IL119586A - Discontinuous library of a single biological unit and a method for its preparation - Google Patents

Discontinuous library of a single biological unit and a method for its preparation

Info

Publication number
IL119586A
IL119586A IL11958696A IL11958696A IL119586A IL 119586 A IL119586 A IL 119586A IL 11958696 A IL11958696 A IL 11958696A IL 11958696 A IL11958696 A IL 11958696A IL 119586 A IL119586 A IL 119586A
Authority
IL
Israel
Prior art keywords
fragments
library
discontinuous
organism
genome
Prior art date
Application number
IL11958696A
Other languages
English (en)
Other versions
IL119586A0 (en
Inventor
Jonathan M Gershoni
David Enshel
Original Assignee
Univ Ramot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot filed Critical Univ Ramot
Priority to IL11958696A priority Critical patent/IL119586A/en
Publication of IL119586A0 publication Critical patent/IL119586A0/xx
Priority to US09/297,668 priority patent/US6984488B1/en
Priority to AU47928/97A priority patent/AU4792897A/en
Priority to PCT/IL1997/000353 priority patent/WO1998020169A1/fr
Priority to EP97910607A priority patent/EP1012347A4/fr
Publication of IL119586A publication Critical patent/IL119586A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
IL11958696A 1996-11-07 1996-11-07 Discontinuous library of a single biological unit and a method for its preparation IL119586A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IL11958696A IL119586A (en) 1996-11-07 1996-11-07 Discontinuous library of a single biological unit and a method for its preparation
US09/297,668 US6984488B1 (en) 1996-11-07 1997-11-04 Determination and control of bimolecular interactions
AU47928/97A AU4792897A (en) 1996-11-07 1997-11-04 Determination and control of bimolecular interactions
PCT/IL1997/000353 WO1998020169A1 (fr) 1996-11-07 1997-11-04 Definition et gestion d'interactions bimoleculaires
EP97910607A EP1012347A4 (fr) 1996-11-07 1997-11-04 Definition et gestion d'interactions bimoleculaires

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11958696A IL119586A (en) 1996-11-07 1996-11-07 Discontinuous library of a single biological unit and a method for its preparation

Publications (2)

Publication Number Publication Date
IL119586A0 IL119586A0 (en) 1997-02-18
IL119586A true IL119586A (en) 2001-09-13

Family

ID=11069461

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11958696A IL119586A (en) 1996-11-07 1996-11-07 Discontinuous library of a single biological unit and a method for its preparation

Country Status (5)

Country Link
US (1) US6984488B1 (fr)
EP (1) EP1012347A4 (fr)
AU (1) AU4792897A (fr)
IL (1) IL119586A (fr)
WO (1) WO1998020169A1 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2334170A1 (fr) 1998-07-27 2000-02-10 Genentech, Inc. Efficacite de transformation amelioree de l'expression a la surface des phages par modification d'une proteine de coque
US20070160576A1 (en) 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
US20030148408A1 (en) 2001-09-18 2003-08-07 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
KR100576674B1 (ko) 2001-06-20 2006-05-10 제넨테크, 인크. 종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물
KR100801388B1 (ko) 2002-01-02 2008-02-05 제넨테크, 인크. 종양의 진단 및 치료 방법 및 이를 위한 조성물
MXPA04010092A (es) 2002-04-16 2004-12-13 Genentech Inc Composiciones y metodos para el diagnostico y tratamiento de tumores.
PL1641822T3 (pl) 2003-07-08 2013-10-31 Genentech Inc Heterologiczne polipeptydy IL-17 A/F i ich zastosowania terapeutyczne
US7329725B1 (en) 2003-10-29 2008-02-12 Nastech Pharmaceutical Company Inc. Phage displayed Trp cage ligands
PT2161283E (pt) 2003-11-17 2014-08-29 Genentech Inc Composições que compreendem anticorpos contra cd79b conjugados a um agente de inibição do crescimento ou agente citotóxico e métodos para o tratamento de tumor de origem hematopoiética
MX2007010922A (es) 2005-03-10 2007-10-12 Genentech Inc Metodos y composiciones para modular la integridad vascular.
EP2614839A3 (fr) 2006-04-05 2015-01-28 Genentech, Inc. Méthode d'utilisation du BOC/CDO pour moduler l'émission des signaux du hedgehog
WO2008021290A2 (fr) 2006-08-09 2008-02-21 Homestead Clinical Corporation Protéines spécifiques d'organes et procédés d'utilisation
US20100297103A1 (en) 2006-09-14 2010-11-25 Medical & Biological Laboratories Co., Ltd. Antibody having enhanced adcc activity and method for production thereof
WO2008083203A1 (fr) * 2006-12-28 2008-07-10 Saint Louis University Identification des épitopes de protéines d'enveloppe virale multivalents
US7875431B2 (en) 2007-02-22 2011-01-25 Genentech, Inc. Methods for detecting inflammatory bowel disease
CA2728473A1 (fr) 2008-06-20 2009-12-23 National University Corporation Okayama University Anticorps contre un complexe ldl/.beta.2gpi oxyde et son utilisation
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
WO2011050194A1 (fr) 2009-10-22 2011-04-28 Genentech, Inc. Procédés et compositions pour moduler l'activation d'hepsine d'une protéine de stimulation de macrophage
JP5856065B2 (ja) 2009-11-30 2016-02-09 ジェネンテック， インコーポレイテッド 腫瘍の診断と治療のための組成物と方法
JP5988436B2 (ja) 2010-02-23 2016-09-07 ジェネンテック， インコーポレイテッド 腫瘍の診断と治療のための組成物と方法
KR20130079384A (ko) 2010-05-03 2013-07-10 제넨테크, 인크. 종양의 진단 및 치료를 위한 조성물 및 방법
CA2831136A1 (fr) 2011-03-21 2012-09-27 Biodesy, Llc Classification d'inhibiteurs de kinase a l'aide de techniques optiques non lineaires
JP2014533927A (ja) 2011-09-15 2014-12-18 ジェネンテック， インコーポレイテッド 分化を促進する方法
CA2850836A1 (fr) 2011-10-15 2013-04-18 Genentech, Inc. Procedes d'utilisation d'antagonistes de scd1
CN104168920A (zh) 2012-01-18 2014-11-26 霍夫曼-拉罗奇有限公司 使用fgf19调控剂的方法
US20130209473A1 (en) 2012-02-11 2013-08-15 Genentech, Inc. R-spondin translocations and methods using the same
WO2013137920A1 (fr) 2012-03-16 2013-09-19 Genentech, Inc. Protéines synthétiques stabilisées du point de vue conformationnel
BR112014020173A8 (pt) 2012-03-16 2017-07-11 Hoffmann La Roche Métodos para o tratamento de um melanoma, utilizações de um inibidor, composições, conjunto, método de inibição, método de identificação, método de ajuste do tratamento e invenção
US9139863B2 (en) 2012-03-16 2015-09-22 Genentech, Inc. Engineered conformationally-stabilized proteins
EP2841951B1 (fr) 2012-04-25 2019-12-11 Biodesy, Inc. Procédés de détection de modulateurs allostériques de protéines
WO2013170191A1 (fr) 2012-05-11 2013-11-14 Genentech, Inc. Procédés d'utilisation d'antagonistes de biosynthèse de nicotinamide adénine dinucléotide à partir de nicotinamide
KR102158924B1 (ko) 2013-03-15 2020-09-22 제넨테크, 인크. Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법
WO2015116902A1 (fr) 2014-01-31 2015-08-06 Genentech, Inc. Récepteurs couplés aux protéines g dans la signalisation hedgehog
KR20170005016A (ko) 2014-05-23 2017-01-11 제넨테크, 인크. MiT 바이오마커 및 그의 사용 방법
CN114057857A (zh) 2014-06-20 2022-02-18 豪夫迈·罗氏有限公司 基于chagasin的支架组合物、方法和应用
EP3237906B8 (fr) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Fixation de protéines à des interfaces destinées à être utilisées en détection optique non linéaire
JP6952605B2 (ja) 2015-04-24 2021-10-20 ジェネンテック， インコーポレイテッド 多特異性抗原結合タンパク質
CA3011746A1 (fr) 2016-02-06 2017-08-10 Epimab Biotherapeutics, Inc. Technologie fit-immunoglobuline et ses utilisations
WO2018049275A1 (fr) 2016-09-09 2018-03-15 Genentech, Inc. Inhibiteurs peptidiques sélectifs de frizzled
WO2018152496A1 (fr) 2017-02-17 2018-08-23 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Compositions et méthodes de diagnostic et de traitement de l'infection par le virus zika
US11236151B2 (en) 2017-04-25 2022-02-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibodies and methods for the diagnosis and treatment of Epstein Barr virus infection
CN111094334A (zh) 2017-07-19 2020-05-01 美国卫生与公众服务部 用于诊断和治疗乙肝病毒感染的抗体和方法
WO2020227554A1 (fr) 2019-05-09 2020-11-12 Genentech, Inc. Procédés de préparation d'anticorps

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691170A (en) * 1989-04-18 1997-11-25 Therion Biologics Generation of hybrid genes and proteins by virus-mediated recombination
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
JPH1066577A (ja) * 1996-08-07 1998-03-10 Novo Nordisk As 核酸プールおよびその製造方法

Also Published As

Publication number Publication date
WO1998020169A1 (fr) 1998-05-14
AU4792897A (en) 1998-05-29
US6984488B1 (en) 2006-01-10
IL119586A0 (en) 1997-02-18
EP1012347A4 (fr) 2005-03-16
EP1012347A1 (fr) 2000-06-28

Similar Documents

Publication Publication Date Title
IL119586A (en) Discontinuous library of a single biological unit and a method for its preparation
US6165722A (en) Representations of bimolecular interactions
RU2136697C1 (ru) Способ получения олигопептидов
Steward et al. Synthetic peptides: a next generation of vaccines?
Jorgensen et al. Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics
Manoutcharian et al. Recombinant bacteriophage-based multiepitope vaccine against Taenia solium pig cysticercosis
KR100851728B1 (ko) 특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는 방법
US20050208628A1 (en) Methods and vectors for generating antibodies in avian species and uses therefor
US6605448B1 (en) Method and means for sorting and identifying biological information
WO2001088162A2 (fr) Procedes et vecteurs destines a generer des anticorps dans des especes aviaires et utilisations
CN102512670A (zh) 化脓链球菌抗原
DE69535360T2 (de) Synthetische peptide und impfstoffe welche diese beinhalten
EP0552267A1 (fr) Bacteriophages modifies par genie genetique et vaccins les contenant.
CN110408637B (zh) 一种草鱼出血病酵母口服疫苗及应用
JP4875497B2 (ja) バクテリオファージナノ粒子を含む方法および組成物
WO1987001374A2 (fr) Procede et moyen de triage et d'identification d'informations biologiques
Lee et al. Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation
Collar et al. Epitope-based vaccines against the chlamydia trachomatis major outer membrane protein variable domain 4 elicit protection in mice
WO2022067062A1 (fr) Développement rapide d'un vaccin prophylactique à large spectre pour le sars-cov-2 à l'aide d'un système d'administration d'antigène à médiation par phage
AU3919993A (en) Delivery and expression of a hybrid surface protein on the surface of gram positive bacteria
EP1238102B1 (fr) Polynucleotides microbiens exprimes durant l'infection d'un hote
WO1992019263A1 (fr) Vaccins intestinaux s'administrant par voie orale et s'utilisant contre des maladies provoquees par des organismes enteropathogenes au moyen d'antigenes capsules dans des microspheres biodegradables et biocompatibles
Ogrina et al. Comparison of bacterial expression systems based on potato virus y-like particles for vaccine generation
WO1995005454A1 (fr) Bacteriophages mis au point par genie genetique et vaccins les contenant
JPH02223594A (ja) ヒトライノウイルスペプチド

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
HC Change of name of proprietor(s)

Owner name: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Free format text: FORMER NAMES:RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH AND INDUSTRIAL;DEVELOPMENT LTD.

MM9K Patent not in force due to non-payment of renewal fees