IL119586A - Discontinuous library of a single biological unit and a method for its preparation - Google Patents

Discontinuous library of a single biological unit and a method for its preparation

Info

Publication number
IL119586A
IL119586A IL11958696A IL11958696A IL119586A IL 119586 A IL119586 A IL 119586A IL 11958696 A IL11958696 A IL 11958696A IL 11958696 A IL11958696 A IL 11958696A IL 119586 A IL119586 A IL 119586A
Authority
IL
Israel
Prior art keywords
fragments
library
discontinuous
organism
genome
Prior art date
Application number
IL11958696A
Other languages
English (en)
Other versions
IL119586A0 (en
Inventor
Jonathan M Gershoni
David Enshel
Original Assignee
Univ Ramot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot filed Critical Univ Ramot
Priority to IL11958696A priority Critical patent/IL119586A/en
Publication of IL119586A0 publication Critical patent/IL119586A0/xx
Priority to EP97910607A priority patent/EP1012347A4/fr
Priority to US09/297,668 priority patent/US6984488B1/en
Priority to AU47928/97A priority patent/AU4792897A/en
Priority to PCT/IL1997/000353 priority patent/WO1998020169A1/fr
Publication of IL119586A publication Critical patent/IL119586A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
IL11958696A 1996-11-07 1996-11-07 Discontinuous library of a single biological unit and a method for its preparation IL119586A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IL11958696A IL119586A (en) 1996-11-07 1996-11-07 Discontinuous library of a single biological unit and a method for its preparation
EP97910607A EP1012347A4 (fr) 1996-11-07 1997-11-04 Definition et gestion d'interactions bimoleculaires
US09/297,668 US6984488B1 (en) 1996-11-07 1997-11-04 Determination and control of bimolecular interactions
AU47928/97A AU4792897A (en) 1996-11-07 1997-11-04 Determination and control of bimolecular interactions
PCT/IL1997/000353 WO1998020169A1 (fr) 1996-11-07 1997-11-04 Definition et gestion d'interactions bimoleculaires

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11958696A IL119586A (en) 1996-11-07 1996-11-07 Discontinuous library of a single biological unit and a method for its preparation

Publications (2)

Publication Number Publication Date
IL119586A0 IL119586A0 (en) 1997-02-18
IL119586A true IL119586A (en) 2001-09-13

Family

ID=11069461

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11958696A IL119586A (en) 1996-11-07 1996-11-07 Discontinuous library of a single biological unit and a method for its preparation

Country Status (5)

Country Link
US (1) US6984488B1 (fr)
EP (1) EP1012347A4 (fr)
AU (1) AU4792897A (fr)
IL (1) IL119586A (fr)
WO (1) WO1998020169A1 (fr)

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CA2334170A1 (fr) 1998-07-27 2000-02-10 Genentech, Inc. Efficacite de transformation amelioree de l'expression a la surface des phages par modification d'une proteine de coque
US20070160576A1 (en) 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
KR100576674B1 (ko) 2001-06-20 2006-05-10 제넨테크, 인크. 종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물
ATE516042T1 (de) 2001-09-18 2011-07-15 Genentech Inc Zusammensetzungen und verfahren zur behandlung und diagnose von tumoren
NZ556415A (en) 2002-01-02 2009-02-28 Genentech Inc Compositions and methods for the diagnosis and treatment of glioma tumor
AU2003230874A1 (en) 2002-04-16 2003-11-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
AU2004259638C1 (en) 2003-07-08 2018-12-20 Novartis Pharma Ag IL-17 A/F heterologous polypeptides and therapeutic uses thereof
US7329725B1 (en) 2003-10-29 2008-02-12 Nastech Pharmaceutical Company Inc. Phage displayed Trp cage ligands
NZ576411A (en) 2003-11-17 2010-04-30 Genentech Inc Compositions and methods for the treatment of tumor of hematopoietic origin
EP2050763A3 (fr) 2005-03-10 2009-07-15 Genentech, Inc. Procédés et compositions de modulation d'intégrité vasculaire
EP2007428A2 (fr) 2006-04-05 2008-12-31 Genentech, Inc. Méthode d'utilisation du boc/cdo pour moduler l'émission des signaux du hedgehog
AU2007284651B2 (en) 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
JPWO2008032833A1 (ja) 2006-09-14 2010-01-28 株式会社医学生物学研究所 Ａｄｃｃ活性を増強させた抗体及びその製造方法
EP2118124A1 (fr) * 2006-12-28 2009-11-18 Saint Louis University Identification des epitopes de proteines d'enveloppe virale multivalents
DK2436781T3 (en) 2007-02-22 2016-01-11 Genentech Inc Methods for the detection of inflammatory bowel disease
EP2319869B1 (fr) 2008-06-20 2016-08-17 National University Corporation Okayama University ANTICORPS CONTRE UN COMPLEXE LDL/ß²GPT OXIDÉ ET SON UTILISATION
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
CN102711826B (zh) 2009-10-22 2017-03-29 霍夫曼-拉罗奇有限公司 用于调控巨噬细胞刺激性蛋白的hepsin活化的方法和组合物
JP5856065B2 (ja) 2009-11-30 2016-02-09 ジェネンテック， インコーポレイテッド 腫瘍の診断と治療のための組成物と方法
CN102985113B (zh) 2010-02-23 2015-05-20 霍夫曼-拉罗奇有限公司 用于肿瘤诊断和治疗的组合物和方法
JP2013533732A (ja) 2010-05-03 2013-08-29 ジェネンテック， インコーポレイテッド 腫瘍の診断と治療のための組成物と方法
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
EP2756300A1 (fr) 2011-09-15 2014-07-23 F.Hoffmann-La Roche Ag Procédés de promotion de la différenciation
CA2850836A1 (fr) 2011-10-15 2013-04-18 Genentech, Inc. Procedes d'utilisation d'antagonistes de scd1
WO2013109856A2 (fr) 2012-01-18 2013-07-25 Genentech, Inc. Procédés d'utilisation de modulateurs fgf19
RU2014133069A (ru) 2012-02-11 2016-04-10 Дженентек, Инк. Транслокации r-спондина и способы с их использованием
RU2014141617A (ru) 2012-03-16 2016-05-10 Дженентек, Инк. Сконструированные конформационно-стабилизированные белки
US9139863B2 (en) 2012-03-16 2015-09-22 Genentech, Inc. Engineered conformationally-stabilized proteins
WO2013135745A1 (fr) 2012-03-16 2013-09-19 F. Hoffmann-La Roche Ag Procédés de traitement d'un mélanome avec des inhibiteurs de pak1
CN106290917B (zh) 2012-04-25 2020-06-05 比奥德赛公司 用于检测蛋白质的变构调节剂的方法
WO2013170191A1 (fr) 2012-05-11 2013-11-14 Genentech, Inc. Procédés d'utilisation d'antagonistes de biosynthèse de nicotinamide adénine dinucléotide à partir de nicotinamide
AU2014235453A1 (en) 2013-03-15 2015-10-08 Genentech, Inc. Biomarkers and methods of treating PD-1 and PD-L1 related conditions
WO2015116902A1 (fr) 2014-01-31 2015-08-06 Genentech, Inc. Récepteurs couplés aux protéines g dans la signalisation hedgehog
CN106661622B (zh) 2014-05-23 2020-08-21 豪夫迈·罗氏有限公司 Mit生物标志物和使用它们的方法
WO2015196070A1 (fr) 2014-06-20 2015-12-23 Genentech, Inc. Compositions d'échafaudage à base de chagasine, procédés et utilisations
WO2016106286A1 (fr) 2014-12-23 2016-06-30 Biodesy, Inc. Fixation de protéines à des interfaces destinées à être utilisées en détection optique non linéaire
CN107787332B (zh) 2015-04-24 2022-09-09 豪夫迈·罗氏有限公司 多特异性抗原结合蛋白
US11421028B2 (en) 2016-02-06 2022-08-23 Epimab Biotherapeutics, Inc. Fabs-in-tandem immunoglobulin and uses thereof
WO2018049275A1 (fr) 2016-09-09 2018-03-15 Genentech, Inc. Inhibiteurs peptidiques sélectifs de frizzled
WO2018152496A1 (fr) 2017-02-17 2018-08-23 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Compositions et méthodes de diagnostic et de traitement de l'infection par le virus zika
WO2018200742A1 (fr) 2017-04-25 2018-11-01 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Anticorps et procédés de diagnostic et de traitement d'infection par le virus d'epstein barr
WO2019018629A1 (fr) 2017-07-19 2019-01-24 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Anticorps et procédés de diagnostic et de traitement d'infection par le virus de l'hépatite b
CN112074541A (zh) 2018-05-03 2020-12-11 上海岸迈生物科技有限公司 Pd-1和lag-3的高亲和力抗体以及由其制备的双特异性结合蛋白
AU2020268399A1 (en) 2019-05-09 2021-10-28 Genentech, Inc. Methods of making antibodies

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US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
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JPH1066577A (ja) * 1996-08-07 1998-03-10 Novo Nordisk As 核酸プールおよびその製造方法

Also Published As

Publication number Publication date
EP1012347A4 (fr) 2005-03-16
WO1998020169A1 (fr) 1998-05-14
AU4792897A (en) 1998-05-29
US6984488B1 (en) 2006-01-10
EP1012347A1 (fr) 2000-06-28
IL119586A0 (en) 1997-02-18

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Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
HC Change of name of proprietor(s)

Owner name: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Free format text: FORMER NAMES:RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH AND INDUSTRIAL;DEVELOPMENT LTD.

MM9K Patent not in force due to non-payment of renewal fees