ATE519114T1 - Verfahren zur identifizierung neuer leitverbindungen für arzneistoffkandidaten - Google Patents

Verfahren zur identifizierung neuer leitverbindungen für arzneistoffkandidaten

Info

Publication number
ATE519114T1
ATE519114T1 AT07733988T AT07733988T ATE519114T1 AT E519114 T1 ATE519114 T1 AT E519114T1 AT 07733988 T AT07733988 T AT 07733988T AT 07733988 T AT07733988 T AT 07733988T AT E519114 T1 ATE519114 T1 AT E519114T1
Authority
AT
Austria
Prior art keywords
ligands
disclosed
target
leads
synthesis
Prior art date
Application number
AT07733988T
Other languages
English (en)
Inventor
Beat Ernst
Brian Cutting
Sachin V Shelke
Original Assignee
Univ Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Basel filed Critical Univ Basel
Application granted granted Critical
Publication of ATE519114T1 publication Critical patent/ATE519114T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/027—Keto-aldonic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT07733988T 2006-03-14 2007-03-14 Verfahren zur identifizierung neuer leitverbindungen für arzneistoffkandidaten ATE519114T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78210406P 2006-03-14 2006-03-14
PCT/IB2007/000643 WO2007105094A1 (en) 2006-03-14 2007-03-14 Method for the identification of new leads for drug candidates

Publications (1)

Publication Number Publication Date
ATE519114T1 true ATE519114T1 (de) 2011-08-15

Family

ID=38180473

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07733988T ATE519114T1 (de) 2006-03-14 2007-03-14 Verfahren zur identifizierung neuer leitverbindungen für arzneistoffkandidaten

Country Status (4)

Country Link
US (1) US20090239760A1 (de)
EP (1) EP2013624B1 (de)
AT (1) ATE519114T1 (de)
WO (1) WO2007105094A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009004899A1 (ja) * 2007-06-15 2009-01-08 National University Corporation Hokkaido University シアリダーゼ阻害剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018469A2 (en) 1995-11-14 1997-05-22 Abbott Laboratories Use of nuclear magnetic resonance to design ligands to target biomolecules
US5698401A (en) 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
EP1130009A1 (de) * 2000-03-01 2001-09-05 Therascope AG Erzeugung und Screenen einer dynamischen kombinatorischen Verbindungsbibliothek
JP2004534085A (ja) * 2001-06-19 2004-11-11 ソージ ケルム シグレック阻害剤
DK1875239T3 (da) 2005-04-27 2012-01-23 Siemens Medical Solutions Fremgangsmåde til fremstilling af billeddannelsessonder under anvendelse af klik-kemi

Also Published As

Publication number Publication date
US20090239760A1 (en) 2009-09-24
EP2013624B1 (de) 2011-08-03
WO2007105094A1 (en) 2007-09-20
EP2013624A1 (de) 2009-01-14

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties