ATE519114T1 - Verfahren zur identifizierung neuer leitverbindungen für arzneistoffkandidaten - Google Patents
Verfahren zur identifizierung neuer leitverbindungen für arzneistoffkandidatenInfo
- Publication number
- ATE519114T1 ATE519114T1 AT07733988T AT07733988T ATE519114T1 AT E519114 T1 ATE519114 T1 AT E519114T1 AT 07733988 T AT07733988 T AT 07733988T AT 07733988 T AT07733988 T AT 07733988T AT E519114 T1 ATE519114 T1 AT E519114T1
- Authority
- AT
- Austria
- Prior art keywords
- ligands
- disclosed
- target
- leads
- synthesis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 229940000406 drug candidate Drugs 0.000 title abstract 2
- 150000002611 lead compounds Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 abstract 6
- 102000017099 Myelin-Associated Glycoprotein Human genes 0.000 abstract 2
- 108010013731 Myelin-Associated Glycoprotein Proteins 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 230000003281 allosteric effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000009509 drug development Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000010791 quenching Methods 0.000 abstract 1
- 230000000171 quenching effect Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000001338 self-assembly Methods 0.000 abstract 1
- 238000001308 synthesis method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
- G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- High Energy & Nuclear Physics (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78210406P | 2006-03-14 | 2006-03-14 | |
| PCT/IB2007/000643 WO2007105094A1 (en) | 2006-03-14 | 2007-03-14 | Method for the identification of new leads for drug candidates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE519114T1 true ATE519114T1 (de) | 2011-08-15 |
Family
ID=38180473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07733988T ATE519114T1 (de) | 2006-03-14 | 2007-03-14 | Verfahren zur identifizierung neuer leitverbindungen für arzneistoffkandidaten |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20090239760A1 (de) |
| EP (1) | EP2013624B1 (de) |
| AT (1) | ATE519114T1 (de) |
| WO (1) | WO2007105094A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2009004899A1 (ja) * | 2007-06-15 | 2010-08-26 | 国立大学法人北海道大学 | シアリダーゼ阻害剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0870197B2 (de) | 1995-11-14 | 2006-11-08 | Abbott Laboratories | Verwendung von kernspinresonanz zur bestimmung von liganden für zielbiomoleküle |
| US5698401A (en) | 1995-11-14 | 1997-12-16 | Abbott Laboratories | Use of nuclear magnetic resonance to identify ligands to target biomolecules |
| EP1130009A1 (de) * | 2000-03-01 | 2001-09-05 | Therascope AG | Erzeugung und Screenen einer dynamischen kombinatorischen Verbindungsbibliothek |
| US7820714B2 (en) * | 2001-06-19 | 2010-10-26 | Sorge Kelm | Siglec inhibitors |
| EP1875239B1 (de) | 2005-04-27 | 2011-10-05 | Siemens Medical Solutions USA, Inc. | Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie |
-
2007
- 2007-03-14 AT AT07733988T patent/ATE519114T1/de not_active IP Right Cessation
- 2007-03-14 EP EP07733988A patent/EP2013624B1/de not_active Not-in-force
- 2007-03-14 WO PCT/IB2007/000643 patent/WO2007105094A1/en not_active Ceased
- 2007-03-14 US US12/282,882 patent/US20090239760A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2013624A1 (de) | 2009-01-14 |
| EP2013624B1 (de) | 2011-08-03 |
| US20090239760A1 (en) | 2009-09-24 |
| WO2007105094A1 (en) | 2007-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |