IL124795A - Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity and their preparation - Google Patents

Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity and their preparation

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Publication number
IL124795A
IL124795A IL12479596A IL12479596A IL124795A IL 124795 A IL124795 A IL 124795A IL 12479596 A IL12479596 A IL 12479596A IL 12479596 A IL12479596 A IL 12479596A IL 124795 A IL124795 A IL 124795A
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IL
Israel
Prior art keywords
groups
formula
alkyl
together represent
smooth muscle
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IL12479596A
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English (en)
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IL124795A0 (en
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Venantius Ltd
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Publication of IL124795A0 publication Critical patent/IL124795A0/xx
Publication of IL124795A publication Critical patent/IL124795A/xx

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/45—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with a bicyclo ring system containing nine carbon atoms
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    • C07C233/32—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
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    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
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    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
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    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
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    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
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    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C07C65/36—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic containing rings other than six-membered aromatic rings
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL12479596A 1995-12-06 1996-12-06 Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity and their preparation IL124795A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IE950922 1995-12-06
IE960762 1996-10-31
PCT/IE1996/000081 WO1997020805A1 (en) 1995-12-06 1996-12-06 Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilising and/or antiinflammatory activity

Publications (2)

Publication Number Publication Date
IL124795A0 IL124795A0 (en) 1999-01-26
IL124795A true IL124795A (en) 2001-01-28

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ID=26319864

Family Applications (3)

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IL12475696A IL124756A0 (en) 1995-12-06 1996-12-06 Indane dimer compounds and their pharmaceutical use
IL12479596A IL124795A (en) 1995-12-06 1996-12-06 Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity and their preparation
IL124756A IL124756A (en) 1995-12-06 1998-06-04 Indian compounds and pharmaceutical preparations containing them

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JP (3) JP2000502328A (xx)
KR (2) KR19990071978A (xx)
AT (3) ATE246668T1 (xx)
AU (3) AU1169397A (xx)
CA (2) CA2239694C (xx)
DE (3) DE69629390T2 (xx)
DK (1) DK0865419T3 (xx)
GB (3) GB2322858A (xx)
IE (1) IE960865A1 (xx)
IL (3) IL124756A0 (xx)
WO (3) WO1997020805A1 (xx)

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JP2002510300A (ja) 1997-06-05 2002-04-02 ヴィーナンティアス・リミテッド インダン化合物及びそれらの医薬学的使用
JP2001064202A (ja) * 1999-08-25 2001-03-13 Kissei Pharmaceut Co Ltd 心不全予防治療剤
DE10142660A1 (de) 2001-08-31 2003-03-20 Aventis Pharma Gmbh Verwendung von Derivaten von C2-substituierten Indan-1-ol-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
DE10142722A1 (de) 2001-08-31 2003-03-27 Aventis Pharma Deutschland GmbH, 65929 Frankfurt C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10142666A1 (de) 2001-08-31 2003-03-20 Aventis Pharma Gmbh Verwendung von C2-substituierten Indan-1-ol-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
DE10142665B4 (de) 2001-08-31 2004-05-06 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-one und ihre Derivate
DE10142668A1 (de) 2001-08-31 2003-03-20 Aventis Pharma Gmbh Verwendung von C2-substituierten Indan-1-on-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
DE10142662B4 (de) * 2001-08-31 2004-07-08 Aventis Pharma Deutschland Gmbh Derivate von C2-substituierten Indan-1-ol-Systemen und ihre Verwendung als Arzneimittel
DE10142661B4 (de) * 2001-08-31 2004-06-09 Aventis Pharma Deutschland Gmbh Mehrfach substituierte Indan-1-ol-Systeme und ihre Verwendung als Arzneimittel
DE10142667B4 (de) 2001-08-31 2004-06-09 Aventis Pharma Deutschland Gmbh C2-substituierte Indan-1-ole und ihre Derivate und ihre Verwendung als Arzneimittel
DE10142659A1 (de) 2001-08-31 2003-03-20 Aventis Pharma Gmbh Verwendung von mehrfach substituierten Indan-1-ol. Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
DE10142663B4 (de) * 2001-08-31 2004-08-19 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-ol-Systeme
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
TWI537245B (zh) * 2011-07-22 2016-06-11 維南提亞有限公司 用於治療自體免疫發炎疾病之化合物
US9260376B2 (en) 2011-07-22 2016-02-16 Venantius Limited Compounds for use in the treatment of immune related inflammatory disease
TWI537246B (zh) * 2011-07-22 2016-06-11 維南提亞有限公司 用於治療發炎性腸病之化合物
EP2864279B1 (en) 2012-05-24 2016-11-02 Venantius Limited Compounds for use in the treatment of autoimmune inflammatory disease
EP2855416A1 (en) * 2012-05-24 2015-04-08 Venantius Limited Indane dimers for use in the treatment of autoimmune inflammatory disease
TWI799691B (zh) * 2019-03-29 2023-04-21 景凱生物科技股份有限公司 具有側鏈烷基與烯基延伸的苯基衍生物及包括有其的藥學組合物
CN111533764B (zh) * 2020-05-12 2023-06-06 杭州师范大学 一种利用多米诺反应制备硅氧基茚衍生物的方法

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GB2322858A (en) 1998-09-09
DE69631688D1 (de) 2004-04-01
CA2239694A1 (en) 1997-06-12
CA2239694C (en) 2008-05-06
US6423752B1 (en) 2002-07-23
WO1997020805A1 (en) 1997-06-12
IE960865A1 (en) 1997-06-06
IL124795A0 (en) 1999-01-26
CA2239853C (en) 2006-11-28
JP2000506497A (ja) 2000-05-30
EP0874800A1 (en) 1998-11-04
US6300376B1 (en) 2001-10-09
GB9812216D0 (en) 1998-08-05
ATE260241T1 (de) 2004-03-15
US20020052530A1 (en) 2002-05-02
ATE246668T1 (de) 2003-08-15
AU1169197A (en) 1997-06-27
GB9812213D0 (en) 1998-08-05
GB2322859A (en) 1998-09-09
DE69629387D1 (de) 2003-09-11
IL124756A0 (en) 1999-01-26
AU1169397A (en) 1997-06-27
DE69629390D1 (de) 2003-09-11
EP0873301B1 (en) 2004-02-25
EP0865419A1 (en) 1998-09-23
KR19990072007A (ko) 1999-09-27
EP0865419B1 (en) 2003-08-06
JP2000502072A (ja) 2000-02-22
DE69631688T2 (de) 2005-01-20
IL124756A (en) 2006-04-10
DE69629390T2 (de) 2004-06-24
WO1997020806A1 (en) 1997-06-12
WO1997020802A1 (en) 1997-06-12
US6297399B1 (en) 2001-10-02
DK0865419T3 (da) 2003-11-10
KR19990071978A (ko) 1999-09-27
AU724648B2 (en) 2000-09-28
ATE246670T1 (de) 2003-08-15
JP2000502328A (ja) 2000-02-29
EP0874800B1 (en) 2003-08-06
GB2323088A (en) 1998-09-16
GB9812215D0 (en) 1998-08-05
EP0873301A1 (en) 1998-10-28
CA2239853A1 (en) 1997-06-12
DE69629387T2 (de) 2004-06-24
AU1169297A (en) 1997-06-27

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