928A/en not_active IP Right Cessation
- 1997-03-20 DE DE69713499T patent/DE69713499T3/de not_active Expired - Lifetime
- 1997-03-20 US US08/821,400 patent/US5916560A/en not_active Expired - Lifetime
- 1997-03-20 ES ES97916037T patent/ES2177967T5/es not_active Expired - Lifetime
- 1997-03-20 AU AU23310/97A patent/AU710998B2/en not_active Ceased
- 1997-03-20 CA CA2246352A patent/CA2246352C/en not_active Expired - Lifetime
-
1998
- 1998-09-18 NO NO19984369A patent/NO326922B1/no not_active IP Right Cessation
-
2001
- 2001-05-22 US US09/862,255 patent/US20020031510A1/en not_active Abandoned
-
2005
- 2005-01-04 US US11/028,793 patent/US20050202011A1/en not_active Abandoned
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2008
- 2008-09-10 US US12/207,997 patent/US20090186037A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2246352A1 (en) | 1997-09-25 |
EP0892643B2 (en) | 2009-09-02 |
DK0892643T3 (da) | 2002-10-14 |
EP0892643A1 (en) | 1999-01-27 |
ATE219376T1 (de) | 2002-07-15 |
ES2177967T3 (es) | 2002-12-16 |
IL125928A0 (en) | 1999-04-11 |
DK0892643T4 (da) | 2009-12-14 |
US20090186037A1 (en) | 2009-07-23 |
DE69713499T2 (de) | 2003-01-30 |
ES2177967T5 (es) | 2009-12-17 |
AU2331097A (en) | 1997-10-10 |
DE69713499T3 (de) | 2010-05-06 |
NO984369L (no) | 1998-11-18 |
US20050202011A1 (en) | 2005-09-15 |
PT892643E (pt) | 2002-09-30 |
NO984369D0 (no) | 1998-09-18 |
CA2246352C (en) | 2011-11-08 |
JP2001518066A (ja) | 2001-10-09 |
DE69713499D1 (de) | 2002-07-25 |
AU710998B2 (en) | 1999-10-07 |
EP0892643B1 (en) | 2002-06-19 |
US5916560A (en) | 1999-06-29 |
US20020031510A1 (en) | 2002-03-14 |
JP4751493B2 (ja) | 2011-08-17 |
WO1997034633A1 (en) | 1997-09-25 |
NO326922B1 (no) | 2009-03-16 |
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