IL123654A - Process for the preparation of solid mixtures of cyclodextrins and pharmaceutical preparations containing such solid mixtures - Google Patents

Process for the preparation of solid mixtures of cyclodextrins and pharmaceutical preparations containing such solid mixtures

Info

Publication number
IL123654A
IL123654A IL12365496A IL12365496A IL123654A IL 123654 A IL123654 A IL 123654A IL 12365496 A IL12365496 A IL 12365496A IL 12365496 A IL12365496 A IL 12365496A IL 123654 A IL123654 A IL 123654A
Authority
IL
Israel
Prior art keywords
mixture
cyclodextrins
melt
cyclodextrin
solid mixture
Prior art date
Application number
IL12365496A
Other languages
English (en)
Hebrew (he)
Other versions
IL123654A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26139823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL123654(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL123654A0 publication Critical patent/IL123654A0/xx
Publication of IL123654A publication Critical patent/IL123654A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL12365496A 1995-11-23 1996-11-20 Process for the preparation of solid mixtures of cyclodextrins and pharmaceutical preparations containing such solid mixtures IL123654A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95203219 1995-11-23
PCT/EP1996/005118 WO1997018839A1 (en) 1995-11-23 1996-11-20 Solid mixtures of cyclodextrins prepared via melt-extrusion
US09/081,808 US6365188B1 (en) 1995-11-23 1998-05-20 Solid mixtures of cyclodextrins prepared via meltextrusion

Publications (2)

Publication Number Publication Date
IL123654A0 IL123654A0 (en) 1998-10-30
IL123654A true IL123654A (en) 2001-08-08

Family

ID=26139823

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12365496A IL123654A (en) 1995-11-23 1996-11-20 Process for the preparation of solid mixtures of cyclodextrins and pharmaceutical preparations containing such solid mixtures

Country Status (16)

Country Link
US (1) US6365188B1 (cs)
EP (1) EP0862463A1 (cs)
JP (1) JP3310299B2 (cs)
CN (1) CN1198655C (cs)
AU (1) AU725204B2 (cs)
BR (1) BR9611562A (cs)
CZ (1) CZ154398A3 (cs)
HU (1) HUP9900730A3 (cs)
IL (1) IL123654A (cs)
NO (1) NO981078L (cs)
NZ (1) NZ322907A (cs)
PL (1) PL189122B1 (cs)
SK (1) SK67298A3 (cs)
TR (1) TR199800729T2 (cs)
WO (1) WO1997018839A1 (cs)
ZA (1) ZA969831B (cs)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ154398A3 (cs) * 1995-11-23 1998-08-12 Janssen Pharmaceutica N.V. Pevné směsi cyklodextrinů připravené vytlačováním taveniny
KR19990001564A (ko) * 1997-06-16 1999-01-15 유충식 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
ES2174538T3 (es) 1997-11-28 2002-11-01 Knoll Ag Procedimiento para la obtencion de substancias exentas de disolventes, no cristalinas, biologicamente activas.
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
WO2000027825A1 (en) 1998-11-10 2000-05-18 Janssen Pharmaceutica N.V. Hiv replication inhibiting pyrimidines
US6194395B1 (en) 1999-02-25 2001-02-27 Orthro-Mcneil Pharmaceutical, Inc. Cyclodextrin cladribine formulations
DE19911097A1 (de) * 1999-03-12 2000-09-14 Basf Ag Verfahren zur Herstellung von festen cyclodextrinhaltigen Dosierungsformen
CN1156461C (zh) 1999-03-24 2004-07-07 R·P·希拉技术股份有限公司 改良的水溶性药物制剂
ATE234833T1 (de) 1999-05-04 2003-04-15 Janssen Pharmaceutica Nv Antimykotische ether
FR2803748A1 (fr) * 2000-01-14 2001-07-20 Ethypharm Lab Prod Ethiques Composition d'itraconazole et procede de preparation
JP2003525291A (ja) 2000-03-01 2003-08-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２，４−二置換チアゾリル誘導体
US6835717B2 (en) * 2000-03-08 2004-12-28 The Johns Hopkins University School Of Medicine β-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases
WO2001085700A2 (en) 2000-05-08 2001-11-15 Janssen Pharmaceutica N.V. Hiv replication inhibiting pyrimidines and triazines
US6932861B2 (en) 2000-11-28 2005-08-23 Fmc Corporation Edible PGA coating composition
ITRN20000051A1 (it) 2000-12-22 2002-06-22 Ascor Chimici Srl Metodo e apparecchiatura per formare sferule composite contenenti principi attivi del tipo farmaceutico e/o integratori alimentari o cosmeti
GB0113841D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
AU2002324045C1 (en) 2001-08-13 2008-05-29 Janssen Pharmaceutica N.V. 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
ATE396971T1 (de) 2002-03-13 2008-06-15 Janssen Pharmaceutica Nv Sulfonylaminoderivate als neue inhibitoren von histondeacetylase
EP1485364B1 (en) 2002-03-13 2009-03-11 Janssen Pharmaceutica N.V. Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase
CA2686429C (en) 2002-08-09 2010-11-16 Janssen Pharmaceutica N.V. Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
EP1597237B1 (en) 2003-02-07 2016-07-27 Janssen Pharmaceutica NV Pyrimidine derivatives for the prevention of HIV infection
AP2005003365A0 (en) 2003-02-07 2005-09-30 Janssen Pharmaceutica Nv Hiv inhibiting 1, 2, 4-triazines.
CL2004000306A1 (es) 2003-02-20 2005-04-08 Tibotec Pharm Ltd Compuestos derivados de pirimidina sustituidas con indano; proceso para su preparacion; composicion farmaceutica que lo comprende; combinacion farmaceutica; y su uso para el tratamiento o profilaxis de una enfermedad infecciosa.
CA2520522C (en) 2003-03-28 2012-05-29 Ivax Corporation Cladribine formulations for improved oral and transmucosal delivery
RS20050735A (en) * 2003-03-28 2008-06-05 Ares Trading S.A., Cladribine formulations for improved oral and transmucosal delivery
AU2004274185B2 (en) 2003-09-25 2009-12-10 Janssen Pharmaceutica N.V. HIV replication inhibiting purine derivatives
US20050118265A1 (en) * 2003-11-28 2005-06-02 Anandi Krishnan Antifungal oral dosage forms and the methods for preparation
SG156687A1 (en) 2004-07-28 2009-11-26 Janssen Pharmaceutica Nv Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
AU2005271161B2 (en) 2004-08-10 2011-05-12 Janssen Pharmaceutica N.V. HIV inhibiting 1,2,4-triazin-6-one derivatives
BRPI0516746A (pt) 2004-09-30 2008-09-23 Tibotec Pharm Ltd 5-heterociclil pirimidinas para inibição de hiv
US8946248B2 (en) 2004-09-30 2015-02-03 Janssen R&D Ireland HIV inhibiting 5-substituted pyrimidines
WO2006045828A1 (en) 2004-10-29 2006-05-04 Tibotec Pharmaceuticals Ltd. Hiv inhibiting bicyclic pyrimidine derivatives
ES2373820T3 (es) 2005-01-27 2012-02-09 Tibotec Pharmaceuticals Derivados de 2-(4-cianofenilamino)pirimidina que inhiben el vih.
JP5118978B2 (ja) 2005-03-04 2013-01-16 テイボテク・フアーマシユーチカルズ Ｈｉｖ阻害２−（４−シアノフェニル）−６−ヒドロキシルアミノピリミジン
US20090028938A1 (en) * 2005-08-08 2009-01-29 Abbott Gmbh & Co. Kg Dosage forms with improved bioavailability
WO2007047253A2 (en) * 2005-10-11 2007-04-26 Eastman Chemical Company Pharmaceutical formulations of cyclodextrins and antifungal azole compounds
WO2007082874A1 (en) 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
EP1832281A1 (en) * 2006-03-10 2007-09-12 Abbott GmbH & Co. KG Process for producing a solid dispersion of an active ingredient
EP2004632B1 (en) 2006-03-30 2014-03-12 Janssen R&D Ireland Hiv inhibiting 5-amido substituted pyrimidines
AU2007233739B2 (en) 2006-03-30 2013-01-17 Janssen Sciences Ireland Uc HIV inhibiting 5-(hydroxymethylene and aminomethylene) substituted pyrimidines
AU2007341228B2 (en) 2006-12-29 2013-04-18 Janssen Sciences Ireland Uc HIV inhibiting 5,6-substituted pyrimidines
CA2674178C (en) 2006-12-29 2015-11-10 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 6-substituted pyrimidines
MX2010011962A (es) * 2008-04-30 2010-11-30 Novartis Ag Proceso continuo para hacer composiciones farmaceuticas.
JP2012525895A (ja) 2009-05-07 2012-10-25 ジーイーエイ・ファーマ・システムズ・リミテッド 錠剤の製造モジュール及び錠剤の連続製造方法
US20120148678A1 (en) 2010-12-08 2012-06-14 Advanced Technologies And Regenerative Medicine, Llc. Sustained release of poorly water soluble active compounds
US10532102B2 (en) 2016-08-19 2020-01-14 Foresee Pharmaceuticals Co., Ltd. Pharmaceutical composition and methods of uses
CN107441504A (zh) * 2017-09-06 2017-12-08 广州中医药大学 番茄红素包合物及其制备方法及番茄红素包合物片剂、胶囊和颗粒
US20220401579A1 (en) * 2019-11-30 2022-12-22 Dispersol Technologies, Llc Inclusion complexes of pharmaceuticals and cyclic oligomers
CN110898015A (zh) * 2019-12-31 2020-03-24 上海汉维生物医药科技有限公司 一种伊曲康唑制剂的制备方法
CN115317369A (zh) * 2022-08-12 2022-11-11 江苏集萃新型药物制剂技术研究所有限公司 制备固体分散体的装置和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61152765A (ja) * 1984-12-27 1986-07-11 Nippon Ekishiyou Kk シクロデキストリン類で包接された化合物を含有した合成樹脂製品及びその製造方法
US5009900A (en) * 1989-10-02 1991-04-23 Nabisco Brands, Inc. Glassy matrices containing volatile and/or labile components, and processes for preparation and use thereof
DE69327877T2 (de) * 1992-10-14 2000-10-05 Nippon Shinyaku Co., Ltd. Verfahren zur verschiebung eines kristallzustandes
WO1994011031A1 (fr) * 1992-11-10 1994-05-26 Nippon Shinyaku Co., Ltd. Procede de production d'un compose d'encapsulation
FR2705677B1 (fr) * 1993-05-28 1995-08-11 Roquette Freres Micro-granules obtenus par extrusion-sphéronisation contenant une cyclodextrine.
CZ154398A3 (cs) * 1995-11-23 1998-08-12 Janssen Pharmaceutica N.V. Pevné směsi cyklodextrinů připravené vytlačováním taveniny
KR100331529B1 (ko) 1999-06-16 2002-04-06 민경윤 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법

Also Published As

Publication number Publication date
CN1200677A (zh) 1998-12-02
PL326161A1 (en) 1998-08-31
US6365188B1 (en) 2002-04-02
NZ322907A (en) 1998-12-23
CZ154398A3 (cs) 1998-08-12
AU725204B2 (en) 2000-10-05
ZA969831B (en) 1998-05-22
JP3310299B2 (ja) 2002-08-05
SK67298A3 (en) 1998-11-04
NO981078L (no) 1998-05-22
HUP9900730A2 (hu) 1999-07-28
EP0862463A1 (en) 1998-09-09
HUP9900730A3 (en) 2001-04-28
WO1997018839A1 (en) 1997-05-29
JPH11501050A (ja) 1999-01-26
BR9611562A (pt) 1999-03-02
AU7694396A (en) 1997-06-11
CN1198655C (zh) 2005-04-27
IL123654A0 (en) 1998-10-30
TR199800729T2 (xx) 1998-07-21
NO981078D0 (no) 1998-03-11
PL189122B1 (pl) 2005-06-30

Similar Documents

Publication Publication Date Title
AU725204B2 (en) Solid mixtures of cyclodextrins prepared via melt-extrusion
Giri et al. Cellulose and its derivatives for application in 3D printing of pharmaceuticals
Leuner et al. Improving drug solubility for oral delivery using solid dispersions
JP5022086B2 (ja) 医薬の剤形の使用方法
EP2822539B1 (en) Nanocrystalline solid dispersion compositions
DE69222182T2 (de) Verfahren für die herstellung einer festen dispersion
WO2003043602A1 (en) Solid dispersions containing substituted cyclodextrin and insoluble drug and their preparations
KR102065325B1 (ko) 셀룰로즈 에테르를 포함하는 용융-압출된 조성물
Singhal et al. Hot melt extrusion technique
EP1845945B1 (de) Herstellung von dosierungsformen mit einer festen dispersion eines mikrokristallinen wirkstoffs
Rajadhyax et al. Hot melt extrusion in engineering of drug cocrystals: a review
BR112018071722B1 (pt) Uso do amino açúcar como plastificante, composição em pó e seu processo de produção
US20240108639A1 (en) Compositions and methods of making cocrystals using dielectric heating with dispersive and distributive mixing
KR100441109B1 (ko) 용융-압출하여제조된사이클로덱스트린의고체혼합물
Halagali et al. The Hot Melt Extrusion (HME) in Pharmaceutical Technology: A Comprehensive Review

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees