IL119586A - Discontinuous library of a single biological unit and a method for its preparation - Google Patents
Discontinuous library of a single biological unit and a method for its preparationInfo
- Publication number
- IL119586A IL119586A IL11958696A IL11958696A IL119586A IL 119586 A IL119586 A IL 119586A IL 11958696 A IL11958696 A IL 11958696A IL 11958696 A IL11958696 A IL 11958696A IL 119586 A IL119586 A IL 119586A
- Authority
- IL
- Israel
- Prior art keywords
- fragments
- library
- discontinuous
- organism
- genome
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11958696A IL119586A (en) | 1996-11-07 | 1996-11-07 | Discontinuous library of a single biological unit and a method for its preparation |
EP97910607A EP1012347A4 (fr) | 1996-11-07 | 1997-11-04 | Definition et gestion d'interactions bimoleculaires |
US09/297,668 US6984488B1 (en) | 1996-11-07 | 1997-11-04 | Determination and control of bimolecular interactions |
AU47928/97A AU4792897A (en) | 1996-11-07 | 1997-11-04 | Determination and control of bimolecular interactions |
PCT/IL1997/000353 WO1998020169A1 (fr) | 1996-11-07 | 1997-11-04 | Definition et gestion d'interactions bimoleculaires |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11958696A IL119586A (en) | 1996-11-07 | 1996-11-07 | Discontinuous library of a single biological unit and a method for its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
IL119586A0 IL119586A0 (en) | 1997-02-18 |
IL119586A true IL119586A (en) | 2001-09-13 |
Family
ID=11069461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11958696A IL119586A (en) | 1996-11-07 | 1996-11-07 | Discontinuous library of a single biological unit and a method for its preparation |
Country Status (5)
Country | Link |
---|---|
US (1) | US6984488B1 (fr) |
EP (1) | EP1012347A4 (fr) |
AU (1) | AU4792897A (fr) |
IL (1) | IL119586A (fr) |
WO (1) | WO1998020169A1 (fr) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2334170A1 (fr) | 1998-07-27 | 2000-02-10 | Genentech, Inc. | Efficacite de transformation amelioree de l'expression a la surface des phages par modification d'une proteine de coque |
US20070160576A1 (en) | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
KR100576674B1 (ko) | 2001-06-20 | 2006-05-10 | 제넨테크, 인크. | 종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물 |
ATE516042T1 (de) | 2001-09-18 | 2011-07-15 | Genentech Inc | Zusammensetzungen und verfahren zur behandlung und diagnose von tumoren |
NZ556415A (en) | 2002-01-02 | 2009-02-28 | Genentech Inc | Compositions and methods for the diagnosis and treatment of glioma tumor |
AU2003230874A1 (en) | 2002-04-16 | 2003-11-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
AU2004259638C1 (en) | 2003-07-08 | 2018-12-20 | Novartis Pharma Ag | IL-17 A/F heterologous polypeptides and therapeutic uses thereof |
US7329725B1 (en) | 2003-10-29 | 2008-02-12 | Nastech Pharmaceutical Company Inc. | Phage displayed Trp cage ligands |
NZ576411A (en) | 2003-11-17 | 2010-04-30 | Genentech Inc | Compositions and methods for the treatment of tumor of hematopoietic origin |
EP2050763A3 (fr) | 2005-03-10 | 2009-07-15 | Genentech, Inc. | Procédés et compositions de modulation d'intégrité vasculaire |
EP2007428A2 (fr) | 2006-04-05 | 2008-12-31 | Genentech, Inc. | Méthode d'utilisation du boc/cdo pour moduler l'émission des signaux du hedgehog |
AU2007284651B2 (en) | 2006-08-09 | 2014-03-20 | Institute For Systems Biology | Organ-specific proteins and methods of their use |
JPWO2008032833A1 (ja) | 2006-09-14 | 2010-01-28 | 株式会社医学生物学研究所 | Adcc活性を増強させた抗体及びその製造方法 |
EP2118124A1 (fr) * | 2006-12-28 | 2009-11-18 | Saint Louis University | Identification des epitopes de proteines d'enveloppe virale multivalents |
DK2436781T3 (en) | 2007-02-22 | 2016-01-11 | Genentech Inc | Methods for the detection of inflammatory bowel disease |
EP2319869B1 (fr) | 2008-06-20 | 2016-08-17 | National University Corporation Okayama University | ANTICORPS CONTRE UN COMPLEXE LDL/ß²GPT OXIDÉ ET SON UTILISATION |
US9182406B2 (en) | 2008-08-04 | 2015-11-10 | Biodesy, Inc. | Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability |
CN102711826B (zh) | 2009-10-22 | 2017-03-29 | 霍夫曼-拉罗奇有限公司 | 用于调控巨噬细胞刺激性蛋白的hepsin活化的方法和组合物 |
JP5856065B2 (ja) | 2009-11-30 | 2016-02-09 | ジェネンテック, インコーポレイテッド | 腫瘍の診断と治療のための組成物と方法 |
CN102985113B (zh) | 2010-02-23 | 2015-05-20 | 霍夫曼-拉罗奇有限公司 | 用于肿瘤诊断和治疗的组合物和方法 |
JP2013533732A (ja) | 2010-05-03 | 2013-08-29 | ジェネンテック, インコーポレイテッド | 腫瘍の診断と治療のための組成物と方法 |
US9428789B2 (en) | 2011-03-21 | 2016-08-30 | Biodesy, Inc. | Classification of kinase inhibitors using nonlinear optical techniques |
EP2756300A1 (fr) | 2011-09-15 | 2014-07-23 | F.Hoffmann-La Roche Ag | Procédés de promotion de la différenciation |
CA2850836A1 (fr) | 2011-10-15 | 2013-04-18 | Genentech, Inc. | Procedes d'utilisation d'antagonistes de scd1 |
WO2013109856A2 (fr) | 2012-01-18 | 2013-07-25 | Genentech, Inc. | Procédés d'utilisation de modulateurs fgf19 |
RU2014133069A (ru) | 2012-02-11 | 2016-04-10 | Дженентек, Инк. | Транслокации r-спондина и способы с их использованием |
RU2014141617A (ru) | 2012-03-16 | 2016-05-10 | Дженентек, Инк. | Сконструированные конформационно-стабилизированные белки |
US9139863B2 (en) | 2012-03-16 | 2015-09-22 | Genentech, Inc. | Engineered conformationally-stabilized proteins |
WO2013135745A1 (fr) | 2012-03-16 | 2013-09-19 | F. Hoffmann-La Roche Ag | Procédés de traitement d'un mélanome avec des inhibiteurs de pak1 |
CN106290917B (zh) | 2012-04-25 | 2020-06-05 | 比奥德赛公司 | 用于检测蛋白质的变构调节剂的方法 |
WO2013170191A1 (fr) | 2012-05-11 | 2013-11-14 | Genentech, Inc. | Procédés d'utilisation d'antagonistes de biosynthèse de nicotinamide adénine dinucléotide à partir de nicotinamide |
AU2014235453A1 (en) | 2013-03-15 | 2015-10-08 | Genentech, Inc. | Biomarkers and methods of treating PD-1 and PD-L1 related conditions |
WO2015116902A1 (fr) | 2014-01-31 | 2015-08-06 | Genentech, Inc. | Récepteurs couplés aux protéines g dans la signalisation hedgehog |
CN106661622B (zh) | 2014-05-23 | 2020-08-21 | 豪夫迈·罗氏有限公司 | Mit生物标志物和使用它们的方法 |
WO2015196070A1 (fr) | 2014-06-20 | 2015-12-23 | Genentech, Inc. | Compositions d'échafaudage à base de chagasine, procédés et utilisations |
WO2016106286A1 (fr) | 2014-12-23 | 2016-06-30 | Biodesy, Inc. | Fixation de protéines à des interfaces destinées à être utilisées en détection optique non linéaire |
CN107787332B (zh) | 2015-04-24 | 2022-09-09 | 豪夫迈·罗氏有限公司 | 多特异性抗原结合蛋白 |
US11421028B2 (en) | 2016-02-06 | 2022-08-23 | Epimab Biotherapeutics, Inc. | Fabs-in-tandem immunoglobulin and uses thereof |
WO2018049275A1 (fr) | 2016-09-09 | 2018-03-15 | Genentech, Inc. | Inhibiteurs peptidiques sélectifs de frizzled |
WO2018152496A1 (fr) | 2017-02-17 | 2018-08-23 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Compositions et méthodes de diagnostic et de traitement de l'infection par le virus zika |
WO2018200742A1 (fr) | 2017-04-25 | 2018-11-01 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Anticorps et procédés de diagnostic et de traitement d'infection par le virus d'epstein barr |
WO2019018629A1 (fr) | 2017-07-19 | 2019-01-24 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Anticorps et procédés de diagnostic et de traitement d'infection par le virus de l'hépatite b |
CN112074541A (zh) | 2018-05-03 | 2020-12-11 | 上海岸迈生物科技有限公司 | Pd-1和lag-3的高亲和力抗体以及由其制备的双特异性结合蛋白 |
AU2020268399A1 (en) | 2019-05-09 | 2021-10-28 | Genentech, Inc. | Methods of making antibodies |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5691170A (en) * | 1989-04-18 | 1997-11-25 | Therion Biologics | Generation of hybrid genes and proteins by virus-mediated recombination |
US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US6031071A (en) * | 1996-01-24 | 2000-02-29 | Biophage, Inc. | Methods of generating novel peptides |
JPH1066577A (ja) * | 1996-08-07 | 1998-03-10 | Novo Nordisk As | 核酸プールおよびその製造方法 |
-
1996
- 1996-11-07 IL IL11958696A patent/IL119586A/en not_active IP Right Cessation
-
1997
- 1997-11-04 WO PCT/IL1997/000353 patent/WO1998020169A1/fr not_active Application Discontinuation
- 1997-11-04 US US09/297,668 patent/US6984488B1/en not_active Expired - Fee Related
- 1997-11-04 EP EP97910607A patent/EP1012347A4/fr not_active Withdrawn
- 1997-11-04 AU AU47928/97A patent/AU4792897A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1012347A4 (fr) | 2005-03-16 |
WO1998020169A1 (fr) | 1998-05-14 |
AU4792897A (en) | 1998-05-29 |
US6984488B1 (en) | 2006-01-10 |
EP1012347A1 (fr) | 2000-06-28 |
IL119586A0 (en) | 1997-02-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
KB | Patent renewed | ||
HC | Change of name of proprietor(s) |
Owner name: RAMOT AT TEL-AVIV UNIVERSITY LTD. Free format text: FORMER NAMES:RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH AND INDUSTRIAL;DEVELOPMENT LTD. |
|
MM9K | Patent not in force due to non-payment of renewal fees |