IL114629A - Intermediates for the preparation of cephalosporins - Google Patents
Intermediates for the preparation of cephalosporinsInfo
- Publication number
- IL114629A IL114629A IL114629A IL11462991A IL114629A IL 114629 A IL114629 A IL 114629A IL 114629 A IL114629 A IL 114629A IL 11462991 A IL11462991 A IL 11462991A IL 114629 A IL114629 A IL 114629A
- Authority
- IL
- Israel
- Prior art keywords
- rnnr
- rnr
- hydrogen atom
- rnsr
- rnor
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052698 phosphorus Inorganic materials 0.000 abstract 4
- 125000004185 ester group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 abstract 1
- 101150065749 Churc1 gene Proteins 0.000 abstract 1
- RSPISYXLHRIGJD-UHFFFAOYSA-N OOOO Chemical compound OOOO RSPISYXLHRIGJD-UHFFFAOYSA-N 0.000 abstract 1
- 102100038239 Protein Churchill Human genes 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9007491A FR2663332B1 (fr) | 1990-06-15 | 1990-06-15 | Nouvelles cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium quaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus. |
| IL9831891A IL98318A (en) | 1990-06-15 | 1991-05-31 | New cephalosporins, method of preparation, preparations containing them and intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL114629A true IL114629A (en) | 1997-06-10 |
Family
ID=9397653
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9831891A IL98318A (en) | 1990-06-15 | 1991-05-31 | New cephalosporins, method of preparation, preparations containing them and intermediates |
| IL114629A IL114629A (en) | 1990-06-15 | 1991-05-31 | Intermediates for the preparation of cephalosporins |
| IL11462995A IL114629A0 (en) | 1990-06-15 | 1995-07-17 | Intermediates for the preparation of cephalosporins |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9831891A IL98318A (en) | 1990-06-15 | 1991-05-31 | New cephalosporins, method of preparation, preparations containing them and intermediates |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11462995A IL114629A0 (en) | 1990-06-15 | 1995-07-17 | Intermediates for the preparation of cephalosporins |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5416080A (es) |
| EP (1) | EP0462009B1 (es) |
| JP (1) | JP3080692B2 (es) |
| KR (1) | KR960009266B1 (es) |
| AT (1) | ATE172733T1 (es) |
| CA (1) | CA2044700A1 (es) |
| CZ (1) | CZ282244B6 (es) |
| DE (1) | DE69130410T2 (es) |
| DK (1) | DK0462009T3 (es) |
| ES (1) | ES2124698T3 (es) |
| FR (1) | FR2663332B1 (es) |
| HU (1) | HUT58101A (es) |
| IE (1) | IE912032A1 (es) |
| IL (3) | IL98318A (es) |
| NZ (1) | NZ238577A (es) |
| PT (1) | PT97971B (es) |
| RU (1) | RU2078085C1 (es) |
| SK (1) | SK280156B6 (es) |
| UA (1) | UA26431A (es) |
| ZA (1) | ZA914457B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5397779A (en) * | 1990-06-15 | 1995-03-14 | Roussel-Uclaf | Cephalosporins |
| US5587372A (en) * | 1991-12-12 | 1996-12-24 | Roussel Uclaf | Cephalosporins |
| ATE196472T1 (de) * | 1991-12-12 | 2000-10-15 | Hoechst Marion Roussel Inc | Antibiotische cephalosporine einen substituierten benzyloxyimino-radikal in position 7 tragend |
| FR2699177A1 (fr) * | 1992-12-11 | 1994-06-17 | Roussel Uclaf | Nouvelles céphalosporines comportant en position 7 un radical oxyimino substitué, leur procédé et intermédiaires de préparation et leur application comme médicaments. |
| EP0628562A1 (fr) * | 1993-06-10 | 1994-12-14 | Roussel Uclaf | Céphalosporines comportant en position 7 un radical oxymino substitué, leurs intermédiaires, leurs procédé de préparation et leur application comme médicaments |
| KR100257130B1 (ko) * | 1993-09-11 | 2000-05-15 | 성재갑 | 신규 세팔로스포린계 항생제 및 이의 제조방법 |
| US7427680B2 (en) * | 2001-01-12 | 2008-09-23 | The Regents Of The University Of California | Fluorogenic substrates for BETA-lactamase gene expression |
| KR0164458B1 (ko) * | 1995-04-04 | 1999-01-15 | 김은영 | 암모니오세팔로스포린 계열 항생제 및 그의 제조방법 |
| FR2737893B1 (fr) * | 1995-08-16 | 1997-09-12 | Roussel Uclaf | Nouvelles cephalosporines comportant en position 7, un radical benzyloxyimino substitue, leur procede et intermediaires de preparation, leur application comme medicaments |
| US5872249A (en) * | 1995-09-01 | 1999-02-16 | Korea Institute Of Science And Technology | 3-ammoniopropenyl cephalosporin compounds as antibacterial agents and process for preparing the same |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| US7214825B2 (en) * | 2003-10-17 | 2007-05-08 | Honeywell International Inc. | O-(3-chloropropenyl) hydroxylamine free base |
| EP1706403B9 (en) | 2003-12-22 | 2012-07-25 | K.U.Leuven Research & Development | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment |
| SI1841765T1 (sl) | 2004-12-21 | 2009-08-31 | Gilead Sciences Inc | Imidazo(4,5-c)piridinska spojina in postopek za antivirusno zdravljenje |
| TW200637559A (en) * | 2005-03-29 | 2006-11-01 | Shionogi & Co | 3-propenylcefem derivative |
| MX2009000235A (es) | 2006-07-07 | 2009-01-23 | Gilead Sciences Inc | Compuesto de piridazina novedoso y uso del mismo. |
| UA99466C2 (en) | 2007-07-06 | 2012-08-27 | Гилиад Сайенсиз, Инк. | Crystalline pyridazine compound |
| CN114805394A (zh) * | 2022-05-27 | 2022-07-29 | 山东普洛得邦医药有限公司 | 一种头孢克肟的合成方法 |
| CN115260213A (zh) * | 2022-05-27 | 2022-11-01 | 山东普洛得邦医药有限公司 | 一种头孢地尼的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4486586A (en) * | 1983-02-10 | 1984-12-04 | Bristol-Myers Company | Cephalosporin derivatives |
| CA1276929C (en) * | 1984-04-09 | 1990-11-27 | Masahisa Oka | Cephalosporin antibacterial agents |
| US4840945A (en) * | 1985-04-01 | 1989-06-20 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
| DE3650157T2 (de) * | 1985-12-26 | 1995-05-04 | Eisai Co Ltd | Cephalosporin-verbindungen. |
| GB8623211D0 (en) * | 1986-09-26 | 1986-10-29 | Glaxo Group Ltd | Chemical compounds |
| IL84128A (en) * | 1986-10-13 | 1992-12-01 | Eisai Co Ltd | 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them |
| FR2622585B1 (fr) * | 1987-11-03 | 1991-04-19 | Roussel Uclaf | Nouvelles cephalosporines comportant en position 3 un radical vinyle substitue, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus |
| ATE155469T1 (de) * | 1988-03-16 | 1997-08-15 | Eisai Co Ltd | Verfahren zur herstellung von cephemderivaten |
| US5373001A (en) * | 1990-06-15 | 1994-12-13 | Roussel Uclaf | Cephalosporins |
-
1990
- 1990-06-15 FR FR9007491A patent/FR2663332B1/fr not_active Expired - Fee Related
-
1991
- 1991-05-31 IL IL9831891A patent/IL98318A/en active IP Right Grant
- 1991-05-31 IL IL114629A patent/IL114629A/xx active IP Right Grant
- 1991-06-11 ZA ZA914457A patent/ZA914457B/xx unknown
- 1991-06-13 JP JP03167421A patent/JP3080692B2/ja not_active Expired - Fee Related
- 1991-06-13 ES ES91401570T patent/ES2124698T3/es not_active Expired - Lifetime
- 1991-06-13 DK DK91401570T patent/DK0462009T3/da active
- 1991-06-13 AT AT91401570T patent/ATE172733T1/de not_active IP Right Cessation
- 1991-06-13 EP EP91401570A patent/EP0462009B1/fr not_active Expired - Lifetime
- 1991-06-13 DE DE69130410T patent/DE69130410T2/de not_active Expired - Fee Related
- 1991-06-14 CZ CS911830A patent/CZ282244B6/cs unknown
- 1991-06-14 KR KR1019910010030A patent/KR960009266B1/ko not_active IP Right Cessation
- 1991-06-14 IE IE203291A patent/IE912032A1/en not_active IP Right Cessation
- 1991-06-14 PT PT97971A patent/PT97971B/pt not_active IP Right Cessation
- 1991-06-14 SK SK1830-91A patent/SK280156B6/sk unknown
- 1991-06-14 HU HU911985A patent/HUT58101A/hu unknown
- 1991-06-14 CA CA002044700A patent/CA2044700A1/fr not_active Abandoned
- 1991-06-14 UA UA5052193A patent/UA26431A/uk unknown
- 1991-06-17 NZ NZ238577A patent/NZ238577A/en unknown
-
1992
- 1992-08-03 RU SU925052193A patent/RU2078085C1/ru active
-
1993
- 1993-06-21 US US08/080,572 patent/US5416080A/en not_active Expired - Fee Related
-
1995
- 1995-07-17 IL IL11462995A patent/IL114629A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69130410T2 (de) | 1999-04-22 |
| DK0462009T3 (da) | 1999-07-05 |
| JP3080692B2 (ja) | 2000-08-28 |
| IL98318A0 (en) | 1992-06-21 |
| ES2124698T3 (es) | 1999-02-16 |
| ATE172733T1 (de) | 1998-11-15 |
| DE69130410D1 (de) | 1998-12-03 |
| AU643289B2 (en) | 1993-11-11 |
| KR920000766A (ko) | 1992-01-29 |
| AU7837091A (en) | 1991-12-19 |
| CZ282244B6 (cs) | 1997-06-11 |
| CA2044700A1 (fr) | 1991-12-16 |
| JPH04230289A (ja) | 1992-08-19 |
| PT97971B (pt) | 1998-11-30 |
| ZA914457B (en) | 1992-08-26 |
| US5416080A (en) | 1995-05-16 |
| IL114629A0 (en) | 1995-11-27 |
| KR960009266B1 (ko) | 1996-07-16 |
| RU2078085C1 (ru) | 1997-04-27 |
| HU911985D0 (en) | 1991-12-30 |
| EP0462009A1 (fr) | 1991-12-18 |
| FR2663332B1 (fr) | 1997-11-07 |
| FR2663332A1 (fr) | 1991-12-20 |
| PT97971A (pt) | 1992-03-31 |
| CS183091A3 (en) | 1992-10-14 |
| SK280156B6 (sk) | 1999-09-10 |
| NZ238577A (en) | 1992-04-28 |
| HUT58101A (en) | 1992-01-28 |
| EP0462009B1 (fr) | 1998-10-28 |
| IL98318A (en) | 1996-01-31 |
| IE912032A1 (en) | 1991-12-18 |
| UA26431A (uk) | 1999-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| HCE | Change of name and address of proprietor(s) |