IL124322A - Detection of an entity in a sample - Google Patents
Detection of an entity in a sampleInfo
- Publication number
- IL124322A IL124322A IL12432298A IL12432298A IL124322A IL 124322 A IL124322 A IL 124322A IL 12432298 A IL12432298 A IL 12432298A IL 12432298 A IL12432298 A IL 12432298A IL 124322 A IL124322 A IL 124322A
- Authority
- IL
- Israel
- Prior art keywords
- electrodes
- assay
- target
- bridge
- sample
- Prior art date
Links
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- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- RAOIDOHSFRTOEL-UHFFFAOYSA-N tetrahydrothiophene Chemical group C1CCSC1 RAOIDOHSFRTOEL-UHFFFAOYSA-N 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- DTMHTVJOHYTUHE-UHFFFAOYSA-N thiocyanogen Chemical compound N#CSSC#N DTMHTVJOHYTUHE-UHFFFAOYSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- RCHUVCPBWWSUMC-UHFFFAOYSA-N trichloro(octyl)silane Chemical compound CCCCCCCC[Si](Cl)(Cl)Cl RCHUVCPBWWSUMC-UHFFFAOYSA-N 0.000 description 1
- ZDHXKXAHOVTTAH-UHFFFAOYSA-N trichlorosilane Chemical compound Cl[SiH](Cl)Cl ZDHXKXAHOVTTAH-UHFFFAOYSA-N 0.000 description 1
- 239000005052 trichlorosilane Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000001018 xanthene dye Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Detergent Compositions (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12432298A IL124322A (en) | 1998-05-04 | 1998-05-04 | Detection of an entity in a sample |
| CA2641613A CA2641613C (en) | 1998-05-04 | 1999-05-04 | Detection of a target in a sample |
| EP99918252A EP1075656B1 (en) | 1998-05-04 | 1999-05-04 | Detection of a target in a sample |
| JP2000547465A JP4618886B2 (ja) | 1998-05-04 | 1999-05-04 | サンプル中の標的の検出 |
| CA2820735A CA2820735A1 (en) | 1998-05-04 | 1999-05-04 | Detection of a target in a sample |
| CA002331688A CA2331688C (en) | 1998-05-04 | 1999-05-04 | Detection of a target in a sample |
| AT99918252T ATE515693T1 (de) | 1998-05-04 | 1999-05-04 | Nachweis einer zielsubstanz in einer probe |
| PCT/IL1999/000232 WO1999057550A1 (en) | 1998-05-04 | 1999-05-04 | Detection of a target in a sample |
| AU36259/99A AU3625999A (en) | 1998-05-04 | 1999-05-04 | Detection of a target in a sample |
| US10/452,139 US20030203394A1 (en) | 1998-05-04 | 2003-06-03 | Detection of a target in a sample |
| US13/197,294 US20120309106A1 (en) | 1998-05-04 | 2011-08-03 | Detection of a target in a sample |
| US15/231,264 US20170121761A1 (en) | 1998-05-04 | 2016-08-08 | Electrical detection of a dna or rna target in a sample |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12432298A IL124322A (en) | 1998-05-04 | 1998-05-04 | Detection of an entity in a sample |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL124322A0 IL124322A0 (en) | 1998-12-06 |
| IL124322A true IL124322A (en) | 2002-05-23 |
Family
ID=11071451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12432298A IL124322A (en) | 1998-05-04 | 1998-05-04 | Detection of an entity in a sample |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20120309106A1 (enExample) |
| EP (1) | EP1075656B1 (enExample) |
| JP (1) | JP4618886B2 (enExample) |
| AT (1) | ATE515693T1 (enExample) |
| AU (1) | AU3625999A (enExample) |
| CA (3) | CA2820735A1 (enExample) |
| IL (1) | IL124322A (enExample) |
| WO (1) | WO1999057550A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121312A (en) | 1997-07-14 | 2001-09-13 | Technion Res & Dev Foundation | Microelectronic components, their manufacture and electronic networks containing them |
| IL126776A (en) | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
| JP4555484B2 (ja) | 1999-04-07 | 2010-09-29 | デニス マイケル コノリー | 高解像度のｄｎａ検出の方法および装置 |
| US7364920B2 (en) | 1999-10-27 | 2008-04-29 | Technion Research And Development Foundation Ltd. | Method for gold deposition |
| DE10113550A1 (de) * | 2001-03-20 | 2002-10-02 | Infineon Technologies Ag | Verfahren zum Erfassen von makromolekularen Biopolymeren mittels einer Elektrodenanordnung |
| US6824974B2 (en) | 2001-06-11 | 2004-11-30 | Genorx, Inc. | Electronic detection of biological molecules using thin layers |
| WO2003042396A2 (en) * | 2001-06-11 | 2003-05-22 | Genorx, Inc. | Electronic detection of biological molecules using thin layers |
| US20040023253A1 (en) * | 2001-06-11 | 2004-02-05 | Sandeep Kunwar | Device structure for closely spaced electrodes |
| CN100344960C (zh) * | 2001-12-17 | 2007-10-24 | 清华大学 | 刺激动物细胞并记录其生理信号的装置及其生产使用方法 |
| US20030186245A1 (en) * | 2002-03-28 | 2003-10-02 | Roitman Daniel B. | Biomolecular sensors and detection methods utilizing photoinduced charge separation |
| DE10228260A1 (de) * | 2002-06-25 | 2004-01-22 | Bayer Ag | Methode und Vorrichtung zum impedimetrischen Nachweis eines oder mehrerer Analyten in einer Probe |
| US20040166520A1 (en) * | 2003-01-03 | 2004-08-26 | Connolly D. Michael | Identifying items with nucleic acid taggants |
| DE10322912A1 (de) * | 2003-05-21 | 2004-12-16 | Bayer Technology Services Gmbh | Verfahren zum Nachweis von Nukleinsäuren |
| DE10327683A1 (de) * | 2003-06-20 | 2005-01-20 | Bayer Technology Services Gmbh | Verfahren und Vorrichtung zum quantitativen elektrischen Nachweis von Analyten |
| DE10330717A1 (de) * | 2003-07-03 | 2005-02-10 | Friedrich-Schiller-Universität Jena | Vorrichtung und Verfahren zum Nachweis von Analyt |
| US20050079598A1 (en) * | 2003-10-08 | 2005-04-14 | Davis Randall W. | Apparatus and method for identification of biomolecules, in particular nucleic acid sequences, proteins, and antigens and antibodies |
| JP4389088B2 (ja) * | 2003-11-07 | 2009-12-24 | 公立大学法人大阪府立大学 | 電気抵抗型検出センサおよび検出方法 |
| JP4511592B2 (ja) * | 2004-04-29 | 2010-07-28 | ラマエル，マルク | サンプル中の成分を検出するための方法およびキット |
| CA2567114A1 (en) * | 2004-05-28 | 2005-12-15 | Nanogen, Inc. | Nanoscale electronic detection system and methods for their manufacture |
| JP4873463B2 (ja) * | 2006-06-30 | 2012-02-08 | 独立行政法人産業技術総合研究所 | ナノギャップ電極を有する検出素子及びこれを用いた検出方法 |
| US9395352B2 (en) | 2007-04-06 | 2016-07-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Devices and methods for target molecule characterization |
| US8968540B2 (en) | 2008-10-06 | 2015-03-03 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Trans-base tunnel reader for sequencing |
| JP5838474B2 (ja) * | 2010-02-02 | 2016-01-06 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ | ポリマーの配列を決定するための制御されたトンネルギャップデバイス |
| US9274430B2 (en) | 2012-10-10 | 2016-03-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems and devices for molecule sensing and method of manufacturing thereof |
| KR20250022239A (ko) | 2016-01-28 | 2025-02-14 | 로스웰 엠이 아이엔씨. | 대량 병렬 ｄｎａ 시퀀싱 장치 |
| CN109071212A (zh) * | 2016-01-28 | 2018-12-21 | 罗斯韦尔生物技术股份有限公司 | 使用大规模分子电子传感器阵列测量分析物的方法和装置 |
| JP6854532B2 (ja) | 2016-02-09 | 2021-04-07 | ロズウェル バイオテクノロジーズ，インコーポレイテッド | 電子的、標識フリーのｄｎａおよびゲノムシークエンシング |
| CA3023256A1 (en) * | 2016-05-18 | 2017-11-23 | Integrated Nano-Technologies, Inc. | Method for detection of a pcr product |
| EP3571286A4 (en) | 2017-01-19 | 2020-10-28 | Roswell Biotechnologies, Inc | SEMICONDUCTOR SEQUENCING DEVICES INCLUDING TWO-DIMENSIONAL LAYER MATERIALS |
| US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
| CN110546276A (zh) | 2017-04-25 | 2019-12-06 | 罗斯威尔生命技术公司 | 用于分子传感器的酶电路 |
| CA3057155A1 (en) | 2017-05-09 | 2018-11-15 | Roswell Biotechnologies, Inc. | Binding probe circuits for molecular sensors |
| WO2019046589A1 (en) | 2017-08-30 | 2019-03-07 | Roswell Biotechnologies, Inc. | PROCESSIVE ENZYME MOLECULAR ELECTRONIC SENSORS FOR STORING DNA DATA |
| KR102717872B1 (ko) | 2017-10-10 | 2024-10-14 | 로스웰 엠이 아이엔씨. | 무증폭 dna 데이터 저장을 위한 방법, 장치 및 시스템 |
| US20210373014A1 (en) * | 2017-10-23 | 2021-12-02 | The General Hospital Corporation | An integrated microfluidic electrode array system for enzyme-linked immuno-sorbent assay (easy-elisa) for point-of-care detection of molecular and cellular biomarkers |
| CN112384296B (zh) | 2018-05-17 | 2023-06-27 | 识别分析股份有限公司 | 用于直接电测量酶活性的装置、系统和方法 |
| JP2020041909A (ja) * | 2018-09-11 | 2020-03-19 | 国立大学法人九州大学 | 内分泌攪乱物質等の定量方法及び定量装置 |
| MX2021009150A (es) | 2019-01-30 | 2021-12-10 | Univ Arizona State | Circuitos bioelectronicos, sistemas y metodos para preparar y usar los mismos. |
| KR20220047311A (ko) * | 2019-08-22 | 2022-04-15 | 유니버셜 시퀀싱 테크놀로지 코퍼레이션 | 생체분자 감지 및 검출 방법 |
| US12146852B2 (en) | 2019-09-06 | 2024-11-19 | Roswell Biotechnologies, Inc. | Methods of fabricating nanoscale structures usable in molecular sensors and other devices |
| WO2021222791A1 (en) * | 2020-04-30 | 2021-11-04 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for sequencing biopolymers |
| US12385873B2 (en) | 2020-12-25 | 2025-08-12 | Aurangzeb Nafees Nagy | Detection of target nucleic acid molecules |
| JP7555166B1 (ja) * | 2024-07-04 | 2024-09-24 | 株式会社イムノセンス | 電気化学式免疫センサー |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5137827A (en) * | 1986-03-25 | 1992-08-11 | Midwest Research Technologies, Inc. | Diagnostic element for electrical detection of a binding reaction |
| US4794089A (en) * | 1986-03-25 | 1988-12-27 | Midwest Research Microscopy, Inc. | Method for electronic detection of a binding reaction |
| US4995402A (en) * | 1988-10-12 | 1991-02-26 | Thorne, Smith, Astill Technologies, Inc. | Medical droplet whole blood and like monitoring |
| AU4647589A (en) * | 1988-11-10 | 1990-05-28 | Midwest Research Technologies, Inc. | Method for electrical detection of a binding reaction |
| CA2034266A1 (en) * | 1990-02-27 | 1991-08-28 | Paul A. D'orazio | Thick film reagent spreading and reagent immobilization layer |
| US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
| IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| ES2223067T3 (es) * | 1995-12-01 | 2005-02-16 | Innogenetics N.V. | Sistema de deteccion impedimetrico y metodo de produccion del mismo. |
| US6506895B2 (en) * | 1997-08-15 | 2003-01-14 | Surmodics, Inc. | Photoactivatable nucleic acids |
| IL126776A (en) * | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
-
1998
- 1998-05-04 IL IL12432298A patent/IL124322A/en not_active IP Right Cessation
-
1999
- 1999-05-04 EP EP99918252A patent/EP1075656B1/en not_active Expired - Lifetime
- 1999-05-04 AU AU36259/99A patent/AU3625999A/en not_active Abandoned
- 1999-05-04 AT AT99918252T patent/ATE515693T1/de not_active IP Right Cessation
- 1999-05-04 CA CA2820735A patent/CA2820735A1/en not_active Abandoned
- 1999-05-04 CA CA002331688A patent/CA2331688C/en not_active Expired - Fee Related
- 1999-05-04 WO PCT/IL1999/000232 patent/WO1999057550A1/en not_active Ceased
- 1999-05-04 JP JP2000547465A patent/JP4618886B2/ja not_active Expired - Fee Related
- 1999-05-04 CA CA2641613A patent/CA2641613C/en not_active Expired - Fee Related
-
2011
- 2011-08-03 US US13/197,294 patent/US20120309106A1/en not_active Abandoned
-
2016
- 2016-08-08 US US15/231,264 patent/US20170121761A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL124322A0 (en) | 1998-12-06 |
| JP2002522748A (ja) | 2002-07-23 |
| WO1999057550A1 (en) | 1999-11-11 |
| CA2641613C (en) | 2013-06-25 |
| AU3625999A (en) | 1999-11-23 |
| CA2820735A1 (en) | 1999-11-11 |
| US20120309106A1 (en) | 2012-12-06 |
| CA2641613A1 (en) | 1999-11-11 |
| JP4618886B2 (ja) | 2011-01-26 |
| CA2331688A1 (en) | 1999-11-11 |
| CA2331688C (en) | 2008-12-09 |
| EP1075656A1 (en) | 2001-02-14 |
| ATE515693T1 (de) | 2011-07-15 |
| US20170121761A1 (en) | 2017-05-04 |
| EP1075656B1 (en) | 2011-07-06 |
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| MM9K | Patent not in force due to non-payment of renewal fees |