IL121599A - Process for making paclitaxel - Google Patents

Process for making paclitaxel

Info

Publication number
IL121599A
IL121599A IL12159997A IL12159997A IL121599A IL 121599 A IL121599 A IL 121599A IL 12159997 A IL12159997 A IL 12159997A IL 12159997 A IL12159997 A IL 12159997A IL 121599 A IL121599 A IL 121599A
Authority
IL
Israel
Prior art keywords
formula
acid
group
trihaloacetyl
solvent
Prior art date
Application number
IL12159997A
Other languages
English (en)
Hebrew (he)
Other versions
IL121599A0 (en
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of IL121599A0 publication Critical patent/IL121599A0/xx
Publication of IL121599A publication Critical patent/IL121599A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL12159997A 1996-08-27 1997-08-21 Process for making paclitaxel IL121599A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR19960035754 1996-08-27

Publications (2)

Publication Number Publication Date
IL121599A0 IL121599A0 (en) 1998-02-08
IL121599A true IL121599A (en) 2004-06-20

Family

ID=19470938

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12159997A IL121599A (en) 1996-08-27 1997-08-21 Process for making paclitaxel

Country Status (17)

Country Link
US (1) US6130336A (ko)
EP (1) EP0923565B1 (ko)
JP (1) JP3294280B2 (ko)
KR (1) KR100225535B1 (ko)
AR (1) AR009349A1 (ko)
AT (1) ATE208383T1 (ko)
AU (1) AU3953297A (ko)
DE (1) DE69708126T2 (ko)
DK (1) DK0923565T3 (ko)
ES (1) ES2167777T3 (ko)
ID (1) ID19799A (ko)
IL (1) IL121599A (ko)
PT (1) PT923565E (ko)
TR (1) TR199700863A2 (ko)
WO (1) WO1998008832A1 (ko)
YU (1) YU35997A (ko)
ZA (1) ZA977596B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
IT1308636B1 (it) * 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
DK1854799T3 (da) * 2006-05-12 2011-07-18 Indena Spa Fremgangsmåde til fremstilling af et taxanderivat
WO2016098015A1 (en) * 2014-12-16 2016-06-23 Khashayar Karimian New efficient methods for the synthesis of taxane derivatives such as docetaxel and their structural analogous, and a method for the preparation thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948919A (en) * 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
US5675025A (en) * 1995-06-07 1997-10-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
KR20000010861A (ko) * 1996-05-08 2000-02-25 로렌스 티. 마이젠헬더 탁솔의 제조 방법
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels

Also Published As

Publication number Publication date
DE69708126D1 (de) 2001-12-13
TR199700863A3 (tr) 1999-10-21
EP0923565B1 (en) 2001-11-07
DE69708126T2 (de) 2002-07-11
WO1998008832A1 (en) 1998-03-05
ES2167777T3 (es) 2002-05-16
PT923565E (pt) 2002-04-29
AR009349A1 (es) 2000-04-12
IL121599A0 (en) 1998-02-08
ZA977596B (en) 1998-04-06
EP0923565A1 (en) 1999-06-23
DK0923565T3 (da) 2001-12-27
JP2000501425A (ja) 2000-02-08
TR199700863A2 (xx) 1999-10-21
KR100225535B1 (ko) 1999-10-15
JP3294280B2 (ja) 2002-06-24
ATE208383T1 (de) 2001-11-15
YU35997A (sh) 1999-09-27
KR19980018801A (ko) 1998-06-05
US6130336A (en) 2000-10-10
AU3953297A (en) 1998-03-19
ID19799A (id) 1998-08-06

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees