IL114866A - Process for the preparation of the (-)-N-methyl-N-[4-(4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]benzamide - Google Patents

Process for the preparation of the (-)-N-methyl-N-[4-(4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]benzamide

Info

Publication number
IL114866A
IL114866A IL11486695A IL11486695A IL114866A IL 114866 A IL114866 A IL 114866A IL 11486695 A IL11486695 A IL 11486695A IL 11486695 A IL11486695 A IL 11486695A IL 114866 A IL114866 A IL 114866A
Authority
IL
Israel
Prior art keywords
preparation
benzamide
dichlorophenyl
phenyl
methyl
Prior art date
Application number
IL11486695A
Other languages
English (en)
Other versions
IL114866A0 (en
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL114866A0 publication Critical patent/IL114866A0/xx
Publication of IL114866A publication Critical patent/IL114866A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11486695A 1994-08-24 1995-08-08 Process for the preparation of the (-)-N-methyl-N-[4-(4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]benzamide IL114866A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/294,035 US5512680A (en) 1993-02-26 1994-08-24 Process for the preparation of an optically pure aminoalcohol

Publications (2)

Publication Number Publication Date
IL114866A0 IL114866A0 (en) 1995-12-08
IL114866A true IL114866A (en) 1999-12-22

Family

ID=23131621

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11486695A IL114866A (en) 1994-08-24 1995-08-08 Process for the preparation of the (-)-N-methyl-N-[4-(4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]benzamide

Country Status (24)

Country Link
US (2) US5512680A (ko)
EP (1) EP0698601B1 (ko)
JP (1) JP3037592B2 (ko)
KR (1) KR100275978B1 (ko)
AT (1) ATE172964T1 (ko)
AU (1) AU685971B2 (ko)
BR (1) BR9503776A (ko)
CA (1) CA2156764C (ko)
CZ (1) CZ289654B6 (ko)
DE (1) DE69505756T2 (ko)
DK (1) DK0698601T3 (ko)
ES (1) ES2125574T3 (ko)
FI (1) FI116221B (ko)
HU (1) HU218485B (ko)
IL (1) IL114866A (ko)
MY (1) MY116365A (ko)
NO (1) NO305167B1 (ko)
NZ (1) NZ272827A (ko)
PL (1) PL182914B1 (ko)
RU (1) RU2097376C1 (ko)
SI (1) SI0698601T1 (ko)
SK (1) SK281454B6 (ko)
TW (1) TW410223B (ko)
ZA (1) ZA957025B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2792835B3 (fr) * 1999-04-27 2001-05-25 Sanofi Sa Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression
WO2007020079A2 (en) * 2005-08-17 2007-02-22 Synthon B.V. Orally disintegratable simvastatin tablets
JP2009191006A (ja) * 2008-02-14 2009-08-27 Sumitomo Chemical Co Ltd 光学活性な４−アミノ−３−（３，４−ジクロロフェニル）ブタン−１−オールの製造方法およびその中間体
EP3322691A4 (en) 2015-07-13 2019-03-27 Piramal Enterprises Limited IMPROVED PROCESS FOR THE PREPARATION OF BACLOFEN AND ITS INTERMEDIATE

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
FR2676054B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
US5391819A (en) * 1992-09-30 1995-02-21 Merck & Co., Inc. Process of making chiral 2-aryl-1,4-butanediamine derivatives as useful neurokinin-A antagonists
FR2701946B1 (fr) * 1993-02-26 1995-05-24 Sanofi Elf Procédé pour la préparation d'un aminoalcool optiquement pur.

Also Published As

Publication number Publication date
DE69505756D1 (de) 1998-12-10
HU218485B (hu) 2000-09-28
FI953994A (fi) 1996-02-25
AU685971B2 (en) 1998-01-29
ATE172964T1 (de) 1998-11-15
MY116365A (en) 2004-01-31
NZ272827A (en) 1997-11-24
EP0698601B1 (en) 1998-11-04
DK0698601T3 (da) 1999-07-19
HUT74184A (en) 1996-11-28
CA2156764C (en) 2006-06-13
US5780666A (en) 1998-07-14
CA2156764A1 (en) 1996-02-25
US5512680A (en) 1996-04-30
BR9503776A (pt) 1996-04-16
NO305167B1 (no) 1999-04-12
TW410223B (en) 2000-11-01
JP3037592B2 (ja) 2000-04-24
EP0698601A1 (en) 1996-02-28
HU9502481D0 (en) 1995-10-30
IL114866A0 (en) 1995-12-08
CZ216495A3 (en) 1996-03-13
JPH08176108A (ja) 1996-07-09
RU2097376C1 (ru) 1997-11-27
AU3021695A (en) 1996-03-07
SK281454B6 (sk) 2001-03-12
ES2125574T3 (es) 1999-03-01
ZA957025B (en) 1996-03-26
FI953994A0 (fi) 1995-08-24
KR100275978B1 (ko) 2000-12-15
FI116221B (fi) 2005-10-14
SI0698601T1 (en) 1999-04-30
SK103095A3 (en) 1996-03-06
CZ289654B6 (cs) 2002-03-13
KR960007562A (ko) 1996-03-22
PL182914B1 (pl) 2002-04-30
PL310155A1 (en) 1996-03-04
NO953313D0 (no) 1995-08-23
DE69505756T2 (de) 1999-05-27
NO953313L (no) 1996-02-26

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IL114866A (en) Process for the preparation of the (-)-N-methyl-N-[4-(4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]benzamide
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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
HC Change of name of proprietor(s)
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees