IL121590A - Phenyl-substituted alkenylcarboxylic acid guanidines, process for their preparation, and pharmaceutical compositions containing them - Google Patents
Phenyl-substituted alkenylcarboxylic acid guanidines, process for their preparation, and pharmaceutical compositions containing themInfo
- Publication number
- IL121590A IL121590A IL12159097A IL12159097A IL121590A IL 121590 A IL121590 A IL 121590A IL 12159097 A IL12159097 A IL 12159097A IL 12159097 A IL12159097 A IL 12159097A IL 121590 A IL121590 A IL 121590A
- Authority
- IL
- Israel
- Prior art keywords
- zero
- substituted
- alkyl
- bis
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19633966A DE19633966A1 (de) | 1996-08-22 | 1996-08-22 | Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (2)
Publication Number | Publication Date |
---|---|
IL121590A0 IL121590A0 (en) | 1998-02-08 |
IL121590A true IL121590A (en) | 2002-05-23 |
Family
ID=7803413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12159097A IL121590A (en) | 1996-08-22 | 1997-08-21 | Phenyl-substituted alkenylcarboxylic acid guanidines, process for their preparation, and pharmaceutical compositions containing them |
Country Status (29)
Country | Link |
---|---|
US (1) | US6005010A (ru) |
EP (1) | EP0825178B1 (ru) |
JP (1) | JP4081159B2 (ru) |
KR (1) | KR19980018898A (ru) |
CN (1) | CN1065861C (ru) |
AR (1) | AR008305A1 (ru) |
AT (1) | ATE202338T1 (ru) |
AU (1) | AU713664B2 (ru) |
BR (1) | BR9704483A (ru) |
CA (1) | CA2213714C (ru) |
CZ (1) | CZ265997A3 (ru) |
DE (2) | DE19633966A1 (ru) |
DK (1) | DK0825178T3 (ru) |
ES (1) | ES2158413T3 (ru) |
GR (1) | GR3036123T3 (ru) |
HR (1) | HRP970450B1 (ru) |
HU (1) | HUP9701416A3 (ru) |
ID (1) | ID18066A (ru) |
IL (1) | IL121590A (ru) |
MX (1) | MX9706380A (ru) |
NO (1) | NO309468B1 (ru) |
NZ (1) | NZ328639A (ru) |
PL (1) | PL321748A1 (ru) |
PT (1) | PT825178E (ru) |
RU (1) | RU2193026C2 (ru) |
SI (1) | SI0825178T1 (ru) |
SK (1) | SK282632B6 (ru) |
TR (1) | TR199700827A2 (ru) |
ZA (1) | ZA977494B (ru) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19849722A1 (de) * | 1998-10-28 | 2000-05-04 | Aventis Pharma Gmbh | Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
WO2000067756A1 (en) * | 1999-05-07 | 2000-11-16 | The Trustees Of The Universtiy Of Pennsylvania | Methods for controlling intraocular pressure |
DE19960204A1 (de) * | 1999-12-14 | 2001-06-28 | Aventis Pharma Gmbh | Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE10015248A1 (de) * | 2000-03-28 | 2001-10-04 | Merck Patent Gmbh | Bisamidino-Verbindungen als NHE-3 Inhibitoren |
DE10046993A1 (de) * | 2000-09-22 | 2002-04-11 | Aventis Pharma Gmbh | Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament |
DE10063294A1 (de) | 2000-12-19 | 2002-07-04 | Aventis Pharma Gmbh | Substituierte Heterocyclo-Norbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE10161767A1 (de) * | 2001-12-15 | 2003-06-26 | Merck Patent Gmbh | 2-Guanidino-4-heterocyclyl-chinazoline |
US20030187045A1 (en) * | 2001-12-21 | 2003-10-02 | Uwe Heinelt | Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic |
DE10163239A1 (de) * | 2001-12-21 | 2003-07-10 | Aventis Pharma Gmbh | Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament |
US7049333B2 (en) | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
DE10304374A1 (de) * | 2003-02-04 | 2004-08-05 | Aventis Pharma Deutschland Gmbh | Neue substituierte 2-Aminoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US20050054705A1 (en) * | 2003-02-04 | 2005-03-10 | Aventis Pharma Deutschland Gmbh | N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them |
DE10341240A1 (de) | 2003-09-08 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Substituierte Thienoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE102005001411A1 (de) | 2005-01-12 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
WO2009006066A2 (en) | 2007-06-28 | 2009-01-08 | Sanofi-Aventis U.S. Llc | Process for the preparation of benzimidazol thienylamine compounds and intermediates thereof |
TWI471654B (zh) * | 2007-10-26 | 2015-02-01 | Jsr Corp | A liquid crystal alignment agent, a liquid crystal alignment film, and a liquid crystal display device |
AU2009289846B2 (en) | 2008-09-02 | 2014-10-16 | Sanofi-Aventis | Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
JP5502106B2 (ja) | 2008-12-31 | 2014-05-28 | アーデリクス,インコーポレーテッド | 体液貯留または塩分過負荷と関連する障害および消化管障害の治療におけるnhe媒介性アンチポートを阻害するための組成物および方法 |
US20120088737A2 (en) * | 2009-10-02 | 2012-04-12 | Ajinomoto Co., Inc | Novel acyl guanidine derivatives |
CA2880338A1 (en) | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
CA2909169A1 (en) | 2013-04-12 | 2014-10-16 | Ardelyx, Inc. | Nhe3-binding compounds and methods for inhibiting phosphate transport |
MX2019008171A (es) | 2017-01-09 | 2020-02-05 | Ardelyx Inc | Inhibidores del antiporte mediado por nhe. |
UA126283C2 (uk) | 2017-01-09 | 2022-09-14 | Арделікс, Інк. | Сполуки, придатні для лікування розладів шлунково-кишкового тракту |
EP4397366A2 (en) | 2017-08-04 | 2024-07-10 | Ardelyx, Inc. | Glycyrrhetinic acid derivatives for treating hyperkalemia |
CA3129233A1 (en) | 2019-02-07 | 2020-08-13 | Ardelyx, Inc. | Glycyrrhetinic acid derivatives for use in treating hyperkalemia |
JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス, インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4544670A (en) * | 1982-08-24 | 1985-10-01 | William H. Rorer, Inc. | Method of treating coccidiosis with acyl guanidines |
DE4328352A1 (de) * | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4421536A1 (de) * | 1994-06-20 | 1995-12-21 | Hoechst Ag | Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1996
- 1996-08-22 DE DE19633966A patent/DE19633966A1/de not_active Withdrawn
-
1997
- 1997-08-18 DE DE59703851T patent/DE59703851D1/de not_active Expired - Lifetime
- 1997-08-18 PT PT97114244T patent/PT825178E/pt unknown
- 1997-08-18 SI SI9730153T patent/SI0825178T1/xx unknown
- 1997-08-18 ES ES97114244T patent/ES2158413T3/es not_active Expired - Lifetime
- 1997-08-18 AT AT97114244T patent/ATE202338T1/de not_active IP Right Cessation
- 1997-08-18 DK DK97114244T patent/DK0825178T3/da active
- 1997-08-18 EP EP97114244A patent/EP0825178B1/de not_active Expired - Lifetime
- 1997-08-19 HU HU9701416A patent/HUP9701416A3/hu unknown
- 1997-08-20 AR ARP970103787A patent/AR008305A1/es unknown
- 1997-08-20 TR TR97/00827A patent/TR199700827A2/xx unknown
- 1997-08-20 NZ NZ328639A patent/NZ328639A/xx unknown
- 1997-08-20 CZ CZ972659A patent/CZ265997A3/cs unknown
- 1997-08-20 US US08/915,329 patent/US6005010A/en not_active Expired - Lifetime
- 1997-08-20 CN CN97117484A patent/CN1065861C/zh not_active Expired - Fee Related
- 1997-08-20 SK SK1138-97A patent/SK282632B6/sk unknown
- 1997-08-21 HR HR970450A patent/HRP970450B1/xx not_active IP Right Cessation
- 1997-08-21 AU AU35192/97A patent/AU713664B2/en not_active Ceased
- 1997-08-21 IL IL12159097A patent/IL121590A/en not_active IP Right Cessation
- 1997-08-21 MX MX9706380A patent/MX9706380A/es not_active IP Right Cessation
- 1997-08-21 ID IDP972923A patent/ID18066A/id unknown
- 1997-08-21 ZA ZA9707494A patent/ZA977494B/xx unknown
- 1997-08-21 JP JP22461397A patent/JP4081159B2/ja not_active Expired - Fee Related
- 1997-08-21 NO NO973850A patent/NO309468B1/no not_active IP Right Cessation
- 1997-08-21 RU RU97114306/04A patent/RU2193026C2/ru not_active IP Right Cessation
- 1997-08-22 PL PL97321748A patent/PL321748A1/xx unknown
- 1997-08-22 KR KR1019970040115A patent/KR19980018898A/ko not_active Application Discontinuation
- 1997-08-22 CA CA002213714A patent/CA2213714C/en not_active Expired - Fee Related
- 1997-08-22 BR BR9704483A patent/BR9704483A/pt active Search and Examination
-
2001
- 2001-06-27 GR GR20010400976T patent/GR3036123T3/el not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |