IL115652A - Use of vWF or fragments thereof for the preparation of medicaments having an antidote effect to antithrombotic and/or fibrinolytic agents producing hemorrhages - Google Patents

Use of vWF or fragments thereof for the preparation of medicaments having an antidote effect to antithrombotic and/or fibrinolytic agents producing hemorrhages

Info

Publication number
IL115652A
IL115652A IL11565295A IL11565295A IL115652A IL 115652 A IL115652 A IL 115652A IL 11565295 A IL11565295 A IL 11565295A IL 11565295 A IL11565295 A IL 11565295A IL 115652 A IL115652 A IL 115652A
Authority
IL
Israel
Prior art keywords
hemorrhages
vwf
antithrombotic
medicaments
fragments
Prior art date
Application number
IL11565295A
Other languages
English (en)
Other versions
IL115652A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL115652A0 publication Critical patent/IL115652A0/xx
Publication of IL115652A publication Critical patent/IL115652A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
IL11565295A 1994-10-20 1995-10-18 Use of vWF or fragments thereof for the preparation of medicaments having an antidote effect to antithrombotic and/or fibrinolytic agents producing hemorrhages IL115652A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4437544A DE4437544A1 (de) 1994-10-20 1994-10-20 Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika

Publications (2)

Publication Number Publication Date
IL115652A0 IL115652A0 (en) 1996-01-19
IL115652A true IL115652A (en) 2000-08-31

Family

ID=6531287

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11565295A IL115652A (en) 1994-10-20 1995-10-18 Use of vWF or fragments thereof for the preparation of medicaments having an antidote effect to antithrombotic and/or fibrinolytic agents producing hemorrhages

Country Status (20)

Country Link
US (1) US5571784A (sv)
EP (1) EP0713881A3 (sv)
JP (1) JPH08208504A (sv)
KR (1) KR960013383A (sv)
CN (1) CN1128168A (sv)
AU (1) AU708670B2 (sv)
CA (1) CA2160975A1 (sv)
CZ (1) CZ287878B6 (sv)
DE (1) DE4437544A1 (sv)
FI (1) FI954964A (sv)
HR (1) HRP950525A2 (sv)
HU (1) HU219595B (sv)
IL (1) IL115652A (sv)
NO (1) NO954175L (sv)
NZ (1) NZ280274A (sv)
PL (1) PL183182B1 (sv)
SK (1) SK129695A3 (sv)
TW (1) TW398977B (sv)
UY (1) UY24063A1 (sv)
ZA (1) ZA958838B (sv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5772629A (en) * 1995-10-23 1998-06-30 Localmed, Inc. Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
AT405485B (de) 1997-05-28 1999-08-25 Immuno Ag Eine das vwf-propeptid enthaltende pharmazeutische präparation
AT409335B (de) * 1998-11-10 2002-07-25 Immuno Ag Pharmazeutisches präparat enthaltend einen rezeptor-antagonisten zur behandlung von blutgerinnungsstörungen
US6794412B1 (en) * 1999-03-11 2004-09-21 Bristol-Myers Squibb Pharma Company Treatment of thrombosis by combined use of a factor Xa inhibitor and aspirin
EP1148063A1 (de) * 2000-04-18 2001-10-24 Octapharma AG Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung
JP2003284570A (ja) 2001-04-25 2003-10-07 Chemo Sero Therapeut Res Inst フォンビルブラント因子（ｖＷＦ）切断酵素
DE102008032361A1 (de) 2008-07-10 2010-01-21 Csl Behring Gmbh Der Einsatz von Faktor VIII und vWF bzw. vWF-enthaltenden Konzentraten zur Therapie der durch Thrombocyten-Inhibitoren induzierte Koagulopathie
CN102770449B (zh) * 2010-02-16 2016-02-24 诺沃—诺迪斯克有限公司 具有降低的vwf结合的因子viii分子
EP2796145B1 (en) 2013-04-22 2017-11-01 CSL Ltd. A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
TWI580423B (zh) * 2013-12-24 2017-05-01 財團法人工業技術研究院 緩解或治療痛風之醫藥組合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
US5200510A (en) * 1987-06-16 1993-04-06 Zymogenetics, Inc. Method for purifying factor viii:c, von willebrand factor and complexes thereof
US4774323A (en) * 1987-06-29 1988-09-27 Rorer Pharmaceutical Corporation Purification of von Willebrand Factor solutions using gel permeation chromatography
FR2619314B1 (fr) * 1987-08-11 1990-06-15 Transgene Sa Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
GB8823480D0 (en) * 1988-10-06 1988-11-16 Ciba Geigy Ag Antidote
US5204323B1 (en) 1988-10-06 1995-07-18 Ciba Geigy Corp Hirudin antidotal compositions and methods
FR2673632A1 (fr) * 1991-03-08 1992-09-11 Lille Transfusion Sanguine Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique.
DE4115453A1 (de) * 1991-05-11 1992-11-12 Knoll Ag Neue wirkstoffkombination
US5366869A (en) * 1991-11-08 1994-11-22 Sheldon Goldstein Multiple coagulation test device and method
DE4203965A1 (de) * 1992-02-11 1993-08-12 Max Planck Gesellschaft Antidot fuer hirudin und synthetische thrombininhibitoren
JPH08512291A (ja) * 1993-04-23 1996-12-24 バイオ−テクノロジー・ジェネラル・コーポレーション 血栓溶解の増強方法

Also Published As

Publication number Publication date
HRP950525A2 (en) 1997-04-30
AU3430495A (en) 1996-05-02
PL183182B1 (pl) 2002-06-28
HU219595B (hu) 2001-05-28
IL115652A0 (en) 1996-01-19
EP0713881A2 (de) 1996-05-29
EP0713881A3 (de) 1996-08-21
TW398977B (en) 2000-07-21
CN1128168A (zh) 1996-08-07
NO954175L (no) 1996-04-22
NO954175D0 (no) 1995-10-19
US5571784A (en) 1996-11-05
HUT73762A (en) 1996-09-30
SK129695A3 (en) 1996-10-02
DE4437544A1 (de) 1996-04-25
FI954964A0 (sv) 1995-10-18
FI954964A (sv) 1996-04-21
AU708670B2 (en) 1999-08-12
CZ287878B6 (cs) 2001-03-14
HU9503031D0 (en) 1995-12-28
PL311031A1 (en) 1996-04-29
CA2160975A1 (en) 1996-04-21
UY24063A1 (es) 1995-10-24
CZ271995A3 (en) 1996-05-15
JPH08208504A (ja) 1996-08-13
KR960013383A (ko) 1996-05-22
NZ280274A (en) 1997-01-29
ZA958838B (en) 1996-05-13

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees