ATE201768T1 - Verwendung von kernspinresonanz zur bestimmung von liganden für zielbiomoleküle - Google Patents

Verwendung von kernspinresonanz zur bestimmung von liganden für zielbiomoleküle

Info

Publication number
ATE201768T1
ATE201768T1 AT96939709T AT96939709T ATE201768T1 AT E201768 T1 ATE201768 T1 AT E201768T1 AT 96939709 T AT96939709 T AT 96939709T AT 96939709 T AT96939709 T AT 96939709T AT E201768 T1 ATE201768 T1 AT E201768T1
Authority
AT
Austria
Prior art keywords
target molecule
ligands
nuclear
resonance
target biomolecules
Prior art date
Application number
AT96939709T
Other languages
English (en)
Inventor
Stephen W Fesik
Philip J Hajduk
Edward T Olejniczak
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27415774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE201768(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/558,633 external-priority patent/US5891643A/en
Priority claimed from US08/744,701 external-priority patent/US5989827A/en
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE201768T1 publication Critical patent/ATE201768T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4633—Sequences for multi-dimensional NMR
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT96939709T 1995-11-14 1996-11-13 Verwendung von kernspinresonanz zur bestimmung von liganden für zielbiomoleküle ATE201768T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/558,633 US5891643A (en) 1995-11-14 1995-11-14 Use of nuclear magnetic resonance to design ligands to target biomolecules
US67890396A 1996-07-12 1996-07-12
US08/744,701 US5989827A (en) 1995-11-14 1996-10-31 Use of nuclear magnetic resonance to design ligands to target biomolecules
PCT/US1996/018312 WO1997018469A2 (en) 1995-11-14 1996-11-13 Use of nuclear magnetic resonance to design ligands to target biomolecules

Publications (1)

Publication Number Publication Date
ATE201768T1 true ATE201768T1 (de) 2001-06-15

Family

ID=27415774

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96939709T ATE201768T1 (de) 1995-11-14 1996-11-13 Verwendung von kernspinresonanz zur bestimmung von liganden für zielbiomoleküle

Country Status (12)

Country Link
EP (1) EP0870197B2 (de)
JP (1) JP3300366B2 (de)
AT (1) ATE201768T1 (de)
AU (1) AU711092B2 (de)
DE (1) DE69613146T3 (de)
DK (1) DK0870197T4 (de)
ES (1) ES2159056T5 (de)
GR (1) GR3036454T3 (de)
IL (1) IL123572A (de)
MX (1) MX9803805A (de)
PT (1) PT870197E (de)
WO (1) WO1997018469A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010004528A1 (en) * 1995-11-14 2001-06-21 Stephen W. Fesik Use of 13c nuclear magnetic resonance to detect binding to target molecules
US6344330B1 (en) 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
CA2337153A1 (en) * 1998-07-21 2000-02-03 Stephen Anderson Linking gene sequence to gene function by three dimensional (3d) protein structure determination
US6333149B1 (en) 1999-06-04 2001-12-25 Triad Biotechnology, Inc. NMR-solve method for rapid identification of bi-ligand drug candidates
US6677160B1 (en) 1999-09-29 2004-01-13 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
US6764858B2 (en) 1999-09-29 2004-07-20 Pharmacia & Upjohn Company Methods for creating a compound library
GB9925677D0 (en) * 1999-10-29 1999-12-29 Pharmacia & Upjohn Spa Use of double-quantum 1H-NMR spectroscopy for the identification of ligands interacting with target biomolecules
CN1411554A (zh) * 2000-02-25 2003-04-16 惠氏公司 利用ms/nmr的基于结构的药物设计方法
JP5129424B2 (ja) 2000-09-27 2013-01-30 ユニヴェルシテイト レイデン リガンドの発見または薬物スクリーニング手段としてのｎｍｒ利用法
US7653490B2 (en) 2001-09-10 2010-01-26 Triad Liquidating Company LLC Nuclear magnetic resonance assembly of chemical entities
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
JP4192078B2 (ja) 2003-11-26 2008-12-03 株式会社日立製作所 核磁気共鳴方法
WO2005073747A1 (ja) * 2004-02-02 2005-08-11 Mitsubishi Chemical Corporation Ｎｍｒシグナル帰属方法
US20090239760A1 (en) 2006-03-14 2009-09-24 University Of Basel Method for the Identification of New Leads for Drug Candidates
CN111373057A (zh) * 2017-09-25 2020-07-03 斯基霍克疗法公司 用于筛选和鉴定剪接调节剂的方法和组合物
CN117912601B (zh) * 2024-01-26 2024-11-01 苏州腾迈医药科技有限公司 分子构象的展示方法及装置、介质

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0557276A1 (de) * 1989-12-29 1993-09-01 University Technologies International Inc. (Uti) Verfahren zur modellierung von tertiärstrukturen von biologisch aktiven liganden einschliesslich ihrer agonisten und antagonisten und neue synthetische antagonisten auf angiotensinbasis
US5393669A (en) * 1993-02-05 1995-02-28 Martek Biosciences Corp. Compositions and methods for protein structural determinations
US8558663B2 (en) † 2007-11-30 2013-10-15 Bank Of America Corporation Integration of facial recognition into cross channel authentication
DE102008042959A1 (de) † 2008-10-20 2010-04-22 Zf Friedrichshafen Ag Verfahren zur Steuerung eines Kraftfahrzeug-Antriebsstrangs
US8678903B1 (en) † 2012-09-13 2014-03-25 Chia-Yen Lin Mobile device having a virtual spin wheel and virtual spin wheel control method of the same

Also Published As

Publication number Publication date
WO1997018469A3 (en) 1997-08-07
WO1997018469A2 (en) 1997-05-22
ES2159056T5 (es) 2007-07-16
DK0870197T4 (da) 2007-02-26
PT870197E (pt) 2001-11-30
GR3036454T3 (en) 2001-11-30
IL123572A0 (en) 1998-10-30
AU711092B2 (en) 1999-10-07
JP3300366B2 (ja) 2002-07-08
EP0870197A2 (de) 1998-10-14
JP2002510384A (ja) 2002-04-02
EP0870197B2 (de) 2006-11-08
DE69613146T2 (de) 2003-01-16
AU7680496A (en) 1997-06-05
MX9803805A (es) 1998-09-30
ES2159056T3 (es) 2001-09-16
EP0870197B1 (de) 2001-05-30
DE69613146D1 (de) 2001-07-05
DE69613146T3 (de) 2007-06-14
DK0870197T3 (da) 2001-08-27
IL123572A (en) 2004-06-01

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