IL123572A - Use of two-dimensional <15>n/<1>h nmr correlation spectroscopy in a process for designing high-affinity ligands to target molecules - Google Patents
Use of two-dimensional <15>n/<1>h nmr correlation spectroscopy in a process for designing high-affinity ligands to target moleculesInfo
- Publication number
- IL123572A IL123572A IL12357296A IL12357296A IL123572A IL 123572 A IL123572 A IL 123572A IL 12357296 A IL12357296 A IL 12357296A IL 12357296 A IL12357296 A IL 12357296A IL 123572 A IL123572 A IL 123572A
- Authority
- IL
- Israel
- Prior art keywords
- target molecule
- ligand
- ligands
- binding
- nmr
- Prior art date
Links
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/4633—Sequences for multi-dimensional NMR
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
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- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Pharmacology & Pharmacy (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL14951296A IL149512A (en) | 1995-11-14 | 1996-11-13 | Use of two-dimensional <15>n/<1>h nmr correlation spectroscopy in a process for designing high-affinity ligands to target molecules |
| IL14951496A IL149514A (en) | 1995-11-14 | 1996-11-13 | Use of two dimensional <15>n/<1>n nmr correlation spectroscopy in a process for designing high-affinity ligands to target biomolecules |
| IL14951596A IL149515A (en) | 1995-11-14 | 1996-11-13 | Use of two dimensional <15>n/<1>n nmr correlation spectroscopy in a process for designing high-affinity ligands to target biomolecules |
| IL14951396A IL149513A (en) | 1995-11-14 | 1996-11-13 | Use of two dimensional <15>n/<1>n nmr correlation spectroscopy in a process for designing high affinity ligands to target biomolecules |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/558,633 US5891643A (en) | 1995-11-14 | 1995-11-14 | Use of nuclear magnetic resonance to design ligands to target biomolecules |
| US67890396A | 1996-07-12 | 1996-07-12 | |
| US08/744,701 US5989827A (en) | 1995-11-14 | 1996-10-31 | Use of nuclear magnetic resonance to design ligands to target biomolecules |
| PCT/US1996/018312 WO1997018469A2 (en) | 1995-11-14 | 1996-11-13 | Use of nuclear magnetic resonance to design ligands to target biomolecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL123572A0 IL123572A0 (en) | 1998-10-30 |
| IL123572A true IL123572A (en) | 2004-06-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12357296A IL123572A (en) | 1995-11-14 | 1996-11-13 | Use of two-dimensional <15>n/<1>h nmr correlation spectroscopy in a process for designing high-affinity ligands to target molecules |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0870197B2 (de) |
| JP (1) | JP3300366B2 (de) |
| AT (1) | ATE201768T1 (de) |
| AU (1) | AU711092B2 (de) |
| DE (1) | DE69613146T3 (de) |
| DK (1) | DK0870197T4 (de) |
| ES (1) | ES2159056T5 (de) |
| GR (1) | GR3036454T3 (de) |
| IL (1) | IL123572A (de) |
| MX (1) | MX9803805A (de) |
| PT (1) | PT870197E (de) |
| WO (1) | WO1997018469A2 (de) |
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| US20010004528A1 (en) * | 1995-11-14 | 2001-06-21 | Stephen W. Fesik | Use of 13c nuclear magnetic resonance to detect binding to target molecules |
| US6344330B1 (en) | 1998-03-27 | 2002-02-05 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
| WO2000005414A1 (en) * | 1998-07-21 | 2000-02-03 | Rutgers, The State University | Linking gene sequence to gene function by three dimensional (3d) protein structure determination |
| US6333149B1 (en) | 1999-06-04 | 2001-12-25 | Triad Biotechnology, Inc. | NMR-solve method for rapid identification of bi-ligand drug candidates |
| US6677160B1 (en) | 1999-09-29 | 2004-01-13 | Pharmacia & Upjohn Company | Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules |
| US6764858B2 (en) | 1999-09-29 | 2004-07-20 | Pharmacia & Upjohn Company | Methods for creating a compound library |
| GB9925677D0 (en) * | 1999-10-29 | 1999-12-29 | Pharmacia & Upjohn Spa | Use of double-quantum 1H-NMR spectroscopy for the identification of ligands interacting with target biomolecules |
| JP2003524167A (ja) * | 2000-02-25 | 2003-08-12 | ワイス | Ｍｓ／ｎｍｒを用いた構造に基づく薬物設計の方法 |
| JP5129424B2 (ja) | 2000-09-27 | 2013-01-30 | ユニヴェルシテイト レイデン | リガンドの発見または薬物スクリーニング手段としてのｎｍｒ利用法 |
| US7653490B2 (en) | 2001-09-10 | 2010-01-26 | Triad Liquidating Company LLC | Nuclear magnetic resonance assembly of chemical entities |
| NO20025738D0 (no) * | 2002-11-29 | 2002-11-29 | Amersham Health As | Metode |
| JP4192078B2 (ja) | 2003-11-26 | 2008-12-03 | 株式会社日立製作所 | 核磁気共鳴方法 |
| US20080293150A1 (en) * | 2004-02-02 | 2008-11-27 | Toshiyuki Kohno | Nmr Signal Assignment Method |
| ATE519114T1 (de) | 2006-03-14 | 2011-08-15 | Univ Basel | Verfahren zur identifizierung neuer leitverbindungen für arzneistoffkandidaten |
| US20230152257A1 (en) * | 2017-09-25 | 2023-05-18 | Skyhawk Therapeutics, Inc. | Methods and compositions for screening and identification of splicing |
| ES3018082T3 (en) * | 2019-06-25 | 2025-05-14 | Actome Gmbh | Method and kit for measuring of analytes in bi-component systems and uses thereof |
| CN117912601B (zh) * | 2024-01-26 | 2024-11-01 | 苏州腾迈医药科技有限公司 | 分子构象的展示方法及装置、介质 |
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| CA2072363A1 (en) * | 1989-12-29 | 1991-06-30 | Graham J. Moore | Methods for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin |
| US5393669A (en) * | 1993-02-05 | 1995-02-28 | Martek Biosciences Corp. | Compositions and methods for protein structural determinations |
| US8558663B2 (en) † | 2007-11-30 | 2013-10-15 | Bank Of America Corporation | Integration of facial recognition into cross channel authentication |
| DE102008042959A1 (de) † | 2008-10-20 | 2010-04-22 | Zf Friedrichshafen Ag | Verfahren zur Steuerung eines Kraftfahrzeug-Antriebsstrangs |
| US8678903B1 (en) † | 2012-09-13 | 2014-03-25 | Chia-Yen Lin | Mobile device having a virtual spin wheel and virtual spin wheel control method of the same |
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1996
- 1996-11-13 EP EP96939709A patent/EP0870197B2/de not_active Expired - Lifetime
- 1996-11-13 ES ES96939709T patent/ES2159056T5/es not_active Expired - Lifetime
- 1996-11-13 PT PT96939709T patent/PT870197E/pt unknown
- 1996-11-13 DK DK96939709T patent/DK0870197T4/da active
- 1996-11-13 AU AU76804/96A patent/AU711092B2/en not_active Expired
- 1996-11-13 DE DE69613146T patent/DE69613146T3/de not_active Expired - Lifetime
- 1996-11-13 IL IL12357296A patent/IL123572A/en not_active IP Right Cessation
- 1996-11-13 AT AT96939709T patent/ATE201768T1/de active
- 1996-11-13 WO PCT/US1996/018312 patent/WO1997018469A2/en not_active Ceased
- 1996-11-13 JP JP51908697A patent/JP3300366B2/ja not_active Expired - Lifetime
-
1998
- 1998-05-13 MX MX9803805A patent/MX9803805A/es unknown
-
2001
- 2001-08-27 GR GR20010401304T patent/GR3036454T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69613146D1 (de) | 2001-07-05 |
| WO1997018469A3 (en) | 1997-08-07 |
| ES2159056T3 (es) | 2001-09-16 |
| ATE201768T1 (de) | 2001-06-15 |
| ES2159056T5 (es) | 2007-07-16 |
| WO1997018469A2 (en) | 1997-05-22 |
| DK0870197T4 (da) | 2007-02-26 |
| GR3036454T3 (en) | 2001-11-30 |
| JP3300366B2 (ja) | 2002-07-08 |
| DE69613146T3 (de) | 2007-06-14 |
| EP0870197B2 (de) | 2006-11-08 |
| EP0870197B1 (de) | 2001-05-30 |
| PT870197E (pt) | 2001-11-30 |
| AU711092B2 (en) | 1999-10-07 |
| MX9803805A (es) | 1998-09-30 |
| DE69613146T2 (de) | 2003-01-16 |
| AU7680496A (en) | 1997-06-05 |
| EP0870197A2 (de) | 1998-10-14 |
| DK0870197T3 (da) | 2001-08-27 |
| JP2002510384A (ja) | 2002-04-02 |
| IL123572A0 (en) | 1998-10-30 |
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