IL123567A - History of 2 quinolones inhibiting frenzyl transferase, the process for their preparation and the pharmaceutical preparations containing them - Google Patents

History of 2 quinolones inhibiting frenzyl transferase, the process for their preparation and the pharmaceutical preparations containing them

Info

Publication number
IL123567A
IL123567A IL12356796A IL12356796A IL123567A IL 123567 A IL123567 A IL 123567A IL 12356796 A IL12356796 A IL 12356796A IL 12356796 A IL12356796 A IL 12356796A IL 123567 A IL123567 A IL 123567A
Authority
IL
Israel
Prior art keywords
alkyl
formula
compound
hydrogen
alkyloxy
Prior art date
Application number
IL12356796A
Other languages
English (en)
Hebrew (he)
Other versions
IL123567A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL123567A0 publication Critical patent/IL123567A0/xx
Publication of IL123567A publication Critical patent/IL123567A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL12356796A 1995-10-31 1996-10-25 History of 2 quinolones inhibiting frenzyl transferase, the process for their preparation and the pharmaceutical preparations containing them IL123567A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95202945 1995-10-31
PCT/EP1996/004661 WO1997016443A1 (en) 1995-10-31 1996-10-25 Farnesyl transferase inhibiting 2-quinolone derivatives

Publications (2)

Publication Number Publication Date
IL123567A0 IL123567A0 (en) 1998-10-30
IL123567A true IL123567A (en) 2002-11-10

Family

ID=8220785

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12356796A IL123567A (en) 1995-10-31 1996-10-25 History of 2 quinolones inhibiting frenzyl transferase, the process for their preparation and the pharmaceutical preparations containing them

Country Status (28)

Country Link
US (1) US5968952A (cs)
EP (2) EP1106610B1 (cs)
JP (1) JP4257869B2 (cs)
KR (1) KR100417620B1 (cs)
CN (1) CN1101391C (cs)
AR (1) AR004699A1 (cs)
AT (2) ATE212627T1 (cs)
AU (1) AU712435B2 (cs)
CA (1) CA2231143C (cs)
CY (1) CY2287B1 (cs)
CZ (1) CZ290954B6 (cs)
DE (2) DE69618999T2 (cs)
DK (1) DK1019395T3 (cs)
EA (1) EA000719B1 (cs)
ES (2) ES2171736T3 (cs)
HU (1) HU224032B1 (cs)
IL (1) IL123567A (cs)
MY (1) MY116577A (cs)
NO (1) NO314037B1 (cs)
NZ (1) NZ321576A (cs)
PL (1) PL184168B1 (cs)
PT (1) PT1019395E (cs)
SI (1) SI1019395T1 (cs)
SK (1) SK282642B6 (cs)
TR (1) TR199800720T2 (cs)
TW (1) TW349948B (cs)
WO (1) WO1997016443A1 (cs)
ZA (1) ZA969087B (cs)

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CA2335435A1 (en) * 1998-06-16 1999-12-23 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Imidazolyl derivatives
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CN1152716C (zh) 1998-07-06 2004-06-09 詹森药业有限公司 具体内射线感受性的法呢基蛋白质转移酶抑制剂
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DE69923849T2 (de) * 1998-08-27 2006-01-12 Pfizer Products Inc., Groton Quinolin-2-on-derivate verwendbar als antikrebsmittel
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US6284755B1 (en) 1998-12-08 2001-09-04 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US6316436B1 (en) 1998-12-08 2001-11-13 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
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CA2397240A1 (en) * 2000-02-29 2001-09-07 Peter Albert Palmer Farnesyl protein transferase inhibitor combinations with camptothecin compounds
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JP2003525239A (ja) * 2000-02-29 2003-08-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ タキサン化合物とのファルネシルタンパク質トランスフェラーゼ阻害剤の組み合わせ剤
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US20030027808A1 (en) * 2000-02-29 2003-02-06 Palmer Peter Albert Farnesyl protein transferase inhibitor combinations with platinum compounds
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US6844357B2 (en) * 2000-05-01 2005-01-18 Pfizer Inc. Substituted quinolin-2-one derivatives useful as antiproliferative agents
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ATE434615T1 (de) * 2000-11-21 2009-07-15 Janssen Pharmaceutica Nv Farnesyltransferase hemmende benzoheterocyclische derivate
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Also Published As

Publication number Publication date
AR004699A1 (es) 1999-03-10
ZA969087B (en) 1998-04-29
NO980928L (no) 1998-04-29
DE69618999T2 (de) 2002-09-26
HK1027576A1 (en) 2001-01-19
AU7493396A (en) 1997-05-22
EP1106610B1 (en) 2004-06-16
KR19990063639A (ko) 1999-07-26
CZ290954B6 (cs) 2002-11-13
MX9802067A (es) 1998-08-30
NO980928D0 (no) 1998-03-04
TR199800720T2 (xx) 1998-09-21
EP1019395B1 (en) 2002-01-30
ES2171736T3 (es) 2002-09-16
HUP9802424A3 (en) 2003-02-28
CA2231143A1 (en) 1997-05-09
ATE269322T1 (de) 2004-07-15
DK1019395T3 (da) 2002-05-06
JPH11514635A (ja) 1999-12-14
NO314037B1 (no) 2003-01-20
SK282642B6 (sk) 2002-10-08
SK55698A3 (en) 1999-02-11
HUP9802424A2 (hu) 1999-10-28
TW349948B (en) 1999-01-11
CN1200732A (zh) 1998-12-02
KR100417620B1 (ko) 2004-05-27
DE69618999D1 (de) 2002-03-14
CZ127298A3 (cs) 1998-12-16
DE69632751D1 (de) 2004-07-22
EA000719B1 (ru) 2000-02-28
EP1106610A1 (en) 2001-06-13
CN1101391C (zh) 2003-02-12
CY2287B1 (en) 2003-07-04
PL184168B1 (pl) 2002-09-30
HK1036064A1 (en) 2001-12-21
PT1019395E (pt) 2002-07-31
SI1019395T1 (en) 2002-06-30
IL123567A0 (en) 1998-10-30
EP1019395A1 (en) 2000-07-19
EA199800395A1 (ru) 1998-10-29
JP4257869B2 (ja) 2009-04-22
PL328230A1 (en) 1999-01-18
HU224032B1 (hu) 2005-05-30
CA2231143C (en) 2005-06-21
US5968952A (en) 1999-10-19
NZ321576A (en) 1999-05-28
AU712435B2 (en) 1999-11-04
WO1997016443A1 (en) 1997-05-09
ES2233557T3 (es) 2005-06-16
ATE212627T1 (de) 2002-02-15
DE69632751T2 (de) 2005-08-04
MY116577A (en) 2004-02-28

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