MX9803805A - Uso de resonancia magnetica nuclear para diseñar ligandos dirigidos a biomoleculas. - Google Patents

Uso de resonancia magnetica nuclear para diseñar ligandos dirigidos a biomoleculas.

Info

Publication number
MX9803805A
MX9803805A MX9803805A MX9803805A MX9803805A MX 9803805 A MX9803805 A MX 9803805A MX 9803805 A MX9803805 A MX 9803805A MX 9803805 A MX9803805 A MX 9803805A MX 9803805 A MX9803805 A MX 9803805A
Authority
MX
Mexico
Prior art keywords
target molecule
ligands
magnetic resonance
nuclear magnetic
target biomolecules
Prior art date
Application number
MX9803805A
Other languages
English (en)
Inventor
Stephen W Fesik
Philip J Hajduk
Edward T Olejniczak
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27415774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9803805(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/558,633 external-priority patent/US5891643A/en
Priority claimed from US08/744,701 external-priority patent/US5989827A/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX9803805A publication Critical patent/MX9803805A/es

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46NMR spectroscopy
    • G01R33/4633Sequences for multi-dimensional NMR
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invencion proporciona un proceso para diseñar compuestos que se fijen a una molécula objetivo específica. El proceso incluye los pasos de a) identificar un primer ligando para la molécula objetivo, usando espectroscopía de correlacion de resonancia magnética nuclear de 15N/1H bidimensional; b) identificar un segundo ligando para la molécula objetivo usando espectroscopía de correlacion de resonancia magnética nuclear de 15N/1H bidimensional; c) formar un complejo ternario mediante la fijacion del primero y segundo ligandos a la molécula objetivo; d) determinar la estructura tridimensional del complejo y, de esta manera, la orientacion espacial del primero y segundo ligandos en la molécula objetivo; y e) enlazar el primero y segundo ligados para formar el fármaco, en donde se mantenga la orientacion espacial del paso d).
MX9803805A 1995-11-14 1998-05-13 Uso de resonancia magnetica nuclear para diseñar ligandos dirigidos a biomoleculas. MX9803805A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/558,633 US5891643A (en) 1995-11-14 1995-11-14 Use of nuclear magnetic resonance to design ligands to target biomolecules
US67890396A 1996-07-12 1996-07-12
US08/744,701 US5989827A (en) 1995-11-14 1996-10-31 Use of nuclear magnetic resonance to design ligands to target biomolecules

Publications (1)

Publication Number Publication Date
MX9803805A true MX9803805A (es) 1998-09-30

Family

ID=27415774

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9803805A MX9803805A (es) 1995-11-14 1998-05-13 Uso de resonancia magnetica nuclear para diseñar ligandos dirigidos a biomoleculas.

Country Status (12)

Country Link
EP (1) EP0870197B2 (es)
JP (1) JP3300366B2 (es)
AT (1) ATE201768T1 (es)
AU (1) AU711092B2 (es)
DE (1) DE69613146T3 (es)
DK (1) DK0870197T4 (es)
ES (1) ES2159056T5 (es)
GR (1) GR3036454T3 (es)
IL (1) IL123572A (es)
MX (1) MX9803805A (es)
PT (1) PT870197E (es)
WO (1) WO1997018469A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010004528A1 (en) * 1995-11-14 2001-06-21 Stephen W. Fesik Use of 13c nuclear magnetic resonance to detect binding to target molecules
US6344330B1 (en) 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
ATE343645T1 (de) * 1998-07-21 2006-11-15 Univ Rutgers Verbinden einer gensequenz mit einer genfunktion mittels dreidimensionaler (3d) proteinstrukturbestimmung
US6333149B1 (en) 1999-06-04 2001-12-25 Triad Biotechnology, Inc. NMR-solve method for rapid identification of bi-ligand drug candidates
US6677160B1 (en) 1999-09-29 2004-01-13 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
US6764858B2 (en) 1999-09-29 2004-07-20 Pharmacia & Upjohn Company Methods for creating a compound library
GB9925677D0 (en) * 1999-10-29 1999-12-29 Pharmacia & Upjohn Spa Use of double-quantum 1H-NMR spectroscopy for the identification of ligands interacting with target biomolecules
CA2401014A1 (en) * 2000-02-25 2001-08-30 American Home Products Corporation Methods of structure-based drug design using ms/nmr
CA2423914C (en) 2000-09-27 2010-11-30 Universiteit Leiden Method for applying nmr for ligand discovery or as a drug screening tool
US7653490B2 (en) 2001-09-10 2010-01-26 Triad Liquidating Company LLC Nuclear magnetic resonance assembly of chemical entities
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
JP4192078B2 (ja) 2003-11-26 2008-12-03 株式会社日立製作所 核磁気共鳴方法
WO2005073747A1 (ja) * 2004-02-02 2005-08-11 Mitsubishi Chemical Corporation Nmrシグナル帰属方法
EP2013624B1 (en) 2006-03-14 2011-08-03 Universität Basel Method for the identification of new leads for drug candidates
KR20200057071A (ko) * 2017-09-25 2020-05-25 스카이호크 테라퓨틱스, 인코포레이티드 스플라이싱 조절제의 스크리닝 및 확인을 위한 방법 및 조성물
CN117912601B (zh) * 2024-01-26 2024-11-01 苏州腾迈医药科技有限公司 分子构象的展示方法及装置、介质

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE904705A1 (en) * 1989-12-29 1991-07-17 Univ Technologies Int Methods for modelling tertiary structures of biologically¹active ligands including agonists and antagonists thereto¹and novel synthetic antagonists based on angiotensin
US5393669A (en) * 1993-02-05 1995-02-28 Martek Biosciences Corp. Compositions and methods for protein structural determinations
US8558663B2 (en) 2007-11-30 2013-10-15 Bank Of America Corporation Integration of facial recognition into cross channel authentication
DE102008042959A1 (de) 2008-10-20 2010-04-22 Zf Friedrichshafen Ag Verfahren zur Steuerung eines Kraftfahrzeug-Antriebsstrangs
US8678903B1 (en) 2012-09-13 2014-03-25 Chia-Yen Lin Mobile device having a virtual spin wheel and virtual spin wheel control method of the same

Also Published As

Publication number Publication date
PT870197E (pt) 2001-11-30
JP3300366B2 (ja) 2002-07-08
DE69613146T3 (de) 2007-06-14
EP0870197B1 (en) 2001-05-30
DK0870197T4 (da) 2007-02-26
AU711092B2 (en) 1999-10-07
JP2002510384A (ja) 2002-04-02
ES2159056T5 (es) 2007-07-16
WO1997018469A3 (en) 1997-08-07
DE69613146T2 (de) 2003-01-16
WO1997018469A2 (en) 1997-05-22
GR3036454T3 (en) 2001-11-30
DK0870197T3 (da) 2001-08-27
IL123572A0 (en) 1998-10-30
DE69613146D1 (de) 2001-07-05
AU7680496A (en) 1997-06-05
EP0870197A2 (en) 1998-10-14
IL123572A (en) 2004-06-01
ES2159056T3 (es) 2001-09-16
ATE201768T1 (de) 2001-06-15
EP0870197B2 (en) 2006-11-08

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