IL117047A - A method of purifying diacetylarine to obtain diacetylarine-free alu amodine - Google Patents

A method of purifying diacetylarine to obtain diacetylarine-free alu amodine

Info

Publication number
IL117047A
IL117047A IL11704796A IL11704796A IL117047A IL 117047 A IL117047 A IL 117047A IL 11704796 A IL11704796 A IL 11704796A IL 11704796 A IL11704796 A IL 11704796A IL 117047 A IL117047 A IL 117047A
Authority
IL
Israel
Prior art keywords
diacetylrhein
aloe
emodin
hydrolysis
acetone
Prior art date
Application number
IL11704796A
Other languages
English (en)
Hebrew (he)
Other versions
IL117047A0 (en
Original Assignee
Steba Beheer Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4184836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL117047(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Steba Beheer Bv filed Critical Steba Beheer Bv
Publication of IL117047A0 publication Critical patent/IL117047A0/xx
Publication of IL117047A publication Critical patent/IL117047A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL11704796A 1995-02-07 1996-02-06 A method of purifying diacetylarine to obtain diacetylarine-free alu amodine IL117047A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH00342/95A CH689279A5 (fr) 1995-02-07 1995-02-07 Procédé de purification de la diacétylrhéine.

Publications (2)

Publication Number Publication Date
IL117047A0 IL117047A0 (en) 1996-06-18
IL117047A true IL117047A (en) 1998-12-06

Family

ID=4184836

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11704796A IL117047A (en) 1995-02-07 1996-02-06 A method of purifying diacetylarine to obtain diacetylarine-free alu amodine

Country Status (11)

Country Link
US (1) US5756782A (ja)
EP (1) EP0754173B1 (ja)
JP (2) JP3782109B2 (ja)
AT (1) ATE178882T1 (ja)
CA (1) CA2187210C (ja)
CH (1) CH689279A5 (ja)
DE (1) DE69602062T2 (ja)
ES (1) ES2132872T3 (ja)
GR (1) GR3030759T3 (ja)
IL (1) IL117047A (ja)
WO (1) WO1996024572A1 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292132B1 (it) * 1997-06-11 1999-01-25 Synteco S R L Procedimento per la preparazione di diacereina
IT1312309B1 (it) * 1999-05-07 2002-04-15 Synteco Spa Procedimento per la purificazione di diacereina
ITMI20022535A1 (it) * 2002-11-29 2004-05-30 Synteco Spa Procedimento per la purificazione della diacereina.
MXPA03008622A (es) * 2003-09-23 2005-03-30 Interquim S A De C V Metodo de purificacion de diacereina cruda por la via del tolueno.
KR100885677B1 (ko) 2007-05-22 2009-02-25 주식회사 엔지켐 디아세레인의 정제 방법
ITMI20080011A1 (it) * 2008-01-04 2009-07-05 Chimico Internaz S P A Procedimento per la preparazione di diacereina
EP2196450A1 (en) 2008-12-09 2010-06-16 Evultis S.A. Process for the preparation of pure diacetylrhein (diacerein)
US8598232B2 (en) * 2008-12-09 2013-12-03 Evultis Sa Process for the preparation of non-genotoxic diacetylrhein (diacerein) and formulations comprising non-genotoxic diacetylrhein
EP2218707A1 (en) * 2009-02-16 2010-08-18 Evultis S.A. Process for the preparation of non-genotoxic Diacetylrhein (Diacerein)
WO2011099834A2 (es) * 2010-02-15 2011-08-18 Interquim, S.A. De C.V. Procedimiento para la purificación de diacereina cruda vía sal de potasio/dimetil formamida
CN115521205B (zh) * 2022-09-22 2023-11-10 北京百奥药业有限责任公司 双醋瑞因钠盐的晶型及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA761627B (en) * 1976-03-16 1978-01-25 C Friedmann Improvements in or relating to the treatment of arthritis
IT1189097B (it) * 1986-05-02 1988-01-28 Proter Spa Sali di diacetilreina e loro impiego terapeutico nel trattamento dell'artrosi
DE4120989C2 (de) * 1991-06-25 1995-07-27 Madaus Ag Verfahren zur Herstellung von Diacetylrhein
DE4120990C2 (de) * 1991-06-25 1995-07-27 Madaus Ag Verfahren zur Herstellung von Diacetylrhein
US5393898A (en) * 1991-06-25 1995-02-28 Madaus Ag Method of preparing diacetyl rhein
IT1264545B1 (it) * 1993-07-30 1996-10-02 Medidom Lab Procedimento per la preparazione della diacereina

Also Published As

Publication number Publication date
IL117047A0 (en) 1996-06-18
CA2187210C (en) 2007-09-11
DE69602062T2 (de) 1999-12-16
GR3030759T3 (en) 1999-11-30
EP0754173B1 (fr) 1999-04-14
JP3782109B2 (ja) 2006-06-07
JPH09511766A (ja) 1997-11-25
ES2132872T3 (es) 1999-08-16
CA2187210A1 (en) 1996-08-15
CH689279A5 (fr) 1999-01-29
EP0754173A1 (fr) 1997-01-22
JP4104576B2 (ja) 2008-06-18
JP2004244424A (ja) 2004-09-02
DE69602062D1 (de) 1999-05-20
ATE178882T1 (de) 1999-04-15
WO1996024572A1 (fr) 1996-08-15
US5756782A (en) 1998-05-26

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
HP Change in proprietorship
HP Change in proprietorship
HP Change in proprietorship

Owner name: STEBA BIOTECH N.V.

Free format text: FORMER OWNER:LITWEN TRADING LIMITED

KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees