IL123572A - Use of two-dimensional <15>n/<1>h nmr correlation spectroscopy in a process for designing high-affinity ligands to target molecules - Google Patents

Use of two-dimensional <15>n/<1>h nmr correlation spectroscopy in a process for designing high-affinity ligands to target molecules

Info

Publication number
IL123572A
IL123572A IL12357296A IL12357296A IL123572A IL 123572 A IL123572 A IL 123572A IL 12357296 A IL12357296 A IL 12357296A IL 12357296 A IL12357296 A IL 12357296A IL 123572 A IL123572 A IL 123572A
Authority
IL
Israel
Prior art keywords
target molecule
ligand
ligands
binding
nmr
Prior art date
Application number
IL12357296A
Other languages
English (en)
Other versions
IL123572A0 (en
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27415774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL123572(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/558,633 external-priority patent/US5891643A/en
Priority claimed from US08/744,701 external-priority patent/US5989827A/en
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to IL14951596A priority Critical patent/IL149515A/en
Priority to IL14951296A priority patent/IL149512A/en
Priority to IL14951396A priority patent/IL149513A/en
Priority to IL14951496A priority patent/IL149514A/en
Publication of IL123572A0 publication Critical patent/IL123572A0/xx
Publication of IL123572A publication Critical patent/IL123572A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4633—Sequences for multi-dimensional NMR
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL12357296A 1995-11-14 1996-11-13 Use of two-dimensional <15>n/<1>h nmr correlation spectroscopy in a process for designing high-affinity ligands to target molecules IL123572A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IL14951596A IL149515A (en) 1995-11-14 1996-11-13 Use of two dimensional <15>n/<1>n nmr correlation spectroscopy in a process for designing high-affinity ligands to target biomolecules
IL14951296A IL149512A (en) 1995-11-14 1996-11-13 Use of two-dimensional <15>n/<1>h nmr correlation spectroscopy in a process for designing high-affinity ligands to target molecules
IL14951396A IL149513A (en) 1995-11-14 1996-11-13 Use of two dimensional <15>n/<1>n nmr correlation spectroscopy in a process for designing high affinity ligands to target biomolecules
IL14951496A IL149514A (en) 1995-11-14 1996-11-13 Use of two dimensional <15>n/<1>n nmr correlation spectroscopy in a process for designing high-affinity ligands to target biomolecules

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/558,633 US5891643A (en) 1995-11-14 1995-11-14 Use of nuclear magnetic resonance to design ligands to target biomolecules
US67890396A 1996-07-12 1996-07-12
US08/744,701 US5989827A (en) 1995-11-14 1996-10-31 Use of nuclear magnetic resonance to design ligands to target biomolecules
PCT/US1996/018312 WO1997018469A2 (en) 1995-11-14 1996-11-13 Use of nuclear magnetic resonance to design ligands to target biomolecules

Publications (2)

Publication Number Publication Date
IL123572A0 IL123572A0 (en) 1998-10-30
IL123572A true IL123572A (en) 2004-06-01

Family

ID=27415774

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12357296A IL123572A (en) 1995-11-14 1996-11-13 Use of two-dimensional <15>n/<1>h nmr correlation spectroscopy in a process for designing high-affinity ligands to target molecules

Country Status (12)

Country Link
EP (1) EP0870197B2 (de)
JP (1) JP3300366B2 (de)
AT (1) ATE201768T1 (de)
AU (1) AU711092B2 (de)
DE (1) DE69613146T3 (de)
DK (1) DK0870197T4 (de)
ES (1) ES2159056T5 (de)
GR (1) GR3036454T3 (de)
IL (1) IL123572A (de)
MX (1) MX9803805A (de)
PT (1) PT870197E (de)
WO (1) WO1997018469A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010004528A1 (en) * 1995-11-14 2001-06-21 Stephen W. Fesik Use of 13c nuclear magnetic resonance to detect binding to target molecules
US6344330B1 (en) 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
DE69933774D1 (de) * 1998-07-21 2006-12-07 Univ Rutgers Verbinden einer gensequenz mit einer genfunktion mittels dreidimensionaler (3d) proteinstrukturbestimmung
US6333149B1 (en) 1999-06-04 2001-12-25 Triad Biotechnology, Inc. NMR-solve method for rapid identification of bi-ligand drug candidates
US6764858B2 (en) 1999-09-29 2004-07-20 Pharmacia & Upjohn Company Methods for creating a compound library
US6677160B1 (en) 1999-09-29 2004-01-13 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
GB9925677D0 (en) * 1999-10-29 1999-12-29 Pharmacia & Upjohn Spa Use of double-quantum 1H-NMR spectroscopy for the identification of ligands interacting with target biomolecules
BR0108606A (pt) * 2000-02-25 2003-01-07 Wyeth Corp Métodos de planejamento de droga com base na estrutura empregando-se em/rmn
JP5129424B2 (ja) 2000-09-27 2013-01-30 ユニヴェルシテイト レイデン リガンドの発見または薬物スクリーニング手段としてのｎｍｒ利用法
US7653490B2 (en) 2001-09-10 2010-01-26 Triad Liquidating Company LLC Nuclear magnetic resonance assembly of chemical entities
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
JP4192078B2 (ja) 2003-11-26 2008-12-03 株式会社日立製作所 核磁気共鳴方法
EP1715357A4 (de) * 2004-02-02 2009-09-16 Mitsubishi Chem Corp Nmr-signalzuweisungsverfahren
US20090239760A1 (en) 2006-03-14 2009-09-24 University Of Basel Method for the Identification of New Leads for Drug Candidates
KR20200057071A (ko) * 2017-09-25 2020-05-25 스카이호크 테라퓨틱스, 인코포레이티드 스플라이싱 조절제의 스크리닝 및 확인을 위한 방법 및 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0557276A1 (de) * 1989-12-29 1993-09-01 University Technologies International Inc. (Uti) Verfahren zur modellierung von tertiärstrukturen von biologisch aktiven liganden einschliesslich ihrer agonisten und antagonisten und neue synthetische antagonisten auf angiotensinbasis
US5393669A (en) * 1993-02-05 1995-02-28 Martek Biosciences Corp. Compositions and methods for protein structural determinations
US8558663B2 (en) † 2007-11-30 2013-10-15 Bank Of America Corporation Integration of facial recognition into cross channel authentication
DE102008042959A1 (de) † 2008-10-20 2010-04-22 Zf Friedrichshafen Ag Verfahren zur Steuerung eines Kraftfahrzeug-Antriebsstrangs
US8678903B1 (en) † 2012-09-13 2014-03-25 Chia-Yen Lin Mobile device having a virtual spin wheel and virtual spin wheel control method of the same

Also Published As

Publication number Publication date
WO1997018469A3 (en) 1997-08-07
ES2159056T5 (es) 2007-07-16
DE69613146T3 (de) 2007-06-14
ES2159056T3 (es) 2001-09-16
DE69613146D1 (de) 2001-07-05
AU7680496A (en) 1997-06-05
EP0870197B1 (de) 2001-05-30
PT870197E (pt) 2001-11-30
ATE201768T1 (de) 2001-06-15
IL123572A0 (en) 1998-10-30
MX9803805A (es) 1998-09-30
EP0870197B2 (de) 2006-11-08
WO1997018469A2 (en) 1997-05-22
DK0870197T4 (da) 2007-02-26
EP0870197A2 (de) 1998-10-14
DK0870197T3 (da) 2001-08-27
GR3036454T3 (en) 2001-11-30
JP3300366B2 (ja) 2002-07-08
DE69613146T2 (de) 2003-01-16
AU711092B2 (en) 1999-10-07
JP2002510384A (ja) 2002-04-02

Similar Documents

Publication Publication Date Title
US5698401A (en) Use of nuclear magnetic resonance to identify ligands to target biomolecules
US5891643A (en) Use of nuclear magnetic resonance to design ligands to target biomolecules
US5989827A (en) Use of nuclear magnetic resonance to design ligands to target biomolecules
WO1997018471A9 (en) Use of nuclear magnetic resonance to identify ligands to target biomolecules
EP0870197B1 (de) Verwendung von kernspinresonanz zur bestimmung von liganden für zielbiomoleküle
EP0975954B1 (de) Verwendung von eindimensionaler kernspinresonanz fur identifizierung von liganden fur ziel-biomolekule
IL145135A (en) Use of 13c-nmr to detect binding
IL149514A (en) Use of two dimensional &lt;15&gt;n/&lt;1&gt;n nmr correlation spectroscopy in a process for designing high-affinity ligands to target biomolecules
CA2237336C (en) Use of nuclear magnetic resonance to design ligands to target biomolecules
MXPA98003810A (en) Use of nuclear magnetic resonance to identify ligands directed to biomolecu
KR100456054B1 (ko) 특정 아미노산이 표지된 단백질과 2ｄ ｎｍｒ 기법을이용하여 단백질의 활성 부위에 결합하는 화합물을검색하는 방법
KR100888805B1 (ko) 특정 아미노산이 표지된 단백질과 1ｄ ｎｍｒ 기법을이용하여 단백질의 활성 부위에 결합하는 화합물을검색하는 방법
Archer et al. New NMR methods for structural studies of proteins to aid in drug design
AU772620B2 (en) Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired